Jing Yang

Jing Yang, PhD

Associate Professor of Cancer Biology in Medicine, Academic Institute
Associate Member, Research Institute
Houston Methodist
Weill Cornell Medical College

Yang lab

Areas Of Expertise

Tumor microenvironment Multiple myeloma Obesity Bone disease Adipocytes Tumor metabolism

Bone marrow microenvironment: roles and therapeutic implications in obesity-associated cancer
Cheng, F, He, J & Yang, J 2023, , Trends in Cancer, vol. 9, no. 7, pp. 566-577. https://doi.org/10.1016/j.trecan.2023.03.007

Osteocyte-derived exosomes confer multiple myeloma resistance to chemotherapy through acquisition of cancer stem cell-like features
Cheng, F, Wang, Z, You, G, Liu, Y, He, J & Yang, J 2023, , Leukemia, vol. 37, no. 6, pp. 1392-1396. https://doi.org/10.1038/s41375-023-01896-y

Osteocyte CIITA aggravates osteolytic bone lesions in myeloma
Liu, H, He, J, Bagheri-Yarmand, R, Li, Z, Liu, R, Wang, Z, Bach, DH, Huang, YH, Lin, P, Guise, TA, Gagel, RF & Yang, J 2022, , Nature Communications, vol. 13, no. 1, 3684, pp. 3684. https://doi.org/10.1038/s41467-022-31356-7

Quantifying Workload and Stress in Intensive Care Unit Nurses: Preliminary Evaluation Using Continuous Eye-Tracking
Ahmadi, N, Sasangohar, F, Yang, J, Yu, D, Danesh, V, Klahn, S & Masud, F 2022, , Human Factors, pp. 187208221085335. https://doi.org/10.1177/00187208221085335

Induction of m6A methylation in adipocyte exosomal LncRNAs mediates myeloma drug resistance
Wang, Z, He, J, Bach, DH, Huang, YH, Li, Z, Liu, H, Lin, P & Yang, J 2022, , Journal of Experimental and Clinical Cancer Research, vol. 41, no. 1, 4, pp. 4. https://doi.org/10.1186/s13046-021-02209-w

Promotion of Bone Lesions Through the Myeloma Integrin a6-Mediated Osteolytic Signaling
Liu, H, Wang, Z, He, J, Li, Z, Gao, JY, Liu, R, Lin, P & Yang, J 2021, , Frontiers in Oncology, vol. 11, 692190. https://doi.org/10.3389/fonc.2021.692190

Acetyl-CoA Synthetase 2: A Critical Linkage in Obesity-Induced Tumorigenesis in Myeloma
Li, Z, Liu, H, He, J, Wang, Z, Yin, Z, You, G, Wang, Z, Davis, RE, Lin, P, Bergsagel, PL, Manasanch, EE, Wong, STC, Esnaola, NF, Chang, JC, Orlowski, RZ, Yi, Q & Yang, J 2021, , Cell Metabolism, vol. 33, no. 1, pp. 78-93.e7. https://doi.org/10.1016/j.cmet.2020.12.011

Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)1: Autophagy
Autophagy Guidelines Group 2021, , Autophagy, vol. 17, no. 1, pp. 1-382. https://doi.org/10.1080/15548627.2020.1797280

Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)1: Autophagy
Autophagy Guidelines Group 2021, , Autophagy, vol. 17, no. 1, pp. 1-382. https://doi.org/10.1080/15548627.2020.1797280

Myeloma cells shift osteoblastogenesis to adipogenesis by inhibiting the ubiquitin ligase MURF1 in mesenchymal stem cells
Liu, Z, Liu, H, He, J, Lin, P, Tong, Q & Yang, J 2020, , Science signaling, vol. 13, no. 633, eaay8203. https://doi.org/10.1126/scisignal.aay8203

Reprogrammed marrow adipocytes contribute to myeloma-induced bone disease
Liu, H, He, J, Koh, SP, Zhong, Y, Liu, Z, Wang, Z, Zhang, Y, Li, Z, Tam, BT, Lin, P, Xiao, M, Young, KH, Amini, B, Starbuck, MW, Lee, HC, Navone, NM, Davis, RE, Tong, Q, Bergsagel, PL, Hou, J, Yi, Q, Orlowski, RZ, Gagel, RF & Yang, J 2019, , Science translational medicine, vol. 11, no. 494, eaau9087. https://doi.org/10.1126/scitranslmed.aau9087

