Jianting Sheng

Jianting Sheng, PhD

Instructor of Computational Biology and Mathematics in Oncology, Academic Institute
Instructor, Research Institute
Houston Methodist


Publications

Author Correction: Radiation-activated secretory proteins of Scgb1a1 + club cells increase the efficacy of immune checkpoint blockade in lung cancer (Nature Cancer, (2021), 2, 9, (919-931), 10.1038/s43018-021-00245-1)
Ban, Y, Markowitz, GJ, Zou, Y, Ramchandani, D, Kraynak, J, Sheng, J, Lee, SB, Wong, STC, Altorki, NK, Gao, D & Mittal, V 2022, , Nature Cancer, vol. 3, no. 2, pp. 262. https://doi.org/10.1038/s43018-022-00330-z

Radiation-activated secretory proteins of Scgb1a1 + club cells increase the efficacy of immune checkpoint blockade in lung cancer
Ban, Y, Markowitz, GJ, Zou, Y, Ramchandani, D, Kraynak, J, Sheng, J, Lee, SB, Wong, STC, Altorki, NK, Gao, D & Mittal, V 2021, , Nature Cancer, vol. 2, no. 9, pp. 919-931. https://doi.org/10.1038/s43018-021-00245-1

Sio: A spatioimageomics pipeline to identify prognostic biomarkers associated with the ovarian tumor microenvironment
Zhu, Y, Ferri-Borgogno, S, Sheng, J, Yeung, TL, Burks, JK, Cappello, P, Jazaeri, AA, Kim, JH, Han, GH, Birrer, MJ, Mok, SC & Wong, STC 2021, , Cancers, vol. 13, no. 8, 1777. https://doi.org/10.3390/cancers13081777

ITLN1 modulates invasive potential and metabolic reprogramming of ovarian cancer cells in omental microenvironment
Au-Yeung, CL, Yeung, TL, Achreja, A, Zhao, H, Yip, KP, Kwan, SY, Onstad, M, Sheng, J, Zhu, Y, Baluya, DL, Co, NN, Rynne-Vidal, A, Schmandt, R, Anderson, ML, Lu, KH, Wong, STC, Nagrath, D & Mok, SC 2020, , Nature Communications, vol. 11, no. 1, 3546. https://doi.org/10.1038/s41467-020-17383-2

Differential contributions of pre- And post-EMT tumor cells in breast cancer metastasis
Lourenco, AR, Ban, Y, Crowley, MJ, Lee, SB, Ramchandani, D, Du, W, Elemento, O, George, JT, Jolly, MK, Levine, H, Sheng, J, Wong, ST, Altorki, NK & Gao, D 2020, , Cancer research, vol. 80, no. 2, pp. 163-169. https://doi.org/10.1158/0008-5472.CAN-19-1427

Anticancer immunotherapy by MFAP5 blockade inhibits fibrosis and enhances chemosensitivity in ovarian and pancreatic cancer
Yeung, TL, Leung, CS, Yip, KP, Sheng, J, Vien, L, Bover, LC, Birrer, MJ, Wong, STC & Mok, SC 2019, , Clinical Cancer Research, vol. 25, no. 21, pp. 6417-6428. https://doi.org/10.1158/1078-0432.CCR-19-0187

Imatinib revives the therapeutic potential of metformin on ewing sarcoma by attenuating tumor hypoxic response and inhibiting convergent signaling pathways
Nan, X, Wang, J, Cheng, H, Yin, Z, Sheng, J, Qiu, B, Lau, CC, Yustein, JT, Zhao, H & Wong, STC 2019, , Cancer Letters. https://doi.org/10.1016/j.canlet.2019.10.034

An image informatics pipeline for imaging mass cytometry to characterize the immune landscape in pre-and on-Treatment immune therapy and its application in recurrent platinium-resistant epithelial ovarian cancer
Zhu, Y, Yeung, TL, Sheng, J, Hinchcliff, EM, Burks, JK, Jazaeri, AA, Mok, SC & Wong, ST 2019, . in 2019 IEEE EMBS International Conference on Biomedical and Health Informatics, BHI 2019 - Proceedings., 8834496, Institute of Electrical and Electronics Engineers Inc. 2019 IEEE EMBS International Conference on Biomedical and Health Informatics, BHI 2019, Chicago, United States, 5/19/19. https://doi.org/10.1109/BHI.2019.8834496

The Modulatory Role of MicroRNA-873 in the Progression of KRAS-Driven Cancers
Mokhlis, HA, Bayraktar, R, Kabil, NN, Caner, A, Kahraman, N, Rodriguez-Aguayo, C, Zambalde, EP, Sheng, J, Karagoz, K, Kanlikilicer, P, Abdel Aziz, AAH, Abdelghany, TM, Ashour, AA, Wong, S, Gatza, ML, Calin, GA, Lopez-Berestein, G & Ozpolat, B 2019, , Molecular Therapy - Nucleic Acids, vol. 14, pp. 301-317. https://doi.org/10.1016/j.omtn.2018.11.019

Dual suppressive effect of miR-34A on the FOXM1/EEF2-kinase axis regulates triple-negative breast cancer growth and invasion
Bayraktar, R, Ivan, C, Bayraktar, E, Kanlikilicer, P, Kabil, NN, Kahraman, N, Mokhlis, HA, Karakas, D, Rodriguez-Aguayo, C, Arslan, A, Sheng, J, Wong, S, Lopez-Berestein, G, Calin, GA & Ozpolat, B 2018, , Clinical Cancer Research, vol. 24, no. 17, pp. 4225-4241. https://doi.org/10.1158/1078-0432.CCR-17-1959

