Hong Zhao

Hong Zhao, MD, PhD

Associate Professor of Molecular Biology in Oncology, Academic Institute
Co-director, Advanced Cellular and Tissue Microscopy Core, Research Institute
Houston Methodist
Weill Cornell Medical College


Advanced Cellular and Tissue Microscopy Core


hzhao@houstonmethodist.org
Biography

Dr. Zhao joined the Houston Methodist Research Institute in 2008. She is a member of the American Association for Cancer Research and the International Association for Biological and Medical Research. She has been published in prestigious journals including Science Translational Medicine, Cancer Cell, Cancer Research, et al. 

Description of Research

Dr. Zhao's research uses systems biology approaches to study and combat brain metastatic cancer. Her projects integrate "dry lab" computational modeling with "wet lab" experimental testing to discover effective  treatment strategies and explore personalized drug combinations. 

Areas Of Expertise

Computational modeling Brain metastasis Breast cancer Systems biology Imaging
Education & Training

PhD, Shanghai Medical College of Fudan University
Postdoctoral Fellowship, Brigham and Women’s Hospital, Harvard University, Boston, MA
Postdoctoral Fellowship, The Methodist Hospital
Publications

Artificial intelligence-augmented, label-free molecular imaging method for tissue identification, cancer diagnosis, and cancer margin detection
Li, J, Liu, J, Wang, Y, He, Y, Liu, K, Raghunathan, R, Shen, SS, He, T, Yu, X, Danforth, R, Zheng, F, Zhao, H & Wong, STC 2021, , Biomedical Optics Express, vol. 12, no. 9, pp. 5559-5582. https://doi.org/10.1364/BOE.428738

The Progress of Label-Free Optical Imaging in Alzheimer’s Disease Screening and Diagnosis
Liu, K, Li, J, Raghunathan, R, Zhao, H, Li, X & Wong, STC 2021, , Frontiers in Aging Neuroscience, vol. 13, 699024. https://doi.org/10.3389/fnagi.2021.699024

Novel STAT3 small-molecule inhibitors identified by structure-based virtual ligand screening incorporating SH2 domain flexibility
Kong, R, Bharadwaj, U, Eckols, TK, Kolosov, M, Wu, H, Cruz-Pavlovich, FJS, Shaw, A, Ifelayo, OI, Zhao, H, Kasembeli, MM, Wong, STC & Tweardy, DJ 2021, , Pharmacological Research, vol. 169, 105637. https://doi.org/10.1016/j.phrs.2021.105637

64Cu/177Lu-DOTA-diZD, a Small-Molecule-Based Theranostic Pair for Triple-Negative Breast Cancer
Huang, Y, Yang, Z, Li, F, Zhao, H, Li, C, Yu, N, Hamilton, DJ & Li, Z 2021, , Journal of Medicinal Chemistry, vol. 64, no. 5, pp. 2705-2713. https://doi.org/10.1021/acs.jmedchem.0c01957

Deep learning powers cancer diagnosis in digital pathology
He, Y, Zhao, H & Wong, STC 2021, , Computerized Medical Imaging and Graphics, vol. 88, 101820. https://doi.org/10.1016/j.compmedimag.2020.101820

Emerging treatment strategies for breast cancer brain metastasis: from translational therapeutics to real-world experience
Ren, D, Cheng, H, Wang, X, Vishnoi, M, Teh, BS, Rostomily, R, Chang, JC, Wong, ST & Zhao, H 2020, , Therapeutic Advances in Medical Oncology, vol. 12. https://doi.org/10.1177/1758835920936151

OCIAD1 contributes to neurodegeneration in Alzheimer’s disease by inducing mitochondria dysfunction, neuronal vulnerability and synaptic damages
Li, X, Wang, L, Cykowski, MD, He, T, Liu, T, Chakranarayan, J, Rivera, A, Zhao, H, Powell, SZ-E, Xia, W & Wong, ST 2020, , EBioMedicine, vol. 51, 102569. https://doi.org/10.1016/j.ebiom.2019.11.030

Imatinib revives the therapeutic potential of metformin on ewing sarcoma by attenuating tumor hypoxic response and inhibiting convergent signaling pathways
Nan, X, Wang, J, Cheng, H, Yin, Z, Sheng, J, Qiu, B, Lau, CC, Yustein, JT, Zhao, H & Wong, STC 2019, , Cancer Letters. https://doi.org/10.1016/j.canlet.2019.10.034

COMPOSITIONS AND METHODS FOR SELECTIVELY INHIBITING INTESTINAL CARBOXYLESTERASE 2 ENZYME ACTIVITY
Zhao, H 2019, , Patent No. 10,314,811 .

