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Joy Mitra, PhD

Instructor, Academic Institute
Instructor, Research Institute
Houston Methodist


Publications

TDP43 interacts with MLH1 and MSH6 proteins in a DNA damage-inducible manner
Provasek, VE, Kodavati, M, Kim, B, Mitra, J & Hegde, ML 2024, , Molecular Brain, vol. 17, no. 1, 32. https://doi.org/10.1186/s13041-024-01108-3

FUS unveiled in mitochondrial DNA repair and targeted ligase-1 expression rescues repair-defects in FUS-linked motor neuron disease
Kodavati, M, Wang, H, Guo, W, Mitra, J, Hegde, PM, Provasek, V, Rao, VHM, Vedula, I, Zhang, A, Mitra, S, Tomkinson, AE, Hamilton, DJ, Van Den Bosch, L & Hegde, ML 2024, , Nature Communications, vol. 15, no. 1, 2156. https://doi.org/10.1038/s41467-024-45978-6

Human DNA polymerase ? promotes RNA-templated error-free repair of DNA double-strand breaks
Chakraborty, A, Tapryal, N, Islam, A, Sarker, AH, Manohar, K, Mitra, J, Hegde, ML & Hazra, T 2023, , Journal of Biological Chemistry, vol. 299, no. 3, 102991. https://doi.org/10.1016/j.jbc.2023.102991

Mitochondrial DNA damage-repair defects in mutant FUS-linked motor neuron diseases and its mitigation via targeted expression of DNA Ligase I
Wang, H, Kodavati, M, Guo, W, Mitra, J, Zhang, A, Mitra, S, Tomkinson, AE, Hamilton, DJ, Van Den Bosch, L & Hegde, M 2022, , 7th US-EU Conference on Endogenous DNA Damage and Repair, Newyork, United States, 11/6/22 - 11/9/22.

SARS-CoV-2 and the central nervous system: Emerging insights into hemorrhage-associated neurological consequences and therapeutic considerations
Mitra, J, Kodavati, M, Provasek, VE, Rao, KS, Mitra, S, Hamilton, DJ, Horner, PJ, Vahidy, FS, Britz, GW, Kent, TA & Hegde, ML 2022, , Ageing Research Reviews, vol. 80, 101687. https://doi.org/10.1016/j.arr.2022.101687

Editorial: Defective DNA damage response–Repair axis in post-mitotic neurons in human health and neurodegenerative diseases
Konopka, A, Atkin, JD & Mitra, J 2022, , Frontiers in Cellular Neuroscience, vol. 16, 1009760. https://doi.org/10.3389/fncel.2022.1009760

DNA Double-Strand Breaks as Pathogenic Lesions in Neurological Disorders
Provasek, VE, Mitra, J, Malojirao, VH & Hegde, ML 2022, , International journal of molecular sciences, vol. 23, no. 9, 4653. https://doi.org/10.3390/ijms23094653

Heritable pattern of oxidized DNA base repair coincides with pre-targeting of repair complexes to open chromatin
Bacolla, A, Sengupta, S, Ye, Z, Yang, C, Mitra, J, De-Paula, RB, Hegde, ML, Ahmed, Z, Mort, M, Cooper, DN, Mitra, S & Tainer, JA 2021, , Nucleic Acids Research, vol. 49, no. 1, pp. 221-243. https://doi.org/10.1093/nar/gkaa1120

The Chemical Basis of Intracerebral Hemorrhage and Cell Toxicity With Contributions From Eryptosis and Ferroptosis
Derry, PJ, Vo, ATT, Gnanansekaran, A, Mitra, J, Liopo, AV, Hegde, ML, Tsai, AL, Tour, JM & Kent, TA 2020, , Frontiers in Cellular Neuroscience, vol. 14, 603043. https://doi.org/10.3389/fncel.2020.603043

Deficiency in classical nonhomologous end-joining-mediated repair of transcribed genes is linked to SCA3 pathogenesis
Chakraborty, A, Tapryal, N, Venkova, T, Mitra, J, Vasquez, V, Sarker, AH, Duarte-Silva, S, Huai, W, Ashizawa, T, Ghosh, G, MacIel, P, Sarkar, PS, Hegde, ML, Chen, X & Hazra, TK 2020, , Proceedings of the National Academy of Sciences of the United States of America, vol. 117, no. 14, pp. 8154-8165. https://doi.org/10.1073/pnas.1917280117

