Fransisca Leonard, PhD

Instructor in Nanomedicine, Institute for Academic Medicine
Instructor, Research Institute
Houston Methodist

fleonard@houstonmethodist.org

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NETWORK

Education & Training

ME, Technical University of Berlin

PhD, Universität des Saarlandes

Publications

Pre-existing H4K16ac levels in euchromatin drive DNA repair by homologous recombination in S-phase

Horikoshi, N, Sharma, D, Leonard, F, Pandita, RK, Charaka, VK, Hambarde, S, Horikoshi, NT, Gaur Khaitan, P, Chakraborty, S, Cote, J, Godin, B, Hunt, CR & Pandita, TK 2019, Communications Biology, vol. 2, no. 1, 253. https://doi.org/10.1038/s42003-019-0498-z

Thioaptamer targeted discoidal microparticles increase self immunity and reduce Mycobacterium tuberculosis burden in mice

Leonard, F, Ha, NP, Sule, P, Alexander, JF, Volk, DE, Lokesh, GLR, Liu, X, Cirillo, JD, Gorenstein, DG, Yuan, J, Chatterjee, S, Graviss, EA & Godin, B 2017, Journal of Controlled Release, vol. 266, pp. 238-247. https://doi.org/10.1016/j.jconrel.2017.09.038

Gemcitabine enhances the transport of nanovector-albumin-bound paclitaxel in gemcitabine-resistant pancreatic ductal adenocarcinoma

Borsoi, C, Leonard, F, Lee, Y, Zaid, M, Elganainy, D, Alexander, JF, Kai, M, Liu, YT, Kang, Y, Liu, X, Koay, EJ, Ferrari, M, Godin, B & Yokoi, K 2017, Cancer Letters, vol. 403, pp. 296-304. https://doi.org/10.1016/j.canlet.2017.06.026

Unraveling bio-social hierarchy in cancer collective invasion: Symbiosis between leaders and followers

Leonard, F & Godin, B 2017, Translational Cancer Research, vol. 6, pp. S1084-S1087. https://doi.org/10.21037/tcr.2017.08.09

Macrophage polarization contributes to the anti-tumoral efficacy of mesoporous nanovectors loaded with albumin-bound paclitaxel

Leonard, F, Curtis, LT, Ware, MJ, Nosrat, T, Liu, X, Yokoi, K, Frieboes, HB & Godin, B 2017, Frontiers in Immunology, vol. 8, no. JUN, 693. https://doi.org/10.3389/fimmu.2017.00693

Magnetically bioprinted human myometrial 3D cell rings as a model for uterine contractility

Souza, GR, Tseng, H, Gage, JA, Mani, A, Desai, P, Leonard, F, Liao, A, Longo, M, Refuerzo, JS & Godin, B 2017, International Journal of Molecular Sciences, vol. 18, no. 4, 683. https://doi.org/10.3390/ijms18040683

Uterus-targeted liposomes for preterm labor management: Studies in pregnant mice

Refuerzo, JS, Leonard, F, Bulayeva, N, Gorenstein, D, Chiossi, G, Ontiveros, A, Longo, M & Godin, B 2016, Scientific Reports, vol. 6, 34710. https://doi.org/10.1038/srep34710

Enhanced performance of macrophage-encapsulated nanoparticle albumin-bound-paclitaxel in hypo-perfused cancer lesions

Leonard, F, Curtis, LT, Yesantharao, P, Tanei, T, Alexander, JF, Wu, M, Lowengrub, J, Liu, X, Ferrari, M, Yokoi, K, Frieboes, HB & Godin, B 2016, Nanoscale, vol. 8, no. 25, pp. 12544-12552. https://doi.org/10.1039/c5nr07796f

Chapter 4: Nanocarrier-Based Anticancer Therapies with the Focus on Strategies for Targeting the Tumor Microenvironment

Leonard, F 2016, . in Intracellular Delivery III:Market Entry Barriers of Nanomedicines. Springer, pp. 67-122.

