Gavin W. Britz, MBBCh, MPH, MBA, FAANS

Candy and Tom Knudson Distinguished Centennial Chair in Neurosurgery, Department of Neurosurgery
Professor of Neurosurgery, Academic Institute
Full Member, Research Institute
Co-director, Center for Translational Neural Prosthetics and Interfaces
Co-director, Center for Neuroregeneration
Director, Neurological Institute
Houston Methodist
Weill Cornell Medical College

Britz Lab - Cerebrovascular Research



Dr. Gavin Britz is the Chairman of Department of Neurosurgery, the Candy and Tom Knudson Distinguished Centennial Chair in Neurosurgery, Director of the Houston Methodist Neurological Institute and Professor of Neurosurgery at Weill Cornell Medical College. Dr. Britz earned his MBBCh at the University of the Witwatersrand School of Medicine, South Africa in 1987.  He completed a surgical internship in general surgery and fellowship in general surgery at Johns Hopkins Hospital, Baltimore in 1993 and in 2002 he completed his residency in neurosurgery at the University of Washington in Seattle.  During his residency he attended St. George’s Medical School, The University of London, UK and served as a Neurosurgical Registrar and Senior Registrar.  After residency, he took a cerebrovascular fellowship in 2002 and an Interventional Neuroradiology Fellowship in 2003 at the University of Washington Medical School, Seattle.  In 2003 he earned his MPH at the University of Washington, Seattle. He also obtained an MBA from George Washington University in 2015. He held faculty appointments at the University of Washington and Duke University before becoming a member of Houston Methodist Research Institute in 2014.

Description of Research

My basic science research focuses on understanding the cerebral microcirculation. This is largely in relation to the alteration of the microcirculation following an aneurysmal subarachnoid hemorrhage. Subarachnoid hemorrhage resulting from rupture of a brain aneurysm often demonstrates significant morbidity and mortality in spite of aneurysm obliteration to prevent re-hemorrhage. In humans, delayed vascular constriction can occur 5-7 days after SAH: proximal blood vessels lose reactivity and demonstrate narrowing unresponsive to smooth muscle relaxants, often leading to delayed cerebral ischemia. However, ischemic deficits can also arise from regions with minimal vasoconstriction on angiography or transcranial Doppler studies, and drugs preventing large vessel vasoconstriction may fail to improve clinical outcome. Microvascular dysfunction and acute brain injury from SAH are also important in the evolution of ischemia. Animal models of SAH can replicate features of human SAH, particularly partial vessel rupture and release of arterial blood, ischemic and cognitive changes but demonstrate a shorter time course of vasoconstriction (maximum at 2-3 days). Hippocampus has a less robust blood supply than neocortex, with resulting lower oxygen values in vivo, in addition to a predisposition to ischemia and cell loss. My laboratory has clearly demonstrated that both the pial and penetrating arterioles are affected and therefore may account for some of the morbidity despite successful treatment of the aneurysm.

My clinical research includes evaluating new and novel tools to treat a wide variety of problems such as brain aneurysms and skull base tumors.

Areas Of Expertise

Brain Tumors Aneurysms Acoustic Neuroma AVM arteriovenous malformation Moyamoya Meningioma Carotid Endarterectomy Neuro-Vascular Surgery Pituitary Surgery Skull Based Surgery Trigeminal Neuralgia
Education & Training

MBA, George Washington University
Clinical Fellowship, Johns Hopkins University and Hospital
Clinical Fellowship, University of Washington
MPH, University of Washington
Residency, University of Washington
Internship, University of the Witwatersrand
MBBCh, University of the Witwatersrand

The Minimally Invasive Lateral Occipital Infracortical Supra-/Transtentorial Approach in Surgery of Lesions of the Pineal Region: A Possible Alternative to the Standard Approaches
Feigl, GC, Britz, G, Staribacher, D & Kuzmin, D 2023, , World neurosurgery.

Fractured Lumbar Drain Catheter Retrieval Using an Endoscopic Transforaminal Approach to the Lumbar Spine
Sulhan, S, Sadrameli, SS, Barber, S, Holman, P, Britz, G & Huang, M 2022, , Operative neurosurgery (Hagerstown, Md.), vol. 23, no. 5, pp. e331-e334.

Systems and methods for improving cerebrospinal fluid (csf) drainage
Golanov, EV, Britz, GW, Regnier-Golanov, A, Karmonik, C & Eskuri, A Oct. 27 2022, , Patent No. WO2022226155A1.

SARS-CoV-2 and the central nervous system: Emerging insights into hemorrhage-associated neurological consequences and therapeutic considerations
Mitra, J, Kodavati, M, Provasek, VE, Rao, KS, Mitra, S, Hamilton, DJ, Horner, PJ, Vahidy, FS, Britz, GW, Kent, TA & Hegde, ML 2022, , Ageing Research Reviews, vol. 80, 101687.

The First Pilot Study of an Interactive, 360° Augmented Reality Visualization Platform for Neurosurgical Patient Education: A Case Series
Lee, JJ, Klepcha, M, Wong, M, Dang, PN, Sadrameli, SS & Britz, GW 2022, , Operative neurosurgery (Hagerstown, Md.), vol. 23, no. 1, pp. 53-59.

