Eugene C. Lai, MD, PhD

Robert W. Hervey Chair for Parkinson's Research and Treatment, Stanley H. Appel Department of Neurology
Professor of Neurology and Neuroscience, Academic Institute
Full Clinical Member, Research Institute
Houston Methodist
Weill Cornell Medical College


Dr. Eugene C. Lai is a clinician-scientist who has a special interest in the causes and treatments of neurodegenerative diseases, such as Parkinson’s disease, Alzheimer’s disease, amyotrophic lateral sclerosis, and other related disorders. Dr. Lai has expertise in the assessment of motor function and quality of life. He is the principal investigator or co-investigator of many clinical research studies. His work has appeared in more than one hundred scientific publications and book chapters, and has lectured widely on topics in neurodegenerative diseases.

Description of Research

Dr. Lai's research interests are in the causes and treatments of neurodegenerative diseases and the assessment of motor function and quality of life of patients with movement disorders and dementias.

Areas Of Expertise

Dementia Movement disorders Neurodegenerative disease Motor function assessment Quality of life
Education & Training

MD, Baylor College of Medicine

Predictors of multi-domain cognitive decline following DBS for treatment of Parkinson's disease
for the CSP-468 study group 2022, , Parkinsonism and Related Disorders, vol. 95, pp. 23-27.

A 57-year-old woman with falls, slurred speech, and abnormal MRI signal in the pons, middle cerebellar peduncles, and cerebellum
Holloman, A, Panchal, S, Mistry, E, Monroig-Bosque, P, Christensen, P, Lai, E & Cykowski, M 2022, , Brain Pathology, vol. 32, no. 4, e13072, pp. e13072.

Risk factors and machine learning model for predicting hospitalization outcomes in geriatric patients with dementia
Wang, X, Ezeana, CF, Wang, L, Puppala, M, Huang, Y-S, He, Y, Yu, X, Yin, Z, Zhao, H, Lai, EC & Wong, STC 2022, , Alzheimers and Dementia: Translational Research and Clinical Interventions, vol. 8, no. 1, pp. e12351.

Ex vivo expansion of dysfunctional regulatory T lymphocytes restores suppressive function in Parkinson’s disease
Thome, AD, Atassi, F, Wang, J, Faridar, A, Zhao, W, Thonhoff, JR, Beers, DR, Lai, EC & Appel, SH 2021, , npj Parkinsons Disease, vol. 7, no. 1, 41.

Clinical and Imaging Progression in the PARS Cohort: Long-Term Follow-up
Siderowf, A, Jennings, D, Stern, M, Seibyl, J, Eberly, S, Oakes, D, Marek, K, Jennings, D, Marek, K, Seibyl, J, Siderowf, A, Stern, M, Russell, D, Sethi, K, Frank, S, Simuni, T, Hauser, R, Ravina, B, Richards, I, Liang, G, Adler, C, Saunders-Pullman, R, Evatt, ML, Lai, E, Subramanian, I, Hogarth, P & Chung, K 2020, , Movement Disorders, vol. 35, no. 9, pp. 1550-1557.

Effects of a Smartphone-Based Wearable Telerehabilitation System for In-Home Dynamic Weight-Shifting Balance Exercises by Individuals with Parkinson's Disease
An, J, Kim, J, Lai, EC & Lee, BC 2020, . in 42nd Annual International Conferences of the IEEE Engineering in Medicine and Biology Society: Enabling Innovative Technologies for Global Healthcare, EMBC 2020., 9175967, Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS, vol. 2020-July, Institute of Electrical and Electronics Engineers Inc. pp. 5678-5681, 42nd Annual International Conferences of the IEEE Engineering in Medicine and Biology Society, EMBC 2020, Montreal, Canada, 7/20/20.

A new smart balance rehabilitation system technology platform: Development and preliminary assessment of the Smarter Balance System for home-based balance rehabilitation for individuals with Parkinson's disease *
Fung, A, Lai, EC & Lee, BC 2018, . in 40th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2018., 8512528, Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS, vol. 2018-July, Institute of Electrical and Electronics Engineers Inc. pp. 1534-1537, 40th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2018, Honolulu, United States, 7/18/18.

Process and results of implementing disease management program in patients with first-time ischemic stroke
Yang, HR, Ma, L, Jiang, YF, Wu, YC, Lai, EC & Zhu, YH 2018, , Iranian Journal of Public Health, vol. 47, no. 7, pp. 1007-1016.

Usability and Validation of the Smarter Balance System: An Unsupervised Dynamic Balance Exercises System for Individuals With Parkinson's Disease
Fung, A, Lai, EC & Lee, B-C 2018, , IEEE Transactions on Neural Systems and Rehabilitation Engineering, vol. 26, no. 4, pp. 798-806.

