Guillermo Torre, MD, PhD

Professor of Cardiology, Institute for Academic Medicine
Full Member, Research Institute
Houston Methodist
Weill Cornell Medical College


Biography

Dr. Torre-Amione received his first academic appointment in 1995 as a Clinical Instructor at the Baylor College of Medicine in Houston, Texas. He became an Assistant Professor there one year later, the same year he became the Medical Director for the Cardiac Transplant Service at Houston Methodist DeBakey Heart and Vascular Center. Dr.Torre-Amione joined the Houston Methodist Specialty Physician Group and Weill Medical College in 2005.

Description of Research

Dr. Torre-Amione is the director of the Heart Failure Research Laboratory at Houston Methodist, and conducts research examining the mechanisms of immune activation and inflammation as it relates to myocardial dysfunction in the areas of heart failure and cardiac transplantation. The doctor and his colleagues have conducted numerous studies that suggest novel immune modulatory therapies for the treatment of heart failure and transplant patients. Dr. Torre-Amione led the first two FDA-approved trials of Celacade with impressive results, and a Phase III trial is underway. Other studies underway in the Heart Failure Research Laboratory are investigating additional immune response pathways that contribute to the progression of heart failure, including the role of heat shock proteins and cardiac mast cells.

Areas Of Expertise

Heart failure Inflammation Cardiac transplant Immune activation Heat shock proteins Cardiac mast cells
Education & Training

Residency, Baylor College of Medicine
Clinical Fellowship, Baylor College of Medicine
Postdoctoral Fellowship, Baylor College of Medicine
MD, Facultad De Medicina - Instituto Tech.
PhD, University of Chicago
Publications

B-type natriuretic peptide reference interval of newborns from healthy and pre-eclamptic women: a prospective, multicentre, cross-sectional study
Rodriguez, D, Garcia-Rivas, G, Laresgoiti-Servitje, E, Yañez, J, Torre-Amione, G & Jerjes-Sanchez, C 2018, BMJ open, vol. 8, no. 10, pp. e022562. DOI: 10.1136/bmjopen-2018-022562

The use of cardiac CT as a roadmap for resolving coronary stent dislodgement
Torre-Amione, G, de la Pena-Almaguer, E, Quintanilla, J, Valdes, F, Jimenez, V, Rodriguez, D, Trevino, A, Perez, L & Jerjes-Sanchez, C 2018, Archivos de cardiologia de Mexico, vol. 88, no. 4, pp. 318-319. DOI: 10.1016/j.acmx.2018.03.006

The Obesity Paradox is Lost After LVAD Implant
Cruz-Solbes, AS, Nguyen, DT, Graviss, E, Trachtenberg, B, Hussain, I, Bhimaraj, A, Torre-Amione, G, Park, M, Estep, J & Guha, A 2018, HFSA 22nd Annual Scientific Meeting, Nashville, United States, 9/15/18 - 9/18/18, pp. S384. DOI: 10.1016/j.healun.2018.01.988

IABP as a Bridge to Transplantation: Can we Identify Who May Benefit From a LVAD?
Guha, A, Ali, A, Nguyen, DT, Bruckner, B, Trachtenberg, B, Graviss, EA, Bhimaraj, A, Park, MH, Hussain, I, Suarez, EE, Torre-Amione, G & Estep, J 2018, Journal of Heart and Lung Transplantation, vol. 37, no. 4, pp. S267. DOI: 10.1016/j.healun.2018.01.667

Melding a high-risk patient for continuous flow left ventricular assist device into a low-risk patient
Amione-Guerra, J, Cruz-Solbes, AS, Bonilla, HG, Estep, JD, Guha, A, Bhimaraj, A, Suarez, EE, Bruckner, BA, Torre-Amione, G, Park, MH & Trachtenberg, BH 2017, ASAIO Journal, vol. 63, no. 6, pp. 704-712. DOI: 10.1097/MAT.0000000000000591

Prevalence of in-hospital nonsteroidal antiinflammatory drug exposure in patients with a primary diagnosis of heart failure
Alvarez, PA, Putney, D, Ogunti, R, Puppala, M, Ganduglia, C, Torre-Amione, G, Schutt, R, Wong, STC & Estep, JD 2017, Cardiovascular Therapeutics, vol. 35, no. 3. DOI: 10.1111/1755-5922.12256

