George Taffet, MD

Adjunct Professor of Medicine, Institute for Academic Medicine
Houston Methodist
Weill Cornell Medical College


Education & Training

Residency, Baylor College of Medicine
Clinical Fellowship, Baylor College of Medicine
MD, Brown University Program in Medicine
Publications

Postnatal undernutrition alters adult female mouse cardiac structure and function leading to limited exercise capacity
Ferguson, DP, Monroe, TO, Heredia, CP, Fleischmann, R, Rodney, GG, Taffet, G & Fiorotto, ML 2019, Journal of Physiology. https://doi.org/10.1113/JP277637

Improved Cardiovascular Function in Old Mice After N-Acetyl Cysteine and Glycine Supplemented Diet: Inflammation and Mitochondrial Factors
Cieslik, KA, Sekhar, RV, Granillo, A, Reddy, A, Medrano, G, Heredia, CP, Entman, ML, Hamilton, DJ, Li, S, Reineke, E, Gupte, AA, Zhang, A & Taffet, GE 2018, The journals of gerontology. Series A, Biological sciences and medical sciences, vol. 73, no. 9, pp. 1167-1177. https://doi.org/10.1093/gerona/gly034

Multicomponent Interventions Reduce High-Risk Medications for Delirium in Hospitalized Older Adults
Adeola, M, Azad, R, Kassie, GM, Shirkey, B, Taffet, G, Liebl, M & Agarwal, K 2018, Journal of the American Geriatrics Society, vol. 66, no. 8, pp. 1638-1645. https://doi.org/10.1111/jgs.15438

Transient activation of AMPK preceding left ventricular pressure overload reduces adverse remodeling and preserves left ventricular function
Nam, DH, Kim, E, Benham, A, Park, H-K, Soibam, B, Taffet, GE, Kaelber, JT, Suh, JH, Taegtmeyer, H, Entman, ML & Reineke, EL 2018, FASEB journal : official publication of the Federation of American Societies for Experimental Biology, pp. fj201800602R. https://doi.org/10.1096/fj.201800602R

Short-Term Global Cardiovascular Disease Risk Prediction in Older Adults
Saeed, A, Nambi, V, Sun, W, Virani, SS, Taffet, G, Deswal, A, Selvin, E, Matsushita, K, Wagenknecht, LE, Hoogeveen, R, Coresh, J, de Lemos, JA & Ballantyne, CM 2018, Journal of the American College of Cardiology, vol. 71, no. 22, pp. 2527-2536. https://doi.org/10.1016/j.jacc.2018.02.050

Prevalence of Cognitive Impairment Among Elderly Patients Upon Hospital Admission Using Mini-Cog™ Assessments Performed by Advanced Pharmacy Practice Experience Students
Bui, NA, Adeola, M, Azad, R, Swan, JT, Agarwal, KS, Sharma, M, Liebl, MG & Taffet, G 2018, Journal of Pharmacy Practice. https://doi.org/10.1177/0897190018780591

Improved cardiovascular function in old mice after N-Acetyl cysteine and glycine supplemented diet: Inflammation and mitochondrial factors
Cieslik, KA, Sekhar, RV, Granillo, A, Reddy, A, Medrano, G, Heredia, CP, Entman, ML, Hamilton, DJ, Li, S, Reineke, EL, Gupte, AA, Zhang, A & Taffet, G 2018, Journals of Gerontology - Series A Biological Sciences and Medical Sciences, vol. 73, no. 9, pp. 1167-1177. https://doi.org/10.1093/gerona/gly034

Steroid Receptor Coactivator-2 (SRC-2) coordinates cardiomyocyte paracrine signaling to promote pressure overload-induced angiogenesis.
Suh, JH, Lai, L, Nam, D, Kim, J, Jo, J, Taffet, G, Kim, E, Kaelber, J, Lee, H, Entman, ML, Cooke, JP & Reineke, EL 2017, Journal of Biological Chemistry.

