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Fransisca Leonard, PhD

Instructor in Nanomedicine, Academic Institute
Instructor, Research Institute
Houston Methodist


fleonard@houstonmethodist.org
Education & Training

ME, Technical University of Berlin
PhD, Universität des Saarlandes
Publications

Design and in vitro characterization of multistage silicon-PLGA budesonide particles for inflammatory bowel disease
Leonard, F, Srinivasan, S, Liu, X, Collnot, EM, Ferrari, M, Lehr, CM & Godin, B 2020, European Journal of Pharmaceutics and Biopharmaceutics, vol. 151, pp. 61-72. https://doi.org/10.1016/j.ejpb.2020.03.020

Nonlinear response to cancer nanotherapy due to macrophage interactions revealed by mathematical modeling and evaluated in a murine model via CRISPR-modulated macrophage polarization
Leonard, F, Curtis, LT, Hamed, AR, Zhang, C, Chau, E, Sieving, D, Godin, B & Frieboes, HB 2020, Cancer Immunology, Immunotherapy, vol. 69, no. 5, pp. 731-744. https://doi.org/10.1007/s00262-020-02504-z

Immuntherapeutika gegen Kopf-Hals-Plattenepithelkarzinom-Stammzellen
Qian, X, Leonard, F, Wenhao, Y, Sudhoff, H, Hoffmann, TK, Ferrone, S, Kaufmann, AM & Albers, AE 2020, HNO, vol. 68, no. 2, pp. 94-99. https://doi.org/10.1007/s00106-020-00819-y

Pre-existing H4K16ac levels in euchromatin drive DNA repair by homologous recombination in S-phase
Horikoshi, N, Sharma, D, Leonard, F, Pandita, RK, Charaka, VK, Hambarde, S, Horikoshi, NT, Gaur Khaitan, P, Chakraborty, S, Cote, J, Godin, B, Hunt, CR & Pandita, TK 2019, Communications Biology, vol. 2, no. 1, 253. https://doi.org/10.1038/s42003-019-0498-z

Thioaptamer targeted discoidal microparticles increase self immunity and reduce Mycobacterium tuberculosis burden in mice
Leonard, F, Ha, NP, Sule, P, Alexander, JF, Volk, DE, Lokesh, GLR, Liu, X, Cirillo, JD, Gorenstein, DG, Yuan, J, Chatterjee, S, Graviss, EA & Godin, B 2017, Journal of Controlled Release, vol. 266, pp. 238-247. https://doi.org/10.1016/j.jconrel.2017.09.038

Gemcitabine enhances the transport of nanovector-albumin-bound paclitaxel in gemcitabine-resistant pancreatic ductal adenocarcinoma
Borsoi, C, Leonard, F, Lee, Y, Zaid, M, Elganainy, D, Alexander, JF, Kai, M, Liu, YT, Kang, Y, Liu, X, Koay, EJ, Ferrari, M, Godin, B & Yokoi, K 2017, Cancer Letters, vol. 403, pp. 296-304. https://doi.org/10.1016/j.canlet.2017.06.026

Unraveling bio-social hierarchy in cancer collective invasion: Symbiosis between leaders and followers
Leonard, F & Godin, B 2017, Translational Cancer Research, vol. 6, pp. S1084-S1087. https://doi.org/10.21037/tcr.2017.08.09

Macrophage polarization contributes to the anti-tumoral efficacy of mesoporous nanovectors loaded with albumin-bound paclitaxel
Leonard, F, Curtis, LT, Ware, MJ, Nosrat, T, Liu, X, Yokoi, K, Frieboes, HB & Godin, B 2017, Frontiers in immunology, vol. 8, no. JUN, 693. https://doi.org/10.3389/fimmu.2017.00693

Magnetically bioprinted human myometrial 3D cell rings as a model for uterine contractility
Souza, GR, Tseng, H, Gage, JA, Mani, A, Desai, P, Leonard, F, Liao, A, Longo, M, Refuerzo, JS & Godin, B 2017, International journal of molecular sciences, vol. 18, no. 4, 683. https://doi.org/10.3390/ijms18040683

