George Taffet, MD

Adjunct Professor of Medicine, Institute for Academic Medicine
Houston Methodist
Weill Cornell Medical College

Education & Training

Clinical Fellowship, Baylor College of Medicine
Residency, Baylor College of Medicine
MD, Brown University Program in Medicine

Short-Term Global Cardiovascular Disease Risk Prediction in Older Adults
Saeed, A, Nambi, V, Sun, W, Virani, SS, Taffet, GE, Deswal, A, Selvin, E, Matsushita, K, Wagenknecht, LE, Hoogeveen, R, Coresh, J, de Lemos, JA & Ballantyne, CM 2018, Journal of the American College of Cardiology, vol 71, no. 22, pp. 2527-2536. DOI: 10.1016/j.jacc.2018.02.050

Steroid Receptor Coactivator-2 (SRC-2) coordinates cardiomyocyte paracrine signaling to promote pressure overload-induced angiogenesis.
Suh, JH, Lai, L, Nam, D, Kim, J, Jo, J, Taffet, G, Kim, E, Kaelber, J, Lee, H, Entman, ML, Cooke, JP & Reineke, EL 2017, Journal of Biological Chemistry.

Dissecting the role of myeloid and mesenchymal fibroblasts in age-dependent cardiac fibrosis
Trial, JA, Heredia, CP, Taffet, GE, Entman, ML & Cieslik, KA 2017, Basic Research in Cardiology, vol 112, no. 4, 34. DOI: 10.1007/s00395-017-0623-4

Cardiac Resynchronization Therapy in Older Adults with Heart Failure
Lam, PH, Taffet, GE, Ahmed, A & Singh, S 2017, Heart Failure Clinics, vol 13, no. 3, pp. 581-587. DOI: 10.1016/j.hfc.2017.02.011

Murine echocardiography of left atrium, aorta, and pulmonary artery
Granillo, A, Pena, CA, Pham, T, Pandit, LM & Taffet, GE 2017, Journal of Visualized Experiments, vol 2017, no. 120, e55214. DOI: 10.3791/55214

Steroid receptor coactivator-2 (SRC-2) coordinates cardiomyocyte paracrine signaling to promote pressure overload-induced angiogenesis
Suh, JH, Lai, L, Nam, D, Kim, J, Jo, J, Taffet, GE, Kim, E, Kaelber, JT, Lee, HK, Entman, ML, Cooke, JP & Reineke, EL 2017, Journal of Biological Chemistry, vol 292, no. 52, pp. 21643-21652. DOI: 10.1074/jbc.M117.804740

Unrecognized Cognitive Impairment and Its Effect on Heart Failure Readmissions of Elderly Adults
Agarwal, KS, Kazim, R, Xu, J, Borson, S & Taffet, GE 2016, Journal of the American Geriatrics Society, vol 64, no. 11, pp. 2296-2301. DOI: 10.1111/jgs.14471

Left atrial volume and pulmonary artery diameter are noninvasive measures of age-related diastolic dysfunction in mice
Medrano, G, Hermosillo-Rodriguez, J, Pham, T, Granillo, A, Hartley, CJ, Reddy, A, Osuna, PM, Entman, ML & Taffet, GE 2016, Journals of Gerontology - Series A Biological Sciences and Medical Sciences, vol 71, no. 9, pp. 1141-1150. DOI: 10.1093/gerona/glv143

TNF/Ang-II synergy is obligate for fibroinflammatory pathology, but not for changes in cardiorenal function
Mayr, M, Duerrschmid, C, Medrano, G, Taffet, GE, Wang, Y, Entman, ML & Haudek, SB 2016, Physiological Reports, vol 4, no. 8, e12765. DOI: 10.14814/phy2.12765

Measures of healthspan as indices of aging in Mice-A recommendation
Richardson, A, Fischer, KE, Speakman, JR, De Cabo, R, Mitchell, SJ, Peterson, CA, Rabinovitch, P, Chiao, YA, Taffet, G, Miller, RA, Rentería, RC, Bower, J, Ingram, DK, Ladiges, WC, Ikeno, Y, Sierra, F & Austad, SN 2016, Journals of Gerontology - Series A Biological Sciences and Medical Sciences, vol 71, no. 4, pp. 427-430. DOI: 10.1093/gerona/glv080

