Jason Sakamoto

Jason Sakamoto, PhD

Assistant Affiliate Member, Research Institute
Houston Methodist


Biography

Dr. Sakamoto is a faculty member of The Methodist Hospital Research Institute in Houston, Texas, where he leads research efforts developing novel nano-therapeutic drug delivery systems and nano-based proteomics technologies. He is a co-inventor of the multi-stage nanoporous silicon nanovector delivery system technology that is currently being commercialized by Leonardo BioSystems. Dr. Sakamoto serves as an Interim Co-Chair of the Department of Nanomedicine at TMHRI. He also serves as the Chief Operating Officer of the Alliance for NanoHealth. The Alliance is a consortium of eight institutions of the Greater Houston Texas Region. The mission of the Alliance is to collectively bridge the disciplines to develop nanotechnology-based solutions to unresolved problems in medicine and to facilitate the clinical translation of these new technologies through commercialization. Dr. Sakamoto also serves as a consultant for the Arrowhead Research Corporation, assigned to the technology and business development of Leonardo Biosystems.

Prior to his services in Houston, Dr. Sakamoto completed his undergraduate degree in Material Science Engineering from the University of California at Berkeley under the mentorship of Dr. Mauro Ferrari. After graduating, he entered the medical device industry and was employed as coronary and peripheral stent manufacturing and process engineer at the Guidant Corporation in Santa Clara, California. During these years at Guidant, he played a significant role in the regulatory approval process of three medical devices and was responsible for the GMP production of coronary/peripheral stents for over a year. After Guidant, he rejoined Dr. Ferrari's research team and received his doctorate in Biomedical Engineering from The Ohio State University. Upon completion of his Ph.D., Dr. Sakamoto remained as a post-doctoral researcher in Dr. Ferrari's nanomedicine research group, while working as a business development consultant for several biotech start-ups. He has written several publications on nanomedicine including peer-reviewed journal articles and book chapters, and is an inventor on two pending U.S. patent applications.

Description of Research

Dr. Sakamoto leads the Nanochip Proteomics program in the Department of Nanomedicine. This technology analyzes proteomic signatures of the low molecular weight proteome and peptidome found in bodily fluids to monitor disease progression and patient response to therapy. He also develops novel nanovector therapeutics for cancer and other clinical applications.

Areas Of Expertise

Cancer Nanotechnology Proteomics Personalized medicine Multistage
Education & Training

PhD, The Ohio State University
Patents

MULTISTAGE DELIVERY OF ACTIVE AGENTS

Patent Number: US2016051481, Feb 25 2016

Publications

Platforms to test the temporospatial capabilities of carrier systems in delivering growth factors to benefit vascular bioengineering
Argueta, LB, Niles, JA, Sakamoto, J, Liu, X, Vega, SP, Frank, L, Paessler, M, Cortiella, J & Nichols, JE 2021, , Nanomedicine: Nanotechnology, Biology, and Medicine, vol. 36, 102419. https://doi.org/10.1016/j.nano.2021.102419

Advanced implantable drug delivery technologies: transforming the clinical landscape of therapeutics for chronic diseases
Pons-Faudoa, FP, Ballerini, A, Sakamoto, J & Grattoni, A 2019, , Biomedical Microdevices, vol. 21, no. 2, 47. https://doi.org/10.1007/s10544-019-0389-6

Production and transplantation of bioengineered lung into a large-animal model
Nichols, JE, La Francesca, S, Niles, JA, Vega, SP, Argueta, LB, Frank, L, Christiani, DC, Pyles, RB, Himes, BE, Zhang, R, Li, S, Sakamoto, J, Rhudy, J, Hendricks, G, Begarani, F, Liu, X, Patrikeev, I, Pal, R, Usheva, E, Vargas, G, Miller, A, Woodson, L, Wacher, A, Grimaldo, M, Weaver, D, Mlcak, R & Cortiella, J 2018, , Science translational medicine, vol. 10, no. 452. https://doi.org/10.1126/scitranslmed.aao3926

