Joseph C. Masdeu, MD, PhD

Graham Family Distinguished Chair for Neurological Sciences, Stanley H. Appel Department of Neurology
Professor of Neurology, Academic Institute
Full Member, Research Institute
Director, Nantz National Alzheimer Center
Houston Methodist
Weill Cornell Medical College


Research Lab


Biography

Dr. Masdeu trained in Psychiatry at the University of Valencia in Spain and in Neurology at Mt. Sinai Hospital in Chicago. He then served as a Fellow in Neuropathology at Peter Bent Brigham Hospital at Harvard Medical School. He was an Assistant and Associate Professor of Neurology at the Albert Einstein School of Medicine in New York, and has served as a Professor and Chair of Neurology at New York Medical College. Dr. Masdeu became a Professor and Chair of Neurology and Neuroscience at the University of Navarre Medical School in Pamplona, Spain. From 2008-2014, Dr. Masdeu was a senior staff physician and scientist in the Section of Integrative Neuroimaging of the Clinical Brain Disorders Branch at the National Institutes of Health. He is chairman of the Neuroimaging Research Group of the World Federation of Neurology. He has been a director of the American Academy of Neurology and president of the American Society of Neuroimaging. Since 2007, he has been Editor-in-Chief of the Journal of Neuroimaging. He is the author of 144 peer-reviewed papers, 62 book chapters, and seven books, including Localization in Clinical Neurology, a standard in the field, now in its 6th edition. Dr. Masdeu joined the Houston Methodist Research Institute in 2014. 

Description of Research

Dr. Masdeu’s main areas of research have been the following:

-Clarifying the neurobiology of Alzheimer’s disease and other neurodegenerative disorders
-Using spontaneous lesion models and/or imaging to map the localization of function in the human brain
-Developing novel neuroimaging signs and implementing neuroimaging as a biomarker of neurological disease

Areas Of Expertise

Alzheimer’s disease Brain lesions Neuroimaging Psychoses Beta-amyloid
Education & Training

Postdoctoral Fellowship, Brigham and Women's Hospital
PhD, Facultad de Medicina de la Universidad de Navarra, Pamplona
Publications

Imaging Neuroinflammation in Neurodegenerative Disorders
Masdeu, JC, Pascual, B & Fujita, M 2022, , Journal of nuclear medicine : official publication, Society of Nuclear Medicine, vol. 63, no. Suppl 1, pp. 45S-52S. https://doi.org/10.2967/jnumed.121.263200

Imaging Neuroinflammation in Neurodegenerative Disorders
Masdeu, JC, Pascual, B & Fujita, M 2022, , Journal of nuclear medicine : official publication, Society of Nuclear Medicine, vol. 63, pp. 45S-52S. https://doi.org/10.2967/jnumed.121.263200

Comprehensive cross-sectional and longitudinal analyses of plasma neurofilament light across FTD spectrum disorders
ALLFTD consortium 2022, , Cell Reports Medicine, vol. 3, no. 4, 100607. https://doi.org/10.1016/j.xcrm.2022.100607

Comprehensive cross-sectional and longitudinal analyses of plasma neurofilament light across FTD spectrum disorders
ALLFTD consortium 2022, , Cell Reports Medicine, vol. 3, no. 4, pp. 100607. https://doi.org/10.1016/j.xcrm.2022.100607

Translocator Protein 18 kDa PET Imaging Highlights Asymptomatic Isolated Cerebellar Dysplasia
Pascual, B, Hodics, T, Funk, Q, Cykowski, MD, Nakawah, MO & Masdeu, JC 2022, , Neurology, vol. 98, no. 13, pp. 538-539. https://doi.org/10.1212/WNL.0000000000200221

Proposed research criteria for prodromal behavioural variant frontotemporal dementia
ALLFTD consortium 2022, , Brain, vol. 145, no. 3, pp. 1079-1097. https://doi.org/10.1093/brain/awab365

The PET tracer [11C]MK-6884 quantifies M4 muscarinic receptor in rhesus monkeys and patients with Alzheimer's disease
Li, W, Wang, Y, Lohith, TG, Zeng, Z, Tong, L, Mazzola, R, Riffel, K, Miller, P, Purcell, M, Holahan, M, Haley, H, Gantert, L, Hesk, D, Ren, S, Morrow, J, Uslaner, J, Struyk, A, Wai, JMC, Rudd, MT, Tellers, DM, McAvoy, T, Bormans, G, Koole, M, Van Laere, K, Serdons, K, De Hoon, J, Declercq, R, De Lepeleire, I, Pascual, MB, Zanotti Fregonara, P, Yu, M, Arbones, V, Masdeu, JC, Cheng, A, Hussain, A, Bueters, T, Anderson, MS, Hostetler, ED & Basile, AS 2022, , Science translational medicine, vol. 14, no. 627, eabg3684, pp. eabg3684. https://doi.org/10.1126/scitranslmed.abg3684

The PET tracer [11C]MK-6884 quantifies M4 muscarinic receptor in rhesus monkeys and patients with Alzheimer's disease
Li, W, Wang, Y, Lohith, TG, Zeng, Z, Tong, L, Mazzola, R, Riffel, K, Miller, P, Purcell, M, Holahan, M, Haley, H, Gantert, L, Hesk, D, Ren, S, Morrow, J, Uslaner, J, Struyk, A, Wai, JMC, Rudd, MT, Tellers, DM, McAvoy, T, Bormans, G, Koole, M, Van Laere, K, Serdons, K, De Hoon, J, Declercq, R, De Lepeleire, I, Pascual, MB, Zanotti Fregonara, P, Yu, M, Arbones, V, Masdeu, JC, Cheng, A, Hussain, A, Bueters, T, Anderson, MS, Hostetler, ED & Basile, AS 2022, , Science translational medicine, vol. 14, no. 627, eabg3684. https://doi.org/10.1126/scitranslmed.abg3684