Plasma Levels of Endothelial Microparticles Bearing Monomeric C-reactive Protein are Increased in Peripheral Artery Disease
Crawford, JR, Trial, J, Nambi, V, Hoogeveen, RC, Taffet, GE & Entman, ML 2016, Journal of Cardiovascular Translational Research, pp. 1-10. DOI: 10.1007/s12265-016-9678-0

PHD2/3-dependent hydroxylation tunes cardiac response to ß-adrenergic stress via phospholamban
Xie, L, Pi, X, Townley-Tilson, WHD, Li, N, Wehrens, XHT, Entman, ML, Taffet, GE, Mishra, A, Peng, J, Schisler, JC, Meissner, G & Patterson, C 2015, Journal of Clinical Investigation, vol 125, no. 7, pp. 2759-2771. DOI: 10.1172/JCI80369

Heart failure with preserved ejection fraction in the elderly: Scope of the problem
Upadhya, B, Taffet, GE, Cheng, CP & Kitzman, DW 2015, Journal of Molecular and Cellular Cardiology, vol 83, pp. 73-87. DOI: 10.1016/j.yjmcc.2015.02.025

Cardiovascular physiology in the older adults
Dai, X, Hummel, SL, Salazar, JB, Taffet, GE, Zieman, S & Schwartz, JB 2015, Journal of Geriatric Cardiology, vol 12, no. 3, pp. 196-201. DOI: 10.11909/j.issn.1671-5411.2015.03.015

Substance P receptor antagonism: A potential novel treatment option for viral-myocarditis
Robinson, P, Taffet, GE, Engineer, N, Khumbatta, M, Firozgary, B, Reynolds, C, Pham, T, Bulsara, T & Firozgary, G 2015, BioMed Research International, vol 2015, 645153. DOI: 10.1155/2015/645153

High-Sensitivity troponin t and cardiovascular events in systolic blood pressure categories atherosclerosis risk in communities study
Pokharel, Y, Sun, W, De Lemos, JA, Taffet, GE, Virani, SS, Ndumele, CE, Mosley, TH, Hoogeveen, RC, Coresh, J, Wright, JD, Heiss, G, Boerwinkle, EA, Bozkurt, B, Solomon, SD, Ballantyne, CM & Nambi, V 2015, Hypertension, vol 65, no. 1, pp. 78-84. DOI: 10.1161/HYPERTENSIONAHA.114.04206

Hypernatremia in the geriatric population
Shah, MK, Workeneh, B & Taffet, GE 2014, Clinical Interventions in Aging, vol 9, pp. 1987-1992. DOI: 10.2147/CIA.S65214

Vascular and parenchymal amyloid pathology in an Alzheimer disease knock-in mouse model: Interplay with cerebral blood flow
Li, H, Guo, Q, Inoue, T, Polito, VA, Tabuchi, K, Hammer, RE, Pautler, RG, Taffet, GE & Zheng, H 2014, Molecular Neurodegeneration, vol 9, no. 1, 28. DOI: 10.1186/1750-1326-9-28

Young Little mice express a premature cardiovascular aging phenotype
Reddy, AK, Hartley, CJ, Pham, TT, Darlington, G, Entman, ML & Taffet, GE 2014, Journals of Gerontology - Series A Biological Sciences and Medical Sciences, vol 69 A, no. 2, pp. 152-159. DOI: 10.1093/gerona/glt055

Adverse fibrosis in the aging heart depends on signaling between myeloid and mesenchymal cells; role of inflammatory fibroblasts
Cieslik, KA, Trial, J, Crawford, JR, Taffet, GE & Entman, ML 2014, Journal of Molecular and Cellular Cardiology, vol 70, pp. 56-63. DOI: 10.1016/j.yjmcc.2013.10.017