Joy Wolfram

Joy Wolfram, PhD

Assistant Affiliate Member, Research Institute
Houston Methodist


j.wolfram@uq.edu.au
Biography

Dr. Joy Wolfram holds an Associate Professor position at the University of Queensland in Australia. She also holds an affiliate faculty position in the Department of Nanomedicine at the Houston Methodist in Texas. She received her bachelors and masters degrees in biology from the University of Helsinki in Finland. In 2016, she completed her Ph.D. in Nanoscience and Technology at the University of Chinese Academy of Sciences in Beijing, China. 

She has authored over 60 publications and received more than 30 scientific awards from seven different countries. She was included in the Amgen Scholars Ten to Watch List, which highlights the best and brightest up-and-comers in science and medicine across 42 countries. She has developed several nanoparticles for the treatment of various diseases, including cancer. Her goal is to bring new nanomedicines with increased therapeutic efficacy and safety to the clinic. Her mission is also to inspire and support underrepresented minorities in science. She is actively involved in community outreach and scientific education.

Description of Research

The focus of Dr. Wolfram's research is on the development of synthetic and biological nanotherapeutics for the treatment of life-threatening diseases, such as cancer and tissue injury.

Areas Of Expertise

Nanomedicine Cancer Extracellular vesicles Tissue injury
Education & Training

PhD, University of Chinese Academy of Sciences
MS, University of Helsinki
BS, University of Helsinki
Publications

High-throughput analysis of glycan sorting into extracellular vesicles
Pendiuk Goncalves, J, Cruz Villarreal, J, Walker, SA, Tan, XNS, Borges, C & Wolfram, J 2024, , Biochimica et Biophysica Acta - Molecular Cell Research, vol. 1871, no. 2, 119641, pp. 119641. https://doi.org/10.1016/j.bbamcr.2023.119641

Minimal information for studies of extracellular vesicles (MISEV2023): From basic to advanced approaches
MISEV Consortium 2024, , Journal of Extracellular Vesicles, vol. 13, no. 2, e12404. https://doi.org/10.1002/jev2.12404

Extracellular Vesicle and Lipoprotein Interactions
Ghebosu, RE, Pendiuk Goncalves, J & Wolfram, J 2024, , Nano Letters, vol. 24, no. 1, pp. 1-8. https://doi.org/10.1021/acs.nanolett.3c03579

Extracellular vesicle lipids in cancer immunoevasion
Chen, S, Iannotta, D, OMara, ML, Goncalves, JP & Wolfram, J 2023, , Trends in Cancer, vol. 9, no. 11, pp. 883-886. https://doi.org/10.1016/j.trecan.2023.08.006

Vasculature organotropism in drug delivery
Amruta, A, Iannotta, D, Cheetham, SW, Lammers, T & Wolfram, J 2023, , Advanced Drug Delivery Reviews, vol. 201, 115054, pp. 115054. https://doi.org/10.1016/j.addr.2023.115054

Hyaluronic acid: An overlooked extracellular vesicle contaminant
Goncalves, JP, Ghebosu, RE, Tan, XNS, Iannotta, D, Koifman, N & Wolfram, J 2023, , Journal of Extracellular Vesicles, vol. 12, no. 9, 12362. https://doi.org/10.1002/jev2.12362

Glycan Node Analysis Detects Varying Glycosaminoglycan Levels in Melanoma-Derived Extracellular Vesicles
Pendiuk Goncalves, J, Walker, SA, Aguilar Díaz de león, JS, Yang, Y, Davidovich, I, Busatto, S, Sarkaria, J, Talmon, Y, Borges, CR & Wolfram, J 2023, , International journal of molecular sciences, vol. 24, no. 10, 8506. https://doi.org/10.3390/ijms24108506

Diabetic kidney disease induces transcriptome alterations associated with angiogenesis activity in human mesenchymal stromal cells
Bian, X, Conley, SM, Eirin, A, Zimmerman Zuckerman, EA, Smith, AL, Gowan, CC, Snow, ZK, Jarmi, T, Farres, H, Erben, YM, Hakaim, AG, Dietz, MA, Zubair, AC, Wyles, SP, Wolfram, JV, Lerman, LO & Hickson, LTJ 2023, , Stem Cell Research and Therapy, vol. 14, no. 1, 49. https://doi.org/10.1186/s13287-023-03269-9