Systematic Identification of Druggable Epithelial-Stromal Crosstalk Signaling Networks in Ovarian Cancer
Yeung, TL, Sheng, J, Leung, CS, Li, F, Kim, J, Ho, SY, Matzuk, MM, Lu, KH, Wong, ST & Mok, SC 2019, , Journal of the National Cancer Institute, vol. 111, no. 3, pp. 272-282. https://doi.org/10.1093/jnci/djy097

Targeting brain-adaptive cancer stem cells prohibits brain metastatic colonization of triple-negative breast cancer
Ren, D, Zhu, X, Kong, R, Zhao, Z, Sheng, J, Wang, J, Xu, X, Liu, J, Cui, K, Zhang, XHF, Zhao, H & Wong, ST 2018, , Cancer research, vol. 78, no. 8, pp. 2052-2064. https://doi.org/10.1158/0008-5472.CAN-17-2994

Cancer-associated fibroblasts regulate endothelial adhesion protein LPP to promote ovarian cancer chemoresistance
Leung, CS, Yeung, TL, Yip, KP, Wong, KK, Ho, SY, Mangala, LS, Sood, AK, Lopez-Berestein, G, Sheng, J, Wong, STC, Birrer, MJ & Mok, SC 2018, , Journal of Clinical Investigation, vol. 128, no. 2, pp. 589-606. https://doi.org/10.1172/JCI95200

Platelets reduce anoikis and promote metastasis by activating YAP1 signaling
Haemmerle, M, Taylor, ML, Gutschner, T, Pradeep, S, Cho, MS, Sheng, J, Lyons, YM, Nagaraja, AS, Dood, RL, Wen, Y, Mangala, LS, Hansen, JM, Rupaimoole, R, Gharpure, KM, Rodriguez-Aguayo, C, Yim, SY, Lee, JS, Ivan, C, Hu, W, Lopez-Berestein, G, Wong, ST, Karlan, BY, Levine, DA, Liu, J, Afshar-Kharghan, V & Sood, AK 2017, , Nature Communications, vol. 8, no. 1, 310. https://doi.org/10.1038/s41467-017-00411-z

HN1L Promotes Triple-Negative Breast Cancer Stem Cells through LEPR-STAT3 Pathway
Liu, Y, Choi, DS, Sheng, J, Ensor, JE, Liang, DH, Rodriguez-Aguayo, C, Polley, A, Benz, S, Elemento, O, Verma, A, Cong, Y, Wong, H, Qian, W, Li, Z, Granados-Principal, S, Lopez-Berestein, G, Landis, MD, Rosato, RR, Dave, B, Wong, S, Marchetti, D, Sood, AK & Chang, JC 2017, , Stem Cell Reports. https://doi.org/10.1016/j.stemcr.2017.11.010

DrugMoaMiner: A computational tool for mechanism of action discovery and personalized drug sensitivity prediction
Li, F, Wang, L, Kong, R, Sheng, J, Cao, H, Mancuso, J, Xia, X, Stephan, C & Wong, STC 2016, . in 3rd IEEE EMBS International Conference on Biomedical and Health Informatics, BHI 2016., 7455911, 3rd IEEE EMBS International Conference on Biomedical and Health Informatics, BHI 2016, Institute of Electrical and Electronics Engineers Inc. pp. 368-371, 3rd IEEE EMBS International Conference on Biomedical and Health Informatics, BHI 2016, Las Vegas, United States, 2/24/16. https://doi.org/10.1109/BHI.2016.7455911

Epithelial-to-mesenchymal transition is not required for lung metastasis but contributes to chemoresistance
Fischer, KR, Durrans, A, Lee, S, Sheng, J, Li, F, Wong, STC, Choi, H, El Rayes, T, Ryu, S, Troeger, J, Schwabe, RF, Vahdat, LT, Altorki, NK, Mittal, V & Gao, D 2015, , Nature, vol. 527, no. 7579, pp. 472-6. https://doi.org/10.1038/nature15748

Optimal Drug Prediction from Personal Genomics Profiles
Sheng, J, Li, F & Wong, STC 2015, , IEEE Journal of Biomedical and Health Informatics, vol. 19, no. 4, 7060697, pp. 1264-1270. https://doi.org/10.1109/JBHI.2015.2412522

A computational method for clinically relevant cancer stratification and driver mutation module discovery using personal genomics profiles
Wang, L, Li, F, Sheng, J & Wong, STC 2015, , BMC genomics, vol. 16, no. 7, S6. https://doi.org/10.1186/1471-2164-16-S7-S6

Transcriptome Analysis of Individual Stromal Cell Populations Identifies Stroma-Tumor Crosstalk in Mouse Lung Cancer Model
Choi, H, Sheng, J, Gao, D, Li, F, Durrans, A, Ryu, S, Lee, SB, Narula, N, Rafii, S, Elemento, O, Altorki, NK, Wong, STC & Mittal, V 2015, , Cell Reports, vol. 10, no. 7, pp. 1187-1201. https://doi.org/10.1016/j.celrep.2015.01.040