Measurement of troponin and natriuretic peptides shortly after admission in patients with heart failure—does it add useful prognostic information? An analysis of the Value of Endothelin Receptor Inhibition with Tezosentan in Acute heart failure Studies (VERITAS)
for the VERITAS Investigators 2017, European Journal of Heart Failure, vol. 19, no. 6, pp. 739-747. DOI: 10.1002/ejhf.786

Long-Term Effect of Endothelin Receptor Antagonism With Bosentan on the Morbidity and Mortality of Patients With Severe Chronic Heart Failure: Primary Results of the ENABLE Trials
on behalf of the, ENABLE Investigators and Committees & ENABLE Investigators and Committees 2017, JACC: Heart Failure, vol. 5, no. 5, pp. 317-326. DOI: 10.1016/j.jchf.2017.02.021

Risk Stratification of Patients With Current Generation Continuous-Flow Left Ventricular Assist Devices Being Bridged to Heart Transplantation
Guha, A, Nguyen, D, Cruz-Solbes, AS, Amione-Guerra, J, Schutt, RC, Bhimaraj, A, Trachtenberg, BH, Park, MH, Graviss, EA, Gaber, O, Suarez, E, Montane, E, Torre-Amione, G & Estep, JD 2017, ASAIO Journal, pp. 196-202. DOI: 10.1097/MAT.0000000000000635

Rapamycin nanoparticles localize in diseased lung vasculature and prevent pulmonary arterial hypertension
Segura-Ibarra, V, Amione-Guerra, J, Cruz-Solbes, AS, Cara, FE, Iruegas-Nunez, DA, Wu, S, Youker, KA, Bhimaraj, A, Torre-Amione, G, Ferrari, M, Karmouty-Quintana, H, Guha, A & Blanco, E 2017, International Journal of Pharmaceutics, vol. 524, no. 1-2, pp. 257-267. DOI: 10.1016/j.ijpharm.2017.03.069

Myocardial Recovery in Patients With Systolic Heart Failure and Autoantibodies Against ß1-Adrenergic Receptors
Nagatomo, Y, McNamara, DM, Alexis, JD, Cooper, LT, Dec, GW, Pauly, DF, Sheppard, R, Starling, RC, Tang, WHW, McNamara, DM, Janosko, K, McTiernan, C, London, B, Hanley-Yanez, K, Gorcsan, J, Tanaka, H, Suffoletto, M, Starling, RC, Oblak, C, Cooper, LT, McNallan, A, Koenig, LA, Mather, P, Pierson, N, Rubin, S, Bell, Y, Ervin, A, Boehmer, J, Frey, P, Alexis, J, Schrack, J, LaDuke, P, Torre-Amione, G, Arredondo, J, Pauly, DF, Smith, PC, Sheppard, R, Fuoco, S, Wittstein, IS, Breton, E, Thohan, V, Wesley, D, Dec, GW, Cocca-Spofford, D, Markham, DW, Fernandez, L, Debes, C, Zucker, MJ, Adams, L, Liu, P, Renton, J, Narula, J, Allen, B & Westberg, E 2017, Journal of the American College of Cardiology, vol. 69, no. 8, pp. 968-977. DOI: 10.1016/j.jacc.2016.11.067

Systolic blood pressure reduction during the first 24h in acute heart failure admission: Friend or foe?
Cotter, G, Metra, M, Davison, BA, Jondeau, G, Cleland, JGF, Bourge, RC, Milo, O, OConnor, CM, Parker, JD, Torre-Amione, G, van Veldhuisen, DJ, Kobrin, I, Rainisio, M, Senger, S, Edwards, C, Mcmurray, JJV & Teerlink, JR 2017, European Journal of Heart Failure. DOI: 10.1002/ejhf.889

