Gavin W. Britz, MBBCh, MPH, MBA, FAANS

Candy and Tom Knudson Distinguished Centennial Chair in Neurosurgery, Department of Neurosurgery
Professor of Neurosurgery, Academic Institute
Full Member, Research Institute
Co-director, Center for Neuroregeneration
Director, Neurological Institute
Houston Methodist
Weill Cornell Medical College


Britz Lab - Cerebrovascular Research


Phone:
713.441.3800


Biography

Dr. Gavin Britz is the Chairman of Department of Neurosurgery, the Candy and Tom Knudson Distinguished Centennial Chair in Neurosurgery, Director of the Houston Methodist Neurological Institute and Professor of Neurosurgery at Weill Cornell Medical College. Dr. Britz earned his MBBCh at the University of the Witwatersrand School of Medicine, South Africa in 1987.  He completed a surgical internship in general surgery and fellowship in general surgery at Johns Hopkins Hospital, Baltimore in 1993 and in 2002 he completed his residency in neurosurgery at the University of Washington in Seattle.  During his residency he attended St. George’s Medical School, The University of London, UK and served as a Neurosurgical Registrar and Senior Registrar.  After residency, he took a cerebrovascular fellowship in 2002 and an Interventional Neuroradiology Fellowship in 2003 at the University of Washington Medical School, Seattle.  In 2003 he earned his MPH at the University of Washington, Seattle. He also obtained an MBA from George Washington University in 2015. He held faculty appointments at the University of Washington and Duke University before becoming a member of Houston Methodist Research Institute in 2014.

Description of Research

My basic science research focuses on understanding the cerebral microcirculation. This is largely in relation to the alteration of the microcirculation following an aneurysmal subarachnoid hemorrhage. Subarachnoid hemorrhage resulting from rupture of a brain aneurysm often demonstrates significant morbidity and mortality in spite of aneurysm obliteration to prevent re-hemorrhage. In humans, delayed vascular constriction can occur 5-7 days after SAH: proximal blood vessels lose reactivity and demonstrate narrowing unresponsive to smooth muscle relaxants, often leading to delayed cerebral ischemia. However, ischemic deficits can also arise from regions with minimal vasoconstriction on angiography or transcranial Doppler studies, and drugs preventing large vessel vasoconstriction may fail to improve clinical outcome. Microvascular dysfunction and acute brain injury from SAH are also important in the evolution of ischemia. Animal models of SAH can replicate features of human SAH, particularly partial vessel rupture and release of arterial blood, ischemic and cognitive changes but demonstrate a shorter time course of vasoconstriction (maximum at 2-3 days). Hippocampus has a less robust blood supply than neocortex, with resulting lower oxygen values in vivo, in addition to a predisposition to ischemia and cell loss. My laboratory has clearly demonstrated that both the pial and penetrating arterioles are affected and therefore may account for some of the morbidity despite successful treatment of the aneurysm.

My clinical research includes evaluating new and novel tools to treat a wide variety of problems such as brain aneurysms and skull base tumors.

Areas Of Expertise

Brain Tumors Aneurysms Acoustic Neuroma AVM arteriovenous malformation Moyamoya Meningioma Carotid Endarterectomy Neuro-Vascular Surgery Pituitary Surgery Skull Based Surgery Trigeminal Neuralgia
Education & Training

MBA, George Washington University
Clinical Fellowship, Johns Hopkins University and Hospital
Clinical Fellowship, University of Washington
MPH, University of Washington
Residency, University of Washington
Internship, University of the Witwatersrand
MBBCh, University of the Witwatersrand
Publications

Initial experience in a pig model of robotic-assisted intracranial arteriovenous malformation embolization
Desai, VR, Lee, JJ, Tomas, J, Lumsden, AB & Britz, GW 2020, , Operative Neurosurgery, vol. 19, no. 2, pp. 205-209. https://doi.org/10.1093/ons/opz373

Promises and Perils of Artificial Intelligence in Neurosurgery
Panesar, SS, Kliot, M, Parrish, R, Fernandez-Miranda, J, Cagle, Y & Britz, GW 2020, , Neurosurgery, vol. 87, no. 1, pp. 33-44. https://doi.org/10.1093/neuros/nyz471

The July Effect and its Impact on External Ventricular Drain Placement by Neurosurgical Trainees - Analysis of the National Inpatient Sample
Austerman, R, Rajendran, S, Lee, J & Britz, G 2020, , World neurosurgery. https://doi.org/10.1016/j.wneu.2020.06.057

Pivotal Trial of the Neuroform Atlas Stent for Treatment of Anterior Circulation Aneurysms: One-Year Outcomes
ATLAS Investigators 2020, Stroke, vol. 51, no. 7, pp. 2087-2094. https://doi.org/10.1161/STROKEAHA.119.028418

The History of Neurosurgery at Houston Methodist Hospital
Grossman, RG, Lee, J, Baskin, DS, Harper, R & Britz, GW 2020, , World neurosurgery, vol. 142, pp. 283-290. https://doi.org/10.1016/j.wneu.2020.06.194

