John J. Mahmarian, MD

Professor of Cardiology, Institute for Academic Medicine
Full Clinical Member, Research Institute
Houston Methodist
Weill Cornell Medical College


Biography

Dr. Mahmarian received his first faculty appointment in 1987 as an Instructor of Medicine at the Baylor College of Medicine in Houston, Texas. He quickly established himself as a leader in nuclear cardiology research and was promoted to full Professor in 2005 just prior to joining the Houston Methodist Specialty Physician Group and the faculty of the Weill Medical College of Cornell University.

Description of Research

Dr. Mahmarian´s early research efforts focused on quantification of ischemia as measured by SPECT sestimibi, thereby laying the groundwork for the use of this technique in international trials of ischemia. His current research is focused on combining the results of CT acquired coronary angiography with SPECT results (fusion imaging), as well as testing new agents for pharmacologic stress testing and imaging modalities (e.g. "hot spot" imaging).

Areas Of Expertise

CT Imaging Nuclear cardiology Ischemia SPECT Stress testing
Education & Training

Residency, Baylor College of Medicine
Clinical Fellowship, Baylor College of Medicine
MD, New York Medical College
Publications

Single Photon Emission Computed Tomography (SPECT) Myocardial Perfusion Imaging Guidelines: Instrumentation, Acquisition, Processing, and Interpretation
Dorbala, S, Ananthasubramaniam, K, Armstrong, IS, Chareonthaitawee, P, DePuey, EG, Einstein, AJ, Gropler, RJ, Holly, TA, Mahmarian, JJ, Park, MA, Polk, DM, Russell, R, Slomka, PJ, Thompson, RC & Wells, RG 2018, Journal of Nuclear Cardiology, pp. 1-63. DOI: 10.1007/s12350-018-1283-y

Nuclear cardiology practices and radiation exposure in Africa: Results from the IAEA Nuclear Cardiology Protocols Study (INCAPS)
Bouyoucef, SE, Mercuri, M, Pascual, TNB, Allam, AH, Vangu, M, Vitola, JV, Better, N, Karthikeyan, G, Mahmarian, J, Rehani, MM, Kashyap, R, Dondi, M, Paez, D, Einstein, AJ, Einstein, AJ, Pascual, TNB, Paez, D, Dondi, M, Better, N, Bouyoucef, SE, Karthikeyan, G, Kashyap, R, Lele, V, Magboo, VPC, Mercuri, M, Mut, F, Rehani, MM, Vitola, JV, Alexánderson, E, Allam, A, Al-Mallah, MH, Better, N, Bouyoucef, SE, Bom, H, Flotats, A, Jerome, S, Kaufmann, PA, Lele, V, Luxenburg, O, Shaw, LJ, Underwood, SR, Vitola, J, Amouri, W, Essabbah, H, Gassama, SS, Makhdomi, KB, El Mustapha, GIE, El Ouchdi, N, Qaïs, N, Soni, N & INCAPS investigators group 2017, Cardiovascular Journal of Africa, vol. 28, no. 4, pp. 229-234. DOI: 10.5830/CVJA-2016-091

Regadenoson stress during low-level exercise: The EXERRT trial—does it move the needle?
Mahmarian, JJ 2017, Journal of Nuclear Cardiology, pp. 1-6. DOI: 10.1007/s12350-017-0873-4

Nuclear Cardiology Practice in Asia: Analysis of Radiation Exposure and Best Practice for Myocardial Perfusion Imaging - Results From the IAEA Nuclear Cardiology Protocols Cross-Sectional Study (INCAPS)
Pascual, TNB, Mercuri, M, El-Haj, N, Bom, HH-S, Lele, V, Al-Mallah, MH, Luxenburg, O, Karthikeyan, G, Vitola, J, Mahmarian, JJ, Better, N, Shaw, LJ, Rehani, MM, Kashyap, R, Paez, D, Dondi, M, Einstein, AJ & INCAPS Investigators Group 2017, Circulation Journal, vol. 81, no. 4, pp. 501-510. DOI: 10.1253/circj.CJ-16-0677

