Hong Zhao

Hong Zhao, MD, PhD

Associate Professor of Molecular Biology in Oncology, Academic Institute
Associate Member & Manager, Advanced Cellular and Tissue Microscopy Core, Research Institute
Houston Methodist
Weill Cornell Medical College

Advanced Cellular and Tissue Microscopy Core


Dr. Zhao joined the Houston Methodist Research Institute in 2008. She is a member of the American Association for Cancer Research and the International Association for Biological and Medical Research. She has been published in prestigious journals including the Journal of Neurosurgery.

Description of Research

Dr. Zhao's research uses systems biology approaches to study and combat brain metastasis of breast cancer. Her projects integrate "dry lab" computational modeling with "wet lab" experimental testing to discover effective new drug treatment strategies and explore personalized drug combinations. She is using a systems biology strategy in combination with repositioned FDA-approved drugs that can breach the blood-brain barrier to target the signaling network of primary breast tumors that are in the process of metastasizing to the brain.

Areas Of Expertise

Computational modeling Brain metastasis Breast cancer Systems biology Imaging
Education & Training

PhD, Shanghai Medical College of Fudan University
Postdoctoral Fellowship, Brigham and Women’s Hospital, Harvard University, Boston, MA
Postdoctoral Fellowship, The Methodist Hospital

64Cu/177Lu-DOTA-diZD, a Small-Molecule-Based Theranostic Pair for Triple-Negative Breast Cancer
Huang, Y, Yang, Z, Li, F, Zhao, H, Li, C, Yu, N, Hamilton, DJ & Li, Z 2021, , Journal of Medicinal Chemistry, vol. 64, no. 5, pp. 2705-2713. https://doi.org/10.1021/acs.jmedchem.0c01957

Deep learning powers cancer diagnosis in digital pathology
He, Y, Zhao, H & Wong, STC 2021, , Computerized Medical Imaging and Graphics, vol. 88, 101820. https://doi.org/10.1016/j.compmedimag.2020.101820

Emerging treatment strategies for breast cancer brain metastasis: from translational therapeutics to real-world experience
Ren, D, Cheng, H, Wang, X, Vishnoi, M, Teh, BS, Rostomily, R, Chang, JC, Wong, ST & Zhao, H 2020, , Therapeutic Advances in Medical Oncology, vol. 12. https://doi.org/10.1177/1758835920936151

OCIAD1 contributes to neurodegeneration in Alzheimer’s disease by inducing mitochondria dysfunction, neuronal vulnerability and synaptic damages
Li, X, Wang, L, Cykowski, MD, He, T, Liu, T, Chakranarayan, J, Rivera, A, Zhao, H, Powell, SZ-E, Xia, W & Wong, ST 2020, , EBioMedicine, vol. 51, 102569. https://doi.org/10.1016/j.ebiom.2019.11.030

Imatinib revives the therapeutic potential of metformin on ewing sarcoma by attenuating tumor hypoxic response and inhibiting convergent signaling pathways
Nan, X, Wang, J, Cheng, H, Yin, Z, Sheng, J, Qiu, B, Lau, CC, Yustein, JT, Zhao, H & Wong, STC 2019, , Cancer Letters. https://doi.org/10.1016/j.canlet.2019.10.034

Zhao, H 2019, , Patent No. 10,314,811 .

Epithelial-Mesenchymal Plasticity in Organotropism Metastasis and Tumor Immune Escape
Nan, X, Wang, J, Liu, HN, Wong, STC & Zhao, H 2019, journal of clinical medicine, vol. 8, no. 5. https://doi.org/10.3390/jcm8050747

Systems biology-based drug repositioning identifies digoxin as a potential therapy for groups 3 and 4 medulloblastoma
Huang, L, Injac, SG, Cui, K, Braun, F, Lin, Q, Du, Y, Zhang, H, Kogiso, M, Lindsay, H, Zhao, S, Baxter, P, Adekunle, A, Man, TK, Zhao, H, Li, XN, Lau, CC & Wong, ST 2018, , Science translational medicine, vol. 10, no. 464, eaat0150. https://doi.org/10.1126/scitranslmed.aat0150

