Joseph C. Masdeu, MD, PhD

Graham Family Distinguished Chair for Neurological Sciences, Stanley H. Appel Department of Neurology
Professor of Neurology, Institute for Academic Medicine
Full Member, Research Institute
Director, Nantz National Alzheimer Center
Houston Methodist
Weill Cornell Medical College


Research Lab


Biography

Dr. Masdeu trained in Psychiatry at the University of Valencia in Spain and in Neurology at Mt. Sinai Hospital in Chicago. He then served as a Fellow in Neuropathology at Peter Bent Brigham Hospital at Harvard Medical School. He was an Assistant and Associate Professor of Neurology at the Albert Einstein School of Medicine in New York, and has served as a Professor and Chair of Neurology at New York Medical College. Dr. Masdeu became a Professor and Chair of Neurology and Neuroscience at the University of Navarre Medical School in Pamplona, Spain. From 2008-2014, Dr. Masdeu was a senior staff physician and scientist in the Section of Integrative Neuroimaging of the Clinical Brain Disorders Branch at the National Institutes of Health. He is chairman of the Neuroimaging Research Group of the World Federation of Neurology. He has been a director of the American Academy of Neurology and president of the American Society of Neuroimaging. Since 2007, he has been Editor-in-Chief of the Journal of Neuroimaging. He is the author of 144 peer-reviewed papers, 62 book chapters, and seven books, including Localization in Clinical Neurology, a standard in the field, now in its 6th edition. Dr. Masdeu joined the Houston Methodist Research Institute in 2014. 

Description of Research

Dr. Masdeu’s main areas of research have been the following:

-Clarifying the neurobiology of Alzheimer’s disease and other neurodegenerative disorders
-Using spontaneous lesion models and/or imaging to map the localization of function in the human brain
-Developing novel neuroimaging signs and implementing neuroimaging as a biomarker of neurological disease

Areas Of Expertise

Alzheimer’s disease Brain lesions Neuroimaging Psychoses Beta-amyloid
Education & Training

Postdoctoral Fellowship, Brigham and Women's Hospital
PhD, Facultad de Medicina de la Universidad de Navarra, Pamplona
Publications

Education Research: Neuroradiology curriculum in neurology residency training programs: How we teach neuroimaging
Johnson, PD, Sillau, S, Masdeu, JC, Ney, DE & Korb, PJ 2019, Neurology, vol. 92, no. 4, pp. 199-203. https://doi.org/10.1212/WNL.0000000000006812

“Ears of the lynx” MRI sign is associated with SPG11 and SPG15 hereditary spastic paraplegia
Pascual, MB, De Bot, ST, Daniels, MR, França, MC, Toro, C, Riverol, M, Hedera, P, Bassi, MT, Bresolin, N, Van De Warrenburg, BP, Kremer, B, Nicolai, J, Charles, P, Xu, J, Singh, S, Patronas, NJ, Fung, SH, Gregory, MD & Masdeu, JC 2019, American Journal of Neuroradiology, vol. 40, no. 1, pp. 199-203. https://doi.org/10.3174/ajnr.A5935

The validity of 18F-GE180 as a TSPO imaging agent
Zanotti Fregonara, P, Veronese, M, Pascual, MB, Rostomily, RC, Turkheimer, F & Masdeu, JC 2019, European Journal of Nuclear Medicine and Molecular Imaging. https://doi.org/10.1007/s00259-019-4268-4

Head-to-head comparison of 11C-PBR28 and 11C-ER176 for quantification of the translocator protein in the human brain
Zanotti Fregonara, P, Pascual, MB, Veronese, M, Yu, MM, Beers, D, Appel, SH & Masdeu, JC 2019, European Journal of Nuclear Medicine and Molecular Imaging. https://doi.org/10.1007/s00259-019-04349-w

Functional alterations of myeloid cells during the course of Alzheimer's disease
Thome, AD, Faridar, A, Beers, DR, Thonhoff, JR, Zhao, W, Wen, S, Pascual, B, Masdeu, JC & Appel, SH 2018, Molecular Neurodegeneration, vol. 13, no. 1, pp. 61. https://doi.org/10.1186/s13024-018-0293-1