A multi-faceted genotoxic network of alpha-synuclein in the nucleus and mitochondria of dopaminergic neurons in Parkinson's disease: Emerging concepts and challenges
Vasquez, V, Mitra, J, Wang, H, Hegde, PM, Rao, KS & Hegde, ML 2020, , Progress in Neurobiology, vol. 185, 101729, pp. 101729. https://doi.org/10.1016/j.pneurobio.2019.101729

Pervasive Genomic Damage in Experimental Intracerebral Hemorrhage: Therapeutic Potential of a Mechanistic-Based Carbon Nanoparticle
Dharmalingam, P, Talakatta, G, Mitra, J, Wang, H, Derry, PJ, Nilewski, LG, McHugh, E, Fabian, RH, Mendoza, K, Vasquez, V, Hegde, PM, Kakadiaris, E, Roy, T, Boldogh, I, Hegde, VL, Mitra, S, Tour, JM, Kent, TA & Hegde, M 2020, , ACS Nano.

Loss of endosomal recycling factor RAB11 coupled with complex regulation of MAPK/ERK/AKT signaling in postmortem spinal cord specimens of sporadic amyotrophic lateral sclerosis patients
Mitra, J, Hegde, PM & Hegde, ML 2019, , Molecular Brain, vol. 12, no. 1, 55. https://doi.org/10.1186/s13041-019-0475-y

Mutant FUS causes DNA ligation defects to inhibit oxidative damage repair in Amyotrophic Lateral Sclerosis
Wang, H, Guo, W, Mitra, J, Hegde, PM, Vandoorne, T, Eckelmann, BJ, Mitra, S, Tomkinson, AE, Bosch, LVD & Hegde, M 2018, , Nature Communications, vol. 9, no. 3683.

An Inducible Alpha-Synuclein Expressing Neuronal Cell Line Model for Parkinson's Disease1
Vasquez, V, Mitra, J, Perry, G, Rao, KS & Hegde, ML 2018, , Journal of Alzheimers Disease, vol. 66, no. 2, pp. 453-460. https://doi.org/10.3233/JAD-180610

Tissue specific expression and in-silico characterization of a putative cysteine synthase gene from Lathyrus sativus L.
Chakraborty, S, Mitra, J, Samanta, MK, Sikdar, N, Bhattacharyya, J, Manna, A, Pradhan, S, Chakraborty, A & Pati, BR 2018, , Gene Expression Patterns, vol. 27, pp. 128-134. https://doi.org/10.1016/j.gep.2017.12.001

Heterocyclic Analogs of Sulforaphane Trigger DNA Damage and Impede DNA Repair in Colon Cancer Cells: Interplay of HATs and HDACs
Okonkwo, A, Mitra, J, Johnson, GS, Li, L, Dashwood, WM, Hegde, ML, Yue, C, Dashwood, RH & Rajendran, P 2018, , Molecular Nutrition and Food Research, vol. 62, no. 18, 1800228. https://doi.org/10.1002/mnfr.201800228

An Overview of Human Immunodeficiency Virus Type 1-Associated Common Neurological Complications: Does Aging Pose a Challenge?
Nookala, AR, Mitra, J, Chaudhari, NS, Hegde, ML & Kumar, A 2017, , Journal of Alzheimers Disease, vol. 60, no. s1, pp. S169-S193. https://doi.org/10.3233/JAD-170473

Marker-free transgenic rice expressing the vegetative insecticidal protein (Vip) of Bacillus thuringiensis shows broad insecticidal properties
Pradhan, S, Chakraborty, A, Sikdar, N, Chakraborty, S, Bhattacharyya, J, Mitra, J, Manna, A, Dutta Gupta, S & Sen, SK 2016, , Planta, vol. 244, no. 4, pp. 789-804. https://doi.org/10.1007/s00425-016-2535-1

TDP-43/FUS in motor neuron disease: Complexity and challenges
Guerrero, EN, Wang, H, Mitra, J, Hegde, PM, Stowell, SE, Liachko, NF, Kraemer, BC, Garruto, RM & Hegde, M 2016, , Progress in Neurobiology.

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