Helen Heslop, MD

Adjunct Professor of Medicine, Institute for Academic Medicine
Full Affiliate Member, Research Institute
Houston Methodist


Biography

Dr. Heslop's initial faculty appointment was as Assistant Member of the Division of Bone Marrow Transplantation in the Department of Hematology-Oncology at the St. Jude Children's Research Hospital, in Memphis in 1991. She was promoted to Associate Member in 1994. She also held an appointment as Associate Professor in the Department of Pediatrics at the University of Tennessee in Memphis. Dr. Heslop received her current appointments at the Baylor College of Medicine in Houston, Texas in 1997. She was named as the first Dan L. Duncan Chair for Baylor College of Medicine in 2006.

Description of Research

Dr. Heslop's research centers on adoptive immunotherapy with gene-modified effector cells to improve hemopoietic stem cell transplantation and cancer therapy. She currently directs a Lymphoma SPORE program and a program project grant from the NCI, as well as a Specialized Center of Research from the Leukemia and Lymphoma Society. Her research focus is to develop safe and effective T-cell immunotherapies for lymphoma and other Epstein-Barr virus-associated malignancies, including Hodgkin's Disease and nasopharyngeal cancer. Dr. Heslop also runs studies using third party CTLs to treat viral infections after transplant.

Areas Of Expertise

Cancer Adoptive immunotherapy Effector cells Hemopoietic stem cell transplantation
Publications

Survival outcomes of allogeneic hematopoietic cell transplants with EBV-positive or EBV-negative post-transplant lymphoproliferative disorder, A CIBMTR study
Naik, S, Riches, M, Hari, P, Kim, S, Chen, M, Bachier, C, Shaughnessy, P, Hill, J, Ljungman, P, Battiwalla, M, Chhabra, S, Daly, A, Storek, J, Ustun, C, Diaz, MA, Cerny, J, Beitinjaneh, A, Yared, J, Brown, V, Page, K, Dahi, PB, Ganguly, S, Seo, S, Chao, N, Freytes, CO, Saad, A, Savani, BN, Woo Ahn, K, Boeckh, M, Heslop, H, Lazarus, HM, Auletta, JJ & Kamble, RT 2019, Transplant Infectious Disease, vol. 21, no. 5, e13145. https://doi.org/10.1111/tid.13145

Allogeneic hematopoietic stem cell transplant for relapsed and refractory non-Hodgkin lymphoma in pediatric patients
Naik, S, Martinez, CA, Omer, B, Sasa, G, Yassine, K, Allen, CE, Kamdar, K, Orth, R, Wu, M, Leung, K, Gottschalk, S, Brenner, MK, Heslop, H & Krance, RA 2019, Blood Advances, vol. 3, no. 18, pp. 2689-2695. https://doi.org/10.1182/bloodadvances.2018026203

"mini" bank of only 8 donors supplies CMV-directed T cells to diverse recipients
Tzannou, I, Watanabe, A, Naik, S, Daum, R, Kuvalekar, M, Leung, KS, Martinez, C, Sasa, G, Wu, M, Gee, AP, Krance, RA, Gottschalk, S, Heslop, H & Omer, B 2019, Blood Advances, vol. 3, no. 17, pp. 2571-2580. https://doi.org/10.1182/bloodadvances.2019000371

Epigenetic Inhibition Puts Target Antigen in the Crosshairs of CAR T Cells
Steffin, DHM & Heslop, H 2019, Molecular Therapy, vol. 27, no. 5, pp. 900-901. https://doi.org/10.1016/j.ymthe.2019.04.007

Adoptive Immunotherapy with Antigen-Specific T Cells Expressing a Native TCR
Leung, W & Heslop, H 2019, Cancer immunology research, vol. 7, no. 4, pp. 528-533. https://doi.org/10.1158/2326-6066.CIR-18-0888

Clinical Utilization of Chimeric Antigen Receptor T Cells in B Cell Acute Lymphoblastic Leukemia: An Expert Opinion from the European Society for Blood and Marrow Transplantation and the American Society for Blood and Marrow Transplantation
Kansagra, AJ, Frey, NV, Bar, M, Laetsch, TW, Carpenter, PA, Savani, BN, Heslop, H, Bollard, CM, Komanduri, KV, Gastineau, DA, Chabannon, C, Perales, MA, Hudecek, M, Aljurf, M, Andritsos, L, Barrett, JA, Bachanova, V, Bonini, C, Ghobadi, A, Gill, SI, Hill, J, Kenderian, S, Kebriaei, P, Nagler, A, Maloney, D, Liu, HD, Shah, NN, Kharfan-Dabaja, MA, Shpall, EJ, Mufti, GJ, Johnston, L, Jacoby, E, Bazarbachi, A, DiPersio, JF, Pavletic, SZ, Porter, DL, Grupp, SA, Sadelain, M, Litzow, MR, Mohty, M & Hashmi, SK 2019, Biology of Blood and Marrow Transplantation. https://doi.org/10.1016/j.bbmt.2018.12.068