Coronary artery calcium score as a predictor for incident stroke: Systematic review and meta-analysis
Chaikriangkrai, K, Jhun, HY, Palamaner Subash Shantha, G, Bin Abdulhak, A, Sigurdsson, G, Nabi, F, Mahmarian, JJ & Chang, SM 2017, International Journal of Cardiology. DOI: 10.1016/j.ijcard.2017.01.132

Prognostic Value of Coronary Artery Calcium Score in Acute Chest Pain Patients Without Known Coronary Artery Disease: Systematic Review and Meta-analysis
Chaikriangkrai, K, Palamaner Subash Shantha, G, Jhun, HY, Ungprasert, P, Sigurdsson, G, Nabi, F, Mahmarian, JJ & Chang, SM 2016, Annals of Emergency Medicine, vol. 68, no. 6, pp. 659-670. DOI: 10.1016/j.annemergmed.2016.07.020

CMR First-Pass Perfusion for Suspected Inducible Myocardial Ischemia
Hendel, RC, Friedrich, MG, Schulz-Menger, J, Zemmrich, C, Bengel, F, Berman, DS, Camici, PG, Flamm, SD, Le Guludec, D, Kim, R, Lombardi, M, Mahmarian, J, Sechtem, U & Nagel, E 2016, JACC: Cardiovascular Imaging, vol. 9, no. 11, pp. 1338-1348. DOI: 10.1016/j.jcmg.2016.09.010

Nuclear cardiology practice and associated radiation doses in Europe: results of the IAEA Nuclear Cardiology Protocols Study (INCAPS) for the 27 European countries
Lindner, O, Pascual, TNB, Mercuri, M, Acampa, W, Burchert, W, Flotats, A, Kaufmann, PA, Kitsiou, A, Knuuti, J, Underwood, SR, Vitola, JV, Mahmarian, JJ, Karthikeyan, G, Better, N, Rehani, MM, Kashyap, R, Dondi, M, Paez, D & Einstein, AJ 2016, European Journal of Nuclear Medicine and Molecular Imaging, vol. 43, no. 4, pp. 718-728. DOI: 10.1007/s00259-015-3270-8

Gender Differences in Radiation Dose from Nuclear Cardiology Studies Across the World Findings from the INCAPS Registry
INCAPS Investigators Group 2016, JACC: Cardiovascular Imaging, vol. 9, no. 4, pp. 376-384. DOI: 10.1016/j.jcmg.2016.01.001

Optimizing evaluation of patients with low-to-intermediate-risk acute chest pain: A randomized study comparing stress myocardial perfusion tomography incorporating stress-only imaging versus cardiac CT
Nabi, F, Kassi, M, Muhyieddeen, K, Chang, SM, Xu, J, Peterson, L, Wray, N, Shirkey, B, Ashton, C & Mahmarian, J 2016, Journal of Nuclear Medicine, vol. 57, no. 3, pp. 378-384. DOI: 10.2967/jnumed.115.166595

Nuclear Cardiology Practices and Radiation Exposure in the Oceania Region: Results From the IAEA Nuclear Cardiology Protocols Study (INCAPS)
Biswas, S, Better, N, Pascual, TNB, Mercuri, M, Vitola, JV, Karthikeyan, G, Westcott, J, Alexánderson, E, Allam, AH, Al-Mallah, MH, Bom, HHS, Bouyoucef, SE, Flotats, A, Jerome, S, Kaufman, PA, Lele, V, Luxenburg, O, Mahmarian, JJ, Shaw, LJ, Underwood, SR, Rehani, M, Kashyap, R, Dondi, M, Paez, D & Einstein, AJ 2017, Heart Lung and Circulation, vol. 26, no. 1, pp. 25–34. DOI: 10.1016/j.hlc.2016.05.112

Clinical Utility of Multidetector Computed Tomography in Redo Valve Procedures
Chaikriangkrai, K, Maragiannis, D, Belousova, T, Little, S, Nabi, F, Mahmarian, J & Chang, SM 2016, Journal of Cardiac Surgery, pp. 139-46. DOI: 10.1111/jocs.12694

