John J. Mahmarian, MD

Professor of Cardiology, Academic Institute
Full Clinical Member, Research Institute
Houston Methodist
Weill Cornell Medical College


Dr. Mahmarian received his first faculty appointment in 1987 as an Instructor of Medicine at the Baylor College of Medicine in Houston, Texas. He quickly established himself as a leader in nuclear cardiology research and was promoted to full Professor in 2005 just prior to joining the Houston Methodist Specialty Physician Group and the faculty of the Weill Medical College of Cornell University.

Description of Research

Dr. Mahmarian´s early research efforts focused on quantification of ischemia as measured by SPECT sestimibi, thereby laying the groundwork for the use of this technique in international trials of ischemia. His current research is focused on combining the results of CT acquired coronary angiography with SPECT results (fusion imaging), as well as testing new agents for pharmacologic stress testing and imaging modalities (e.g. "hot spot" imaging).

Areas Of Expertise

CT Imaging Nuclear cardiology Ischemia SPECT Stress testing
Education & Training

Residency, Baylor College of Medicine
Clinical Fellowship, Baylor College of Medicine
MD, New York Medical College

Vulnerable Atherosclerotic Plaque Imaging by Small-Molecule High-Affinity Positron Emission Tomography Radiopharmaceutical
Yang, Z, Li, F, Yelamanchili, D, Zeng, Z, Rosales, C, Youker, KA, Shen, H, Ferrari, M, Mahmarian, J, Pownall, HJ, Hamilton, DJ & Li, Z 2019, advanced therapeutics, vol. 2, no. 8.

Controversies in Diagnostic Imaging of Patients With Suspected Stable and Acute Chest Pain Syndromes
Shaw, LJ, Blankstein, R, Brown, DL, Dhruva, SS, Douglas, PS, Genders, TSS, Gibbons, RJ, Greenwood, JP, Kwong, R, Leipsic, J, Mahmarian, JJ, Maron, D, Nagel, E, Nicol, E, Nieman, K, Pellikka, PA, Redberg, RF, Weir-McCall, J, Williams, MC & Chandrasekhar, Y 2019, JACC: Cardiovascular Imaging, vol. 12, no. 7, pp. 1254-1278.

Reduction in radiation exposure in cardiovascular computed tomography imaging: Results from the PROspective multicenter registry on radiaTion dose Estimates of cardiac CT angIOgraphy in daily practice in 2017 (PROTECTION VI)
PROTECTION VI investigator 2018, European heart journal, vol. 39, no. 41, pp. 3715-3723.

Imaging to Stratify Coronary Artery Disease Risk in Asymptomatic Patients with Diabetes
Malahfji, M & Mahmarian, JJ 2018, Methodist DeBakey cardiovascular journal, vol. 14, no. 4, pp. 266-272.

Single Photon Emission Computed Tomography (SPECT) Myocardial Perfusion Imaging Guidelines: Instrumentation, Acquisition, Processing, and Interpretation
Dorbala, S, Ananthasubramaniam, K, Armstrong, IS, Chareonthaitawee, P, DePuey, EG, Einstein, AJ, Gropler, RJ, Holly, TA, Mahmarian, JJ, Park, MA, Polk, DM, Russell, R, Slomka, PJ, Thompson, RC & Wells, RG 2018, Journal of Nuclear Cardiology, pp. 1-63.

Nuclear cardiology practices and radiation exposure in Africa: Results from the IAEA Nuclear Cardiology Protocols Study (INCAPS)
Bouyoucef, SE, Mercuri, M, Pascual, TNB, Allam, AH, Vangu, M, Vitola, JV, Better, N, Karthikeyan, G, Mahmarian, J, Rehani, MM, Kashyap, R, Dondi, M, Paez, D, Einstein, AJ, Einstein, AJ, Pascual, TNB, Paez, D, Dondi, M, Better, N, Bouyoucef, SE, Karthikeyan, G, Kashyap, R, Lele, V, Magboo, VPC, Mercuri, M, Mut, F, Rehani, MM, Vitola, JV, Alexánderson, E, Allam, A, Al-Mallah, MH, Better, N, Bouyoucef, SE, Bom, H, Flotats, A, Jerome, S, Kaufmann, PA, Lele, V, Luxenburg, O, Shaw, LJ, Underwood, SR, Vitola, J, Amouri, W, Essabbah, H, Gassama, SS, Makhdomi, KB, El Mustapha, GIE, El Ouchdi, N, Qaïs, N, Soni, N & INCAPS Investigators Group 2017, Cardiovascular Journal of Africa, vol. 28, no. 4, pp. 229-234.

Regadenoson stress during low-level exercise: The EXERRT trial—does it move the needle?
Mahmarian, JJ 2017, Journal of Nuclear Cardiology, pp. 1-6.

Nuclear Cardiology Practice in Asia: Analysis of Radiation Exposure and Best Practice for Myocardial Perfusion Imaging - Results From the IAEA Nuclear Cardiology Protocols Cross-Sectional Study (INCAPS)
Pascual, TNB, Mercuri, M, El-Haj, N, Bom, HH-S, Lele, V, Al-Mallah, MH, Luxenburg, O, Karthikeyan, G, Vitola, J, Mahmarian, JJ, Better, N, Shaw, LJ, Rehani, MM, Kashyap, R, Paez, D, Dondi, M, Einstein, AJ & INCAPS Investigators Group 2017, Circulation Journal, vol. 81, no. 4, pp. 501-510.