The Obesity Paradox in End Stage Heart Failure: Does LVAD Resolve the Paradox?
Cruz-Solbes, AS, Nguyen, DT, Trachtenberg, B, Bhimaraj, A, Torre-Amione, G, Graviss, EA, Estep, JD & Guha, A 2017, Journal of Cardiac Failure, vol. 23, no. 8, pp. S17. DOI: 10.1016/j.cardfail.2017.07.058

Role of Adaptive Immunity in the Development and Progression of Heart Failure: New Evidence
Sánchez-Trujillo, L, Vázquez-Garza, E, Castillo, EC, García-Rivas, G & Torre-Amione, G 2017, Archives of Medical Research, vol. 48, no. 1, pp. 1-11. DOI: 10.1016/j.arcmed.2016.12.008

Silica nanoparticles induce cardiotoxicity interfering with energetic status and Ca2+ handling in adult rat cardiomyocytes
Guerrero-Beltrán, CE, Bernal-Ramírez, J, Lozano, O, Oropeza-Almazán, Y, Castillo, EC, Garza, JR, García, N, Vela, J, García-García, A, Ortega, E, Torre-Amione, G, Ornelas-Soto, N & García-Rivas, G 2017, American Journal of Physiology - Heart and Circulatory Physiology, vol. 312, no. 4, pp. H645-H661. DOI: 10.1152/ajpheart.00564.2016

Small Interfering RNA Targeting Mitochondrial Calcium Uniporter Improves Cardiomyocyte Cell Viability in Hypoxia/Reoxygenation Injury by Reducing Calcium Overload
Oropeza-Almazán, Y, Vázquez-Garza, E, Chapoy-Villanueva, H, Torre-Amione, G & García-Rivas, G 2017, Oxidative Medicine and Cellular Longevity, vol. 2017, 5750897. DOI: 10.1155/2017/5750897

Impact of Cytomegalovirus on Survival after Heart Transplant: Analysis of 20,000 Patients from the UNOS Registry Data
Ashrith, G, Daoud, A, Teeter, LD, Amione-Guerra, J, Cordero-Reyes, AM, Graviss, E, Trachtenberg, BH, Bhimaraj, A, Gaber, A, Scheinin, S, Torre-Amione, G & Estep, JD 2016, Journal of Heart and Lung Transplantation, vol. 35, no. 4, pp. S60. DOI: 10.1016/j.healun.2016.01.165

Rnd3/RhoE Modulates Hypoxia-Inducible Factor 1a/Vascular Endothelial Growth Factor Signaling by Stabilizing Hypoxia-Inducible Factor 1a and Regulates Responsive Cardiac Angiogenesis
Yue, X, Lin, X, Yang, T, Yang, X, Yi, X, Jiang, X, Li, X, Li, T, Guo, J, Dai, Y, Shi, J, Wei, L, Youker, KA, Torre-Amione, G, Yu, Y, Andrade, KC & Chang, J 2016, Hypertension, vol. 67, no. 3, pp. 597-605. DOI: 10.1161/HYPERTENSIONAHA.115.06412

A specifically designed nanoconstruct associates, internalizes, traffics in cardiovascular cells, and accumulates in failing myocardium: A new strategy for heart failure diagnostics and therapeutics
Ruiz-Esparza, GU, Segura-Ibarra, V, Cordero-Reyes, AM, Youker, KA, Serda, RE, Cruz-Solbes, AS, Amione-Guerra, J, Yokoi, K, Kirui, DK, Cara, FE, Paez-Mayorga, J, Flores-Arredondo, JH, Guerrero-Beltrán, CE, Garcia-Rivas, G, Ferrari, M, Blanco, E & Torre-Amione, G 2016, European Journal of Heart Failure, vol. 18, no. 2, pp. 169-178. DOI: 10.1002/ejhf.463

Combination of angiotensin II and l-NG-nitroarginine methyl ester exacerbates mitochondrial dysfunction and oxidative stress to cause heart failure
Hamilton, DJ, Zhang, A, Li, S, Cao, TN, Smith, JA, Vedula, I, Cordero-Reyes, AM, Youker, KA, Torre-Amione, G & Gupte, AA 2016, American Journal of Physiology - Heart and Circulatory Physiology, vol. 310, no. 6, pp. H667-H680. DOI: 10.1152/ajpheart.00746.2015