Jessica S. Thomas

Jessica S. Thomas, MD, PhD

Assistant Professor of Clinical Pathology and Genomic Medicine, Academic Institute
Houston Methodist
Weill Cornell Medical College

Molecular Genetic Pathology Fellowship


Dr. Thomas received an MPH in Health Education in 2001 from the University of Southern Mississippi. She then entered an MD/PhD program at the Louisiana State University Health Sciences Center in New Orleans. She received her PhD from the Department of Microbiology, Immunology, and Parasitology in 2009 and her MD in 2011. Subsequently, she pursued a combined clinical and anatomic pathology residency, and a clinical fellowship in molecular genetic pathology in the Department of Pathology, Microbiology, and Immunology at Vanderbilt University Medical Center. At the completion of her fellowship, she joined the Department of Pathology and Genomic Medicine at Houston Methodist Hospital Houston Methodist as Associate Director of the Molecular Pathology Diagnostic Laboratory. Dr. Thomas is currently an Assistant Professor of Clinical Pathology and Laboratory Medicine with appointments at Weill Cornell Medical College, New York, NY and Houston Methodist Academic Institute. Dr. Thomas was licensed by the Texas Medical Board in August 2016, and has been a Diplomate of the American Board of Pathology in Clinical Pathology since November 2015. She is also board certified by the American Board of Pathology and the American Board of Medical Genetics and Genomics in Molecular Genetic Pathology (September 2016).

Dr. Thomas is actively involved in several professional societies including the Association for Molecular Pathology, the American Medical Association, the Texas Society for Pathologists, and the Academy of Clinical Laboratory Physicians and Scientists. She is also a fellow of the American Society for Clinical Pathology and a fellow with the College of American Pathologists (CAP).

Description of Research

Her clinical, teaching, and research interests are focused on molecular diagnostics, including molecular oncology and molecular infectious diseases, assay development and validation in the clinical laboratory, and trainee education in molecular pathology.


Molecular testing in colorectal cancer
Thomas, JS & Shi, C 2023, . in Diagnostic Molecular Pathology: A Guide to Applied Molecular Testing, Second Edition. Elsevier, pp. 339-358.

A retrospective analysis of molecular testing in cytologically indeterminate thyroid nodules with histologic correlation: Experience at a heterogenous multihospital system
Sura, GH, Thrall, MJ, Rogers, J, Hodjat, P, Christensen, P, Cubb, TD, Khadra, HS, Thomas, JS & Jacobi, EM 2024, , Diagnostic Cytopathology, vol. 52, no. 2, pp. 82-92.

Molecular Signatures of KRAS-Mutated Lung Adenocarcinoma: Analysis of Concomitant EGFR, ALK, STK11, and PD-L1 Status
Hsu, J, Annunziata, JF, Burns, E, Bernicker, EH, Olsen, RJ & Thomas, JS 2022, , Clinical Pathology, vol. 15, pp. 2632010X221102054.

Outcomes and prognostic contributors in patients with KRAS mutated non-small cell pulmonary adenocarcinomas: A single institution experience
Burns, EA, Ensor, JE, Hsu, J, Thomas, JS, Olsen, RJ & Bernicker, EH 2021, , Journal of Thoracic Disease, vol. 13, no. 8, pp. 4785-4796.

Pleomorphic giant cell carcinoma of prostate: Rare tumor with unique clinicopathological, immunohistochemical, and molecular features
El-Zaatari, ZM, Thomas, JS, Divatia, MK, Shen, SS, Ayala, AG, Monroig-Bosque, P, Shehabeldin, A & Ro, JY 2021, , Annals of Diagnostic Pathology, vol. 52, 151719.

Identifying possible germline variants from tumor-only sequencing of hematological malignancies
Shao, J, Subedi, S, Pepper, K, Badgett, S, Christensen, PA, Hendrickson, HL, Thomas, JS, Olsen, RJ & Li, Z 2021, , Leukemia and Lymphoma, vol. 62, no. 2, pp. 482-485.