Harmonizing Immune Effector Toxicity Reporting
Heslop, H & Shpall, EJ 2019, Biology of Blood and Marrow Transplantation. https://doi.org/10.1016/j.bbmt.2019.01.001

Clinical utilization of Chimeric Antigen Receptor T-cells (CAR-T) in B-cell acute lymphoblastic leukemia (ALL)–an expert opinion from the European Society for Blood and Marrow Transplantation (EBMT) and the American Society for Blood and Marrow Transplantation (ASBMT)
Kansagra, AJ, Frey, NV, Bar, M, Laetsch, TW, Carpenter, PA, Savani, BN, Heslop, H, Bollard, CM, Komanduri, KV, Gastineau, DA, Chabannon, C, Perales, MA, Hudecek, M, Aljurf, M, Andritsos, L, Barrett, JA, Bachanova, V, Bonini, C, Ghobadi, A, Gill, SI, Hill, JA, Kenderian, S, Kebriaei, P, Nagler, A, Maloney, D, Liu, HD, Shah, NN, Kharfan-Dabaja, MA, Shpall, EJ, Mufti, GJ, Johnston, L, Jacoby, E, Bazarbachi, A, DiPersio, JF, Pavletic, SZ, Porter, DL, Grupp, SA, Sadelain, M, Litzow, MR, Mohty, M & Hashmi, SK 2019, Bone Marrow Transplantation. https://doi.org/10.1038/s41409-019-0451-2

T-cell receptor sequencing demonstrates persistence of virus-specific T cells after antiviral immunotherapy
Keller, MD, Darko, S, Lang, H, Ransier, A, Lazarski, CA, Wang, Y, Hanley, PJ, Davila, BJ, Heimall, JR, Ambinder, RF, Barrett, AJ, Rooney, CM, Heslop, H, Douek, DC & Bollard, CM 2019, British Journal of Haematology. https://doi.org/10.1111/bjh.16053

Use of Chimeric Antigen Receptor T Cell Therapy in Clinical Practice for Relapsed/Refractory Aggressive B Cell Non-Hodgkin Lymphoma: An Expert Panel Opinion from the American Society for Transplantation and Cellular Therapy
Jain, T, Bar, M, Kansagra, AJ, Chong, EA, Hashmi, SK, Neelapu, SS, Byrne, M, Jacoby, E, Lazaryan, A, Jacobson, CA, Ansell, SM, Awan, FT, Burns, L, Bachanova, V, Bollard, CM, Carpenter, PA, DiPersio, JF, Hamadani, M, Heslop, H, Hill, JA, Komanduri, KV, Kovitz, CA, Lazarus, HM, Serrette, JM, Mohty, M, Miklos, D, Nagler, A, Pavletic, SZ, Savani, BN, Schuster, SJ, Kharfan-Dabaja, MA, Perales, MA & Lin, Y 2019, Biology of Blood and Marrow Transplantation. https://doi.org/10.1016/j.bbmt.2019.08.015

EBV/LMP-specific T cells maintain remissions of T- and B-cell EBV lymphomas after allogeneic bone marrow transplantation
McLaughlin, LP, Rouce, R, Gottschalk, S, Torrano, V, Carrum, G, Wu, MF, Hoq, F, Grilley, B, Marcogliese, AM, Hanley, PJ, Gee, AP, Brenner, M, Rooney, CM, Heslop, H & Bollard, CM 2018, Blood, vol. 132, no. 22, pp. 2351-2361. https://doi.org/10.1182/blood-2018-07-863654

A backpack revs up T-cell activity
Shum, T & Heslop, H 2018, Nature Biotechnology, vol. 36, no. 8, pp. 702-703.

