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Hong Zhao, MD, PhD

Assistant Professor of Molecular Biology in Oncology, Institute for Academic Medicine
Assistant Member & Manager, Advanced Cellular and Tissue Microscopy Core, Research Institute
Houston Methodist
Weill Cornell Medical College

Advanced Cellular and Tissue Microscopy Core

Dr. Zhao joined the Houston Methodist Research Institute in 2008. She is a member of the American Association for Cancer Research and the International Association for Biological and Medical Research. She has been published in prestigious journals including the Journal of Neurosurgery.

Description of Research

Dr. Zhao's research uses systems biology approaches to study and combat brain metastasis of breast cancer. Her projects integrate "dry lab" computational modeling with "wet lab" experimental testing to discover effective new drug treatment strategies and explore personalized drug combinations. She is using a systems biology strategy in combination with repositioned FDA-approved drugs that can breach the blood-brain barrier to target the signaling network of primary breast tumors that are in the process of metastasizing to the brain.

Areas Of Expertise

Computational modeling Brain metastasis Breast cancer Systems biology Imaging
Education & Training

PhD, Shanghai Medical College of Fudan University
Postdoctoral Fellowship, Brigham and Women’s Hospital, Harvard University, Boston, MA
Postdoctoral Fellowship, The Methodist Hospital

Two birds, one stone: Hesperetin alleviates chemotherapyinduced diarrhea and potentiates tumor inhibition
Yu, Y, Kong, R, Cao, H, Yin, Z, Liu, J, Nan, X, Phan, AT, Ding, T, Zhao, H & Wong, ST 2018, Oncotarget, vol. 9, no. 46, pp. 27958-27973.

Targeting brain-adaptive cancer stem cells prohibits brain metastatic colonization of triple-negative breast cancer
Ren, D, Zhu, X, Kong, R, Zhao, Z, Sheng, J, Wang, J, Xu, X, Liu, J, Cui, K, Zhang, XHF, Zhao, H & Wong, ST 2018, Cancer Research, vol. 78, no. 8, pp. 2052-2064.

The Osteogenic Niche Is a Calcium Reservoir of Bone Micrometastases and Confers Unexpected Therapeutic Vulnerability
Wang, H, Tian, L, Liu, J, Goldstein, A, Bado, I, Zhang, W, Arenkiel, BR, Li, Z, Yang, M, Du, S, Zhao, H, Rowley, DR, Wong, ST, Gugala, Z & Zhang, XHF 2018, Cancer Cell.

Two Birds, One Stone: Hesperetin alleviates chemotherapy-induced diarrhea and potentiates tumor inhibition
Zhao, H 2017, Oncotarget.

In Vivo Visualization and Characterization of Epithelial-Mesenchymal Transition in Breast Tumors
Zhao, Z, Zhu, X, Cui, K, Mancuso, J, Federley, R, Fischer, K, Teng, GJ, Mittal, V, Gao, D, Zhao, H & Wong, ST 2016, Cancer Research, vol. 76, no. 8, pp. 2094-2104.

Zhao, H 2016, , Patent No. PCT/US16/47544.

Zhao, H 2016, , Patent No. PCT/US2016/047984.

Inhibition of iNOS as a novel effective targeted therapy against triple-negative breast cancer
Granados-Principal, S, Liu, Y, Guevara, ML, Blanco, E, Choi, DS, Qian, W, Patel, T, Rodriguez, AA, Cusimano, J, Weiss, HL, Zhao, H, Landis, MD, Dave, B, Gross, SS & Chang, JC 2015, Breast Cancer Research, vol. 17, no. 1, 25.

The osteogenic niche promotes early-stage bone colonization of disseminated breast cancer cells
Wang, H, Yu, C, Gao, X, Welte, T, Muscarella, AM, Tian, L, Zhao, H, Zhao, Z, Du, S, Tao, J, Lee, B, Westbrook, TF, Wong, STC, Jin, X, Rosen, JM, Osborne, CK & Zhang, XH-F 2015, Cancer Cell, vol. 27, no. 2, pp. 193-210.

