Guillermo Torre, MD, PhD

Professor of Cardiology, Academic Institute
Full Member, Research Institute
Houston Methodist
Weill Cornell Medical College


Biography

Dr. Torre-Amione received his first academic appointment in 1995 as a Clinical Instructor at the Baylor College of Medicine in Houston, Texas. He became an Assistant Professor there one year later, the same year he became the Medical Director for the Cardiac Transplant Service at Houston Methodist DeBakey Heart and Vascular Center. Dr.Torre-Amione joined the Houston Methodist Specialty Physician Group and Weill Medical College in 2005.

Description of Research

Dr. Torre-Amione is the director of the Heart Failure Research Laboratory at Houston Methodist, and conducts research examining the mechanisms of immune activation and inflammation as it relates to myocardial dysfunction in the areas of heart failure and cardiac transplantation. The doctor and his colleagues have conducted numerous studies that suggest novel immune modulatory therapies for the treatment of heart failure and transplant patients. Dr. Torre-Amione led the first two FDA-approved trials of Celacade with impressive results, and a Phase III trial is underway. Other studies underway in the Heart Failure Research Laboratory are investigating additional immune response pathways that contribute to the progression of heart failure, including the role of heat shock proteins and cardiac mast cells.

Areas Of Expertise

Heart failure Inflammation Cardiac transplant Immune activation Heat shock proteins Cardiac mast cells
Education & Training

Residency, Baylor College of Medicine
Clinical Fellowship, Baylor College of Medicine
Postdoctoral Fellowship, Baylor College of Medicine
MD, Facultad De Medicina - Instituto Tech.
PhD, University of Chicago
Publications

A Systematic Review of the Mechanisms Involved in Immune Checkpoint Inhibitors Cardiotoxicity and Challenges to Improve Clinical Safety
Rubio-Infante, N, Ramírez-Flores, YA, Castillo, EC, Lozano, O, García-Rivas, G & Torre-Amione, G 2022, , Frontiers in Cell and Developmental Biology, vol. 10, 851032. https://doi.org/10.3389/fcell.2022.851032

Long term development of diastolic dysfunction and heart failure with preserved left ventricular ejection fraction in heart transplant recipients
Vejpongsa, P, Torre-Amione, G, Marcos-Abdala, HG, Kumar, S, Youker, K, Bhimaraj, A & Nagueh, SF 2022, , Scientific Reports, vol. 12, no. 1, 3834. https://doi.org/10.1038/s41598-022-07888-9

Stratifying risk outcomes among adult COVID-19 inpatients with high flow oxygen: The R4 score
Aguirre-García, GM, Ramonfaur, D, Torre-Amione, G, Ramírez-Elizondo, MT, Lara-Medrano, R, Moreno-Hoyos, JF, Velázquez-Ávila, ES, Diaz-Garza, CA, Sanchez-Nava, VM, Castilleja-Leal, F, Rhoades, GM & Martínez-Reséndez, MF 2022, , Pulmonology. https://doi.org/10.1016/j.pulmoe.2021.10.001

Methodological and reporting issues for meta-analysis of immune checkpoint inhibitor-associated cardiotoxicity. Letter regarding the article ‘Cardiotoxicity associated with immune checkpoint inhibitor therapy: a meta-analysis’. Reply
Rubio-Infante, N, Ramírez-Flores, YA, Castillo, EC, Lozano, O, García-Rivas, G & Torre-Amione, G 2022, , European Journal of Heart Failure. https://doi.org/10.1002/ejhf.2611

Early increase of serum ferritin among COVID-19 patients is associated with need of invasive mechanical ventilation and with in-hospital death
Ramonfaur, D, Aguirre-García, GM, Diaz-Garza, CA, Torre-Amione, G, Sanchez-Nava, VM, Lara-Medrano, R, Ramírez-Elizondo, MT, Esparza-Sandoval, AC, Ortega-Hernández, FJ & Martínez-Reséndez, MF 2022, , Infectious Diseases. https://doi.org/10.1080/23744235.2022.2101691