Uterus-targeted liposomes for preterm labor management: Studies in pregnant mice
Refuerzo, JS, Leonard, F, Bulayeva, N, Gorenstein, D, Chiossi, G, Ontiveros, A, Longo, M & Godin, B 2016, Scientific Reports, vol. 6, 34710. https://doi.org/10.1038/srep34710

Enhanced performance of macrophage-encapsulated nanoparticle albumin-bound-paclitaxel in hypo-perfused cancer lesions
Leonard, F, Curtis, LT, Yesantharao, P, Tanei, T, Alexander, JF, Wu, M, Lowengrub, J, Liu, X, Ferrari, M, Yokoi, K, Frieboes, HB & Godin, B 2016, Nanoscale, vol. 8, no. 25, pp. 12544-12552. https://doi.org/10.1039/c5nr07796f

Chapter 4: Nanocarrier-Based Anticancer Therapies with the Focus on Strategies for Targeting the Tumor Microenvironment
Leonard, F 2016, . in Intracellular Delivery III:Market Entry Barriers of Nanomedicines. Springer, pp. 67-122.

3D In Vitro Model for Breast Cancer Research Using Magnetic Levitation and Bioprinting Method
Leonard, F & Godin, B 2016, . in J Cao (ed.), Breast Cancer: Methods and Protocols. vol. 1406, Methods in Molecular Biology, vol. 1406, Springer, pp. 239-251. https://doi.org/10.1007/978-1-4939-3444-7_21

Systemic Gene Silencing in Primary T Lymphocytes Using Targeted Lipid Nanoparticles
Ramishetti, S, Kedmi, R, Goldsmith, M, Leonard, F, Sprague, AG, Godin, B, Gozin, M, Cullis, PR, Dykxhoorn, DM & Peer, D 2015, ACS Nano, vol. 9, no. 7, pp. 6706-6716. https://doi.org/10.1021/acsnano.5b02796

Liposomes: A nanoscale drug carrying system to prevent indomethacin passage to the fetus in a pregnant mouse model
Refuerzo, JS, Alexander, JF, Leonard, F, Leon, M, Longo, M & Godin, B 2015, American journal of obstetrics and gynecology, vol. 212, no. 4. https://doi.org/10.1016/j.ajog.2015.02.006

In vivo imaging assessment of porous silicon
Srinivasan, S, Leonard, F, Kuncewicz, TM & Godin, B 2014, . in Porous Silicon for Biomedical Applications. Elsevier, pp. 223-252. https://doi.org/10.1533/9780857097156.2.223

Three-dimensional in vitro co-culture model of breast tumor using magnetic levitation
Jaganathan, H, Gage, J, Leonard, F, Srinivasan, S, Souza, GR, Dave, B & Godin, B 2014, Scientific Reports, vol. 4, 6468. https://doi.org/10.1038/srep06468

Three-dimensional in vitro co-culture model of breast tumor using magnetic levitation
Jaganathan, H, Gage, J, Leonard, F, Srinivasan, S, Souza, GR, Dave, B & Godin, B 2014, Scientific Reports, vol. 4, 6468. https://doi.org/10.1038/srep06468

Bacteriophage associated silicon particles: Design and characterization of a novel theranostic vector with improved payload carrying potential
Srinivasan, S, Alexander, JF, Driessen, WH, Leonard, F, Hu, YT, Liu, X, Arap, W, Pasqualini, R, Ferrari, M & Godin, B 2013, Journal of Materials Chemistry B, vol. 1, no. 39, pp. 5218-5229. https://doi.org/10.1039/c3tb20595a

Biological microniches characterizing pathological lesions. Impact on nanoparticle-based delivery of therapeutics.
Meraz, IM, Segura-Ibarra, V, Leonard, F, Gonzalez, J, Ally, S, Godin, B & Serda, R 2013, Frontiers of Nanoscience, vol. 5, pp. 139-173. https://doi.org/10.1016/B978-0-08-098338-7.00006-6

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