Clinical findings in a multicenter MRI study of mild TBI
Shetty, T, Nguyen, JT, Cogsil, T, Tsiouris, AJ, Niogi, SN, Kim, EU, Dalal, A, Halvorsen, K, Cummings, K, Zhang, T, Masdeu, JC, Mukherjee, P & Marinelli, L 2018, Frontiers in Neurology, vol. 9, no. OCT, 836. https://doi.org/10.3389/fneur.2018.00836

Reader response: The neurologic exam: Is it extinct?
Masdeu, JC 2018, Neurology, vol. 91, no. 7. https://doi.org/10.1212/WNL.0000000000005990

Head-to-head comparison of 11C-PBR28 and 18F-GE180 for quantification of the translocator protein in the human brain
Zanotti-Fregonara, P, Pascual, B, Rizzo, G, Yu, M, Pal, N, Beers, D, Carter, R, Appel, SH, Atassi, N & Masdeu, JC 2018, Journal of Nuclear Medicine, vol. 59, no. 8, pp. 1260-1266. https://doi.org/10.2967/jnumed.117.203109

Longitudinal resting state functional connectivity predicts clinical outcome in mild traumatic brain injury
Madhavan, R, Joel, SE, Mullick, R, Cogsil, T, Niogi, S, Tsiouris, AJ, Mukherjee, P, Masdeu, JC, Marinelli, L & Shetty, T 2018, Journal of Neurotrauma. https://doi.org/10.1089/neu.2018.5739

A biomarker combining imaging and neuropsychological assessment for tracking early Alzheimer’s disease in clinical trials
Alzheimers Disease Neuroimaging Initiative 2018, Current Alzheimer Research, vol. 15, no. 5, pp. 429-442. https://doi.org/10.2174/1567205014666171106150309

BDNF Val66Met polymorphism tunes frontolimbic circuitry during affective contextual learning
Jabbi, M, Cropp, B, Nash, T, Kohn, P, Kippenhan, JS, Masdeu, JC, Mattay, R, Kolachana, B & Berman, KF 2017, NeuroImage, vol. 162, pp. 373-383. https://doi.org/10.1016/j.neuroimage.2017.08.080

Letter re: High hypothetical interest in physician-assisted death in multiple sclerosis
Masdeu, JC 2017, Neurology, vol. 89, no. 13. https://doi.org/10.1212/WNL.0000000000004431

Shuffling off this mortal coil
Masdeu, JC 2017, Economist (United Kingdom), vol. 413, no. 9037.

Tau and Cortical Thickness in Alzheimer Disease
Masdeu, JC 2017, JAMA Neurology, vol. 74, no. 4, pp. 390-392. https://doi.org/10.1001/jamaneurol.2016.5701

Detecting synaptic autoantibodies in psychoses: need for more sensitive methods
Masdeu, JC 2017, Current Opinion in Neurology. https://doi.org/10.1097/WCO.0000000000000447

Future Directions in Imaging Neurodegeneration
Masdeu, JC 2017, Current neurology and neuroscience reports, vol. 17, no. 1, pp. 9. https://doi.org/10.1007/s11910-017-0718-1

Brain CT and MRI: differential diagnosis of imaging findings
Masdeu, JC, Gadhia, RR & Faridar, A 2016, . in JC Masdeu & RG González (eds), Handbook of Clinical Neurology. vol. 136, Handbook of Clinical Neurology, vol. 136, Elsevier B.V. Handbook of clinical neurology, pp. 1037-1054. https://doi.org/10.1016/B978-0-444-53486-6.00054-5

Assisted suicide is wrong
Masdeu, JC 2016, Economist (United Kingdom), vol. 412, no. 9001.

NMDA Receptor Internalization by Autoantibodies: A Reversible Mechanism Underlying Psychosis?
Masdeu, JC, Dalmau, J & Berman, KF 2016, Trends in Neurosciences, vol. 39, no. 5, pp. 300-310. https://doi.org/10.1016/j.tins.2016.02.006

Common Variation in the DOPA Decarboxylase (DDC) Gene and Human Striatal DDC Activity In Vivo
Eisenberg, DP, Kohn, PD, Hegarty, CE, Ianni, AM, Kolachana, B, Gregory, MD, Masdeu, JC & Berman, KF 2016, Neuropsychopharmacology. https://doi.org/10.1038/npp.2016.31

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