George Taffet VIEW CLINICAL PROFILE

George Taffet, MD

Adjunct Professor of Medicine, Academic Institute
Houston Methodist
Weill Cornell Medical College


VIEW CLINICAL PROFILE
Education & Training

Residency, Baylor College of Medicine
Clinical Fellowship, Baylor College of Medicine
MD, Brown University Program in Medicine
Publications

Supplementing Glycine and N-Acetylcysteine (GlyNAC) in Older Adults Improves Glutathione Deficiency, Oxidative Stress, Mitochondrial Dysfunction, Inflammation, Physical Function, and Aging Hallmarks: A Randomized Clinical Trial
Kumar, P, Liu, C, Suliburk, J, Hsu, JW, Muthupillai, R, Jahoor, F, Minard, CG, Taffet, GE & Sekhar, RV 2023, , The journals of gerontology. Series A, Biological sciences and medical sciences, vol. 78, no. 1, pp. 75-89. https://doi.org/10.1093/gerona/glac135

Deprescribing statins, considerations for informed decision making
Thomas, C, Ellison, H & Taffet, GE 2023, , Journal of the American Geriatrics Society. https://doi.org/10.1111/jgs.18362

Sex-specific phenotypes in the aging mouse heart and consequences for chronic fibrosis
Angelini, A, Ortiz-Urbina, J, Trial, JA, Reddy, AK, Malovannaya, A, Jain, A, Entman, ML, Taffet, GE & Cieslik, KA 2022, , American Journal of Physiology - Heart and Circulatory Physiology, vol. 323, no. 2, pp. H285-H300. https://doi.org/10.1152/ajpheart.00078.2022

Midlife determinants of healthy cardiovascular aging: The Atherosclerosis Risk in Communities (ARIC) study
Jia, X, Sun, C, Nambi, V, Virani, SS, Taffet, G, Boerwinkle, E, Bressler, J, Ndumele, C, Windham, BG, de Lemos, JA, Matsushita, K, McEvoy, JW, Hoogeveen, RC, Selvin, E & Ballantyne, CM 2022, , Atherosclerosis, vol. 350, pp. 82-89. https://doi.org/10.1016/j.atherosclerosis.2022.04.028

Author Correction: Aortic acceleration as a noninvasive index of left ventricular contractility in the mouse (Scientific Reports, (2021), 11, 1, (536), 10.1038/s41598-020-79866-y)
Tovar Perez, JE, Ortiz-Urbina, J, Heredia, CP, Pham, TT, Madala, S, Hartley, CJ, Entman, ML, Taffet, GE & Reddy, AK 2021, , Scientific Reports, vol. 11, no. 1, 7859. https://doi.org/10.1038/s41598-021-87101-5

Author Correction: Aortic acceleration as a noninvasive index of left ventricular contractility in the mouse (Scientific Reports, (2021), 11, 1, (536), 10.1038/s41598-020-79866-y)
Perez, JET, Ortiz-Urbina, J, Heredia, CP, Pham, TT, Madala, S, Hartley, CJ, Entman, ML, Taffet, GE & Reddy, AK 2021, , Scientific Reports, vol. 11, no. 1, 23743. https://doi.org/10.1038/s41598-021-03203-0

Exercise Intolerance in Older Adults With Heart Failure With Preserved Ejection Fraction: JACC State-of-the-Art Review
Pandey, A, Shah, SJ, Butler, J, Kellogg, DL, Lewis, GD, Forman, DE, Mentz, RJ, Borlaug, BA, Simon, MA, Chirinos, JA, Fielding, RA, Volpi, E, Molina, AJA, Haykowsky, MJ, Sam, F, Goodpaster, BH, Bertoni, AG, Justice, JN, White, JP, Ding, J, Hummel, SL, LeBrasseur, NK, Taffet, GE, Pipinos, II & Kitzman, D 2021, , Journal of the American College of Cardiology, vol. 78, no. 11, pp. 1166-1187. https://doi.org/10.1016/j.jacc.2021.07.014

NLRP3 inflammasome is a key driver of obesity-induced atrial arrhythmias
Scott, L, Fender, AC, Saljic, A, Li, L, Chen, X, Wang, X, Linz, D, Lang, J, Hohl, M, Twomey, D, Pham, TT, Diaz-Lankenau, R, Chelu, MG, Kamler, M, Entman, ML, Taffet, GE, Sanders, P, Dobrev, D & Li, N 2021, , Cardiovascular Research, vol. 117, no. 7, pp. 1746-1759. https://doi.org/10.1093/cvr/cvab024

Diagnostic accuracy of the 4AT for delirium detection in older adults: systematic review and meta-analysis
Tieges, Z, Maclullich, AMJ, Anand, A, Brookes, C, Cassarino, M, O’connor, M, Ryan, D, Saller, T, Arora, RC, Chang, Y, Agarwal, K, Taffet, G, Quinn, T, Shenkin, SD & Galvin, R 2021, , Age and Ageing, vol. 50, no. 3, pp. 733-743. https://doi.org/10.1093/ageing/afaa224

Aortic acceleration as a noninvasive index of left ventricular contractility in the mouse
Perez, JET, Ortiz-Urbina, J, Heredia, CP, Pham, TT, Madala, S, Hartley, CJ, Entman, ML, Taffet, GE & Reddy, AK 2021, , Scientific Reports, vol. 11, no. 1, 536. https://doi.org/10.1038/s41598-020-79866-y

