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Fransisca Leonard, PhD

Instructor in Nanomedicine, Academic Institute
Instructor, Research Institute
Houston Methodist
Education & Training

ME, Technical University of Berlin
PhD, Universität des Saarlandes

Pre-existing H4K16ac levels in euchromatin drive DNA repair by homologous recombination in S-phase
Horikoshi, N, Sharma, D, Leonard, F, Pandita, RK, Charaka, VK, Hambarde, S, Horikoshi, NT, Gaur Khaitan, P, Chakraborty, S, Cote, J, Godin, B, Hunt, CR & Pandita, TK 2019, Communications Biology, vol. 2, no. 1, 253.

Thioaptamer targeted discoidal microparticles increase self immunity and reduce Mycobacterium tuberculosis burden in mice
Leonard, F, Ha, NP, Sule, P, Alexander, JF, Volk, DE, Lokesh, GLR, Liu, X, Cirillo, JD, Gorenstein, DG, Yuan, J, Chatterjee, S, Graviss, EA & Godin, B 2017, Journal of Controlled Release, vol. 266, pp. 238-247.

Gemcitabine enhances the transport of nanovector-albumin-bound paclitaxel in gemcitabine-resistant pancreatic ductal adenocarcinoma
Borsoi, C, Leonard, F, Lee, Y, Zaid, M, Elganainy, D, Alexander, JF, Kai, M, Liu, YT, Kang, Y, Liu, X, Koay, EJ, Ferrari, M, Godin, B & Yokoi, K 2017, Cancer Letters, vol. 403, pp. 296-304.

Unraveling bio-social hierarchy in cancer collective invasion: Symbiosis between leaders and followers
Leonard, F & Godin, B 2017, Translational Cancer Research, vol. 6, pp. S1084-S1087.

Macrophage polarization contributes to the anti-tumoral efficacy of mesoporous nanovectors loaded with albumin-bound paclitaxel
Leonard, F, Curtis, LT, Ware, MJ, Nosrat, T, Liu, X, Yokoi, K, Frieboes, HB & Godin, B 2017, Frontiers in Immunology, vol. 8, no. JUN, 693.

Magnetically bioprinted human myometrial 3D cell rings as a model for uterine contractility
Souza, GR, Tseng, H, Gage, JA, Mani, A, Desai, P, Leonard, F, Liao, A, Longo, M, Refuerzo, JS & Godin, B 2017, International Journal of Molecular Sciences, vol. 18, no. 4, 683.

Uterus-targeted liposomes for preterm labor management: Studies in pregnant mice
Refuerzo, JS, Leonard, F, Bulayeva, N, Gorenstein, D, Chiossi, G, Ontiveros, A, Longo, M & Godin, B 2016, Scientific Reports, vol. 6, 34710.

Enhanced performance of macrophage-encapsulated nanoparticle albumin-bound-paclitaxel in hypo-perfused cancer lesions
Leonard, F, Curtis, LT, Yesantharao, P, Tanei, T, Alexander, JF, Wu, M, Lowengrub, J, Liu, X, Ferrari, M, Yokoi, K, Frieboes, HB & Godin, B 2016, Nanoscale, vol. 8, no. 25, pp. 12544-12552.

Chapter 4: Nanocarrier-Based Anticancer Therapies with the Focus on Strategies for Targeting the Tumor Microenvironment
Leonard, F 2016, . in Intracellular Delivery III:Market Entry Barriers of Nanomedicines. Springer, pp. 67-122.

3D In Vitro Model for Breast Cancer Research Using Magnetic Levitation and Bioprinting Method
Leonard, F & Godin, B 2016, . in J Cao (ed.), Breast Cancer: Methods and Protocols. vol. 1406, Methods in Molecular Biology, vol. 1406, Springer, pp. 239-251.

Systemic Gene Silencing in Primary T Lymphocytes Using Targeted Lipid Nanoparticles
Ramishetti, S, Kedmi, R, Goldsmith, M, Leonard, F, Sprague, AG, Godin, B, Gozin, M, Cullis, PR, Dykxhoorn, DM & Peer, D 2015, ACS Nano, vol. 9, no. 7, pp. 6706-6716.

Liposomes: A nanoscale drug carrying system to prevent indomethacin passage to the fetus in a pregnant mouse model
Refuerzo, JS, Alexander, JF, Leonard, F, Leon, M, Longo, M & Godin, B 2015, American journal of obstetrics and gynecology, vol. 212, no. 4.

In vivo imaging assessment of porous silicon
Srinivasan, S, Leonard, F, Kuncewicz, TM & Godin, B 2014, . in Porous Silicon for Biomedical Applications. Elsevier, pp. 223-252.

Three-dimensional in vitro co-culture model of breast tumor using magnetic levitation
Jaganathan, H, Gage, J, Leonard, F, Srinivasan, S, Souza, GR, Dave, B & Godin, B 2014, Scientific Reports, vol. 4, 6468.

Three-dimensional in vitro co-culture model of breast tumor using magnetic levitation
Jaganathan, H, Gage, J, Leonard, F, Srinivasan, S, Souza, GR, Dave, B & Godin, B 2014, Scientific Reports, vol. 4, 6468.

Bacteriophage associated silicon particles: Design and characterization of a novel theranostic vector with improved payload carrying potential
Srinivasan, S, Alexander, JF, Driessen, WH, Leonard, F, Ye, H, Liu, X, Arap, W, Pasqualini, R, Ferrari, M & Godin, B 2013, Journal of Materials Chemistry B, vol. 1, no. 39, pp. 5218-5229.

Biological microniches characterizing pathological lesions. Impact on nanoparticle-based delivery of therapeutics.
Meraz, IM, Segura-Ibarra, V, Leonard, F, Gonzalez, J, Ally, S, Godin, B & Serda, R 2013, Frontiers of Nanoscience, vol. 5, pp. 139-173.

Screening of budesonide nanoformulations for treatment of inflammatory bowel disease in an inflamed 3D cell-culture model
Leonard, F, Ali, H, Collnot, EM, Crielaard, BJ, Lammers, T, Storm, G & Lehr, CM 2012, Altex, vol. 29, no. 3, pp. 275-285.

A three-dimensional coculture of enterocytes, monocytes and dendritic cells to model inflamed intestinal mucosa in vitro
Leonard, F, Collnot, EM & Lehr, CM 2010, Molecular Pharmaceutics, vol. 7, no. 6, pp. 2103-2119.

Immobilized cytokines as biomaterials for manufacturing immune cell based vaccines
Leclerc, C, Brose, C, Nouzé, C, Leonard, F, Majlessi, L, Becker, S, Von Briesen, H & Lo-Man, R 2008, Journal of Biomedical Materials Research - Part A, vol. 86, no. 4, pp. 1033-1040.

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