Safety and efficacy of eculizumab in anti-acetylcholine receptor antibody-positive refractory generalised myasthenia gravis (REGAIN): a phase 3, randomised, double-blind, placebo-controlled, multicentre study
REGAIN Study Group 2017, , The Lancet Neurology, vol. 16, no. 12, pp. 976-986.

Post-stroke dyskinesias
Nakawah, MO & Lai, EC 2016, , Neuropsychiatric Disease and Treatment, vol. 12, pp. 2885-2893.

Teaching Video Neuro Images: P/Q-type voltage-gated calcium channel-associated paraneoplastic elliptical nystagmus
Mistry, EA, Lee, AG & Lai, EC 2016, , Neurology, vol. 87, no. 10, pp. e109.

Brain stem disease
Lai, EC 2016, . in Neurology Secrets: Sixth Edition. Elsevier, pp. 114-126.

Cognition in individuals at risk for Parkinson's: Parkinson associated risk syndrome (PARS) study findings
PARS Investigators 2016, , Movement Disorders, vol. 31, no. 1, pp. 86-94.

Differential effects of deep brain stimulation target on motor subtypes in Parkinson's disease
Katz, M, Luciano, MS, Carlson, K, Luo, P, Marks, WJ, Larson, PS, Starr, PA, Follett, KA, Weaver, FM, Stern, MB, Reda, DJ, Ostrem, JL, CSP 468 study group & Lai, E 2015, , Annals of Neurology, vol. 77, no. 4, pp. 710-9.

Neuropsychological changes following deep brain stimulation surgery for Parkinson's disease: Comparisons of treatment at pallidal and subthalamic targets versus best medical therapy
Rothlind, JC, York, MK, Carlson, K, Luo, P, Marks, WJ, Weaver, FM, Stern, M, Follett, K, Reda, D, Chairpersons, KF, Ippolito, D, Stoner, G, Barnett, T, Bukowski, K, De Nicolo, R, Hur, K, Jimenez, J, Motyka, J, Simon, T, Thakkar, B, Woolson, R, Fye, C, Gagne, W, Harris, C, Heemskerk, J, Moy, C, Sheehy, P, OLeary, T, Huang, GD, Fiore, L, Hall, R, Stroupe, K, Burchiel, K, Koller, W, Pahwa, R, Sagher, O, Bakay, R, Chappell, R, Hart, R, Holloway, R, McCabe, G, Schenkman, M, Taha, J, Buckelew, J, Garin, M, Matzek, S, Smith, D, Bronstein, J, Duda, J, Hogarth, P, Horn, S, Lai, EC, Samii, A, Atassi, F, Bello, C, Bunting-Perry, L, Conn, T, Cugley, A, Eubank, N, Fincher, L, Franks, R, Harris, T, Haselman, M, Heath, S, Hirsch, M, Janovsky, V, Lanier, E, Lloyd, M, Loehner, S, OConnor, S, Ordonez, L, Maccarone, H, Massey-Makhoul, K, Matthews, M, Meyn, E, Mimura, K, Morrow, W, Searles, T, Valotta, J, Vasthare, U, Volz, M, Ward, C, Warker, R, Watson, H, Willson, P, Baron, M, Brodsky, M, Calabrese, V, Campbell, G, Colcher, A, Farag, E, Henry, E, Hou, JG, Kang, G, Kleiner-Fisman, G, Kraakevik, J, Nutt, J, Ostrem, J, Sarwar, A, Subramanian, I, Vanek, Z, Baltuch, G, De Salles, A, Eller, J, Holloway, K, Larson, P, Simpson, R, Starr, P, Carne, W, Erikson, T, Kreutzer, J, Mendez, M, Moberg, P, Ragland, J, Seel, R, Soety, E, Storzbach, D, Troster, A & Jaggi, J 2015, , Journal of Neurology, Neurosurgery and Psychiatry, vol. 86, no. 6, pp. 622-629.

Comparing clinical features of young onset, middle onset and late onset Parkinson's disease
Mehanna, R, Moore, S, Hou, JG, Sarwar, AI & Lai, EC 2014, , Parkinsonism and Related Disorders, vol. 20, no. 5, pp. 530-534.

Deep brain stimulation in Parkinson's disease
Mehanna, R & Lai, EC 2013, , Translational Neurodegeneration, vol. 2, no. 1, 22.

Effect of subthalamic nucleus or globus pallidus interna stimulation on oculomotor function in patients with parkinson's disease
Fridley, J, Adams, G, Sun, P, York, M, Atassi, F, Lai, EC, Simpson, R, Viswanathan, A & Yoshor, D 2013, , Stereotactic and Functional Neurosurgery, vol. 91, no. 2, pp. 113-121.

Two different 18F-FDG brain PET metabolic patterns in autoimmune limbic encephalitis
Fisher, RE, Patel, NR, Lai, EC & Schulz, PE 2012, , Clinical Nuclear Medicine, vol. 37, no. 9, pp. e213-e218.