3D In Vitro Model for Breast Cancer Research Using Magnetic Levitation and Bioprinting Method

Leonard, F & Godin, B 2016, . in J Cao (ed.), Breast Cancer: Methods and Protocols. vol. 1406, Methods in Molecular Biology, vol. 1406, Springer, pp. 239-251. https://doi.org/10.1007/978-1-4939-3444-7_21

Systemic Gene Silencing in Primary T Lymphocytes Using Targeted Lipid Nanoparticles

Ramishetti, S, Kedmi, R, Goldsmith, M, Leonard, F, Sprague, AG, Godin, B, Gozin, M, Cullis, PR, Dykxhoorn, DM & Peer, D 2015, ACS Nano, vol. 9, no. 7, pp. 6706-6716. https://doi.org/10.1021/acsnano.5b02796

Liposomes: A nanoscale drug carrying system to prevent indomethacin passage to the fetus in a pregnant mouse model

Refuerzo, JS, Alexander, JF, Leonard, F, Leon, M, Longo, M & Godin, B 2015, American journal of obstetrics and gynecology, vol. 212, no. 4. https://doi.org/10.1016/j.ajog.2015.02.006

In vivo imaging assessment of porous silicon

Srinivasan, S, Leonard, F, Kuncewicz, TM & Godin, B 2014, . in Porous Silicon for Biomedical Applications. Elsevier, pp. 223-252. https://doi.org/10.1533/9780857097156.2.223

Three-dimensional in vitro co-culture model of breast tumor using magnetic levitation

Jaganathan, H, Gage, J, Leonard, F, Srinivasan, S, Souza, GR, Dave, B & Godin, B 2014, Scientific Reports, vol. 4, 6468. https://doi.org/10.1038/srep06468

Three-dimensional in vitro co-culture model of breast tumor using magnetic levitation

Jaganathan, H, Gage, J, Leonard, F, Srinivasan, S, Souza, GR, Dave, B & Godin, B 2014, Scientific Reports, vol. 4, 6468. https://doi.org/10.1038/srep06468

Bacteriophage associated silicon particles: Design and characterization of a novel theranostic vector with improved payload carrying potential

Srinivasan, S, Alexander, JF, Driessen, WH, Leonard, F, Ye, H, Liu, X, Arap, W, Pasqualini, R, Ferrari, M & Godin, B 2013, Journal of Materials Chemistry B, vol. 1, no. 39, pp. 5218-5229. https://doi.org/10.1039/c3tb20595a

Biological microniches characterizing pathological lesions. Impact on nanoparticle-based delivery of therapeutics.

Meraz, IM, Segura-Ibarra, V, Leonard, F, Gonzalez, J, Ally, S, Godin, B & Serda, R 2013, Frontiers of Nanoscience, vol. 5, pp. 139-173. https://doi.org/10.1016/B978-0-08-098338-7.00006-6

Screening of budesonide nanoformulations for treatment of inflammatory bowel disease in an inflamed 3D cell-culture model

Leonard, F, Ali, H, Collnot, EM, Crielaard, BJ, Lammers, T, Storm, G & Lehr, CM 2012, Altex, vol. 29, no. 3, pp. 275-285. https://doi.org/10.14573/altex.2012.3.275

A three-dimensional coculture of enterocytes, monocytes and dendritic cells to model inflamed intestinal mucosa in vitro

Leonard, F, Collnot, EM & Lehr, CM 2010, Molecular Pharmaceutics, vol. 7, no. 6, pp. 2103-2119. https://doi.org/10.1021/mp1000795

Immobilized cytokines as biomaterials for manufacturing immune cell based vaccines

Leclerc, C, Brose, C, Nouzé, C, Leonard, F, Majlessi, L, Becker, S, Von Briesen, H & Lo-Man, R 2008, Journal of Biomedical Materials Research - Part A, vol. 86, no. 4, pp. 1033-1040. https://doi.org/10.1002/jbm.a.31751

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