Eugene C. Lai, MD, PhD

Robert W. Hervey Chair for Parkinson's Research and Treatment, Stanley H. Appel Department of Neurology
Professor of Neurology and Neuroscience, Institute for Academic Medicine
Full Clinical Member, Research Institute
Houston Methodist
Weill Cornell Medical College


Dr. Eugene C. Lai is a clinician-scientist who has a special interest in the causes and treatments of neurodegenerative diseases, such as Parkinson’s disease, Alzheimer’s disease, amyotrophic lateral sclerosis, and other related disorders. Dr. Lai has expertise in the assessment of motor function and quality of life. He is the principal investigator or co-investigator of many clinical research studies. His work has appeared in more than one hundred scientific publications and book chapters, and has lectured widely on topics in neurodegenerative diseases.

Description of Research

Dr. Lai's research interests are in the causes and treatments of neurodegenerative diseases and the assessment of motor function and quality of life of patients with movement disorders and dementias.

Areas Of Expertise

Dementia Movement disorders Neurodegenerative disease Motor function assessment Quality of life
Education & Training

MD, Baylor College of Medicine

Usability and Validation of the Smarter Balance System: An Unsupervised Dynamic Balance Exercises System for Individuals With Parkinson's Disease
Fung, A, Lai, EC & Lee, B-C 2018, IEEE Transactions on Neural Systems and Rehabilitation Engineering, vol. 26, no. 4, pp. 798-806. DOI: 10.1109/TNSRE.2018.2808139

Post-stroke dyskinesias
Nakawah, MO & Lai, EC 2016, Neuropsychiatric Disease and Treatment, vol. 12, pp. 2885-2893. DOI: 10.2147/NDT.S118347

Teaching Video Neuro Images: P/Q-type voltage-gated calcium channel-associated paraneoplastic elliptical nystagmus
Mistry, EA, Lee, AG & Lai, EC 2016, Neurology, vol. 87, no. 10, pp. e109. DOI: 10.1212/WNL.0000000000003068

Brain stem disease
Lai, EC 2016, . in Neurology Secrets: Sixth Edition. Elsevier Inc. pp. 114-126. DOI: 10.1016/B978-0-323-35948-1.00009-7

Cognition in individuals at risk for Parkinson's: Parkinson associated risk syndrome (PARS) study findings
PARS Investigators 2016, Movement Disorders, vol. 31, no. 1, pp. 86-94. DOI: 10.1002/mds.26373

Differential effects of deep brain stimulation target on motor subtypes in Parkinson's disease
Katz, M, Luciano, MS, Carlson, K, Luo, P, Marks, WJ, Larson, PS, Starr, PA, Follett, KA, Weaver, FM, Stern, MB, Reda, DJ, Ostrem, JL, CSP 468 study group & Lai, E 2015, Annals of Neurology, vol. 77, no. 4, pp. 710-9. DOI: 10.1002/ana.24374

Neuropsychological changes following deep brain stimulation surgery for Parkinson's disease: Comparisons of treatment at pallidal and subthalamic targets versus best medical therapy
Rothlind, JC, York, MK, Carlson, K, Luo, P, Marks, WJ, Weaver, FM, Stern, M, Follett, K, Reda, D, Chairpersons, KF, Ippolito, D, Stoner, G, Barnett, T, Bukowski, K, De Nicolo, R, Hur, K, Jimenez, J, Motyka, J, Simon, T, Thakkar, B, Woolson, R, Fye, C, Gagne, W, Harris, C, Heemskerk, J, Moy, C, Sheehy, P, OLeary, T, Huang, GD, Fiore, L, Hall, R, Stroupe, K, Burchiel, K, Koller, W, Pahwa, R, Sagher, O, Bakay, R, Chappell, R, Hart, R, Holloway, R, McCabe, G, Schenkman, M, Taha, J, Buckelew, J, Garin, M, Matzek, S, Smith, D, Bronstein, J, Duda, J, Hogarth, P, Horn, S, Lai, EC, Samii, A, Atassi, F, Bello, C, Bunting-Perry, L, Conn, T, Cugley, A, Eubank, N, Fincher, L, Franks, R, Harris, T, Haselman, M, Heath, S, Hirsch, M, Janovsky, V, Lanier, E, Lloyd, M, Loehner, S, OConnor, S, Ordonez, L, Maccarone, H, Massey-Makhoul, K, Matthews, M, Meyn, E, Mimura, K, Morrow, W, Searles, T, Valotta, J, Vasthare, U, Volz, M, Ward, C, Warker, R, Watson, H, Willson, P, Baron, M, Brodsky, M, Calabrese, V, Campbell, G, Colcher, A, Farag, E, Henry, E, Hou, JG, Kang, G, Kleiner-Fisman, G, Kraakevik, J, Nutt, J, Ostrem, J, Sarwar, A, Subramanian, I, Vanek, Z, Baltuch, G, De Salles, A, Eller, J, Holloway, K, Larson, P, Simpson, R, Starr, P, Carne, W, Erikson, T, Kreutzer, J, Mendez, M, Moberg, P, Ragland, J, Seel, R, Soety, E, Storzbach, D, Troster, A & Jaggi, J 2014, Journal of Neurology, Neurosurgery and Psychiatry. DOI: 10.1136/jnnp-2014-308119

