James C. Major, MD, PhD

Assistant Professor of Clinical Ophthalmology, Institute for Academic Medicine
Houston Methodist
Weill Cornell Medical College

Education & Training

MD, Baylor College of Medicine
Clinical Fellowship, Bascom Palmer Eye Inst & Hosp
Residency, Bascom Palmer Eye Inst & Hosp
Internship, Carilion Roanoke Memorial Hospital

Topographic Correspondence of Macular Atrophy With Choroidal Neovascularization in Ranibizumab-treated Eyes of the TREX-AMD Trial
TREX-AMD Study Group 2018, American Journal of Ophthalmology, vol. 192, pp. 84-90. DOI: 10.1016/j.ajo.2018.05.008

Comparison of monthly vs treat-and-extend regimens for individuals with macular edema who respond well to anti-vascular endothelial growth factor medications: Secondary outcomes from the SCORE2 randomized clinical trial
SCORE2 Investigator Group 2018, JAMA Ophthalmology, vol. 136, no. 4, pp. 337-345. DOI: 10.1001/jamaophthalmol.2017.6843

Effect of adding dexamethasone to continued ranibizumab treatment in patients with persistent diabetic macular edema: A DRCR network phase 2 randomized clinical trial
Diabetic Retinopathy Clinical Research Network 2018, JAMA Ophthalmology, vol. 136, no. 1, pp. 29-38. DOI: 10.1001/jamaophthalmol.2017.4914

Macular Atrophy in Neovascular Age-Related Macular Degeneration with Monthly versus Treat-and-Extend Ranibizumab: Findings from the TREX-AMD Trial
Abdelfattah, NS, Al-Sheikh, M, Pitetta, S, Mousa, A, Sadda, SVR, Wykoff, CC, Wykoff, CC, Croft, DE, Brown, DM, Wang, R, Payne, JF, Clark, L, Abdelfattah, NS, Sadda, SVR, Benz, MS, Chen, E, Fish, RH, Johnson, DL, Kim, RY, Major, JC, OMalley, RE, Schefler, AC, Shah, AR, Vance, SK, Wells, JA & Wong, TP 2017, Ophthalmology, vol. 124, no. 2, pp. 215-223. DOI: 10.1016/j.ophtha.2016.10.002

Khurana, RN, Wykoff, CC, Bansal, AS, Akiyama, K, Palmer, JD, Chen, E, Chang, LK, Major, JC, Wu, C, Wang, R, Croft, DE & Wong, TP 2016, Retina. DOI: 10.1097/IAE.0000000000001307

Choroidal Neovascularization Secondary to Alexandrite Laser Exposure
Wang, R, Wykoff, CC, Christie, L, Croft, DE, Major, JC, Fish, RH & Brown, DM 2016, Retinal Cases and Brief Reports, vol. 10, no. 3, pp. 244-248. DOI: 10.1097/ICB.0000000000000241

ENDOPHTHALMITIS AFTER INTRAVITREAL INJECTION: Role of Prophylactic Topical Ophthalmic Antibiotics
Li, AL, Wykoff, CC, Wang, R, Chen, E, Benz, MS, Fish, RH, Wong, TP, Major, JC, Brown, DM, Schefler, AC, Kim, RY & OMalley, RE 2015, Retina. DOI: 10.1097/IAE.0000000000000901

Diagnostic and Therapeutic Challenges
Phillis, CA, Bourke, RD & Major, JC 2015, Retina. DOI: 10.1097/IAE.0000000000000880

Aflibercept for pigment epithelial detachment for previously treated neovascular age-related macular degeneration
Major, JC, Wykoff, CC, Croft, DE, Wang, R, Mariani, AF, Lehmann, AE & Brown, DM 2015, Canadian Journal of Ophthalmology, vol. 50, no. 5, 715, pp. 373-377. DOI: 10.1016/j.jcjo.2014.12.012

5Q with James C. Major Jr, MD, PHD
Major, JC 2015, Retina Today, vol. 2015, no. September2015, pp. 81-82.

Progressive retinal nonperfusion in ischemic central retinal vein occlusion
Wykoff, CC, Brown, DM, Croft, DE, Major, JC & Wong, TP 2015, Retina, vol. 35, no. 1, pp. 43-47. DOI: 10.1097/IAE.0000000000000277

Occult retinal detachment after mild traumatic brain injury: Case report and literature review
Bedgood, A, Rand, SE & Major, J 2014, Clinical Journal of Sport Medicine. DOI: 10.1097/JSM.0000000000000114

Comparison of spectral-domain and time-domain optical coherence tomography in the detection of neovascular age-related macular degeneration activity
Major, JC, Wykoff, CC, Mariani, AF, Chen, E, Croft, DE & Brown, DM 2014, Retina, vol. 34, no. 1, pp. 48-54. DOI: 10.1097/IAE.0b013e3182965743

Purtscher-like retinopathy associated with pemphigus vulgaris
Mariani, AF, Major, JC, Brown, DM, Wykoff, CC, Benz, MS & Kegley, EN 2013, Retinal Cases and Brief Reports, vol. 7, no. 4, pp. 304-306. DOI: 10.1097/ICB.0b013e31828ef039

Current concepts in managing wet AMD suboptimally responsive to anti-VEGF therapy
Hariprasad, SM & Major, JC 2013, Ophthalmic Surgery Lasers and Imaging Retina, vol. 44, no. 3, pp. 225-226. DOI: 10.3928/23258160-20130503-01

SAVE (super-dose anti-VEGF) trial: 2.0 mg ranibizumab for recalcitrant neovascular age-related macular degeneration: 1-year results
Wykoff, CC, Brown, DM, Chen, E, Major, JC, Croft, DE, Mariani, A & Wong, TP 2013, Ophthalmic Surgery Lasers and Imaging Retina, vol. 44, no. 2, pp. 121-126. DOI: 10.3928/23258160-20130313-04

Super-dose anti-VEGF (SAVE) trial: 2.0 mg Intravitreal ranibizumab for recalcitrant neovascular macular degeneration-primary end point
Brown, DM, Chen, E, Mariani, A & Major, JC 2013, Ophthalmology, vol. 120, no. 2, pp. 349-354. DOI: 10.1016/j.ophtha.2012.08.008

Use of nepafenac (Nevanac®)in combination with intravitreal anti-VEGF agents in the treatment of recalcitrant exudative macular degeneration requiring monthly injections
Chen, E, Benz, MS, Fish, RH, Brown, DM, Wong, TP, Kim, RY & Major, JC 2010, Clinical Ophthalmology, vol. 4, no. 1, pp. 1249-1252. DOI: 10.2147/OPTH.S14092

Spectral domain optical coherence tomography as an effective screening test for hydroxychloroquine retinopathy (the "flying saucer" sign)
Chen, E, Brown, DM, Benz, MS, Fish, RH, Wong, TP, Kim, RY & Major, JC 2010, Clinical Ophthalmology, vol. 4, no. 1, pp. 1151-1158. DOI: 10.2147/OPTH.S14257

Retinal detachment despite aggressive management of aggressive posterior retinopathy of prematurity.
Suk, KK, Berrocal, AM, Murray, TG, Rich, R, Major, JC, Hess, D & Johnson, RA 2010, Journal of pediatric ophthalmology and strabismus, vol. 47 Online.