Two birds, one stone: Hesperetin alleviates chemotherapyinduced diarrhea and potentiates tumor inhibition
Yu, Y, Kong, R, Cao, H, Yin, Z, Liu, J, Nan, X, Phan, AT, Ding, T, Zhao, H & Wong, STC 2018, , Oncotarget, vol. 9, no. 46, pp. 27958-27973. https://doi.org/10.18632/oncotarget.24563

Targeting brain-adaptive cancer stem cells prohibits brain metastatic colonization of triple-negative breast cancer
Ren, D, Zhu, X, Kong, R, Zhao, Z, Sheng, J, Wang, J, Xu, X, Liu, J, Cui, K, Zhang, XHF, Zhao, H & Wong, ST 2018, , Cancer research, vol. 78, no. 8, pp. 2052-2064. https://doi.org/10.1158/0008-5472.CAN-17-2994

The Osteogenic Niche Is a Calcium Reservoir of Bone Micrometastases and Confers Unexpected Therapeutic Vulnerability
Wang, H, Tian, L, Liu, J, Goldstein, A, Bado, I, Zhang, W, Arenkiel, BR, Li, Z, Yang, M, Du, S, Zhao, H, Rowley, DR, Wong, ST, Gugala, Z & Zhang, XHF 2018, , Cancer Cell, vol. 34, no. 5, pp. 823-839.e7. https://doi.org/10.1016/j.ccell.2018.10.002

Two Birds, One Stone: Hesperetin alleviates chemotherapy-induced diarrhea and potentiates tumor inhibition
Zhao, H 2017, Oncotarget.

In Vivo Visualization and Characterization of Epithelial-Mesenchymal Transition in Breast Tumors
Zhao, Z, Zhu, X, Cui, K, Mancuso, J, Federley, R, Fischer, K, Teng, GJ, Mittal, V, Gao, D, Zhao, H & Wong, STC 2016, , Cancer research, vol. 76, no. 8, pp. 2094-2104. https://doi.org/10.1158/0008-5472.CAN-15-2662

Zhao, H 2016, , Patent No. PCT/US16/47544.

Zhao, H 2016, , Patent No. PCT/US2016/047984.

The role of SH3GL3 in myeloma cell migration/invasion, stemness and chemo-resistance
Chen, R, Zhao, H, Wu, D, Zhao, C, Zhao, W & Zhou, X 2016, , Oncotarget, vol. 7, no. 45, pp. 73101-73113. https://doi.org/10.18632/oncotarget.12231

Inhibition of iNOS as a novel effective targeted therapy against triple-negative breast cancer
Granados-Principal, S, Liu, Y, Guevara, ML, Blanco, E, Choi, DS, Qian, W, Patel, T, Rodriguez, AA, Cusimano, J, Weiss, HL, Zhao, H, Landis, MD, Dave, B, Gross, SS & Chang, JC 2015, , Breast Cancer Research, vol. 17, no. 1, 25. https://doi.org/10.1186/s13058-015-0527-x

The osteogenic niche promotes early-stage bone colonization of disseminated breast cancer cells
Wang, H, Yu, C, Gao, X, Welte, T, Muscarella, AM, Tian, L, Zhao, H, Zhao, Z, Du, S, Tao, J, Lee, B, Westbrook, TF, Wong, STC, Jin, X, Rosen, JM, Osborne, CK & Zhang, XH-F 2015, , Cancer Cell, vol. 27, no. 2, pp. 193-210. https://doi.org/10.1016/j.ccell.2014.11.017

Electro-acupuncture up-regulates astrocytic MCT1 expression to improve neurological deficit in middle cerebral artery occlusion rats
Lu, Y, Zhao, H, Wang, Y, Han, B, Wang, T, Zhao, H, Cui, K & Wang, S 2015, , Life sciences, vol. 134, no. 1, pp. 68-72. https://doi.org/10.1016/j.lfs.2015.05.014

Epithelial derived CTGF promotes breast tumor progression via inducing EMT and collagen I fibers deposition
Zhu, X, Zhong, J, Zhao, Z, Sheng, J, Wang, J, Liu, J, Cui, K, Chang, J, Zhao, H & Wong, S 2015, , Oncotarget, vol. 6, no. 28, pp. 25320-25338. https://doi.org/10.18632/oncotarget.4659