Implementing Health Care Quality Measures in Electronic Health Records: A Conceptual Model
Campbell, CM, Murphy, DR, Taffet, GE, Major, AB, Ritchie, CS, Leff, B & Naik, AD 2021, , Journal of the American Geriatrics Society, vol. 69, no. 4, pp. 1079-1085. https://doi.org/10.1111/jgs.17033

Decade-long nationwide trends and disparities in use of comfort care interventions for patients with ischemic stroke
Chu, KM, Jones, EM, Meeks, JR, Pan, AP, Agarwal, KL, Taffet, GE & Vahidy, FS 2021, , Journal of the American Heart Association, vol. 10, no. 8, e019785. https://doi.org/10.1161/JAHA.120.019785

Plasma dehydroepiandrosterone sulfate and cardiovascular disease risk in older men and women
Jia, X, Sun, C, Tang, O, Gorlov, I, Nambi, V, Virani, SS, Villareal, DT, Taffet, GE, Yu, B, Bressler, J, Boerwinkle, E, Gwen Windham, B, De Lemos, JA, Matsushita, K, Selvin, E, Michos, ED, Hoogeveen, RC & Ballantyne, CM 2020, , Journal of Clinical Endocrinology and Metabolism, vol. 105, no. 12, pp. 1-24. https://doi.org/10.1210/clinem/dgaa518

Decreasing Heart Failure Readmissions Among Older Patients With Cognitive Impairment by Engaging Caregivers
Agarwal, KS, Bhimaraj, A, Xu, J, Bionat, S, Pudlo, M, Miranda, D, Campbell, C & Taffet, G 2020, , The Journal of cardiovascular nursing, vol. 35, no. 3, pp. 253-261. https://doi.org/10.1097/JCN.0000000000000670

Erratum: MAP4K4 Inhibition Promotes Survival of Human Stem Cell-Derived Cardiomyocytes and Reduces Infarct Size In Vivo (Cell Stem Cell (2019) 24(4) (579–591.e12), (S193459091930013X), (10.1016/j.stem.2019.01.013))
Fiedler, LR, Chapman, K, Xie, M, Maifoshie, E, Jenkins, M, Golforoush, PA, Bellahcene, M, Noseda, M, Faust, D, Jarvis, A, Newton, G, Paiva, MA, Harada, M, Stuckey, DJ, Song, W, Habib, J, Narasimhan, P, Aqil, R, Sanmugalingam, D, Yan, R, Pavanello, L, Sano, M, Wang, SC, Sampson, RD, Kanayaganam, S, Taffet, GE, Michael, LH, Entman, ML, Tan, TH, Harding, SE, Low, CMR, Tralau-Stewart, C, Perrior, T & Schneider, MD 2020, , Cell Stem Cell, vol. 26, no. 3, pp. 458. https://doi.org/10.1016/j.stem.2020.01.015

Normal and abnormal aging (general perspective for the oncologist)
Taffet, G 2020, . in Geriatric Oncology. Springer International Publishing, pp. 207-213. https://doi.org/10.1007/978-3-319-57415-8_56

Treatment with a DC-SIGN ligand reduces macrophage polarization and diastolic dysfunction in the aging female but not male mouse hearts
Trial, JA, Diaz Lankenau, R, Angelini, A, Tovar Perez, JE, Taffet, GE, Entman, ML & Cieslik, KA 2021, , GeroScience, vol. 43, no. 2, pp. 881-899. https://doi.org/10.1007/s11357-020-00255-4

MAP4K4 Inhibition Promotes Survival of Human Stem Cell-Derived Cardiomyocytes and Reduces Infarct Size In Vivo
Fiedler, LR, Chapman, K, Xie, M, Maifoshie, E, Jenkins, M, Golforoush, PA, Bellahcene, M, Noseda, M, Faust, D, Jarvis, A, Newton, G, Paiva, MA, Harada, M, Stuckey, DJ, Song, W, Habib, J, Narasimham, P, Aqil, R, Sanmugalingam, D, Yan, R, Pavanello, L, Sano, M, Wang, SC, Sampson, RD, Kanayaganam, S, Taffet, G, Michael, LH, Entman, ML, Tan, TH, Harding, SE, Low, CMR, Tralau-Stewart, C, Perrior, T & Schneider, MD 2019, , Cell Stem Cell, vol. 24, no. 4, pp. 579-591.e12. https://doi.org/10.1016/j.stem.2019.01.013

Postnatal undernutrition alters adult female mouse cardiac structure and function leading to limited exercise capacity
Ferguson, DP, Monroe, TO, Heredia, CP, Fleischmann, R, Rodney, GG, Taffet, G & Fiorotto, ML 2019, , Journal of Physiology, vol. 597, no. 7, pp. 1855-1872. https://doi.org/10.1113/JP277637

Improved Cardiovascular Function in Old Mice After N-Acetyl Cysteine and Glycine Supplemented Diet: Inflammation and Mitochondrial Factors
Cieslik, KA, Sekhar, RV, Granillo, A, Reddy, A, Medrano, G, Heredia, CP, Entman, ML, Hamilton, DJ, Li, S, Reineke, E, Gupte, AA, Zhang, A & Taffet, GE 2018, , The journals of gerontology. Series A, Biological sciences and medical sciences, vol. 73, no. 9, pp. 1167-1177. https://doi.org/10.1093/gerona/gly034

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