Jianting Sheng

Jianting Sheng, PhD

Assistant Research Professor of Computational Biology and Mathematics in Radiology, Academic Institute
Assistant Research Member, Research Institute
Houston Methodist
Weill Cornell Medical College


Publications

Spatial Transcriptomics Depict Ligand-Receptor Cross-talk Heterogeneity at the Tumor-Stroma Interface in Long-Term Ovarian Cancer Survivors
Ferri-Borgogno, S, Zhu, Y, Sheng, J, Burks, JK, Gomez, JA, Wong, KK, Wong, STC & Mok, SC 2023, , Cancer research, vol. 83, no. 9, pp. 1503-1516. https://doi.org/10.1158/0008-5472.CAN-22-1821

Exosomal non-coding RNAs as a biomarker to improve early ovarian cancer detection.
Wong, ST, Sheng, J, Mok, S, Cao, Y & Han, C 2023, , AACR Annual Meeting 2023, Orlando, United States, 4/14/23 - 4/19/23. https://doi.org/10.1158/1538-7445.AM2023-3333

Targeting epithelial-mesenchymal plasticity via ribosome biogenesis inhibition reduces chemoresistant metastasis of breast cancer: Abstract 963, Cancer Res (2022) 82 (12_Supplement):963.
Ban, Y, Dong, W, Zou, Y, Lee, SB, Sheng, J, Cao, Y, Wong, ST & Gao, D 2022, . https://doi.org/10.1158/1538-7445.AM2022-963

Spatiotemporal gene expression analysis to identify novel tumor-neural crosstalk in TNBC brain metastases: Cancer Res (2022) 82 (4_Supplement): P5-06-01.
Zhao, H, Wang, X, Sheng, J, Xu, S, Gao, D & Wong, ST 2022, . https://doi.org/10.1158/1538-7445.SABCS21-P5-06-01

Author Correction: Radiation-activated secretory proteins of Scgb1a1 + club cells increase the efficacy of immune checkpoint blockade in lung cancer. Radiation-activated secretory proteins of Scgb1a1 + club cells increase the efficacy of immune checkpoint blockade in lung cancer (Nature Cancer, (2021), 2, 9, (919-931), 10.1038/s43018-021-00245-1)
Ban, Y, Markowitz, GJ, Zou, Y, Ramchandani, D, Kraynak, J, Sheng, J, Lee, SB, Wong, STC, Altorki, NK, Gao, D & Mittal, V 2022, , Nature Cancer, vol. 3, no. 2, pp. 262. https://doi.org/10.1038/s43018-022-00330-z

Radiation-activated secretory proteins of Scgb1a1 + club cells increase the efficacy of immune checkpoint blockade in lung cancer
Ban, Y, Markowitz, GJ, Zou, Y, Ramchandani, D, Kraynak, J, Sheng, J, Lee, SB, Wong, STC, Altorki, NK, Gao, D & Mittal, V 2021, , Nature Cancer, vol. 2, no. 9, pp. 919-931. https://doi.org/10.1038/s43018-021-00245-1

Sio: A spatioimageomics pipeline to identify prognostic biomarkers associated with the ovarian tumor microenvironment
Zhu, Y, Ferri-Borgogno, S, Sheng, J, Yeung, TL, Burks, JK, Cappello, P, Jazaeri, AA, Kim, JH, Han, GH, Birrer, MJ, Mok, SC & Wong, STC 2021, , Cancers, vol. 13, no. 8, 1777. https://doi.org/10.3390/cancers13081777

ITLN1 modulates invasive potential and metabolic reprogramming of ovarian cancer cells in omental microenvironment
Au-Yeung, CL, Yeung, TL, Achreja, A, Zhao, H, Yip, KP, Kwan, SY, Onstad, M, Sheng, J, Zhu, Y, Baluya, DL, Co, NN, Rynne-Vidal, A, Schmandt, R, Anderson, ML, Lu, KH, Wong, STC, Nagrath, D & Mok, SC 2020, , Nature Communications, vol. 11, no. 1, 3546. https://doi.org/10.1038/s41467-020-17383-2

Differential contributions of pre- And post-EMT tumor cells in breast cancer metastasis
Lourenco, AR, Ban, Y, Crowley, MJ, Lee, SB, Ramchandani, D, Du, W, Elemento, O, George, JT, Jolly, MK, Levine, H, Sheng, J, Wong, ST, Altorki, NK & Gao, D 2020, , Cancer research, vol. 80, no. 2, pp. 163-169. https://doi.org/10.1158/0008-5472.CAN-19-1427

Anticancer immunotherapy by MFAP5 blockade inhibits fibrosis and enhances chemosensitivity in ovarian and pancreatic cancer
Yeung, TL, Leung, CS, Yip, KP, Sheng, J, Vien, L, Bover, LC, Birrer, MJ, Wong, STC & Mok, SC 2019, , Clinical Cancer Research, vol. 25, no. 21, pp. 6417-6428. https://doi.org/10.1158/1078-0432.CCR-19-0187

Imatinib revives the therapeutic potential of metformin on ewing sarcoma by attenuating tumor hypoxic response and inhibiting convergent signaling pathways
Nan, X, Wang, J, Cheng, H, Yin, Z, Sheng, J, Qiu, B, Lau, CC, Yustein, JT, Zhao, H & Wong, STC 2019, , Cancer Letters. https://doi.org/10.1016/j.canlet.2019.10.034

