Guillermo Torre, MD, PhD

Professor of Cardiology, Academic Institute
Full Member, Research Institute
Houston Methodist
Weill Cornell Medical College


Biography

Dr. Torre-Amione received his first academic appointment in 1995 as a Clinical Instructor at the Baylor College of Medicine in Houston, Texas. He became an Assistant Professor there one year later, the same year he became the Medical Director for the Cardiac Transplant Service at Houston Methodist DeBakey Heart and Vascular Center. Dr.Torre-Amione joined the Houston Methodist Specialty Physician Group and Weill Medical College in 2005.

Description of Research

Dr. Torre-Amione is the director of the Heart Failure Research Laboratory at Houston Methodist, and conducts research examining the mechanisms of immune activation and inflammation as it relates to myocardial dysfunction in the areas of heart failure and cardiac transplantation. The doctor and his colleagues have conducted numerous studies that suggest novel immune modulatory therapies for the treatment of heart failure and transplant patients. Dr. Torre-Amione led the first two FDA-approved trials of Celacade with impressive results, and a Phase III trial is underway. Other studies underway in the Heart Failure Research Laboratory are investigating additional immune response pathways that contribute to the progression of heart failure, including the role of heat shock proteins and cardiac mast cells.

Areas Of Expertise

Heart failure Inflammation Cardiac transplant Immune activation Heat shock proteins Cardiac mast cells
Education & Training

Residency, Baylor College of Medicine
Clinical Fellowship, Baylor College of Medicine
Postdoctoral Fellowship, Baylor College of Medicine
MD, Facultad De Medicina - Instituto Tech.
PhD, University of Chicago
Publications

The role of B cells in heart failure and implications for future immunomodulatory treatment strategies
García-Rivas, G, Castillo, EC, Gonzalez-Gil, AM, Maravillas-Montero, JL, Brunck, M, Torres-Quintanilla, A, Elizondo-Montemayor, L & Torre-Amione, G 2020, , ESC Heart Failure, vol. 7, no. 4, pp. 1387-1399. https://doi.org/10.1002/ehf2.12744

Percutaneous Left Axillary Artery Placement of Intra-Aortic Balloon Pump in Advanced Heart Failure Patients
Bhimaraj, A, Agrawal, T, Duran, A, Tamimi, O, Amione-Guerra, J, Trachtenberg, B, Guha, A, Hussain, I, Kim, J, Kassi, M, Xu, J, Suarez, EE, Ngo, UQ, Torre-Amione, G & Estep, JD 2020, , JACC: Heart Failure, vol. 8, no. 4, pp. 313-323. https://doi.org/10.1016/j.jchf.2020.01.011

Equipo de respuesta rápida para tromboembolismo venoso del hospital zambrano hellion (PREVENTION-team): mejorando el manejo del tromboembolismo pulmonar y trombosis venosa profunda
Del Toro-Mijares, R, Jerjes-Sánchez, C, Rodríguez, D, Panneflek, J, Vázquez-Guajardo, M, Fabiani, MA, Quintanilla, J, Manautou, L, de la Peña-Almaguer, E, Cadena, A, Cassagne, G & Torre-Amione, G 2020, , Archivos de cardiologia de Mexico, vol. 90, no. 1, pp. 28-38. https://doi.org/10.24875/ACM.19000276

Pulse assessment is important with blood pressure measurement in individuals with continuous flow left ventricular assist devices
Marcos-Abdala, HG, Cruz-Solbes, AS, Hussain, I, Trachtenberg, B, Ashrith, G, Torre-Amione, G, Bruckner, B, Suarez, EE, Estep, JD & Bhimaraj, A 2020, International Journal of Artificial Organs. https://doi.org/10.1177/0391398820927022

Resveratrol Prevents Right Ventricle Remodeling and Dysfunction in Monocrotaline-Induced Pulmonary Arterial Hypertension with a Limited Improvement in the Lung Vasculature
Vázquez-Garza, E, Bernal-Ramírez, J, Jerjes-Sánchez, C, Lozano, O, Acuña-Morín, E, Vanoye-Tamez, M, Ramos-González, MR, Chapoy-Villanueva, H, Pérez-Plata, L, Sánchez-Trujillo, L, Torre-Amione, G, Ramírez-Rivera, A & García-Rivas, G 2020, , Oxidative Medicine and Cellular Longevity, vol. 2020, 1841527. https://doi.org/10.1155/2020/1841527

Discovery of non-HLA antibodies associated with cardiac allograft rejection and development and validation of a non-HLA antigen multiplex panel: From bench to bedside
Butler, CL, Hickey, MJ, Jiang, N, Zheng, Y, Gjertson, D, Zhang, Q, Rao, P, Fishbein, GA, Cadeiras, M, Deng, MC, Banchs, HL, Torre, G, DeNofrio, D, Eisen, HJ, Kobashigawa, J, Starling, RC, Kfoury, A, Van Bakel, A, Ewald, G, Balazs, I, Baas, AS, Cruz, D, Ardehali, R, Biniwale, R, Kwon, M, Ardehali, A, Nsair, A, Ray, B & Reed, EF 2020, , American Journal of Transplantation, vol. 20, no. 10, pp. 2768-2780. https://doi.org/10.1111/ajt.15863

Management of Myocarditis-Related Cardiomyopathy in Adults
Tschöpe, C, Cooper, LT, Torre, G & Van Linthout, S 2019, , Circulation Research, vol. 124, no. 11, pp. 1568-1583. https://doi.org/10.1161/CIRCRESAHA.118.313578

