Joseph C. Masdeu, MD, PhD

Graham Family Distinguished Chair for Neurological Sciences, Stanley H. Appel Department of Neurology
Professor of Neurology, Academic Institute
Full Member, Research Institute
Director, Nantz National Alzheimer Center
Houston Methodist
Weill Cornell Medical College

Research Lab


Dr. Masdeu trained in Psychiatry at the University of Valencia in Spain and in Neurology at Mt. Sinai Hospital in Chicago. He then served as a Fellow in Neuropathology at Peter Bent Brigham Hospital at Harvard Medical School. He was an Assistant and Associate Professor of Neurology at the Albert Einstein School of Medicine in New York, and has served as a Professor and Chair of Neurology at New York Medical College. Dr. Masdeu became a Professor and Chair of Neurology and Neuroscience at the University of Navarre Medical School in Pamplona, Spain. From 2008-2014, Dr. Masdeu was a senior staff physician and scientist in the Section of Integrative Neuroimaging of the Clinical Brain Disorders Branch at the National Institutes of Health. He is chairman of the Neuroimaging Research Group of the World Federation of Neurology. He has been a director of the American Academy of Neurology and president of the American Society of Neuroimaging. Since 2007, he has been Editor-in-Chief of the Journal of Neuroimaging. He is the author of 144 peer-reviewed papers, 62 book chapters, and seven books, including Localization in Clinical Neurology, a standard in the field, now in its 6th edition. Dr. Masdeu joined the Houston Methodist Research Institute in 2014. 

Description of Research

Dr. Masdeu’s main areas of research have been the following:

-Clarifying the neurobiology of Alzheimer’s disease and other neurodegenerative disorders
-Using spontaneous lesion models and/or imaging to map the localization of function in the human brain
-Developing novel neuroimaging signs and implementing neuroimaging as a biomarker of neurological disease

Areas Of Expertise

Alzheimer’s disease Brain lesions Neuroimaging Psychoses Beta-amyloid
Education & Training

Postdoctoral Fellowship, Brigham and Women's Hospital
PhD, Facultad de Medicina de la Universidad de Navarra, Pamplona

Longitudinal Positron Emission Tomography of Dopamine Synthesis in Subjects with GBA1 Mutations
Lopez, G, Eisenberg, DP, Gregory, MD, Ianni, AM, Grogans, SE, Masdeu, JC, Kim, J, Groden, C, Sidransky, E & Berman, KF 2020, Annals of Neurology, vol. 87, no. 4, pp. 652-657.

A 70-Year Old Man with Dystonic and Choreiform Movements
Perez, A, Roman, GC, Powell, SZ-E, Fisher, R, Rivera, AL, Masdeu, JC & Cykowski, MD 2020, Brain Pathology, vol. 30, no. 2, pp. 415-416.

Posterior primary progressive prosopagnosia: Structural and molecular imaging
Pascual, B, Masdeu, JC, Funk, Q, Zanotti-Fregonara, P, Shyer, M, Rockers, E & Schulz, PE 2020, Neurology, vol. 94, no. 8, pp. 360-361.

Neuroimaging of Diseases Causing Dementia
Masdeu, JC 2020, Neurologic Clinics, vol. 38, no. 1, pp. 65-94.

Multimodal 18F-AV-1451 and MRI findings in nonfluent variant of primary progressive aphasia: Possible insights on nodal propagation of tau protein across the syntactic network
Pascual, B, Funk, Q, Zanotti-Fregonara, P, Pal, N, Rockers, E, Yu, MM, Spann, B, Román, GC, Schulz, PE, Karmonik, C, Appel, SH & Masdeu, JC 2020, Journal of Nuclear Medicine, vol. 61, no. 2, pp. 263-269.

Medicare for All?
Masdeu, JC 2020, Annals of Neurology, vol. 87, no. 1, pp. 155-156.

Anatomy of 18F-GE180, a failed radioligand for the TSPO protein
Zanotti-Fregonara, P, Pascual, B, Rostomily, RC, Rizzo, G, Veronese, M, Masdeu, JC & Turkheimer, F 2020, European Journal of Nuclear Medicine and Molecular Imaging.

