James C. Major, MD, PhD

Assistant Professor of Clinical Ophthalmology, Institute for Academic Medicine
Houston Methodist
Weill Cornell Medical College


Education & Training

MD, Baylor College of Medicine
Clinical Fellowship, Bascom Palmer Eye Inst & Hosp
Residency, Bascom Palmer Eye Inst & Hosp
Internship, Carilion Roanoke Memorial Hospital
Publications

Topographic Correspondence of Macular Atrophy With Choroidal Neovascularization in Ranibizumab-treated Eyes of the TREX-AMD Trial
TREX-AMD Study Group 2018, American Journal of Ophthalmology, vol. 192, pp. 84-90. DOI: 10.1016/j.ajo.2018.05.008

Comparison of monthly vs treat-and-extend regimens for individuals with macular edema who respond well to anti-vascular endothelial growth factor medications: Secondary outcomes from the SCORE2 randomized clinical trial
SCORE2 Investigator Group 2018, JAMA Ophthalmology, vol. 136, no. 4, pp. 337-345. DOI: 10.1001/jamaophthalmol.2017.6843

Effect of adding dexamethasone to continued ranibizumab treatment in patients with persistent diabetic macular edema: A DRCR network phase 2 randomized clinical trial
Diabetic Retinopathy Clinical Research Network 2018, JAMA Ophthalmology, vol. 136, no. 1, pp. 29-38. DOI: 10.1001/jamaophthalmol.2017.4914

Macular Atrophy in Neovascular Age-Related Macular Degeneration with Monthly versus Treat-and-Extend Ranibizumab: Findings from the TREX-AMD Trial
Abdelfattah, NS, Al-Sheikh, M, Pitetta, S, Mousa, A, Sadda, SVR, Wykoff, CC, Wykoff, CC, Croft, DE, Brown, DM, Wang, R, Payne, JF, Clark, L, Abdelfattah, NS, Sadda, SVR, Benz, MS, Chen, E, Fish, RH, Johnson, DL, Kim, RY, Major, JC, OMalley, RE, Schefler, AC, Shah, AR, Vance, SK, Wells, JA & Wong, TP 2017, Ophthalmology, vol. 124, no. 2, pp. 215-223. DOI: 10.1016/j.ophtha.2016.10.002

THE ASSOCIATION OF EPIRETINAL MEMBRANE WITH MACULAR HOLE FORMATION AFTER RHEGMATOGENOUS RETINAL DETACHMENT REPAIR
Khurana, RN, Wykoff, CC, Bansal, AS, Akiyama, K, Palmer, JD, Chen, E, Chang, LK, Major, JC, Wu, C, Wang, R, Croft, DE & Wong, TP 2016, Retina. DOI: 10.1097/IAE.0000000000001307

Choroidal Neovascularization Secondary to Alexandrite Laser Exposure
Wang, R, Wykoff, CC, Christie, L, Croft, DE, Major, JC, Fish, RH & Brown, DM 2016, Retinal Cases and Brief Reports, vol. 10, no. 3, pp. 244-248. DOI: 10.1097/ICB.0000000000000241

ENDOPHTHALMITIS AFTER INTRAVITREAL INJECTION: Role of Prophylactic Topical Ophthalmic Antibiotics
Li, AL, Wykoff, CC, Wang, R, Chen, E, Benz, MS, Fish, RH, Wong, TP, Major, JC, Brown, DM, Schefler, AC, Kim, RY & OMalley, RE 2015, Retina. DOI: 10.1097/IAE.0000000000000901

Diagnostic and Therapeutic Challenges
Phillis, CA, Bourke, RD & Major, JC 2015, Retina. DOI: 10.1097/IAE.0000000000000880

Aflibercept for pigment epithelial detachment for previously treated neovascular age-related macular degeneration
Major, JC, Wykoff, CC, Croft, DE, Wang, R, Mariani, AF, Lehmann, AE & Brown, DM 2015, Canadian Journal of Ophthalmology, vol. 50, no. 5, 715, pp. 373-377. DOI: 10.1016/j.jcjo.2014.12.012

5Q with James C. Major Jr, MD, PHD
Major, JC 2015, Retina Today, vol. 2015, no. September2015, pp. 81-82.

Progressive retinal nonperfusion in ischemic central retinal vein occlusion
Wykoff, CC, Brown, DM, Croft, DE, Major, JC & Wong, TP 2015, Retina, vol. 35, no. 1, pp. 43-47. DOI: 10.1097/IAE.0000000000000277

Occult retinal detachment after mild traumatic brain injury: Case report and literature review
Bedgood, A, Rand, SE & Major, J 2014, Clinical Journal of Sport Medicine. DOI: 10.1097/JSM.0000000000000114

Comparison of spectral-domain and time-domain optical coherence tomography in the detection of neovascular age-related macular degeneration activity
Major, JC, Wykoff, CC, Mariani, AF, Chen, E, Croft, DE & Brown, DM 2014, Retina, vol. 34, no. 1, pp. 48-54. DOI: 10.1097/IAE.0b013e3182965743

Purtscher-like retinopathy associated with pemphigus vulgaris
Mariani, AF, Major, JC, Brown, DM, Wykoff, CC, Benz, MS & Kegley, EN 2013, Retinal Cases and Brief Reports, vol. 7, no. 4, pp. 304-306. DOI: 10.1097/ICB.0b013e31828ef039

Current concepts in managing wet AMD suboptimally responsive to anti-VEGF therapy
Hariprasad, SM & Major, JC 2013, Ophthalmic Surgery Lasers and Imaging Retina, vol. 44, no. 3, pp. 225-226. DOI: 10.3928/23258160-20130503-01

SAVE (super-dose anti-VEGF) trial: 2.0 mg ranibizumab for recalcitrant neovascular age-related macular degeneration: 1-year results
Wykoff, CC, Brown, DM, Chen, E, Major, JC, Croft, DE, Mariani, A & Wong, TP 2013, Ophthalmic Surgery Lasers and Imaging Retina, vol. 44, no. 2, pp. 121-126. DOI: 10.3928/23258160-20130313-04

Super-dose anti-VEGF (SAVE) trial: 2.0 mg Intravitreal ranibizumab for recalcitrant neovascular macular degeneration-primary end point
Brown, DM, Chen, E, Mariani, A & Major, JC 2013, Ophthalmology, vol. 120, no. 2, pp. 349-354. DOI: 10.1016/j.ophtha.2012.08.008

Use of nepafenac (Nevanac®)in combination with intravitreal anti-VEGF agents in the treatment of recalcitrant exudative macular degeneration requiring monthly injections
Chen, E, Benz, MS, Fish, RH, Brown, DM, Wong, TP, Kim, RY & Major, JC 2010, Clinical Ophthalmology, vol. 4, no. 1, pp. 1249-1252. DOI: 10.2147/OPTH.S14092

Spectral domain optical coherence tomography as an effective screening test for hydroxychloroquine retinopathy (the "flying saucer" sign)
Chen, E, Brown, DM, Benz, MS, Fish, RH, Wong, TP, Kim, RY & Major, JC 2010, Clinical Ophthalmology, vol. 4, no. 1, pp. 1151-1158. DOI: 10.2147/OPTH.S14257

Retinal detachment despite aggressive management of aggressive posterior retinopathy of prematurity.
Suk, KK, Berrocal, AM, Murray, TG, Rich, R, Major, JC, Hess, D & Johnson, RA 2010, Journal of pediatric ophthalmology and strabismus, vol. 47 Online.