Unraveling multilayered extracellular vesicles: Speculation on cause
Broad, K, Walker, SA, Davidovich, I, Witwer, K, Talmon, Y & Wolfram, J 2023, , Journal of Extracellular Vesicles, vol. 12, no. 2, e12309, pp. e12309. https://doi.org/10.1002/jev2.12309

Clinical Translation of Extracellular Vesicles
Ghodasara, A, Raza, A, Wolfram, J, Salomon, C & Popat, A 2023, , Advanced Healthcare Materials, vol. 12, no. 28, 2301010, pp. e2301010. https://doi.org/10.1002/adhm.202301010

Reconstituted Extracellular Vesicles from Human Platelets Decrease Viral Myocarditis in Mice
Beetler, DJ, Bruno, KA, Watkins, MM, Xu, V, Chekuri, I, Giresi, P, Di Florio, DN, Whelan, ER, Edenfield, BH, Walker, SA, Morales-Lara, AC, Hill, AR, Jain, A, Auda, ME, Macomb, LP, Shapiro, KA, Keegan, KC, Wolfram, J, Behfar, A, Stalboerger, PG, Terzic, A, Farres, H, Cooper, LT & Fairweather, DL 2023, , Small, vol. 19, no. 49, 2303317. https://doi.org/10.1002/smll.202303317

Transforming undergraduate laboratory courses with interlinked real-world challenges
Iannotta, D, Goncalves, JP, Ghebosu, RE, Gopalakrishnan, A, Cooper-White, J & Wolfram, J 2024, , Trends in Biotechnology, vol. 42, no. 1, pp. 1-4. https://doi.org/10.1016/j.tibtech.2023.10.006

Chemically-Induced Lipoprotein Breakdown for Improved Extracellular Vesicle Purification
Iannotta, D, Amruta, A, Lai, A, Nair, S, Koifman, N, Lappas, M, Salomon, C & Wolfram, J 2024, , Small, vol. 20, no. 18, 2307240. https://doi.org/10.1002/smll.202307240

Entry and exit of extracellular vesicles to and from the blood circulation
Iannotta, D, A, A, Kijas, AW, Rowan, AE & Wolfram, J 2024, , Nature Nanotechnology, vol. 19, no. 1, pp. 13-20. https://doi.org/10.1038/s41565-023-01522-z

Extracellular vesicles as personalized medicine
Beetler, DJ, Di Florio, DN, Bruno, KA, Ikezu, T, March, KL, Cooper, LT, Wolfram, J & Fairweather, DL 2023, , Molecular Aspects of Medicine, vol. 91, 101155. https://doi.org/10.1016/j.mam.2022.101155

The cancer cell-derived extracellular vesicle glycocode in immunoevasion
Goncalves, JP, Deliwala, VJ, Kolarich, D, Souza-Fonseca-Guimaraes, F & Wolfram, J 2022, , Trends in Immunology, vol. 43, no. 11, pp. 864-867. https://doi.org/10.1016/j.it.2022.09.004

Extracellular vesicle glucose transporter-1 and glycan features in monocyte-endothelial inflammatory interactions
Yang, M, Walker, SA, Aguilar Díaz de león, JS, Davidovich, I, Broad, K, Talmon, Y, Borges, CR & Wolfram, J 2022, , Nanomedicine: Nanotechnology, Biology, and Medicine, vol. 42, 102515, pp. 102515. https://doi.org/10.1016/j.nano.2022.102515

Considerations for extracellular vesicle and lipoprotein interactions in cell culture assays
Busatto, S, Yang, Y, Iannotta, D, Davidovich, I, Talmon, Y & Wolfram, J 2022, , Journal of Extracellular Vesicles, vol. 11, no. 4, e12202, pp. e12202. https://doi.org/10.1002/jev2.12202

Patients as biomedical researchers
Liskey, D, Cynkin, L & Wolfram, J 2022, , Trends in Molecular Medicine, vol. 28, no. 12, pp. 1022-1024. https://doi.org/10.1016/j.molmed.2022.09.002

Injectable Drug Delivery Systems for Osteoarthritis and Rheumatoid Arthritis
Bruno, MC, Cristiano, MC, Celia, C, DAvanzo, N, Mancuso, A, Paolino, D, Wolfram, J & Fresta, M 2022, , ACS Nano, vol. 16, no. 12, pp. 19665-19690. https://doi.org/10.1021/acsnano.2c06393