Irene M. Min

Irene M. Min, PhD

Associate Research Professor of Radiology, Academic Institute
Houston Methodist
Weill Cornell Medical College


Description of Research

My research focuses on immune cell activities in endocrine cancers with a goal to redirect T lymphocytes for therapeutic strategies and to harness T cell specificity and function for cancer elimination. We developed a novel immunotherapeutic, which specifically targets advanced thyroid cancer. 

Publications

Developing a predictive model for metastatic potential in pancreatic neuroendocrine tumor
Greenberg, JA, Shah, Y, Ivanov, NA, Marshall, T, Kulm, S, Williams, J, Tran, C, Scognamiglio, T, Heymann, JJ, Lee-Saxton, YJ, Egan, C, Majumdar, S, Min, IM, Zarnegar, R, Howe, J, Keutgen, XM, Fahey Iii, TJ, Elemento, O & Finnerty, BM 2024, , Journal of Clinical Endocrinology and Metabolism. https://doi.org/10.1210/clinem/dgae380

Low-dose targeted radionuclide therapy synergizes with CAR T cells and enhances tumor response
Yang, Y, Vedvyas, Y, Alcaina, Y, Son, JY, Min, IM & Jin, MM 2024, , Frontiers in immunology, vol. 15, 1355388, pp. 1355388. https://doi.org/10.3389/fimmu.2024.1355388

Chimeric Antigen Receptor T Cell Therapy Targeting Epithelial Cell Adhesion Molecule in Gastric Cancer: Mechanisms of Tumor Resistance
Yang, Y, Louie, R, Puc, J, Vedvyas, Y, Alcaina, Y, Min, IM, Britz, M, Luciani, F & Jin, MM 2023, , Cancers, vol. 15, no. 23, 5552. https://doi.org/10.3390/cancers15235552

Activation of the JAK/STAT Pathway Leads to BRAF Inhibitor Resistance in BRAFV600E Positive Thyroid Carcinoma
Limberg, J, Egan, CE, Gray, KD, Singh, M, Loewenstein, Z, Yang, Y, Riascos, MC, Asadi, HA, Safe, P, Eshaky, SE, Liang, H, Ullmann, TM, Wang, W, Li, W, Zhang, T, Xiang, J, Stefanova, D, Jin, MM, Zarnegar, R, Fahey, TJ & Min, IM 2023, , Molecular Cancer Research, vol. 21, no. 5, pp. 397-410. https://doi.org/10.1158/1541-7786.MCR-21-0832

Inducible expression of interleukin-12 augments the efficacy of affinity-tuned chimeric antigen receptors in murine solid tumor models
Yang, Y, Yang, H, Alcaina, Y, Puc, J, Birt, A, Vedvyas, Y, Gallagher, M, Alla, S, Riascos, MC, McCloskey, JE, Du, K, Gonzalez-Valdivieso, J, Min, I, de Stanchina, E, Britz, M, von Hofe, E & Jin, MM 2023, , Nature Communications, vol. 14, no. 1, 2068, pp. 2068. https://doi.org/10.1038/s41467-023-37646-y, https://doi.org/10.1038/s41467-023-37646-y

Targeted delivery of low-dose radiation alleviates tumor resistance to CAR-T cell therapy
Yang, Y, Alcaina, Y, Vedvyas, Y, Riascos, MC, Fung, EK, Vaughn, B, Cheal, SM, Min, IM, Vanpouille-Box, C & Jin, MM 2023, . in Cancer Research. vol. 83 (7_Supplement): 5084, AACR Annual Meeting 2023, Orlando, United States, 4/14/23. <https://aacrjournals.org/cancerres/article/83/7_Supplement/5084/724191/Abstract-5084-Targeted-delivery-of-low-dose?searchresult=1>

Metastatic pancreatic neuroendocrine tumors feature elevated T cell infiltration
Greenberg, J, Limberg, J, Verma, A, Kim, D, Chen, X, Lee, YJ, Moore, MD, Ullmann, TM, Thiesmeyer, JW, Loewenstein, Z, Chen, KJ, Egan, CE, Stefanova, D, Bareja, R, Zarnegar, R, Finnerty, BM, Scognamiglio, T, Du, YCN, Elemento, O, Fahey, TJ & Min, IM 2022, , JCI insight, vol. 7, no. 23, e160130. https://doi.org/10.1172/jci.insight.160130

Sex-Based Clinicopathologic and Survival Differences Among Patients with Pancreatic Neuroendocrine Tumors
Greenberg, JA, Ivanov, NA, Egan, CE, Lee, YJ, Zarnegar, R, Fahey, TJ, Finnerty, BM & Min, IM 2022, , Journal of Gastrointestinal Surgery, vol. 26, no. 11, pp. 2321-2329. https://doi.org/10.1007/s11605-022-05345-6

Exposure to Polybrominated Diphenyl Ether Flame Retardants Causes Deoxyribonucleic Acid Damage in Human Thyroid Cells In Vitro
Ullmann, TM, Liang, H, Mora, H, Greenberg, J, Gray, KD, Limberg, J, Stefanova, D, Zhu, X, Finnerty, B, Beninato, T, Zarnegar, R, Min, I & Fahey, TJ 2022, , Journal of Surgical Research, vol. 279, pp. 77-83. https://doi.org/10.1016/j.jss.2022.04.069

CSPG4 Is a Potential Therapeutic Target in Anaplastic Thyroid Cancer
Egan, CE, Stefanova, D, Ahmed, A, Raja, VJ, Thiesmeyer, JW, Chen, KJ, Greenberg, JA, Zhang, T, He, B, Finnerty, BM, Zarnegar, R, Jin, MM, Scognamiglio, T, Dephoure, N, Fahey, T & Min, IM 2021, , Thyroid, vol. 31, no. 10, pp. 1481-1493. https://doi.org/10.1089/thy.2021.0067