Remote versus early corticosteroid wean outcomes in heart transplant recipients in the contemporary era
Salgado, BC, Fida, N, Krisl, J, Berens, PM, Graviss, EA, Nguyen, DT, Hussain, I, Kim, JH, Suarez, E, Trachtenberg, B, Torre-Amione, G, Bhimaraj, A & Guha, A 2021, , Clinical Transplantation, vol. 35, no. 8, e14382. https://doi.org/10.1111/ctr.14382

Pulse assessment is important with blood pressure measurement in individuals with continuous flow left ventricular assist devices
Marcos-Abdala, HG, Cruz-Solbes, AS, Hussain, I, Trachtenberg, B, Ashrith, G, Torre-Amione, G, Bruckner, B, Suarez, EE, Estep, JD & Bhimaraj, A 2021, , International Journal of Artificial Organs, vol. 44, no. 2, pp. 124-129. https://doi.org/10.1177/0391398820927022

Role of Endothelial and Mesenchymal Cell Transitions in Heart Failure and Recovery Thereafter
Wang, G, Cruz, AS, Youker, K, Marcos-Abdala, HG, Thandavarayan, RA, Cooke, JP, Torre-Amione, G, Chen, K & Bhimaraj, A 2021, , Frontiers in Genetics, vol. 11, 609262, pp. 609262. https://doi.org/10.3389/fgene.2020.609262

Outbreak of Candida auris infection in a COVID-19 hospital in Mexico
Villanueva-Lozano, H, Treviño-Rangel, RDJ, González, GM, Ramírez-Elizondo, MT, Lara-Medrano, R, Aleman-Bocanegra, MC, Guajardo-Lara, CE, Gaona-Chávez, N, Castilleja-Leal, F, Torre-Amione, G & Martínez-Reséndez, MF 2021, , Clinical Microbiology and Infection, vol. 27, no. 5, pp. 813-816. https://doi.org/10.1016/j.cmi.2020.12.030

Endothelial Dysfunction-related Neurological Bleeds with Continuous Flow-Left Ventricular Assist Devices Measured by Digital Thermal Monitor
Ali, A, Uribe, C, Araujo-Gutierrez, R, Cruz-Solbes, AS, Marcos-Abdala, HG, Youker, KA, Guha, A, Torre-Amione, G, Nguyen, DT, Graviss, EA, Cooke, JP & Bhimaraj, A 2021, , ASAIO Journal, pp. 561-566. https://doi.org/10.1097/MAT.0000000000001281

Endothelial Dysfunction-related Neurological Bleeds with Continuous Flow-Left Ventricular Assist Devices Measured by Digital Thermal Monitor
Ali, A, Uribe, C, Araujo-Gutierrez, R, Cruz-Solbes, AS, Marcos-Abdala, HG, Youker, KA, Guha, A, Torre-Amione, G, Nguyen, DT, Graviss, EA, Cooke, JP & Bhimaraj, A 2021, , ASAIO Journal, vol. 67, no. 5, pp. 561-566. https://doi.org/10.1097/MAT.0000000000001281

Cardiotoxicity associated with immune checkpoint inhibitor therapy: a meta-analysis
Rubio-Infante, N, Ramírez-Flores, YA, Castillo, EC, Lozano, O, García-Rivas, G & Torre-Amione, G 2021, , European Journal of Heart Failure, vol. 23, no. 10, pp. 1739-1747. https://doi.org/10.1002/ejhf.2289

Nanovaccine for Heart Failure
Youker, KA, Torre-Amione, G & Shen, H May. 27 2021, , Patent No. WO2021101968.