The PET tracer [11C]MK-6884 quantifies M4 muscarinic receptor in rhesus monkeys and patients with Alzheimer's disease
Li, W, Wang, Y, Lohith, TG, Zeng, Z, Tong, L, Mazzola, R, Riffel, K, Miller, P, Purcell, M, Holahan, M, Haley, H, Gantert, L, Hesk, D, Ren, S, Morrow, J, Uslaner, J, Struyk, A, Wai, JMC, Rudd, MT, Tellers, DM, McAvoy, T, Bormans, G, Koole, M, Van Laere, K, Serdons, K, De Hoon, J, Declercq, R, De Lepeleire, I, Pascual, MB, Zanotti-Fregonara, P, Yu, M, Arbones, V, Masdeu, JC, Cheng, A, Hussain, A, Bueters, T, Anderson, MS, Hostetler, ED & Basile, AS 2022, , Science translational medicine, vol. 14, no. 627, eabg3684. https://doi.org/10.1126/scitranslmed.abg3684

Alterations in brain synaptic proteins and mRNAs in mood disorders: a systematic review and meta-analysis of postmortem brain studies
Leung, E, Lau, EW, Liang, A, de Dios, C, Suchting, R, Östlundh, L, Masdeu, JC, Fujita, M, Sanches, M, Soares, JC & Selvaraj, S 2022, , Molecular Psychiatry, vol. 27, no. 3, pp. 1362-1372. https://doi.org/10.1038/s41380-021-01410-9

Patterns of amygdala region pathology in LATE-NC: subtypes that differ with regard to TDP-43 histopathology, genetic risk factors, and comorbid pathologies
Cykowski, MD, Arumanayagam, AS, Powell, SZ, Rivera, AL, Abner, EL, Roman, GC, Masdeu, JC & Nelson, PT 2022, , Acta Neuropathologica, vol. 143, no. 5, pp. 531-545. https://doi.org/10.1007/s00401-022-02416-5

Higher CSF sTNFR1-related proteins associate with better prognosis in very early Alzheimer’s disease
Alzheimers Disease Neuroimaging Initiative 2021, , Nature Communications, vol. 12, no. 1, 4001. https://doi.org/10.1038/s41467-021-24220-7

Plasma phosphorylated-tau181 as a predictive biomarker for Alzheimer’s amyloid, tau and FDG PET status
Alzheimers Disease Neuroimaging Initiative 2021, , Translational Psychiatry, vol. 11, no. 1, 585. https://doi.org/10.1038/s41398-021-01709-9

Staging tau pathology with tau PET in Alzheimer’s disease: a longitudinal study
for the Alzheimer’s Disease Neuroimaging Initiative 2021, , Translational Psychiatry, vol. 11, no. 1, 483. https://doi.org/10.1038/s41398-021-01602-5

SARS-CoV-2 Susceptibility and COVID-19 Mortality Among Older Adults With Cognitive Impairment: Cross-Sectional Analysis From Hospital Records in a Diverse US Metropolitan Area
Pan, AP, Meeks, J, Potter, T, Masdeu, JC, Seshadri, S, Smith, ML, Ory, MG & Vahidy, FS 2021, , Frontiers in Neurology, vol. 12, 692662, pp. 692662. https://doi.org/10.3389/fneur.2021.692662

Neuroinflammation is highest in areas of disease progression in semantic dementia
Pascual, B, Funk, Q, Zanotti Fregonara, P, Cykowski, MD, Veronese, M, Rockers, E, Bradbury, K, Yu, M, Nakawah, MO, Román, GC, Schulz, PE, Arumanayagam, AS, Beers, D, Faridar, A, Fujita, M, Appel, SH & Masdeu, JC 2021, , Brain, vol. 144, no. 5, pp. 1565-1575. https://doi.org/10.1093/brain/awab057

Neuroinflammation is highest in areas of disease progression in semantic dementia
Pascual, B, Funk, Q, Zanotti-Fregonara, P, Cykowski, MD, Veronese, M, Rockers, E, Bradbury, K, Yu, M, Nakawah, MO, Román, GC, Schulz, PE, Arumanayagam, AS, Beers, D, Faridar, A, Fujita, M, Appel, SH & Masdeu, JC 2021, , Brain, vol. 144, no. 5, pp. 1565-1575. https://doi.org/10.1093/brain/awab057

Parametric Mapping for TSPO PET Imaging with Spectral Analysis Impulsive Response Function
Veronese, M, Tuosto, M, Marques, TR, Howes, O, Pascual, B, Yu, M, Masdeu, JC, Turkheimer, F, Bertoldo, A & Zanotti-Fregonara, P 2021, , Molecular Imaging and Biology, vol. 23, no. 4, pp. 560-571. https://doi.org/10.1007/s11307-020-01575-9

Polymorphism in the ZNF804A Gene and Variation in D1 and D2/D3 Dopamine Receptor Availability in the Healthy Human Brain: A Dual Positron Emission Tomography Study
Hegarty, CE, Ianni, AM, Kohn, PD, Kolachana, B, Gregory, M, Masdeu, JC, Eisenberg, DP & Berman, KF 2021, , Biological Psychiatry: Cognitive Neuroscience and Neuroimaging. https://doi.org/10.1016/j.bpsc.2020.12.006

The Longitudinal Early-onset Alzheimer's Disease Study (LEADS): Framework and methodology
the LEADS Consortium 2021, , Alzheimers and Dementia, vol. 17, no. 12, pp. 2043-2055. https://doi.org/10.1002/alz.12350