Genetic and mechanistic diversity in pediatric hemophagocytic lymphohistiocytosis
Chinn, IK, Eckstein, OS, Peckham-Gregory, EC, Goldberg, BR, Forbes, LR, Nicholas, SK, Mace, EM, Vogel, TP, Abhyankar, HA, Diaz, MI, Heslop, H, Krance, RA, Martinez, CA, Nguyen, TC, Bashir, DA, Goldman, JR, Stray-Pedersen, A, Pedroza, LA, Cecilia Poli, M, Aldave-Becerra, JC, McGhee, SA, Al-Herz, W, Chamdin, A, Coban-Akdemir, ZH, Jhangiani, SN, Muzny, DM, Cao, TN, Hong, DN, Gibbs, RA, Lupski, JR, Orange, JS, McClain, KL & Allen, CE 2018, Blood, vol. 132, no. 1, pp. 89-100. https://doi.org/10.1182/blood-2017-11-814244

The use of chimeric antigen receptor T cells in patients with non-hodgkin lymphoma
Lulla, PD, Hill, LC, Ramos, CA & Heslop, H 2018, Clinical Advances in Hematology and Oncology, vol. 16, no. 5, pp. 375-386.

Tumor-specific t-cells engineered to overcome tumor immune evasion induce clinical responses in patients with relapsed hodgkin lymphoma
Bollard, CM, Tripic, T, Cruz, CR, Dotti, G, Gottschalk, S, Torrano, V, Dakhova, O, Carrum, G, Ramos, CA, Liu, H, Wu, MF, Marcogliese, AN, Barese, C, Zu, Y, Lee, DY, O’Connor, O, Gee, AP, Brenner, M, Heslop, H & Rooney, CM 2018, Journal of Clinical Oncology, vol. 36, no. 11, pp. 1128-1139. https://doi.org/10.1200/JCO.2017.74.3179

Seek and You Will Not Find: Ending the Hunt for Replication-Competent Retroviruses during Human Gene Therapy
Heslop, H & Brenner, M 2018, Molecular Therapy, vol. 26, no. 1, pp. 1-2. https://doi.org/10.1016/j.ymthe.2017.12.004

Generation of multivirus-specific T cells by a single stimulation of peripheral blood mononuclear cells with a peptide mixture using serum-free medium
NISHIYAMA-FUJITA, YURIKO, KAWANA-TACHIKAWA, AI, ONO, TOSHIAKI, TANAKA, YUKIE, KATO, TAKAFUMI, Heslop, H, MORIO, TOMOHIRO & TAKAHASHI, SATOSHI 2018, Cytotherapy. https://doi.org/10.1016/j.jcyt.2018.05.009

Outcomes after Allogeneic Transplant in Patients with Wiskott-Aldrich Syndrome
Ngwube, A, Hanson, IC, Orange, J, Rider, NL, Seeborg, F, Shearer, W, Noroski, L, Nicholas, S, Forbes, L, Leung, K, Sasa, G, Naik, S, Hegde, M, Omer, B, Ahmed, N, Allen, C, Gottschalk, S, Wu, MF, Liu, H, Brenner, M, Heslop, H, Krance, R & Martinez, C 2018, Biology of Blood and Marrow Transplantation. https://doi.org/10.1016/j.bbmt.2017.11.019

High Incidence of Autoimmune Disease after Hematopoietic Stem Cell Transplantation for Chronic Granulomatous Disease
Yanir, AD, Hanson, IC, Shearer, WT, Noroski, LM, Forbes, LR, Seeborg, FO, Nicholas, S, Chinn, I, Orange, JS, Rider, NL, Leung, KS, Naik, S, Carrum, G, Sasa, G, Hegde, M, Omer, BA, Ahmed, N, Allen, CE, Khaled, Y, Wu, MF, Liu, H, Gottschalk, SM, Heslop, H, Brenner, M, Krance, RA & Martinez, CA 2018, Biology of Blood and Marrow Transplantation. https://doi.org/10.1016/j.bbmt.2018.03.029

Current Allogeneic Hematopoietic Stem Cell Transplantation for Pediatric Acute Lymphocytic Leukemia: Success, Failure and Future Perspectives—A Single-Center Experience, 2008 to 2016
Yanir, AD, Martinez, CA, Sasa, G, Leung, K, Gottschalk, S, Omer, B, Ahmed, N, Hegde, M, Eunji, J, Liu, H, Heslop, H, Brenner, M, Krance, RA & Naik, S 2018, Biology of Blood and Marrow Transplantation. https://doi.org/10.1016/j.bbmt.2018.03.001

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