Epithelial-Mesenchymal Plasticity in Organotropism Metastasis and Tumor Immune Escape
Nan, X, Wang, J, Liu, HN, Wong, STC & Zhao, H 2019, journal of clinical medicine, vol. 8, no. 5. https://doi.org/10.3390/jcm8050747

Epithelial-mesenchymal plasticity in organotropism metastasis and tumor immune escape
Nan, X, Wang, J, Liu, HN, Wong, STC & Zhao, H 2019, , Journal of Clinical Medicine, vol. 8, no. 5, 747. https://doi.org/10.3390/jcm8050747

Systems biology-based drug repositioning identifies digoxin as a potential therapy for groups 3 and 4 medulloblastoma
Huang, L, Injac, SG, Cui, K, Braun, F, Lin, Q, Du, Y, Zhang, H, Kogiso, M, Lindsay, H, Zhao, S, Baxter, P, Adekunle, A, Man, TK, Zhao, H, Li, XN, Lau, CC & Wong, ST 2018, , Science translational medicine, vol. 10, no. 464, eaat0150. https://doi.org/10.1126/scitranslmed.aat0150

Two birds, one stone: Hesperetin alleviates chemotherapyinduced diarrhea and potentiates tumor inhibition
Yu, Y, Kong, R, Cao, H, Yin, Z, Liu, J, Nan, X, Phan, AT, Ding, T, Zhao, H & Wong, STC 2018, , Oncotarget, vol. 9, no. 46, pp. 27958-27973. https://doi.org/10.18632/oncotarget.24563

Targeting brain-adaptive cancer stem cells prohibits brain metastatic colonization of triple-negative breast cancer
Ren, D, Zhu, X, Kong, R, Zhao, Z, Sheng, J, Wang, J, Xu, X, Liu, J, Cui, K, Zhang, XHF, Zhao, H & Wong, ST 2018, , Cancer research, vol. 78, no. 8, pp. 2052-2064. https://doi.org/10.1158/0008-5472.CAN-17-2994

The Osteogenic Niche Is a Calcium Reservoir of Bone Micrometastases and Confers Unexpected Therapeutic Vulnerability
Wang, H, Tian, L, Liu, J, Goldstein, A, Bado, I, Zhang, W, Arenkiel, BR, Li, Z, Yang, M, Du, S, Zhao, H, Rowley, DR, Wong, ST, Gugala, Z & Zhang, XHF 2018, , Cancer Cell, vol. 34, no. 5, pp. 823-839.e7. https://doi.org/10.1016/j.ccell.2018.10.002

Two Birds, One Stone: Hesperetin alleviates chemotherapy-induced diarrhea and potentiates tumor inhibition
Zhao, H 2017, Oncotarget.

In Vivo Visualization and Characterization of Epithelial-Mesenchymal Transition in Breast Tumors
Zhao, Z, Zhu, X, Cui, K, Mancuso, J, Federley, R, Fischer, K, Teng, GJ, Mittal, V, Gao, D, Zhao, H & Wong, STC 2016, , Cancer research, vol. 76, no. 8, pp. 2094-2104. https://doi.org/10.1158/0008-5472.CAN-15-2662

COMPOSITIONS AND METHODS FOR SELECTIVELY INHIBITING MAMMALIAN INTESTINAL CARBOXYLESTERASE 2 ENZYME ACTIVITY
Zhao, H 2016, , Patent No. PCT/US16/47544.

COMPOSITIONS AND METHODS FOR TREATING EWING FAMILY TUMORS
Zhao, H 2016, , Patent No. PCT/US2016/047984.

The role of SH3GL3 in myeloma cell migration/invasion, stemness and chemo-resistance
Chen, R, Zhao, H, Wu, D, Zhao, C, Zhao, W & Zhou, X 2016, , Oncotarget, vol. 7, no. 45, pp. 73101-73113. https://doi.org/10.18632/oncotarget.12231