Intraspinal mesenchymal chondrosarcoma: An argument for aggressive local resection and adjuvant therapy based on review of the literature
Gopakumar, S, Steele, WJ, Muir, M, Bhogani, Z & Britz, GW 2020, Surgical Neurology International, vol. 11, no. 95, 95. https://doi.org/10.25259/SNI_130_2020

Feasibility of Robotic-Assisted Neurovascular Interventions: Initial Experience in Flow Model and Porcine Model
Britz, GW, Tomas, J & Lumsden, A 2020, , Clinical Neurosurgery, vol. 86, no. 2, pp. 309-314. https://doi.org/10.1093/neuros/nyz064

Current utilization and future directions of robotic-assisted endovascular surgery
Legeza, P, Britz, GW, Loh, T & Lumsden, A 2020, , Expert Review of Medical Devices. https://doi.org/10.1080/17434440.2020.1814742

In Reply: Clinical Outcomes of Stereotactic Radiosurgery for Cerebral Arteriovenous Malformations in Pediatric Patients: Systematic Review and Meta-Analysis
Desai, VR, Lee, JJ & Britz, GW 2019, Clinical Neurosurgery, vol. 85, no. 6, pp. E1131-E1132. https://doi.org/10.1093/neuros/nyz375

Telerobotic stroke intervention: A novel solution to the care dissemination dilemma
Panesar, SS, Volpi, JJ, Lumsden, AB, Desai, V, Kleiman, N, Sample, TL, Elkins, E & Britz, GW 2020, , Journal of Neurosurgery, vol. 132, no. 3, pp. 971-978. https://doi.org/10.3171/2019.8.JNS191739

Operative treatment of a superior cerebellar artery perforator dissecting aneurysm
Lee, JJ, Huang, M, Guerrero, J, Desai, VR, Jenson, A, Austerman, R, Diaz, OM & Britz, GW 2020, , Operative Neurosurgery, vol. 19, no. 2, pp. E203-E208. https://doi.org/10.1093/ons/opz407

Commentary: Microsurgical Clipping of Anterior Choroidal Artery Aneurysms: A Systematic Approach to Reducing Ischemic Complications in an Experience with 146 Patients
Britz, GW & Desai, VR 2019, Operative Neurosurgery, vol. 17, no. 4, pp. E143-E144. https://doi.org/10.1093/ons/opz079

Contemporary Management of Increased Intraoperative Intracranial Pressure: Evidence-Based Anesthetic and Surgical Review
Desai, VR, Sadrameli, SS, Hoppe, S, Lee, JJ, Jenson, A, Steele, WJ, Nguyen, H, McDonagh, DL & Britz, GW 2019, World neurosurgery, vol. 129, pp. 120-129. https://doi.org/10.1016/j.wneu.2019.05.224

Endovascular Robotics: The Future of Cerebrovascular Surgery
Panesar, SS & Britz, GW 2019, World neurosurgery, vol. 129, pp. 327-329. https://doi.org/10.1016/j.wneu.2019.06.126

Maxillary Artery to Intracranial Bypass
Zaki Ghali, MG, Srinivasan, VM & Britz, GW 2019, World neurosurgery, vol. 128, pp. 532-540. https://doi.org/10.1016/j.wneu.2019.03.015

Intracranial Venous Hypertension in Craniosynostosis: Mechanistic Underpinnings and Therapeutic Implications
Ghali, GZ, Zaki Ghali, MG, Ghali, EZ, Srinivasan, VM, Wagner, KM, Rothermel, A, Taylor, J, Johnson, J, Kan, P, Lam, S & Britz, GW 2019, , World neurosurgery, vol. 127, pp. 549-558. https://doi.org/10.1016/j.wneu.2018.07.260

Commentary: The Experience with Flow Diverters in the Treatment of Posterior Inferior Cerebellar Artery Aneurysms
Britz, GW & Desai, VR 2019, Operative Neurosurgery, vol. 17, no. 1, opy367, pp. E3-E4. https://doi.org/10.1093/ons/opy367

Intraarterial Thrombolysis as Rescue Therapy for Large Vessel Occlusions: Analysis From the North American Solitaire Stent-Retriever Acute Stroke Registry
Zaidi, SF, Castonguay, AC, Jumaa, MA, Malisch, TW, Linfante, I, Marden, FA, Abraham, MG, Chebl, AB, Novakovic, R, Taqi, MA, Nogueira, RG, Martin, CO, Holloway, WE, Mueller-Kronast, N, English, JD, Dabus, G, Bozorgchami, H, Xavier, A, Rai, AT, Froehler, MT, Badruddin, A, Nguyen, TN, Yoo, AJ, Shaltoni, H, Janardhan, V, Chen, PR, Britz, GW, Kaushal, R, Nanda, A, Gupta, R & Zaidat, OO 2019, , Stroke, vol. 50, no. 4, pp. 1003-1006. https://doi.org/10.1161/STROKEAHA.118.024442

Comments
Britz, GW 2019, Clinical neurosurgery, vol. 84, no. 1, pp. 82-83. https://doi.org/10.1093/neuros/nyy002

Curative Embolization of Arteriovenous Malformations
Zaki Ghali, MG, Kan, P & Britz, GW 2019, World neurosurgery. https://doi.org/10.1016/j.wneu.2019.01.166