An image informatics pipeline for imaging mass cytometry to characterize the immune landscape in pre-and on-Treatment immune therapy and its application in recurrent platinium-resistant epithelial ovarian cancer
Zhu, Y, Yeung, TL, Sheng, J, Hinchcliff, EM, Burks, JK, Jazaeri, AA, Mok, SC & Wong, ST 2019, . in 2019 IEEE EMBS International Conference on Biomedical and Health Informatics, BHI 2019 - Proceedings., 8834496, Institute of Electrical and Electronics Engineers Inc. 2019 IEEE EMBS International Conference on Biomedical and Health Informatics, BHI 2019, Chicago, United States, 5/19/19. https://doi.org/10.1109/BHI.2019.8834496

The Modulatory Role of MicroRNA-873 in the Progression of KRAS-Driven Cancers
Mokhlis, HA, Bayraktar, R, Kabil, NN, Caner, A, Kahraman, N, Rodriguez-Aguayo, C, Zambalde, EP, Sheng, J, Karagoz, K, Kanlikilicer, P, Abdel Aziz, AAH, Abdelghany, TM, Ashour, AA, Wong, S, Gatza, ML, Calin, GA, Lopez-Berestein, G & Ozpolat, B 2019, , Molecular Therapy - Nucleic Acids, vol. 14, pp. 301-317. https://doi.org/10.1016/j.omtn.2018.11.019

Dual suppressive effect of miR-34A on the FOXM1/EEF2-kinase axis regulates triple-negative breast cancer growth and invasion
Bayraktar, R, Ivan, C, Bayraktar, E, Kanlikilicer, P, Kabil, NN, Kahraman, N, Mokhlis, HA, Karakas, D, Rodriguez-Aguayo, C, Arslan, A, Sheng, J, Wong, S, Lopez-Berestein, G, Calin, GA & Ozpolat, B 2018, , Clinical Cancer Research, vol. 24, no. 17, pp. 4225-4241. https://doi.org/10.1158/1078-0432.CCR-17-1959

Systematic Identification of Druggable Epithelial-Stromal Crosstalk Signaling Networks in Ovarian Cancer
Yeung, TL, Sheng, J, Leung, CS, Li, F, Kim, J, Ho, SY, Matzuk, MM, Lu, KH, Wong, ST & Mok, SC 2019, , Journal of the National Cancer Institute, vol. 111, no. 3, pp. 272-282. https://doi.org/10.1093/jnci/djy097

Targeting brain-adaptive cancer stem cells prohibits brain metastatic colonization of triple-negative breast cancer
Ren, D, Zhu, X, Kong, R, Zhao, Z, Sheng, J, Wang, J, Xu, X, Liu, J, Cui, K, Zhang, XHF, Zhao, H & Wong, ST 2018, , Cancer research, vol. 78, no. 8, pp. 2052-2064. https://doi.org/10.1158/0008-5472.CAN-17-2994

Cancer-associated fibroblasts regulate endothelial adhesion protein LPP to promote ovarian cancer chemoresistance
Leung, CS, Yeung, TL, Yip, KP, Wong, KK, Ho, SY, Mangala, LS, Sood, AK, Lopez-Berestein, G, Sheng, J, Wong, STC, Birrer, MJ & Mok, SC 2018, , Journal of Clinical Investigation, vol. 128, no. 2, pp. 589-606. https://doi.org/10.1172/JCI95200

Platelets reduce anoikis and promote metastasis by activating YAP1 signaling
Haemmerle, M, Taylor, ML, Gutschner, T, Pradeep, S, Cho, MS, Sheng, J, Lyons, YM, Nagaraja, AS, Dood, RL, Wen, Y, Mangala, LS, Hansen, JM, Rupaimoole, R, Gharpure, KM, Rodriguez-Aguayo, C, Yim, SY, Lee, JS, Ivan, C, Hu, W, Lopez-Berestein, G, Wong, ST, Karlan, BY, Levine, DA, Liu, J, Afshar-Kharghan, V & Sood, AK 2017, , Nature Communications, vol. 8, no. 1, 310. https://doi.org/10.1038/s41467-017-00411-z

HN1L Promotes Triple-Negative Breast Cancer Stem Cells through LEPR-STAT3 Pathway
Liu, Y, Choi, DS, Sheng, J, Ensor, JE, Liang, DH, Rodriguez-Aguayo, C, Polley, A, Benz, S, Elemento, O, Verma, A, Cong, Y, Wong, H, Qian, W, Li, Z, Granados-Principal, S, Lopez-Berestein, G, Landis, MD, Rosato, RR, Dave, B, Wong, S, Marchetti, D, Sood, AK & Chang, JC 2017, , Stem Cell Reports. https://doi.org/10.1016/j.stemcr.2017.11.010

DrugMoaMiner: A computational tool for mechanism of action discovery and personalized drug sensitivity prediction
Li, F, Wang, L, Kong, R, Sheng, J, Cao, H, Mancuso, J, Xia, X, Stephan, C & Wong, STC 2016, . in 3rd IEEE EMBS International Conference on Biomedical and Health Informatics, BHI 2016., 7455911, 3rd IEEE EMBS International Conference on Biomedical and Health Informatics, BHI 2016, Institute of Electrical and Electronics Engineers Inc. pp. 368-371, 3rd IEEE EMBS International Conference on Biomedical and Health Informatics, BHI 2016, Las Vegas, United States, 2/24/16. https://doi.org/10.1109/BHI.2016.7455911

VIEW FULL PUBLICATIONS