Electro-acupuncture up-regulates astrocytic MCT1 expression to improve neurological deficit in middle cerebral artery occlusion rats
Lu, Y, Zhao, H, Wang, Y, Han, B, Wang, T, Zhao, H, Cui, K & Wang, S 2015, Life Sciences, vol. 134, no. 1, pp. 68-72.

Epithelial derived CTGF promotes breast tumor progression via inducing EMT and collagen I fibers deposition
Zhu, X, Zhong, J, Zhao, Z, Sheng, J, Wang, J, Liu, J, Cui, K, Chang, JC, Zhao, H & Wong, ST 2015, Oncotarget, vol. 6, no. 28, pp. 25320-25338.

Old drug new use - Amoxapine and its metabolites as potent bacterial ß-glucuronidase inhibitors for alleviating cancer drug toxicity
Kong, R, Liu, T, Zhu, X, Ahmad, S, Williams, AL, Phan, AT, Zhao, H, Scott, JE, Yeh, LA & Wong, ST 2014, Clinical Cancer Research, vol. 20, no. 13, pp. 3521-3530.

Localization and expression pattern of MDM2 in axon initial segments of neuron in rodent brain
Zhao, H, Wang, DD, Xu, YX & Zhu, CQ 2014, Sheng li xue bao : [Acta physiologica Sinica], vol. 66, no. 2, pp. 107-117.

Chloroquine eliminates cancer stem cells through deregulation of Jak2 and DNMT1
Choi, DS, Blanco, E, Kim, YS, Rodriguez, AA, Zhao, H, Huang, THM, Chen, CL, Jin, G, Landis, MD, Burey, LA, Qian, W, Granados, SM, Dave, B, Wong, HH, Ferrari, M, Wong, ST & Chang, JC 2014, Stem Cells, vol. 32, no. 9, pp. 2309-2323.

Computational analysis of image-based drug profiling predicts synergistic drug combinations: Applications in triple-negative breast cancer
Brandl, MB, Pasquier, E, Li, F, Beck, D, Zhang, S, Zhao, H, Kavallaris, M & Wong, ST 2014, Molecular Oncology, vol. 8, no. 8, pp. 1548-1560.

Transcriptional signaling pathways inversely regulated in Alzheimer's disease and glioblastoma multiform
Liu, T, Ren, D, Zhu, X, Yin, Z, Jin, G, Zhao, Z, Robinson, D, Li, X, Wong, K, Cui, K, Zhao, H & Wong, STC 2013, Scientific Reports, vol. 3, 3467.

Novel modeling of cancer cell signaling pathways enables systematic drug repositioning for distinct breast cancer metastases
Zhao, H, Jin, G, Cui, K, Ren, D, Liu, T, Chen, P, Wong, S, Li, F, Fan, Y, Rodriguez, A, Chang, J & Wong, STC 2013, Cancer Research, vol. 73, no. 20, pp. 6149-6163.

C/EBPa inhibits hepatocellular carcinoma by reducing Notch3/Hes1/p27 cascades
Shi, YC, Zhao, H, Yin, C, Zeng, X, Zhang, Q, Xu, WP, Wei, J, Chen, F & Xie, WF 2013, Digestive and Liver Disease, vol. 45, no. 10, pp. 844-851.

Chapter 17: Bioimage Informatics for Systems Pharmacology
Li, F, Yin, Z, Jin, G, Zhao, H & Wong, ST 2013, PLoS Computational Biology, vol. 9, no. 4, e1003043.

A quantitative analysis of F-actin features and distribution in fluorescence microscopy images to distinguish cells with different modes of motility
Cheng, J, Zhu, X, Cheng, H, Zhao, H & Wong, STC 2013, . in 2013 35th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2013. vol. 2013, 6609456, pp. 136-139, 2013 35th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2013, Osaka, Japan, 7/3/13.

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