Positron Emission Tomography Imaging with [18F]flortaucipir and Postmortem Assessment of Alzheimer Disease Neuropathologic Changes
Fleisher, AS, Pontecorvo, MJ, Devous, MD, Lu, M, Arora, AK, Truocchio, SP, Aldea, P, Flitter, M, Locascio, T, Devine, M, Siderowf, A, Beach, TG, Montine, TJ, Serrano, GE, Curtis, C, Perrin, A, Salloway, S, Daniel, M, Wellman, C, Joshi, AD, Irwin, DJ, Lowe, VJ, Seeley, WW, Ikonomovic, MD, Masdeu, JC, Kennedy, I, Harris, T, Navitsky, M, Southekal, S & Mintun, MA 2020, JAMA Neurology.

End of life: Expert care and support, not physician-hastened death
Masdeu, JC, Aksamit, AJ, Carver, AC, Foley, KM, Kass, JS, Martin, RA, McCusker, EA, McQuillen, MP, Mehanna, R, Payne, R, Victor, SJ & Warach, S 2019, Neurology, vol. 93, no. 17, pp. 729-734.

Head-to-head comparison of 11C-PBR28 and 11C-ER176 for quantification of the translocator protein in the human brain
Zanotti Fregonara, P, Pascual, MB, Veronese, M, Yu, MM, Beers, D, Appel, SH & Masdeu, JC 2019, European Journal of Nuclear Medicine and Molecular Imaging, vol. 46, no. 9, pp. 1822-1829.

Education Research: Neuroradiology curriculum in neurology residency training programs: How we teach neuroimaging
Johnson, PD, Sillau, S, Masdeu, JC, Ney, DE & Korb, PJ 2019, Neurology, vol. 92, no. 4, pp. 199-203.

“Ears of the lynx” MRI sign is associated with SPG11 and SPG15 hereditary spastic paraplegia
Pascual, MB, De Bot, ST, Daniels, MR, França, MC, Toro, C, Riverol, M, Hedera, P, Bassi, MT, Bresolin, N, Van De Warrenburg, BP, Kremer, B, Nicolai, J, Charles, P, Xu, J, Singh, S, Patronas, NJ, Fung, SH, Gregory, MD & Masdeu, JC 2019, American Journal of Neuroradiology, vol. 40, no. 1, pp. 199-203.

The validity of 18F-GE180 as a TSPO imaging agent
Zanotti Fregonara, P, Veronese, M, Pascual, MB, Rostomily, RC, Turkheimer, F & Masdeu, JC 2019, European Journal of Nuclear Medicine and Molecular Imaging.

Letter to the Editor re: Confirmation of Specific Binding of the 18-kDa Translocator Protein (TSPO) Radioligand [18F]GE-180: a Blocking Study Using XBD173 in Multiple Sclerosis Normal Appearing White and Grey Matter
Zanotti Fregonara, P, Veronese, M, Rizzo, G, Pascual, MB, Masdeu, JC & Turkheimer, FE 2019, Molecular Imaging and Biology.

Functional alterations of myeloid cells during the course of Alzheimer's disease
Thome, AD, Faridar, A, Beers, DR, Thonhoff, JR, Zhao, W, Wen, S, Pascual, B, Masdeu, JC & Appel, SH 2018, Molecular Neurodegeneration, vol. 13, no. 1, pp. 61.

Clinical findings in a multicenter MRI study of mild TBI
Shetty, T, Nguyen, JT, Cogsil, T, Tsiouris, AJ, Niogi, SN, Kim, EU, Dalal, A, Halvorsen, K, Cummings, K, Zhang, T, Masdeu, JC, Mukherjee, P & Marinelli, L 2018, Frontiers in Neurology, vol. 9, no. OCT, 836.

Reader response: The neurologic exam: Is it extinct?
Masdeu, JC 2018, Neurology, vol. 91, no. 7.

Head-to-head comparison of 11C-PBR28 and 18F-GE180 for quantification of the translocator protein in the human brain
Zanotti Fregonara, P, Pascual, MB, Rizzo, G, Yu, MM, Pal, N, Beers, D, Carter, R, Appel, SH, Atassi, N & Masdeu, JC 2018, Journal of Nuclear Medicine, vol. 59, no. 8, pp. 1260-1266.

Longitudinal resting state functional connectivity predicts clinical outcome in mild traumatic brain injury
Madhavan, R, Joel, SE, Mullick, R, Cogsil, T, Niogi, S, Tsiouris, AJ, Mukherjee, P, Masdeu, JC, Marinelli, L & Shetty, T 2018, Journal of Neurotrauma.

A biomarker combining imaging and neuropsychological assessment for tracking early Alzheimer’s disease in clinical trials
Alzheimers Disease Neuroimaging Initiative 2018, Current Alzheimer Research, vol. 15, no. 5, pp. 429-442.

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