Comparing clinical features of young onset, middle onset and late onset Parkinson's disease
Mehanna, R, Moore, S, Hou, JG, Sarwar, AI & Lai, EC 2014, Parkinsonism and Related Disorders, vol. 20, no. 5, pp. 530-534. DOI: 10.1016/j.parkreldis.2014.02.013

Deep brain stimulation in Parkinson's disease
Mehanna, R & Lai, EC 2013, Translational Neurodegeneration, vol. 2, no. 1, 22. DOI: 10.1186/2047-9158-2-22

Effect of subthalamic nucleus or globus pallidus interna stimulation on oculomotor function in patients with parkinson's disease
Fridley, J, Adams, G, Sun, P, York, M, Atassi, F, Lai, E, Simpson, R, Viswanathan, A & Yoshor, D 2013, Stereotactic and Functional Neurosurgery, vol. 91, no. 2, pp. 113-121. DOI: 10.1159/000343200

Erratum: Cognitive rehabilitation for executive dysfunction in parkinson's disease: Application and current directions (Parkinson's Disease)
Calleo, J, Burrows, C, Levin, H, Marsh, L, Lai, E & York, MK 2012, Parkinsons Disease. DOI: 10.1155/2012/907513

Two different 18F-FDG brain PET metabolic patterns in autoimmune limbic encephalitis
Fisher, RE, Patel, NR, Lai, EC & Schulz, PE 2012, Clinical nuclear medicine, vol. 37, no. 9. DOI: 10.1097/RLU.0b013e31824852c7

An exploratory study of activity in veterans with Parkinson's disease
Trail, M, Petersen, NJ, Nelson, N & Lai, EC 2012, Journal of Neurology, vol. 259, no. 8, pp. 1686-1693. DOI: 10.1007/s00415-011-6400-7

Randomized trial of deep brain stimulation for Parkinson disease: Thirty-six-month outcomes
Weaver, FM, Follett, KA, Stern, M, Luo, P, Harris, CL, Hur, K, Marks, WJ, Rothlind, J, Sagher, O, Moy, C, Pahwa, R, Burchiel, K, Hogarth, P, Lai, EC, Duda, JE, Holloway, K, Samii, A, Horn, S, Bronstein, JM, Stoner, G, Starr, PA, Simpson, R, Baltuch, G, De Salles, A, Huang, GD & Reda, DJ 2012, Neurology, vol. 79, no. 1, pp. 55-65. DOI: 10.1212/WNL.0b013e31825dcdc1

The relation of falls to fatigue, depression and daytime sleepiness in Parkinson's disease
Bryant, MS, Rintala, DH, Hou, JG, Rivas, SP, Fernandez, AL, Lai, EC & Protas, EJ 2012, European Neurology, vol. 67, no. 6, pp. 326-330. DOI: 10.1159/000335877

Assessment of appropriate medication administration for hospitalized patients with Parkinson's disease
Hou, JG, Wu, LJ, Moore, S, Ward, C, York, M, Atassi, F, Fincher, L, Nelson, N, Sarwar, A & Lai, EC 2012, Parkinsonism and Related Disorders, vol. 18, no. 4, pp. 377-381. DOI: 10.1016/j.parkreldis.2011.12.007

Impaired olfaction and other prodromal features in the Parkinson At-Risk Syndrome study
Siderowf, A, Jennings, D, Eberly, S, Oakes, D, Hawkins, KA, Ascherio, A, Stern, MB, Marek, K, Russell, D, Fiocco, A, Cotto, C, Sethi, K, Jackson, P, Frank, S, Hohler, A, Thomas, CA, James, RC, Simuni, T, Borushko, E, Stern, M, Rick, J, Hauser, R, Khavarian, L, McClain, T, Richard, I, Deely, C, Liang, GS, Reys, L, Adler, CH, Duffy, AK, Saunders-Pullman, R, Evatt, ML, McGinn, L, Lai, E, Johnson, S, Atassi, F, DeBakey, ME, Subramanian, I, Gratiano, A, Chung, K, Lobb, B, OConner, S, Albelo, MR, Cioffi, C, Gadoury, A, Howard, B, Iannucci, V, Lasch, S, Mendick, S, Miles, D, Miles, K, Virden, E & Wisniewski, G 2012, Movement Disorders, vol. 27, no. 3, pp. 406-412. DOI: 10.1002/mds.24892

Cognitive rehabilitation for executive dysfunction in Parkinson's disease: Application and current directions
Calleo, J, Burrows, C, Levin, H, Marsh, L, Lai, E & York, MK 2012, Parkinsons Disease. DOI: 10.1155/2012/512892

Effects of levodopa on forward and backward gait patterns in persons with Parkinson's disease
Bryant, MS, Rintala, DH, Hou, JG, Lai, EC & Protas, EJ 2011, NeuroRehabilitation, vol. 29, no. 3, pp. 247-252. DOI: 10.3233/NRE-2011-0700

Gait variability in Parkinson's disease: Influence of walking speed and dopaminergic treatment
Bryant, MS, Rintala, DH, Hou, JG, Charness, AL, Fernandez, AL, Collins, RL, Baker, J, Lai, EC & Protas, EJ 2011, Neurological Research, vol. 33, no. 9, pp. 959-964. DOI: 10.1179/1743132811Y.0000000044