Unknown

Jianfei Qian, DVM, PhD

Assistant Research Professor of Cancer Biology in Medicine, Academic Institute
Assistant Research Member, Research Institute
Houston Methodist
Weill Cornell Medical College


jqian2@houstonmethodist.org
Description of Research

Immunology is one of the most rapidly growing areas in the biomedical research field. Because no single method is ideal for curing all tumors, multiple disciplines and methods are needed to explore improvements in cancer therapy. Based on my previous findings, I will continue to develop new methods for immunotherapy in MM and related tumors using an interdisciplinary approach. My research will be focused on targeting DKK1 or other novel TAAs for cancer immunotherapy. I will explore the potential of using a novel and universally expressed TAA for immunotherapy of myeloma patients, and further investigate peptide, protein, DNA vaccines or antibody, CAR-T cells for immunotherapy in MM or other cancers.

Areas Of Expertise

Immunotherapy
Publications

Development of therapeutic monoclonal antibodies against DKK1 peptide-HLA-A2 complex to treat human cancers
Qian, J, Wang, Q, Xiao, L, Xiong, W, Xian, M, Su, P, Yang, M, Zhang, C, Li, Y, Zhong, L, Ganguly, S, Zu, Y & Yi, Q 2024, , Journal for immunotherapy of cancer, vol. 12, no. 1, e008145. https://doi.org/10.1136/jitc-2023-008145

A novel role of lysophosphatidic acid (LPA) in human myeloma resistance to proteasome inhibitors
Su, P, Xiao, L, Ye, L, Wang, Z, Xiong, W, Wang, Q, Ma, X, Xian, M, Yang, M, Zu, Y, Pingali, SR, Qian, J & Yi, Q 2022, , Journal of Hematology and Oncology, vol. 15, no. 1, 55, pp. 55. https://doi.org/10.1186/s13045-022-01269-5

IL-9/STAT3/fatty acid oxidation-mediated lipid peroxidation contributes to Tc9 cell longevity and enhanced antitumor activity
Xiao, L, Ma, X, Ye, L, Su, P, Xiong, W, Bi, E, Wang, Q, Xian, M, Yang, M, Qian, J & Yi, Q 2022, , Journal of Clinical Investigation, vol. 132, no. 7, e153247. https://doi.org/10.1172/JCI153247

Correction: Enhanced Lipid Accumulation and Metabolism Are Required for the Differentiation and Activation of Tumor-Associated Macrophages
Su, P, Wang, Q, Bi, E, Ma, X, Liu, L, Yang, M, Qian, J & Yi, Q 2022, , Cancer research, vol. 82, no. 5, pp. 945. https://doi.org/10.1158/0008-5472.CAN-21-4296

RAR? activation sensitizes human myeloma cells to carfilzomib treatment through the OAS-RNase L innate immune pathway
Wang, Q, Lin, Z, Wang, Z, Ye, L, Xian, M, Xiao, L, Su, P, Bi, E, Huang, YH, Qian, J, Liu, L, Ma, X, Yang, M, Xiong, W, Zu, Y, Pingali, SR, Xu, B & Yi, Q 2022, , Blood, vol. 139, no. 1, pp. 59-72. https://doi.org/10.1182/blood.2020009856

RAR? activation sensitizes human myeloma cells to carfilzomib treatment through the OAS-RNase L innate immune pathway
Wang, Q, Lin, Z, Wang, Z, Ye, L, Xian, M, Xiao, L, Su, P, Bi, E, Huang, YH, Qian, J, Liu, L, Ma, X, Yang, M, Xiong, W, Zu, Y, Pingali, SR, Xu, B & Yi, Q 2022, , Blood, vol. 139, no. 1, pp. 59-72. https://doi.org/10.1182/blood.2020009856, https://doi.org/10.1182/blood.2020009856

CD36-mediated ferroptosis dampens intratumoral CD8+ T cell effector function and impairs their antitumor ability
Ma, X, Xiao, L, Liu, L, Ye, L, Su, P, Bi, E, Wang, Q, Yang, M, Qian, J & Yi, Q 2021, , Cell Metabolism, vol. 33, no. 5, pp. 1001-1012.e5. https://doi.org/10.1016/j.cmet.2021.02.015

Identification of an immunogenic DKK1 long peptide for immunotherapy of human multiple myeloma
Li, R, Zheng, C, Wang, Q, Bi, E, Yang, M, Hou, J, Fu, W, Yi, Q & Qian, J 2021, , Haematologica, vol. 106, no. 3, pp. 838-846. https://doi.org/10.3324/haematol.2019.236836

Enhanced CAR-T activity against established tumors by polarizing human T cells to secrete interleukin-9
Liu, L, Bi, E, Ma, X, Xiong, W, Qian, J, Ye, L, Su, P, Wang, Q, Xiao, L, Yang, M, Lu, Y & Yi, Q 2020, , Nature Communications, vol. 11, no. 1, 5902. https://doi.org/10.1038/s41467-020-19672-2

