Jimmy D. Gollihar

Jimmy D. Gollihar, PhD

Scientist, Academic Institute
Assistant Affiliate Member, Research Institute
Houston Methodist


Gollihar Lab - ADAPT


Publications

Functional expression of opioid receptors and other human GPCRs in yeast engineered to produce human sterols
Bean, BDM, Mulvihill, CJ, Garge, RK, Boutz, DR, Rousseau, O, Floyd, BM, Cheney, W, Gardner, EC, Ellington, AD, Marcotte, EM, Gollihar, JD, Whiteway, M & Martin, VJJ 2022, , Nature Communications, vol. 13, no. 1, 2882. https://doi.org/10.1038/s41467-022-30570-7

Functional expression of opioid receptors and other human GPCRs in yeast engineered to produce human sterols
Bean, BDM, Mulvihill, CJ, Garge, RK, Boutz, DR, Rousseau, O, Floyd, BM, Cheney, W, Gardner, EC, Ellington, AD, Marcotte, EM, Gollihar, JD, Whiteway, M & Martin, VJJ 2022, , Nature Communications, vol. 13, no. 1, 2882, pp. 2882. https://doi.org/10.1038/s41467-022-30570-7, https://doi.org/10.1038/s41467-022-30570-7

Signals of Significantly Increased Vaccine Breakthrough, Decreased Hospitalization Rates, and Less Severe Disease in Patients with Coronavirus Disease 2019 Caused by the Omicron Variant of Severe Acute Respiratory Syndrome Coronavirus 2 in Houston, Texas
Christensen, PA, Olsen, RJ, Long, SW, Snehal, R, Davis, JJ, Ojeda Saavedra, M, Reppond, K, Shyer, MN, Cambric, J, Gadd, R, Thakur, RM, Batajoo, A, Mangham, R, Pena, S, Trinh, T, Kinskey, JC, Williams, G, Olson, R, Gollihar, J & Musser, JM 2022, , American Journal of Pathology, vol. 192, no. 4, pp. 642-652. https://doi.org/10.1016/j.ajpath.2022.01.007

Orthogonal control of gene expression in plants using synthetic promoters and CRISPR-based transcription factors
Kar, S, Bordiya, Y, Rodriguez, N, Kim, J, Gardner, EC, Gollihar, JD, Sung, S & Ellington, AD 2022, , Plant Methods, vol. 18, no. 1, 42, pp. 42. https://doi.org/10.1186/s13007-022-00867-1

Delta Variants of SARS-CoV-2 Cause Significantly Increased Vaccine Breakthrough COVID-19 Cases in Houston, Texas
Christensen, PA, Olsen, RJ, Long, SW, Subedi, S, Davis, JJ, Hodjat, P, Walley, DR, Kinskey, JC, Ojeda Saavedra, M, Pruitt, L, Reppond, K, Shyer, MN, Cambric, J, Gadd, R, Thakur, RM, Batajoo, A, Mangham, R, Pena, S, Trinh, T, Yerramilli, P, Nguyen, M, Olson, R, Snehal, R, Gollihar, J & Musser, JM 2022, , American Journal of Pathology, vol. 192, no. 2, pp. 320-331. https://doi.org/10.1016/j.ajpath.2021.10.019

Antibody escape and cryptic cross-domain stabilization in the SARS-CoV-2 Omicron spike protein
Javanmardi, K, Segall-Shapiro, TH, Chou, CW, Boutz, DR, Olsen, RJ, Xie, X, Xia, H, Shi, PY, Johnson, CD, Annapareddy, A, Weaver, S, Musser, JM, Ellington, AD, Finkelstein, IJ & Gollihar, JD 2022, , Cell Host and Microbe, vol. 30, no. 9, pp. 1242-1254.e6. https://doi.org/10.1016/j.chom.2022.07.016

Rapid characterization of spike variants via mammalian cell surface display
Javanmardi, K, Chou, CW, Terrace, CI, Annapareddy, A, Kaoud, TS, Guo, Q, Lutgens, J, Zorkic, H, Horton, AP, Gardner, EC, Nguyen, G, Boutz, DR, Goike, J, Voss, WN, Kuo, HC, Dalby, KN, Gollihar, JD & Finkelstein, IJ 2021, , Molecular Cell, vol. 81, no. 24, pp. 5099-5111.e8. https://doi.org/10.1016/j.molcel.2021.11.024