Dissecting the role of myeloid and mesenchymal fibroblasts in age-dependent cardiac fibrosis
Trial, JA, Heredia, CP, Taffet, GE, Entman, ML & Cieslik, KA 2017, Basic Research in Cardiology, vol. 112, no. 4, 34. https://doi.org/10.1007/s00395-017-0623-4

Cardiac Resynchronization Therapy in Older Adults with Heart Failure
Lam, PH, Taffet, G, Ahmed, A & Singh, S 2017, Heart Failure Clinics, vol. 13, no. 3, pp. 581-587. https://doi.org/10.1016/j.hfc.2017.02.011

Murine echocardiography of left atrium, aorta, and pulmonary artery
Granillo, A, Pena, CA, Pham, T, Pandit, LM & Taffet, G 2017, Journal of Visualized Experiments, vol. 2017, no. 120, e55214. https://doi.org/10.3791/55214

Hospital and physician rating websites: Ethical challenges without context
Taffet, G 2017, . in Ethical Considerations and Challenges in Geriatrics. Springer International Publishing, pp. 137-145. https://doi.org/10.1007/978-3-319-44084-2_12

Steroid receptor coactivator-2 (SRC-2) coordinates cardiomyocyte paracrine signaling to promote pressure overload-induced angiogenesis
Suh, JH, Lai, L, Nam, D, Kim, J, Jo, J, Taffet, GE, Kim, E, Kaelber, JT, Lee, HK, Entman, ML, Cooke, JP & Reineke, EL 2017, Journal of Biological Chemistry, vol. 292, no. 52, pp. 21643-21652. https://doi.org/10.1074/jbc.M117.804740

Unrecognized Cognitive Impairment and Its Effect on Heart Failure Readmissions of Elderly Adults
Agarwal, KS, Kazim, R, Xu, S, Borson, S & Taffet, G 2016, Journal of the American Geriatrics Society, vol. 64, no. 11, pp. 2296-2301. https://doi.org/10.1111/jgs.14471

Left atrial volume and pulmonary artery diameter are noninvasive measures of age-related diastolic dysfunction in mice
Medrano, G, Hermosillo-Rodriguez, J, Pham, T, Granillo, A, Hartley, CJ, Reddy, A, Osuna, PM, Entman, ML & Taffet, G 2016, Journals of Gerontology - Series A Biological Sciences and Medical Sciences, vol. 71, no. 9, pp. 1141-1150. https://doi.org/10.1093/gerona/glv143

Measures of healthspan as indices of aging in Mice-A recommendation
Richardson, A, Fischer, KE, Speakman, JR, De Cabo, R, Mitchell, SJ, Peterson, CA, Rabinovitch, P, Chiao, YA, Taffet, G, Miller, RA, Rentería, RC, Bower, J, Ingram, DK, Ladiges, WC, Ikeno, Y, Sierra, F & Austad, SN 2016, Journals of Gerontology - Series A Biological Sciences and Medical Sciences, vol. 71, no. 4, pp. 427-430. https://doi.org/10.1093/gerona/glv080

TNF/Ang-II synergy is obligate for fibroinflammatory pathology, but not for changes in cardiorenal function
Mayr, M, Duerrschmid, C, Medrano, G, Taffet, G, Wang, Y, Entman, ML & Haudek, SB 2016, Physiological Reports, vol. 4, no. 8, e12765. https://doi.org/10.14814/phy2.12765

Plasma Levels of Endothelial Microparticles Bearing Monomeric C-reactive Protein are Increased in Peripheral Artery Disease
Crawford, JR, Trial, J, Nambi, V, Hoogeveen, RC, Taffet, G & Entman, ML 2016, Journal of Cardiovascular Translational Research, pp. 1-10. https://doi.org/10.1007/s12265-016-9678-0