Phase II clinical trial testing the safety of a humanised monoclonal antibody anti-CD20 in patients with heart failure with reduced ejection fraction, ICFEr-RITU2: Study protocol
Sánchez-Trujillo, L, Jerjes-Sanchez, C, Rodriguez, D, Panneflek, J, Ortiz-Ledesma, C, Garcia-Rivas, G & Torre-Amione, G 2019, , BMJ open, vol. 9, no. 3, 022826. https://doi.org/10.1136/bmjopen-2018-022826

Mitochondrial hyperacetylation in the failing hearts of obese patients mediated partly by a reduction in SIRT3: The involvement of the mitochondrial permeability transition pore
García-Rivas, G, Castillo, EC, Morales, JA, Chapoy-Villanueva, H, Silva-Platas, C, Treviño-Saldaña, N, Guerrero-Beltrán, CE, Bernal-Ramírez, J, Torres-Quintanilla, A, García, N, Youker, K & Torre-Amione, G 2019, , Cellular Physiology and Biochemistry, vol. 53, no. 3, pp. 465-479. https://doi.org/10.33594/000000151

Temporal frame of immune cell infiltration during heart failure establishment: Lessons from animal models
Brenes-Castro, D, Castillo, EC, Vázquez-Garza, E, Torre-Amione, G & García-Rivas, G 2018, , International journal of molecular sciences, vol. 19, no. 12, 3719. https://doi.org/10.3390/ijms19123719

El uso de TC cardiaca como Guía para resolución de un stent coronario dislocado
Torre, G, de la Pena-Almaguer, E, Quintanilla, J, Valdes, F, Jimenez, V, Rodriguez, D, Trevino, A, Perez, L & Jerjes-Sanchez, C 2018, , Archivos de cardiologia de Mexico, vol. 88, no. 4, pp. 318-319. https://doi.org/10.1016/j.acmx.2018.03.006

B-type natriuretic peptide reference interval of newborns from healthy and pre-eclamptic women: A prospective, multicentre, cross-sectional study
Rodriguez, D, Garcia-Rivas, G, Laresgoiti-Servitje, E, Yañez, J, Torre-Amione, G & Jerjes-Sanchez, C 2018, , BMJ open, vol. 8, no. 10, e022562. https://doi.org/10.1136/bmjopen-2018-022562

IABP as a Bridge to Transplantation: Can we Identify Who May Benefit From a LVAD?
Guha, A, Ali, A, Nguyen, DT, Bruckner, B, Trachtenberg, B, Graviss, EA, Bhimaraj, A, Park, MH, Hussain, I, Suarez, EE, Torre-Amione, G & Estep, J 2018, Journal of Heart and Lung Transplantation, vol. 37, no. 4, pp. S267. https://doi.org/10.1016/j.healun.2018.01.667

Melding a high-risk patient for continuous flow left ventricular assist device into a low-risk patient
Amione-Guerra, J, Cruz-Solbes, AS, Bonilla, HG, Estep, JD, Guha, A, Bhimaraj, A, Suarez, EE, Bruckner, BA, Torre-Amione, G, Park, MH & Trachtenberg, BH 2017, , ASAIO Journal, vol. 63, no. 6, pp. 704-712. https://doi.org/10.1097/MAT.0000000000000591

Prevalence of in-hospital nonsteroidal antiinflammatory drug exposure in patients with a primary diagnosis of heart failure
Alvarez, PA, Putney, D, Ogunti, R, Puppala, M, Ganduglia, C, Torre-Amione, G, Schutt, R, Wong, STC & Estep, JD 2017, Cardiovascular Therapeutics, vol. 35, no. 3. https://doi.org/10.1111/1755-5922.12256

Measurement of troponin and natriuretic peptides shortly after admission in patients with heart failure—does it add useful prognostic information? An analysis of the Value of Endothelin Receptor Inhibition with Tezosentan in Acute heart failure Studies (VERITAS)
for the VERITAS Investigators 2017, , European Journal of Heart Failure, vol. 19, no. 6, pp. 739-747. https://doi.org/10.1002/ejhf.786

Long-Term Effect of Endothelin Receptor Antagonism With Bosentan on the Morbidity and Mortality of Patients With Severe Chronic Heart Failure: Primary Results of the ENABLE Trials
ENABLE Investigators and Committees & ENABLE Investigators and Committees 2017, JACC: Heart Failure, vol. 5, no. 5, pp. 317-326. https://doi.org/10.1016/j.jchf.2017.02.021

Cardiovascular efficacy and safety of bococizumab in high-risk patients
SPIRE Cardiovascular Outcome Investigators 2017, , New England Journal of Medicine, vol. 376, no. 16, pp. 1527-1539. https://doi.org/10.1056/NEJMoa1701488

Risk Stratification of Patients With Current Generation Continuous-Flow Left Ventricular Assist Devices Being Bridged to Heart Transplantation
Guha, A, Nguyen, D, Cruz-Solbes, AS, Amione-Guerra, J, Schutt, RC, Bhimaraj, A, Trachtenberg, BH, Park, MH, Graviss, EA, Gaber, O, Suarez, E, Montane, E, Torre-Amione, G & Estep, JD 2017, , ASAIO Journal, pp. 196-202. https://doi.org/10.1097/MAT.0000000000000635

Rapamycin nanoparticles localize in diseased lung vasculature and prevent pulmonary arterial hypertension
Segura-Ibarra, V, Amione-Guerra, J, Cruz-Solbes, AS, Cara, FE, Iruegas-Nunez, DA, Wu, S, Youker, KA, Bhimaraj, A, Torre-Amione, G, Ferrari, M, Karmouty-Quintana, H, Guha, A & Blanco, E 2017, , International Journal of Pharmaceutics, vol. 524, no. 1-2, pp. 257-267. https://doi.org/10.1016/j.ijpharm.2017.03.069