Trajectory of Growth of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Variants in Houston, Texas, January through May 2021, Based on 12,476 Genome Sequences
Olsen, RJ, Christensen, PA, Long, SW, Subedi, S, Hodjat, P, Olson, R, Nguyen, M, Davis, JJ, Yerramilli, P, Saavedra, MO, Pruitt, L, Reppond, K, Shyer, MN, Cambric, J, Gadd, R, Thakur, RM, Batajoo, A, Finkelstein, IJ, Gollihar, J & Musser, JM 2021, , American Journal of Pathology, vol. 191, no. 10, pp. 1754-1773. https://doi.org/10.1016/j.ajpath.2021.07.002

Discovery of new vascular disrupting agents based on evolutionarily conserved drug action, pesticide resistance mutations, and humanized yeast
Garge, RK, Cha, HJ, Lee, C, Gollihar, JD, Kachroo, AH, Wallingford, JB & Marcotte, EM 2021, , Genetics, vol. 219, no. 1, iyab101. https://doi.org/10.1093/genetics/iyab101

Prevalent, protective, and convergent IgG recognition of SARS-CoV-2 non-RBD spike epitopes
Voss, WN, Hou, YJ, Johnson, NV, Delidakis, G, Kim, JE, Javanmardi, K, Horton, AP, Bartzoka, F, Paresi, CJ, Tanno, Y, Chou, CW, Abbasi, SA, Pickens, W, George, K, Boutz, DR, Towers, DM, McDaniel, JR, Billick, D, Goike, J, Rowe, L, Batra, D, Pohl, J, Lee, J, Gangappa, S, Sambhara, S, Gadush, M, Wang, N, Person, MD, Iverson, BL, Gollihar, JD, Dye, JM, Herbert, AS, Finkelstein, IJ, Baric, RS, McLellan, JS, Georgiou, G, Lavinder, JJ & Ippolito, GC 2021, , Science, vol. 372, no. 6546, pp. 1108-1112. https://doi.org/10.1126/science.abg5268

Limited window for donation of convalescent plasma with high live-virus neutralizing antibody titers for COVID-19 immunotherapy
Gontu, A, Srinivasan, S, Salazar, E, Nair, MS, Nissly, RH, Greenawalt, D, Bird, IM, Herzog, CM, Ferrari, MJ, Poojary, I, Katani, R, Lindner, SE, Minns, AM, Rossi, R, Christensen, PA, Castillo, B, Chen, J, Eagar, TN, Yi, X, Zhao, P, Leveque, C, Olsen, RJ, Bernard, DW, Gollihar, J, Kuchipudi, SV, Musser, JM & Kapur, V 2021, , Communications Biology, vol. 4, no. 1, 267. https://doi.org/10.1038/s42003-021-01813-y

Sequence Analysis of 20,453 Severe Acute Respiratory Syndrome Coronavirus 2 Genomes from the Houston Metropolitan Area Identifies the Emergence and Widespread Distribution of Multiple Isolates of All Major Variants of Concern
Long, SW, Olsen, RJ, Christensen, PA, Subedi, S, Olson, R, Davis, JJ, Saavedra, MO, Yerramilli, P, Pruitt, L, Reppond, K, Shyer, MN, Cambric, J, Finkelstein, IJ, Gollihar, J & Musser, JM 2021, , American Journal of Pathology, vol. 191, no. 6, pp. 983-992. https://doi.org/10.1016/j.ajpath.2021.03.004

Convalescent plasma anti–SARS-CoV-2 spike protein ectodomain and receptor-binding domain IgG correlate with virus neutralization
Salazar, E, Kuchipudi, SV, Christensen, PA, Eagar, T, Yi, X, Zhao, P, Jin, Z, Long, SW, Olsen, RJ, Chen, J, Castillo, B, Leveque, C, Towers, D, Lavinder, J, Gollihar, J, Cardona, J, Ippolito, G, Nissly, R, Bird, I, Greenawalt, D, Rossi, RM, Gontu, A, Srinivasan, S, Poojary, I, Cattadori, IM, Hudson, PJ, Josleyn, NM, Prugar, L, Huie, K, Herbert, A, Bernard, DW, Dye, JM, Kapur, V & Musser, JM 2020, , Journal of Clinical Investigation, vol. 130, no. 12, pp. 6728-6738. https://doi.org/10.1172/JCI141206