MIF as a biomarker and therapeutic target for overcoming resistance to proteasome inhibitors in human myeloma
Wang, Q, Zhao, D, Xian, M, Wang, Z, Bi, E, Su, P, Qian, J, Ma, X, Yang, M, Liu, L, Zu, Y, Pingali, SR, Chen, K, Cai, Z & Yi, Q 2020, , Blood, vol. 136, no. 22, pp. 2557-2573. https://doi.org/10.1182/blood.2020005795

Enhanced lipid accumulation and metabolism are required for the differentiation and activation of tumor-associated macrophages
Su, P, Wang, Q, Bi, E, Ma, X, Liu, L, Yang, M, Qian, J & Yi, Q 2020, , Cancer research, vol. 80, no. 7, pp. 1438-1450. https://doi.org/10.1158/0008-5472.CAN-19-2994

Identification of an immunogenic DKK1 long peptide for immunotherapy of human multiple myeloma
Li, R, Zheng, C, Wang, Q, Bi, E, Yang, M, Hou, J, Fu, W, Yi, Q & Qian, J 2021, , Haematologica, vol. 106, no. 3, pp. 838-846. https://doi.org/10.3324/haematol.2019.236836

Cholesterol Induces CD8+ T Cell Exhaustion in the Tumor Microenvironment
Ma, X, Bi, E, Lu, Y, Su, P, Huang, C, Liu, L, Wang, Q, Yang, M, Kalady, MF, Qian, J, Zhang, A, Gupte, AA, Hamilton, DJ, Zheng, C & Yi, Q 2019, , Cell Metabolism, vol. 30, no. 1, pp. 143-156.e5. https://doi.org/10.1016/j.cmet.2019.04.002

E-cadherin expression on multiple myeloma cells activates tumor-promoting properties in plasmacytoid DCs
Bi, E, Li, R, Bover, LC, Li, H, Su, P, Ma, X, Huang, C, Wang, Q, Liu, L, Yang, M, Lin, Z, Qian, J, Fu, W, Liu, Y-J & Yi, Q 2018, , The Journal of clinical investigation, vol. 128, no. 11, pp. 4821-4831. https://doi.org/10.1172/JCI121421

Th9 Cells Represent a Unique Subset of CD4+ T Cells Endowed with the Ability to Eradicate Advanced Tumors
Lu, Y, Wang, Q, Xue, G, Bi, E, Ma, X, Wang, A, Qian, J, Dong, C & Yi, Q 2018, , Cancer Cell, vol. 33, no. 6, pp. 1048-1060.e7. https://doi.org/10.1016/j.ccell.2018.05.004

Cholesterol negatively regulates IL-9-producing CD8+ T cell differentiation and antitumor activity
Ma, X, Bi, E, Huang, C, Lu, Y, Xue, G, Guo, X, Wang, A, Yang, M, Qian, J, Dong, C & Yi, Q 2018, , The Journal of experimental medicine, vol. 215, no. 6, pp. 1555-1569. https://doi.org/10.1084/jem.20171576

Therapeutic effects of CSF1R-blocking antibodies in multiple myeloma
Wang, Q, Lu, Y, Li, R, Jiang, Y, Zheng, Y, Qian, J, Bi, E, Zheng, C, Hou, J, Wang, S & Yi, Q 2018, , Leukemia, vol. 32, no. 1, pp. 176-183. https://doi.org/10.1038/leu.2017.193

Foxo1 and Foxp1 play opposing roles in regulating the differentiation and antitumor activity of TH9 cells programmed by IL-7
Bi, E, Ma, X, Lu, Y, Yang, M, Wang, Q, Xue, G, Qian, J, Wang, S & Yi, Q 2017, , Science signaling, vol. 10, no. 500. https://doi.org/10.1126/scisignal.aak9741

Role of myeloma-derived MIF in myeloma cell adhesion to bone marrow and chemotherapy response
Yuhuan, Z, Qiang, W, Li, T, Qian, J, Lu, Y, Li, Y, Bi, E, Reu, F, Qin, Y, Drazba, J, Hsi, E, Jing, Y, Cai, Z & Yi, Q 2016, , Journal of the National Cancer Institute, vol. 108, no. 11. https://doi.org/10.1093/jnci/djw131

IL-15 enhances the antitumor effect of human antigen-specific CD8+ T cells by cellular senescence delay
Weng, J, Moriarty, KE, Baio, FE, Chu, F, Kim, S-D, He, J, Jie, Z, Xie, X, Ma, W, Qian, J, Zhang, L, Yang, J, Yi, Q, Neelapu, SS & Kwak, LW 2016, , OncoImmunology, vol. 5, no. 12, pp. e1237327. https://doi.org/10.1080/2162402X.2016.1237327

VIEW FULL PUBLICATIONS