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Hong Zhao, MD, PhD

Assistant Professor of Systems Medicine and Bioengineering, Institute for Academic Medicine
Assistant Member, Research Institute
Houston Methodist
Weill Cornell Medical College

Dr. Zhao joined the Houston Methodist Research Institute in 2008. She is a member of the American Association for Cancer Research and the International Association for Biological and Medical Research. She has been published in prestigious journals including the Journal of Neurosurgery.

Description of Research

Dr. Zhao's research uses systems biology approaches to study and combat brain metastasis of breast cancer. Her projects integrate "dry lab" computational modeling with "wet lab" experimental testing to discover effective new drug treatment strategies and explore personalized drug combinations. She is using a systems biology strategy in combination with repositioned FDA-approved drugs that can breach the blood-brain barrier to target the signaling network of primary breast tumors that are in the process of metastasizing to the brain.

Areas Of Expertise

Computational modeling Brain metastasis Breast cancer Systems biology Imaging
Education & Training

PhD, Shanghai Medical College of Fudan University
Postdoctoral Fellowship, Brigham and Women’s Hospital, Harvard University, Boston, MA
Postdoctoral Fellowship, The Methodist Hospital

Two birds, one stone: Hesperetin alleviates chemotherapyinduced diarrhea and potentiates tumor inhibition
Yu, Y, Kong, R, Cao, H, Yin, Z, Liu, J, Nan, X, Phan, AT, Ding, T, Zhao, H & Wong, STC 2018, Oncotarget, vol 9, no. 46, pp. 27958-27973. DOI: 10.18632/oncotarget.24563

Targeting brain-adaptive cancer stem cells prohibits brain metastatic colonization of triple-negative breast cancer
Ren, D, Zhu, X, Kong, R, Zhao, Z, Sheng, J, Wang, J, Xu, X, Liu, J, Cui, K, Zhang, XHF, Zhao, H & Wong, STC 2018, Cancer Research, vol 78, no. 8, pp. 2052-2064. DOI: 10.1158/0008-5472.CAN-17-2994

Two Birds, One Stone: Hesperetin alleviates chemotherapy-induced diarrhea and potentiates tumor inhibition
Zhao, H 2017, Oncotarget.

In Vivo Visualization and Characterization of Epithelial-Mesenchymal Transition in Breast Tumors
Zhao, Z, Zhu, X, Cui, K, Mancuso, J, Federley, R, Fischer, K, Teng, GJ, Mittal, V, Gao, D, Zhao, H & Wong, STC 2016, Cancer Research, vol 76, no. 8, pp. 2094-2104. DOI: 10.1158/0008-5472.CAN-15-2662

Zhao, H 2016, , Patent No. PCT/US16/47544.

Zhao, H 2016, , Patent No. PCT/US2016/047984.

Inhibition of iNOS as a novel effective targeted therapy against triple-negative breast cancer
Granados-Principal, S, Liu, Y, Guevara, ML, Blanco, E, Choi, DS, Qian, W, Patel, T, Rodriguez, AA, Cusimano, J, Weiss, HL, Zhao, H, Landis, MD, Dave, B, Gross, SS & Chang, JC 2015, Breast Cancer Research, vol 17, no. 1, 25. DOI: 10.1186/s13058-015-0527-x

The osteogenic niche promotes early-stage bone colonization of disseminated breast cancer cells
Wang, H, Yu, C, Gao, X, Welte, T, Muscarella, AM, Tian, L, Zhao, H, Zhao, Z, Du, S, Tao, J, Lee, B, Westbrook, TF, Wong, STC, Jin, X, Rosen, JM, Osborne, CK & Zhang, XH-F 2015, Cancer Cell, vol 27, no. 2, pp. 193-210. DOI: 10.1016/j.ccell.2014.11.017

Electro-acupuncture up-regulates astrocytic MCT1 expression to improve neurological deficit in middle cerebral artery occlusion rats
Lu, Y, Zhao, H, Wang, Y, Han, B, Wang, T, Zhao, H, Cui, K & Wang, S 2015, Life Sciences, vol 134, no. 1, pp. 68-72. DOI: 10.1016/j.lfs.2015.05.014