Additive prognostic value of coronary artery calcium score and renal function in patients with acute chest pain without known coronary artery disease: up to 5-year follow-up
Chaikriangkrai, K, Nabi, F, Mahmarian, JJ & Chang, SM 2015, International Journal of Cardiovascular Imaging, vol. 31, no. 8, pp. 1619-1626. DOI: 10.1007/s10554-015-0732-9

Prevalence and implications of subclinical coronary artery disease in patients with atrial fibrillation
Chaikriangkrai, K, Valderrabano, M, Bala, SK, Alchalabi, S, Graviss, EA, Nabi, F, Mahmarian, J & Chang, SM 2015, American Journal of Cardiology, vol. 116, no. 8, pp. 1219-1223. DOI: 10.1016/j.amjcard.2015.07.041

Abstract 491: Detection of Subclinical Coronary Artery Disease by Calcium Score in Patients With Atrial Fibrillation: Potential Clinical Implications
Chaikriangkrai, K, Valderrabano, M, Khaleel Bala, S, Alchalabi, S, Graviss, E, Nabi, F, Mahmarian, J & Chang, SM 2015, Arteriosclerosis, thrombosis, and vascular biology, vol. 35, no. Suppl 1, pp. A491.

ImageGuide™ Update
Tilkemeier, PL, Mahmarian, JJ, Wolinsky, DG & Denton, EA 2015, Journal of Nuclear Cardiology, vol. 22, no. 5, pp. 994-997. DOI: 10.1007/s12350-015-0217-1

Current worldwide nuclear cardiology practices and radiation exposure: results from the 65 country IAEA Nuclear Cardiology Protocols Cross-Sectional Study (INCAPS)
Einstein, AJ, Pascual, TNB, Mercuri, M, Karthikeyan, G, Vitola, JV, Mahmarian, JJ, Better, N, Bouyoucef, SE, Hee-Seung Bom, H, Lele, V, Magboo, VPC, Alexánderson, E, Allam, AH, Al-Mallah, MH, Flotats, A, Jerome, S, Kaufmann, PA, Luxenburg, O, Shaw, LJ, Underwood, SR, Rehani, MM, Kashyap, R, Paez, D, Dondi, M & INCAPS Investigators Group 2015, European Heart Journal, vol. 36, no. 26, pp. 1689-96. DOI: 10.1093/eurheartj/ehv117

Value of CACS compared with ETT and myocardial perfusion imaging for predicting long-term cardiac outcome in asymptomatic and symptomatic patients at low risk for coronary disease: Clinical implications in a multimodality imaging world
Chang, SM, Nabi, F, Xu, J, Pratt, CM, Mahmarian, AC, Frias, ME & Mahmarian, JJ 2015, JACC: Cardiovascular Imaging, vol. 8, no. 2, pp. 134-144. DOI: 10.1016/j.jcmg.2014.11.008

Nuclear cardiology: 2014 innovations and developments
Mahmarian, JJ, Chang, S & Nabi, F 2015, Methodist DeBakey Cardiovascular Journal, vol. 10, no. 3, pp. 163-71. DOI: 10.14797/mdcj-10-3-163

Current worldwide nuclear cardiology practices andradiationexposure: Results from the 65country IAEA nuclear cardiology protocols cross-sectional study (INCAPS)
Einstein, AJ, Pascual, TB, Mercuri, M, Karthikeyan, G, Vitola, JV, Mahmarian, JJ, Better, N, Bouyoucef, SE, Bom, HS, Lele, V, Magboo, VPC, Alexánderson, E, Allam, AH, Al-Mallah, MH, Flotats, A, Jerome, S, Kaufmann, PA, Luxenburg, O, Shaw, LJ, Richard Underwood, S, Rehani, MM, Kashyap, R, Paez, D & Dondi, M 2015, European Heart Journal, vol. 36, no. 26, pp. 1689-1696. DOI: 10.1093/eurheartj/ehv117s