Nanotechnology toward advancing personalized medicine
Sakamoto, JH, Godin, B, Hu, Y, Blanco, E, van de Ven, AL, Vellaichamy, A, Murphy, MB, La Francesca, S, Schuenemeyer, T, Given, B, Meyn, A & Ferrari, M 2016, . in Handbook of Clinical Nanomedicine: Law, Business, Regulation, Safety, and Risk. vol. 2, Pan Stanford Publishing Pte. Ltd. pp. 1347-1411. https://doi.org/10.4032/9789814669238

Porcine acellular lung matrix for wound healing and abdominal wall reconstruction: A pilot study
Fernandez-Moure, JS, Van Eps, JL, Rhudy, JR, Cabrera, FJ, Acharya, GS, Tasciotti, E, Sakamoto, J & Nichols, JE 2016, , Journal of Tissue Engineering, vol. 7, pp. 2041731415626018. https://doi.org/10.1177/2041731415626018

MULTISTAGE DELIVERY OF ACTIVE AGENTS
FERRARI, MAURO, TASCIOTTI, ENNIO & SAKAMOTO, JASON 2016, , Patent No. US2016051481, IPC No. A61K 31/ 7088 A I.

Porcine acellular lung matrix for wound healing and abdominal wall reconstruction: A pilot study
Fernandez-Moure, JS, Van Eps, JL, Rhudy, JR, Cabrera, FJ, Acharya, GS, Tasciotti, E, Sakamoto, J & Nichols, J 2016, , Journal of Tissue Engineering, vol. 7. https://doi.org/10.1177/2041731415626018

Silencing of tumor necrosis factor receptor-1 in human lung microvascular endothelial cells using particle platforms for siRNA delivery
Bai, L, Andersson, HA, McConnell, KI, Chan, DL, Hernandez, M, Gonzalez, J, Liu, X, Francesca, SL, Sakamoto, JH & Serda, RE 2015, , Current Drug Targets, vol. 16, no. 13, A013, pp. 1531-1539.

Enhanced gene delivery in porcine vasculature tissue following incorporation of adeno-associated virus nanoparticles into porous silicon microparticles
McConnell, KI, Rhudy, J, Yokoi, K, Gu, J, Mack, A, Suh, J, La Francesca, S, Sakamoto, J & Serda, RE 2014, , Journal of Controlled Release, vol. 194, pp. 113-121. https://doi.org/10.1016/j.jconrel.2014.08.020

Multipotent adult progenitor cells decrease cold ischemic injury in ex vivo perfused human lungs: An initial pilot and feasibility study
La Francesca, S, Ting, AE, Sakamoto, J, Rhudy, J, Bonenfant, NR, Borg, ZD, Cruz, FF, Goodwin, M, Lehman, NA, Taggart, JM, Deans, R & Weiss, DJ 2014, , Transplantation Research, vol. 3, no. 1, 19. https://doi.org/10.1186/2047-1440-3-19

Production and assessment of decellularized pig and human lung scaffolds
Nichols, JE, Niles, J, Riddle, M, Vargas, G, Schilagard, T, Ma, L, Edward, K, La Francesca, S, Sakamoto, J, Vega, S, Ogadegbe, M, Mlcak, R, Deyo, D, Woodson, L, Mcquitty, C, Lick, S, Beckles, D, Melo, E & Cortiella, J 2013, , Tissue Engineering - Part A, vol. 19, no. 17-18, pp. 2045-2062. https://doi.org/10.1089/ten.tea.2012.0250