Coronary artery calcium score as a predictor for incident stroke: Systematic review and meta-analysis
Chaikriangkrai, K, Jhun, HY, Palamaner Subash Shantha, G, Bin Abdulhak, A, Sigurdsson, G, Nabi, F, Mahmarian, JJ & Chang, SM 2017, International Journal of Cardiology.

Nuclear Cardiology Practices and Radiation Exposure in the Oceania Region: Results From the IAEA Nuclear Cardiology Protocols Study (INCAPS)
Biswas, S, Better, N, Pascual, TNB, Mercuri, M, Vitola, JV, Karthikeyan, G, Westcott, J, Alexánderson, E, Allam, AH, Al-Mallah, MH, Bom, HHS, Bouyoucef, SE, Flotats, A, Jerome, S, Kaufman, PA, Lele, V, Luxenburg, O, Mahmarian, JJ, Shaw, LJ, Underwood, SR, Rehani, M, Kashyap, R, Dondi, M, Paez, D & Einstein, AJ 2017, Heart Lung and Circulation, vol. 26, no. 1, pp. 25–34.

Prognostic Value of Coronary Artery Calcium Score in Acute Chest Pain Patients Without Known Coronary Artery Disease: Systematic Review and Meta-analysis
Chaikriangkrai, K, Palamaner Subash Shantha, G, Jhun, HY, Ungprasert, P, Sigurdsson, G, Nabi, F, Mahmarian, JJ & Chang, SM 2016, Annals of Emergency Medicine, vol. 68, no. 6, pp. 659-670.

CMR First-Pass Perfusion for Suspected Inducible Myocardial Ischemia
Hendel, RC, Friedrich, MG, Schulz-Menger, J, Zemmrich, C, Bengel, F, Berman, DS, Camici, PG, Flamm, SD, Le Guludec, D, Kim, R, Lombardi, M, Mahmarian, JJ, Sechtem, U & Nagel, E 2016, JACC: Cardiovascular Imaging, vol. 9, no. 11, pp. 1338-1348.

Gender Differences in Radiation Dose from Nuclear Cardiology Studies Across the World Findings from the INCAPS Registry
INCAPS Investigators Group 2016, JACC: Cardiovascular Imaging, vol. 9, no. 4, pp. 376-384.

Nuclear cardiology practice and associated radiation doses in Europe: results of the IAEA Nuclear Cardiology Protocols Study (INCAPS) for the 27 European countries
Lindner, O, Pascual, TNB, Mercuri, M, Acampa, W, Burchert, W, Flotats, A, Kaufmann, PA, Kitsiou, A, Knuuti, J, Underwood, SR, Vitola, JV, Mahmarian, JJ, Karthikeyan, G, Better, N, Rehani, MM, Kashyap, R, Dondi, M, Paez, D & Einstein, AJ 2016, European Journal of Nuclear Medicine and Molecular Imaging, vol. 43, no. 4, pp. 718-728.

Clinical Utility of Multidetector Computed Tomography in Redo Valve Procedures
Chaikriangkrai, K, Maragiannis, D, Belousova, T, Little, SH, Nabi, F, Mahmarian, JJ & Chang, S-M 2016, Journal of Cardiac Surgery, pp. 139-46.

Optimizing evaluation of patients with low-to-intermediate-risk acute chest pain: A randomized study comparing stress myocardial perfusion tomography incorporating stress-only imaging versus cardiac CT
Nabi, F, Kassi, M, Muhyieddeen, K, Chang, SM, Xu, J, Peterson, L, Wray, N, Shirkey, B, Ashton, C & Mahmarian, J 2016, Journal of Nuclear Medicine, vol. 57, no. 3, pp. 378-384.

Estimating the reduction in the radiation burden from nuclear cardiology through use of stress-only imaging in the United States and worldwide
Mercuri, M, Pascual, TNB, Mahmarian, JJ, Shaw, LJ, Dondi, M, Paez, D & Einstein, AJ 2016, JAMA Internal Medicine, vol. 176, no. 2, pp. 269-273.

Comparison of Radiation Doses and Best-Practice Use for Myocardial Perfusion Imaging in US and Non-US Laboratories: Findings From the IAEA (International Atomic Energy Agency) Nuclear Cardiology Protocols Study
Mercuri, M, Pascual, TNB, Mahmarian, JJ, Shaw, LJ, Rehani, MM, Paez, D & Einstein, AJ 2016, JAMA Internal Medicine, vol. 176, no. 2, pp. 266-269.

Additive prognostic value of coronary artery calcium score and renal function in patients with acute chest pain without known coronary artery disease: up to 5-year follow-up
Chaikriangkrai, K, Nabi, F, Mahmarian, JJ & Chang, S-M 2015, International Journal of Cardiovascular Imaging, vol. 31, no. 8, pp. 1619-1626.

Prevalence and implications of subclinical coronary artery disease in patients with atrial fibrillation
Chaikriangkrai, K, Valderrábano, M, Bala, SK, Alchalabi, S, Graviss, EA, Nabi, F, Mahmarian, JJ & Chang, S-M 2015, American Journal of Cardiology, vol. 116, no. 8, pp. 1219-1223.

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