The Imipridone ONC201 Induces Apoptosis and Overcomes Chemotherapy Resistance by Up-Regulation of Bim in Multiple Myeloma
Tu, YS, He, J, Liu, H, Lee, HC, Wang, H, Ishizawa, J, Allen, JE, Andreeff, M, Orlowski, RZ, Davis, RE & Yang, J 2017, , Neoplasia (United States), vol. 19, no. 10, pp. 772-780. https://doi.org/10.1016/j.neo.2017.07.009

Resistin induces multidrug resistance in myeloma by inhibiting cell death and upregulating ABC transporter expression
Pang, J, Shi, Q, Liu, Z, He, J, Liu, H, Lin, P, Cui, J & Yang, J 2017, , Haematologica, vol. 102, no. 7, pp. 1273-1280. https://doi.org/10.3324/haematol.2016.154062

RNA Polymerase I Inhibition with CX-5461 as a Novel Therapeutic Strategy to Target MYC in Multiple Myeloma
Lee, HC, Wang, H, Baladandayuthapani, V, Lin, H, He, J, Jones, RJ, Kuiatse, I, Gu, D, Wang, Z, Ma, W, Lim, J, OBrien, S, Keats, J, Yang, J, Davis, RE & Orlowski, RZ 2017, , British Journal of Haematology, vol. 177, no. 1, pp. 80-94. https://doi.org/10.1111/bjh.14525

C-reactive protein promotes bone destruction in human myeloma through the CD32-p38MAPK-Twist axis
Yang, J, Liu, Z, Liu, H, He, J, Yang, J, Lin, P, Wang, Q, Du, J, Ma, W, Yin, Z, Davis, E, Orlowski, RZ, Hou, J & Yi, Q 2017, , Sci Signal. https://doi.org/10.1126/scisignal.aan6282

Role of myeloma-derived MIF in myeloma cell adhesion to bone marrow and chemotherapy response
Yuhuan, Z, Qiang, W, Li, T, Qian, J, Lu, Y, Li, Y, Bi, E, Reu, F, Qin, Y, Drazba, J, Hsi, E, Jing, Y, Cai, Z & Yi, Q 2016, , Journal of the National Cancer Institute, vol. 108, no. 11. https://doi.org/10.1093/jnci/djw131

Thymidine phosphorylase exerts complex effects on bone resorption and formation in myeloma
Liu, H, Liu, Z, Du, J, He, J, Lin, P, Amini, B, Starbuck, MW, Novane, N, Shah, JJ, Davis, RE, Hou, J, Gagel, RF & Yang, J 2016, , Science translational medicine, vol. 8, no. 353, 353ra113. https://doi.org/10.1126/scitranslmed.aad8949

Tight Junction Protein 1 Modulates Proteasome Capacity and Proteasome Inhibitor Sensitivity in Multiple Myeloma via EGFR/JAK1/STAT3 Signaling
Zhang, XD, Baladandayuthapani, V, Lin, H, Mulligan, G, Li, B, Esseltine, DLW, Qi, L, Xu, J, Hunziker, W, Barlogie, B, Usmani, SZ, Zhang, Q, Crowley, J, Hoering, A, Shah, JJ, Weber, DM, Manasanch, EE, Thomas, SK, Li, BZ, Wang, HH, Zhang, J, Kuiatse, I, Tang, JL, Wang, H, He, J, Yang, J, Milan, E, Cenci, S, Ma, WC, Wang, ZQ, Davis, RE, Yang, L & Orlowski, RZ 2016, , Cancer Cell, vol. 29, no. 5, pp. 639-652. https://doi.org/10.1016/j.ccell.2016.03.026

IL-15 enhances the antitumor effect of human antigen-specific CD8+ T cells by cellular senescence delay
Weng, J, Moriarty, KE, Baio, FE, Chu, F, Kim, S-D, He, J, Jie, Z, Xie, X, Ma, W, Qian, J, Zhang, L, Yang, J, Jing, Y, Yi, Q, Neelapu, SS & Kwak, LW 2016, , OncoImmunology.

Targeting Human ß-Microglobulin with Monoclonal Antibodies in Multiple Myeloma- A Potential in Treatment
Zhang, M, He, J & Yang, J 2016, , Chemotherapy, no. 2167-7700 . <https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4966657/>