Prognostic significance of anaemia in patients with heart failure with preserved and reduced ejection fraction: Results from the MAGGIC individual patient data meta-analysis
Berry, C, Poppe, KK, Gamble, GD, Earle, NJ, Ezekowitz, JA, Squire, IB, McMurray, JJV, McAlister, FA, Komajda, M, Swedberg, K, Maggioni, AP, Ahmed, A, Whalley, GA, Doughty, RN, Tarantini, L, Granger, C, Køber, L, Massie, B, Pocock, S, Somaratne, J, Andersson, B, Bayes-Genis, A, Cowie, M, Cubbon, R, Gonzalez-Juanatey, J, Gorini, M, Gotsman, I, Grigorian-Shamagian, L, Guazzi, M, Kearney, M, Di Lenarda, A, Lenzen, M, Lucci, D, Macín, S, Madsen, B, Martínez-Sellés, M, Oliva, F, Rich, M, Richards, M, Senni, M, Taffet, G, Tribouilloy, C, Troughton, R, Tsutsui, H, Ariti, C, Dobson, J, Hall, C, Lainchbury, J, Hogg, K, Norrie, J, Stevenson, K, Brett, M, Pfeffer, MA, Held, P, Michelson, EL, Olofsson, B, Östergren, J, Yusuf, S, Torp-Pedersen, C, Scholte op Reimer, W, Boersma, E, Vantrimpont, PJMJ, Follath, F, Cleland, J, Zwas, D, Planer, D, Azaz-Livshits, T, Admon, D, Lotan, C, Keren, A, Varela-Roman, A, Mazón-Ramos, P, Rigeiro-Veloso, P, Bandin-Dieguez, MA, Myers, J, Arena, R, Armstrong, PW, Cujec, B, Paterson, I, Wood, DA, Coats, AJS, Thompson, SG, Suresh, V, Poole-Wilson, PA, Sutton, GC, Robles, JAG, Prieto, L, Muñoa, MD, Frades, E, Díaz-Castro, O, Almendral, J, Faggiano, P, Bertoli, D, Porcu, M, Opasich, C, Tavazzi, L, Kirk, V, Bay, M, Parner, J, Krogsgaard, K, Herzog, TM, Boesgaard, S, Hassager, C, Nielsen, OW, Aldershvile, J, Nielsen, H, Kober, L, Perna, ER, Cimbaro Canella, JP, Alvarenga, P, Pantich, R, Ríos, N, Farias, EF, Badaracco, JR, Hansen, JF, Stokholm, KH, Brons, J, Husum, D, Mortensen, LS, Vazquez, R, Puig, T, Fernandez-Palomeque, C, Bardají, A, Pascual-Figal, D, Ordoñez-Llanos, J, Valdes, M, Gabarrus, A, Pavon, R, Pastor, L, Fiol, M, Nieto, V, Macaya, C, Cinca, J, Cygankiewitz, I, Bayes De Luna, A, Newton, JD, Blackledge, HM, Wright, SP, Kerzner, R, Gage, BF, Freedland, KE, Huynh, BC, Rovner, A, Carney, RM, Teasdale, TA, Bleyer, AJ, Kutka, NJ, Luchi, RJ, Rusinaru, D, Mahjoub, H, Soulière, V, Lévy, F, Peltier, M, Tsuchihashi, M, Takeshita, A, MacCarthy, PA, Nolan, J, Lee, AJ, Prescott, RJ, Shah, AM, Brooksby, WP, Fox, KAA, Basante, P, Trillo, R, Garcia-Seara, J, Martinez-Sande, JL & Gude, F 2016, QJM, vol. 109, no. 6, pp. 377-382. https://doi.org/10.1093/qjmed/hcv087

PHD2/3-dependent hydroxylation tunes cardiac response to ß-adrenergic stress via phospholamban
Xie, L, Pi, X, Townley-Tilson, WHD, Li, N, Wehrens, XHT, Entman, ML, Taffet, GE, Mishra, A, Peng, J, Schisler, JC, Meissner, G & Patterson, C 2015, Journal of Clinical Investigation, vol. 125, no. 7, pp. 2759-2771. https://doi.org/10.1172/JCI80369