Epithelial derived CTGF promotes breast tumor progression via inducing EMT and collagen I fibers deposition
Zhu, X, Zhong, J, Zhao, Z, Sheng, J, Wang, J, Liu, J, Cui, K, Chang, J, Zhao, H & Wong, S 2015, Oncotarget, vol 6, no. 28, pp. 25320-25338. DOI: 10.18632/oncotarget.4659

Old drug new use - Amoxapine and its metabolites as potent bacterial ß-glucuronidase inhibitors for alleviating cancer drug toxicity
Kong, R, Liu, T, Zhu, X, Ahmad, S, Williams, AL, Phan, AT, Zhao, H, Scott, JE, Yeh, LA & Wong, STC 2014, Clinical Cancer Research, vol 20, no. 13, pp. 3521-3530. DOI: 10.1158/1078-0432.CCR-14-0395

Localization and expression pattern of MDM2 in axon initial segments of neuron in rodent brain
Zhao, H, Wang, DD, Xu, YX & Zhu, CQ 2014, Sheng li xue bao : [Acta physiologica Sinica], vol 66, no. 2, pp. 107-117.

Computational analysis of image-based drug profiling predicts synergistic drug combinations: Applications in triple-negative breast cancer
Brandl, MB, Pasquier, E, Li, F, Beck, D, Zhang, S, Zhao, H, Kavallaris, M & Wong, STC 2014, Molecular Oncology, vol 8, no. 8, pp. 1548-1560. DOI: 10.1016/j.molonc.2014.06.007

Chloroquine eliminates cancer stem cells through deregulation of Jak2 and DNMT1
Choi, DS, Blanco, E, Kim, YS, Rodriguez, AA, Zhao, H, Huang, THM, Chen, CL, Jin, G, Landis, MD, Burey, LA, Qian, W, Granados, SM, Dave, B, Wong, HH, Ferrari, M, Wong, STC & Chang, JC 2014, Stem Cells, vol 32, no. 9, pp. 2309-2323. DOI: 10.1002/stem.1746

Transcriptional signaling pathways inversely regulated in Alzheimer's disease and glioblastoma multiform
Liu, T, Ren, D, Zhu, X, Yin, Z, Jin, G, Zhao, Z, Robinson, D, Li, X, Wong, K, Cui, K, Zhao, H & Wong, STC 2013, Scientific Reports, vol 3, 3467. DOI: 10.1038/srep03467

Novel modeling of cancer cell signaling pathways enables systematic drug repositioning for distinct breast cancer metastases
Zhao, H, Jin, G, Cui, K, Ren, D, Liu, T, Chen, P, Wong, S, Li, F, Fan, Y, Rodriguez, A, Chang, J & Wong, STC 2013, Cancer Research, vol 73, no. 20, pp. 6149-6163. DOI: 10.1158/0008-5472.CAN-12-4617

C/EBPa inhibits hepatocellular carcinoma by reducing Notch3/Hes1/p27 cascades
Shi, YC, Zhao, H, Yin, C, Zeng, X, Zhang, Q, Xu, WP, Wei, J, Chen, F & Xie, WF 2013, Digestive and Liver Disease, vol 45, no. 10, pp. 844-851. DOI: 10.1016/j.dld.2013.03.013

Chapter 17: Bioimage Informatics for Systems Pharmacology
Li, F, Yin, Z, Jin, G, Zhao, H & Wong, STC 2013, PLoS Computational Biology, vol 9, no. 4, e1003043. DOI: 10.1371/journal.pcbi.1003043

A quantitative analysis of F-actin features and distribution in fluorescence microscopy images to distinguish cells with different modes of motility
Cheng, J, Zhu, X, Cheng, H, Zhao, H & Wong, STC 2013, . in 2013 35th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2013. vol. 2013, 6609456, pp. 136-139, 2013 35th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2013, Osaka, Japan, 7/3/13. DOI: 10.1109/EMBC.2013.6609456

Differential effects of low- and high-dose GW2974, a dual epidermal growth factor receptor and HER2 kinase inhibitor, on glioblastoma multiforme invasion
Wang, L, Liu, Q, Zhao, H, Cui, K, Yao, L, Nie, F, Jin, G, Hao, A & Wong, STC 2013, Journal of Neuroscience Research, vol 91, no. 1, pp. 128-137. DOI: 10.1002/jnr.23140