Subarachnoid hemorrhage induces subacute and early chronic impairment in learning and memory in mice
Golanov, EV, Britz, GW & Regnier-Golanov, A 2022, , Brain 22, Glasgow, United Kingdom, 5/28/22 - 6/1/22 pp. 1-71.

Commentary: Cost-Effectiveness Analysis of Encephaloduroarteriosynangiosis Surgery for Symptomatic Intracranial Atherosclerotic Disease
Britz, GW & Lee, JJ 2022, , Neurosurgery, vol. 90, no. 5, pp. e121-e122.

Alterations to the gut microbiome after sport-related concussion in a collegiate football players cohort: A pilot study
Soriano, S, Curry, K, Sadrameli, SS, Wang, Q, Nute, M, Reeves, E, Kabir, R, Wiese, J, Criswell, A, Schodrof, S, Britz, GW, Gadhia, R, Podell, K, Treangen, T & Villapol, S 2022, , Brain, behavior, & immunity - health, vol. 21, 100438.,

Alterations to the gut microbiome after sport-related concussion in a collegiate football players cohort: A pilot study
Soriano, S, Curry, K, Sadrameli, SS, Wang, Q, Nute, M, Reeves, E, Kabir, R, Wiese, J, Criswell, A, Schodrof, S, Britz, GW, Gadhia, R, Podell, K, Treangen, T & Villapol, S 2022, , Brain, behavior, & immunity - health, vol. 21, pp. 100438.

Ablation of BATF Alleviates Transplant Rejection via Abrogating the Effector Differentiation and Memory Responses of CD8+ T Cells
Li, S, Zou, D, Chen, W, Cheng, Y, Britz, GW, Weng, YL & Liu, Z 2022, , Frontiers in immunology, vol. 13, 882721.

Educational impact of early COVID-19 operating room restrictions on neurosurgery resident training in the United States: A multicenter study: Neurosurgery Education in the COVID-19 Pandemic
Zhang, JK, del Valle, A, Ivankovic, S, Patel, N, Alexopoulos, G, Khan, M, Durrani, S, Patel, M, Tecle, NE, Sujijantarat, N, Jenson, AV, Zammar, SG, Huntoon, K, Goulart, CR, Wilkinson, BM, Bhimireddy, S, Britz, GW, DiLuna, M, Prevedello, DM, Dinh, DH & Mattei, TA 2022, , North American Spine Society Journal, vol. 9, 100104.

Transcarotid access for remote robotic endovascular neurointerventions: a cadaveric proof-of-concept study
Berczeli, M, Chinnadurai, P, Legeza, PT, Britz, GW & Lumsden, AB 2022, , Neurosurgical focus, vol. 52, no. 1, E18.

Miliary pattern in secondary central nervous system T-cell lymphoma
Rajendran, S, Lee, JJ, Le, HB & Britz, G 2022, , Surgical Neurology International, vol. 13, no. 25, 25.

Subarachnoid Hemorrhage Induces Sub-acute and Early Chronic Impairment in Learning and Memory in Mice
Regnier-Golanov, AS, Gulinello, M, Hernandez, MS, Golanov, EV & Britz, GW 2022, , Translational Stroke Research, vol. 13, no. 4, pp. 625-640.

Telerobotic Endovascular Interventions and Their Potential for Cerebrovascular Treatment
Berczeli, M, Britz, GW, Loh, T & Lumsden, AB 2022, , Texas Heart Institute Journal, vol. 49, no. 2, e217608.

METTL3 inhibition reduces N6-methyladenosine levels and prevents allogeneic CD4+ T-cell responses
Li, S, Zou, D, Chen, W, Britz, GW, Liu, Z & Weng, YL 2022, , Immunology and Cell Biology, vol. 100, no. 9, pp. 718-730.

Evaluation of Robotic-Assisted Carotid Artery Stenting in a Virtual Model Using Motion-Based Performance Metrics
Legeza, PT, Lettenberger, AB, Murali, B, Johnson, LR, Berczeli, M, Byrne, MD, Britz, G, O’Malley, MK & Lumsden, AB 2022, , Journal of Endovascular Therapy.

DNA Damage and Repair Deficiency in ALS/FTD-Associated Neurodegeneration: From Molecular Mechanisms to Therapeutic Implication
Wang, H, Kodavati, M, Britz, GW & Hegde, ML 2021, , Frontiers in Molecular Neuroscience, vol. 14, 784361.

A contemporary review of therapeutic and regenerative management of intracerebral hemorrhage
Sadaf, H, Desai, VR, Misra, V, Golanov, E, Hegde, ML, Villapol, S, Karmonik, C, Regnier-Golanov, A, Sayenko, D, Horner, PJ, Krencik, R, Weng, YL, Vahidy, FS & Britz, GW 2021, , Annals of Clinical and Translational Neurology.

Early Experience with Virtual and Synchronized Augmented Reality Platform for Preoperative Planning and Intraoperative Navigation: A Case Series
Louis, RG, Steinberg, GK, Duma, C, Britz, G, Mehta, V, Pace, J, Selman, W & Jean, WC 2021, , Operative Neurosurgery, vol. 21, no. 4, pp. 189-196.