Urinary Bladder Inflammatory Myofibroblastic Tumor with Mutated TP53 and PPFIBP1-ALK Gene Fusion
Barbieri, AN, Tallman, CT, Satkunasivam, R, Annunziata, J, Thomas, JS, Olsen, RJ, Shen, SS, Thrall, MJ & Schwartz, MR 2021, , AJSP: Reviews and Reports, vol. 26, no. 1, pp. 45-49.

Collision Tumor Composed of Renal Oncocytoma and Mucinous Tubular and Spindle Cell Carcinoma: Not a Rare Occurrence
Lin, MS, Jacobi, EM, Mullick, SS, Nguyen, CV, Thomas, JS, Olsen, RJ, Shen, SS, Ayala, AG & Ro, JY 2020, , AJSP: Reviews and Reports, vol. 25, no. 6, pp. 270-275.

Pathology Trainee Redeployment and Education During the COVID-19 Pandemic: An Institutional Experience
Monroig-Bosque, PDC, Hsu, JW, Lin, MS, Shehabeldin, AN, Rogers, JT, Kim, CF, Kalsekar, AG, Jin, Z, Cara, LR, Barbieri, AN, El-Zaatari, Z, Eskandari, G, Sheu, TG, Tomsula, JA, Long, SW, Zieske, AW, Leveque, CM, Salazar, E, Mody, DR, Schwartz, MR, Cykowski, MD, Yi, X, Powell, SZ & Thomas, JS 2020, , Academic Pathology, vol. 7.

Clinical Utility of Reflex Ordered Testing for Molecular Biomarkers in Lung Adenocarcinoma
Anand, K, Phung, TL, Bernicker, EH, Cagle, PT, Olsen, RJ & Thomas, JS 2020, , Clinical Lung Cancer, vol. 21, no. 5, pp. 437-442.

Development and validation of Houston Methodist Variant Viewer version 3: Updates to our application for interpretation of next-generation sequencing data
Christensen, PA, Subedi, S, Pepper, K, Hendrickson, HL, Li, Z, Thomas, JS, Wesley Long, S & Olsen, RJ 2020, , JAMIA Open, vol. 3, no. 2, pp. 299-305.

A BRAF V600E Mutation in RET-Negative Medullary Thyroid Cancer
Robbins, RJ, Thomas, JS, Osuna, PM & Shakil, J 2020, , Case Reports in Endocrinology, vol. 2020, 7641940.

Houston Methodist Variant Viewer: An Application to Support Clinical Laboratory Interpretation of Next-generation Sequencing Data for Cancer
Christensen, PA, Ni, Y, Bao, F, Hendrickson, HL, Greenwood, M, Thomas, JS, Long, SW & Olsen, RJ 2017, , Journal of Pathology Informatics, vol. 8, no. 1, A25.

Comparison of BCR/ABL1 mRNA levels by quantitative real-time PCR in peripheral blood and bone marrow specimens of patients with chronic myelogenous leukemia
Thomas, JS, Jagasia, M & Vnencak-Jones, CL 2017, , Leukemia and Lymphoma, pp. 1-4.

Molecular Testing in Colorectal Cancer
Thomas, JS & Shi, C 2016, . in Diagnostic Molecular Pathology: A Guide to Applied Molecular Testing. Elsevier, pp. 305-320.

Effects of alcohol consumption on antigen-specific cellular and humoral immune responses to SIV in rhesus macaques
Pahar, B, Amedee, AM, Thomas, J, Dufour, JP, Zhang, P, Nelson, S, Veazey, RS & Bagby, GJ 2013, , Journal of Acquired Immune Deficiency Syndromes, vol. 64, no. 4, pp. 332-341.

Characterization of SIV in the oral cavity and in vitro inhibition of SIV by Rhesus Macaque Saliva
Thomas, JS, Lacour, N, Kozlowski, PA, Nelson, S, Bagby, GJ & Amedee, AM 2010, , AIDS Research and Human Retroviruses, vol. 26, no. 8, pp. 901-911.