Discovery of novel gain-of-function mutations guided by structure-based deep learning
Shroff, R, Cole, AW, Diaz, DJ, Morrow, BR, Donnell, I, Annapareddy, A, Gollihar, J, Ellington, AD & Thyer, R 2020, , ACS Synthetic Biology, vol. 9, no. 11, pp. 2927-2935. https://doi.org/10.1021/acssynbio.0c00345

Significantly Decreased Mortality in a Large Cohort of Coronavirus Disease 2019 (COVID-19) Patients Transfused Early with Convalescent Plasma Containing High-Titer Anti–Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Spike Protein IgG
Salazar, E, Christensen, PA, Graviss, EA, Nguyen, DT, Castillo, B, Chen, J, Lopez, BV, Eagar, TN, Yi, X, Zhao, P, Rogers, J, Shehabeldin, A, Joseph, D, Masud, F, Leveque, C, Olsen, RJ, Bernard, DW, Gollihar, J & Musser, JM 2021, , American Journal of Pathology, vol. 191, no. 1, pp. 90-107. https://doi.org/10.1016/j.ajpath.2020.10.008, https://doi.org/10.1016/j.ajpath.2020.10.008

Treatment of Coronavirus Disease 2019 Patients with Convalescent Plasma Reveals a Signal of Significantly Decreased Mortality
Salazar, E, Christensen, PA, Graviss, EA, Nguyen, DT, Castillo, B, Chen, J, Lopez, BV, Eagar, TN, Yi, X, Zhao, P, Rogers, J, Shehabeldin, A, Joseph, D, Leveque, C, Olsen, RJ, Bernard, DW, Gollihar, J & Musser, JM 2020, , American Journal of Pathology, vol. 190, no. 11, pp. 2290-2303. https://doi.org/10.1016/j.ajpath.2020.08.001

Molecular architecture of early dissemination and massive second wave of the SARS-CoV-2 virus in a major metropolitan area
Long, SW, Olsen, RJ, Christensen, PA, Bernard, DW, Davis, JJ, Shukla, M, Nguyen, M, Saavedra, MO, Yerramilli, P, Pruitt, L, Subedi, S, Kuo, HC, Hendrickson, H, Eskandari, G, Nguyen, HAT, Long, JH, Kumaraswami, M, Goike, J, Boutz, D, Gollihar, J, McLellan, JS, Chou, CW, Javanmardi, K, Finkelstein, IJ & Musser, JM 2020, , mBio, vol. 11, no. 6, e02707-20, pp. 1-30. https://doi.org/10.1128/mBio.02707-20

How a B family DNA polymerase has been evolved to copy RNA
Choi, WS, He, P, Pothukuchy, A, Gollihar, J, Ellington, AD & Yang, W 2020, , Proceedings of the National Academy of Sciences of the United States of America, vol. 117, no. 35, pp. 21274-21280. https://doi.org/10.1073/pnas.2009415117

Treatment of Coronavirus Disease 2019 (COVID-19) Patients with Convalescent Plasma
Salazar, E, Perez, KK, Ashraf, M, Chen, J, Castillo, B, Christensen, PA, Eubank, T, Bernard, DW, Eagar, TN, Long, SW, Subedi, S, Olsen, RJ, Leveque, C, Schwartz, MR, Dey, M, Chavez-East, C, Rogers, J, Shehabeldin, A, Joseph, D, Williams, G, Thomas, K, Masud, F, Talley, C, Dlouhy, KG, Lopez, BV, Hampton, C, Lavinder, J, Gollihar, JD, Maranhao, AC, Ippolito, GC, Saavedra, MO, Cantu, CC, Yerramilli, P, Pruitt, L & Musser, JM 2020, , American Journal of Pathology, vol. 190, no. 8, pp. 1680-1690. https://doi.org/10.1016/j.ajpath.2020.05.014

Building biosecurity for synthetic biology
Trump, BD, Galaitsi, SE, Appleton, E, Bleijs, DA, Florin, MV, Gollihar, JD, Hamilton, RA, Kuiken, T, Lentzos, F, Mampuys, R, Merad, M, Novossiolova, T, Oye, K, Perkins, E, Garcia-Reyero, N, Rhodes, C & Linkov, I 2020, , Molecular Systems Biology, vol. 16, no. 7, e9723. https://doi.org/10.15252/msb.20209723