Bispecific CAR T Cells against EpCAM and Inducible ICAM-1 Overcome Antigen Heterogeneity and Generate Superior Antitumor Responses
Yang, Y, McCloskey, JE, Yang, H, Puc, J, Alcaina, Y, Vedvyas, Y, Gomez Gallegos, AA, Ortiz-Sánchez, E, de Stanchina, E, Min, IM, von Hofe, E & Jin, MM 2021, , Cancer immunology research, vol. 9, no. 10, pp. 1158-1174. https://doi.org/10.1158/2326-6066.CIR-21-0062, https://doi.org/10.1158/2326-6066.CIR-21-0062

Publisher Correction: Manufacturing and preclinical validation of CAR T cells targeting ICAM-1 for advanced thyroid cancer therapy (Scientific Reports, (2019), 9, 1, (10634), 10.1038/s41598-019-46938-7)
Vedvyas, Y, McCloskey, JE, Yang, Y, Min, IM, Fahey, TJ, Zarnegar, R, Hsu, YMS, Hsu, JM, van Basien, K, Gaudet, I, Law, P, Kim, NJ, von Hofe, E & Jin, MM 2020, , Scientific Reports, vol. 10, no. 1, 12733. https://doi.org/10.1038/s41598-020-69586-8

PD1 Blockade Enhances ICAM1-Directed CAR T Therapeutic Efficacy in Advanced Thyroid Cancer
Gray, KD, McCloskey, JE, Vedvyas, Y, Kalloo, OR, Eshaky, SE, Yang, Y, Shevlin, E, Zaman, M, Ullmann, TM, Liang, H, Stefanova, D, Christos, PJ, Scognamiglio, T, Tassler, AB, Zarnegar, R, Fahey, TJ, Jin, MM & Min, IM 2020, , Clinical Cancer Research, vol. 26, no. 22, pp. 6003-6016. https://doi.org/10.1158/1078-0432.CCR-20-1523, https://doi.org/10.1158/1078-0432.CCR-20-1523

Chimeric Antigen Receptor T Cell Therapy Targeting ICAM-1 in Gastric Cancer
Jung, M, Yang, Y, McCloskey, JE, Zaman, M, Vedvyas, Y, Zhang, X, Stefanova, D, Gray, KD, Min, IM, Zarnegar, R, Choi, YY, Cheong, JH, Noh, SH, Rha, SY, Chung, HC & Jin, MM 2020, , Molecular Therapy - Oncolytics, vol. 18, pp. 587-601. https://doi.org/10.1016/j.omto.2020.08.009, https://doi.org/10.1016/j.omto.2020.08.009

VCAM-1 Upregulation Contributes to Insensitivity of Vemurafenib in BRAF-Mutant Thyroid Cancer
Chen, S, Su, X, Jiang, X, Zhang, T, Min, I, Ding, Y, Wang, X, Mao, Z, Cao, J, Teng, X, Fahey, TJ, Wang, W & Teng, L 2020, , Translational Oncology, vol. 13, no. 2, pp. 441-451. https://doi.org/10.1016/j.tranon.2019.10.007

Dual inhibition of BRAF and MEK increases expression of sodium iodide symporter in patient-derived papillary thyroid cancer cells in vitro
Ullmann, TM, Liang, H, Moore, MD, Al-Jamed, I, Gray, KD, Limberg, J, Stefanova, D, Buicko, JL, Finnerty, B, Beninato, T, Zarnegar, R, Min, IM & Fahey, TJ 2020, , Surgery (United States), vol. 167, no. 1, pp. 56-63. https://doi.org/10.1016/j.surg.2019.04.076

Manufacturing and preclinical validation of CAR T cells targeting ICAM-1 for advanced thyroid cancer therapy
Vedvyas, Y, McCloskey, JE, Yang, Y, Min, IM, Fahey, TJ, Zarnegar, R, Hsu, YMS, Hsu, JM, Besien, KV, Gaudet, I, Law, P, Kim, NJ, Hofe, EV & Jin, MM 2019, , Scientific Reports, vol. 9, no. 1, 10634, pp. 10634. https://doi.org/10.1038/s41598-019-46938-7, https://doi.org/10.1038/s41598-019-46938-7

Expression of programmed death ligand 1 and 2 in adrenocortical cancer tissues: An exploratory study
Tierney, JF, Vogle, A, Poirier, J, Min, IM, Finnerty, B, Zarnegar, R, Pappas, SG, Scognamiglio, T, Ghai, R, Gattuso, P, Fahey, TJ & Keutgen, XM 2019, , Surgery (United States), vol. 165, no. 1, pp. 196-201. https://doi.org/10.1016/j.surg.2018.04.086

CHL1 expression differentiates Hürthle cell carcinoma from benign Hürthle cell nodules
Li, W, Xia, S, Aronova, A, Min, IM, Verma, A, Scognamiglio, T, Gray, KD, Ullmann, TM, Liang, H, Moore, MD, Elemento, O, Zarnegar, R & Fahey, TJ 2018, , Journal of Surgical Oncology, vol. 118, no. 6, pp. 1042-1049. https://doi.org/10.1002/jso.25214

STMN1 is Overexpressed in Adrenocortical Carcinoma and Promotes a More Aggressive Phenotype In Vitro
Aronova, A, Min, IM, Crowley, MJP, Panjwani, SJ, Finnerty, BM, Scognamiglio, T, Liu, YF, Whitsett, TG, Garg, S, Demeure, MJ, Elemento, O, Zarnegar, R & Fahey, TJ 2018, , Annals of Surgical Oncology, vol. 25, no. 3, pp. 792-800. https://doi.org/10.1245/s10434-017-6296-2

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