Enhancing chemotherapy response with sustained EphA2 silencing using multistage vector delivery
Shen, H, Rodriguez-Aguayo, C, Xu, R, Gonzalez-Villasana, V, Mai, J, Huang, Y, Zhang, G, Guo, X, Bai, L, Qin, G, Deng, X, Li, Q, Erm, DR, Aslan, B, Liu, X, Sakamoto, J, Chavez-Reyes, A, Han, HD, Sood, AK, Ferrari, M & Lopez-Berestein, G 2013, , Clinical Cancer Research, vol. 19, no. 7, pp. 1806-1815. https://doi.org/10.1158/1078-0432.CCR-12-2764

Nanotechnology toward advancing personalized medicine
Sakamoto, JH, Godin, B, Hu, Y, Blanco, E, van de Ven, AL, Vellaichamy, A, Murphy, MB, La Francesca, S, Schuenemeyer, T, Given, B, Meyn, A & Ferrari, M 2013, . in Handbook of Personalized Medicine: Advances in Nanotechnology, Drug Delivery and Therapy. Pan Stanford Publishing Pte. Ltd. pp. 1-58. https://doi.org/10.4032/9789814411202

Modeling the tumor microenvironment as a biobarrier in cancer nanotherapeutics
Frieboes, HB, Yokoi, K, Dave, B, Hussain, F & Godin, B 2012, . in Mass Transport of Nanocarriers. Pan Stanford Publishing Pte. Ltd. pp. 137-183. https://doi.org/10.4032/9789814364423

Human Lung Cancer Cells Grown in an Ex Vivo 3D Lung Model Produce Matrix Metalloproteinases Not Produced in 2D Culture
Mishra, DK, Sakamoto, JH, Thrall, MJ, Baird, BN, Blackmon, SH, Ferrari, M, Kurie, JM & Kim, MP 2012, , PLoS ONE, vol. 7, no. 9, e45308. https://doi.org/10.1371/journal.pone.0045308

Low molecular weight protein enrichment on mesoporous silica thin films for biomarker discovery
Fan, J, Gallagher, JW, Wu, HJ, Landry, MG, Sakamoto, J, Ferrari, M & Hu, Y 2012, , Journal of visualized experiments : JoVE, no. 62, e3876. https://doi.org/10.3791/3876

Nanotechnologies and regenerative medical approaches for space and terrestrial medicine
Grattoni, A, Tasciotti, E, Fine, D, Fernandez-Moure, JS, Sakamoto, J, Hu, Y, Weiner, B, Ferrari, M & Parazynski, S 2012, , Aviation Space and Environmental Medicine, vol. 83, no. 11, pp. 1025-1036. https://doi.org/10.3357/ASEM.3307.2012

Surface engineering on mesoporous silica chips for enriching low molecular weight phosphorylated proteins
Hu, Y, Peng, Y, Lin, K, Shen, H, Brousseau, LC, Sakamoto, J, Sun, T & Ferrari, M 2011, , Nanoscale, vol. 3, no. 2, pp. 421-428. https://doi.org/10.1039/c0nr00720j

Nanotechnology Towards Advancing Personalized Medicine
Sakamoto, J, Godin, B, Hu, YT, Blanco, E, van de Ven, AL, Vellaichamy, A, Murphy, MB, La Francesca, S, Schuenemeyer, T, Given, B, Meyn, A & Ferrari, M 2011, . in Handbook of Personalized Medicine: Advances in Nanotechnology, Drug Delivery and Therapy. Pan Stanford Publishing Pte. Ltd.

Enabling individualized therapy through nanotechnology
Sakamoto, JH, van de Ven, AL, Godin, B, Blanco, E, Serda, RE, Grattoni, A, Ziemys, A, Bouamrani, A, Hu, T, Ranganathan, SI, De Rosa, E, Martinez, JO, Smid, CA, Buchanan, RM, Lee, SY, Srinivasan, S, Landry, M, Meyn, A, Tasciotti, E, Liu, X, Decuzzi, P & Ferrari, M 2010, , Pharmacological Research, vol. 62, no. 2, pp. 57-89. https://doi.org/10.1016/j.phrs.2009.12.011