What Is the Role of the Inflammation in the Pathogenesis of Heart Failure?
Castillo, EC, Vázquez-Garza, E, Yee-Trejo, D, García-Rivas, G & Torre-Amione, G 2020, , Current Cardiology Reports, vol. 22, no. 11, 139. https://doi.org/10.1007/s11886-020-01382-2

Endothelial Dysfunction-related Neurological Bleeds with Continuous Flow-Left Ventricular Assist Devices Measured by Digital Thermal Monitor
Ali, A, Uribe, C, Araujo-Gutierrez, R, Cruz-Solbes, AS, Marcos-Abdala, HG, Youker, KA, Guha, A, Torre-Amione, G, Nguyen, DT, Graviss, EA, Cooke, JP & Bhimaraj, A 2020, , ASAIO journal (American Society for Artificial Internal Organs : 1992). https://doi.org/10.1097/MAT.0000000000001281

The role of B cells in heart failure and implications for future immunomodulatory treatment strategies
García-Rivas, G, Castillo, EC, Gonzalez-Gil, AM, Maravillas-Montero, JL, Brunck, M, Torres-Quintanilla, A, Elizondo-Montemayor, L & Torre-Amione, G 2020, , ESC Heart Failure, vol. 7, no. 4, pp. 1387-1399. https://doi.org/10.1002/ehf2.12744

Percutaneous Left Axillary Artery Placement of Intra-Aortic Balloon Pump in Advanced Heart Failure Patients
Bhimaraj, A, Agrawal, T, Duran, A, Tamimi, O, Amione-Guerra, J, Trachtenberg, B, Guha, A, Hussain, I, Kim, J, Kassi, M, Xu, J, Suarez, EE, Ngo, UQ, Torre-Amione, G & Estep, JD 2020, , JACC: Heart Failure, vol. 8, no. 4, pp. 313-323. https://doi.org/10.1016/j.jchf.2020.01.011

Equipo de respuesta rápida para tromboembolismo venoso del hospital zambrano hellion (PREVENTION-team): mejorando el manejo del tromboembolismo pulmonar y trombosis venosa profunda
Del Toro-Mijares, R, Jerjes-Sánchez, C, Rodríguez, D, Panneflek, J, Vázquez-Guajardo, M, Fabiani, MA, Quintanilla, J, Manautou, L, de la Peña-Almaguer, E, Cadena, A, Cassagne, G & Torre-Amione, G 2020, , Archivos de cardiologia de Mexico, vol. 90, no. 1, pp. 28-38. https://doi.org/10.24875/ACM.19000276

Resveratrol Prevents Right Ventricle Remodeling and Dysfunction in Monocrotaline-Induced Pulmonary Arterial Hypertension with a Limited Improvement in the Lung Vasculature
Vázquez-Garza, E, Bernal-Ramírez, J, Jerjes-Sánchez, C, Lozano, O, Acuña-Morín, E, Vanoye-Tamez, M, Ramos-González, MR, Chapoy-Villanueva, H, Pérez-Plata, L, Sánchez-Trujillo, L, Torre-Amione, G, Ramírez-Rivera, A & García-Rivas, G 2020, , Oxidative Medicine and Cellular Longevity, vol. 2020, 1841527. https://doi.org/10.1155/2020/1841527

Discovery of non-HLA antibodies associated with cardiac allograft rejection and development and validation of a non-HLA antigen multiplex panel: From bench to bedside
Butler, CL, Hickey, MJ, Jiang, N, Zheng, Y, Gjertson, D, Zhang, Q, Rao, P, Fishbein, GA, Cadeiras, M, Deng, MC, Banchs, HL, Torre, G, DeNofrio, D, Eisen, HJ, Kobashigawa, J, Starling, RC, Kfoury, A, Van Bakel, A, Ewald, G, Balazs, I, Baas, AS, Cruz, D, Ardehali, R, Biniwale, R, Kwon, M, Ardehali, A, Nsair, A, Ray, B & Reed, EF 2020, , American Journal of Transplantation, vol. 20, no. 10, pp. 2768-2780. https://doi.org/10.1111/ajt.15863