Eamonn Martin Quigley, MD

David M. Underwood Chair of Medicine in Digestive Disorders, Department of Medicine
Professor of Medicine, Academic Institute
Director, Lynda K. and David M. Underwood Center for Digestive Disorders
Houston Methodist
Weill Cornell Medical College


Biography

Dr. Eamonn M. M. Quigley, past president of the American College of Gastroenterology and the World Gastroenterology Organization, joined the faculty at Houston Methodist Hospital as head of its Gastroenterology and Hepatology division in 2013.

Prior to his move to Houston, Quigley was professor of medicine and human physiology and a principal investigator at the Alimentary Pharmabiotic Centre at the National University of Ireland in Cork. He is internationally known for his research on gastrointestinal motility disorders, primarily irritable bowel syndrome (IBS); gastroesophageal reflux disease (GERD); neurogastroenterology (the relationship between the central nervous system and the gut); the gut microbiome and probiotics in health and disease. A highlight of his ongoing research includes how bacteria in the digestive tract play a major role in pulling nutrients from food to nourish the body, as well as participating in protecting the body from disease.

IBS is the most common, chronic medical condition in the United States. Approximately 40 percent of those with IBS have symptoms severe or frequent enough to disrupt their daily lives. While the cause of IBS has not been clearly identified, Quigley’s clinical research suggests that an alteration of the normal gut bacteria flora may be a cause. His research team is working toward developing new biomarkers for IBS which would eventually lead to the development of new treatments. Quigley’s clinical interests focus on the use of probiotics for the treatment of IBS.

He has published more than 800 peer-reviewed articles, reviews, editorials, book chapters and case reports, mostly in the areas of gut motility, functional gastrointestinal disorders, and GERD. Quigley has received numerous international honors and awards. He served as Editor-in-Chief of the American Journal of Gastroenterology from 1997 to 2003.

Quigley received his medical degree from  University College Cork in Cork, Ireland; completed internal medicine residency in Glasgow, Scotland; and did GI fellowship training at the Mayo Clinic and the University of Manchester in England.  He served as the Chief of Gastroenterology at the University of Nebraska from 1991 to 1998 and as Dean of the Medical School in Cork, Ireland from 2000 to 2007.

Description of Research

Some of his pioneering research over the past several decades has included how the function of the gut is affected in a variety of diseases and conditions, including chronic liver disease, high-dose chemoradiotherapy, intestinal failure and transplantation, and Parkinson’s disease.

Areas Of Expertise

Gastroesophageal Reflux Esophageal disorders/dysphagia Gastrointestinal motility disorders Functional GI disorders Irritable bowel syndrome Gastroparesis Constipation Diarrheal disorders Celiac disease Intestinal & colonic disorders Inflammatory bowel disease/colitis/Crohn's disease General gastroenterology EGD and colonoscopy Capsule endoscopy
Education & Training

Clinical Fellowship, University of Manchester
Residency, Western Infirmary & Associates Hospital
Internship, St. Finbarr's Hospital
MD, National University of Ireland;
Publications

Abnormal balloon expulsion test in patients with fecal incontinence
Neshatian, L, Fosso, CL & Quigley, EM 2020, , Journal of Gastrointestinal and Liver Diseases, vol. 29, no. 3, pp. 345-351. https://doi.org/10.15403/jgld-2273

Efficacy of psychological therapies for irritable bowel syndrome: Systematic review and network meta-analysis
Black, CJ, Thakur, ER, Houghton, LA, Quigley, EMM, Moayyedi, P & Ford, AC 2020, , Gut, vol. 69, no. 8, pp. 1441-1451. https://doi.org/10.1136/gutjnl-2020-321191

“It ain't over … till it's over!” Risk-mitigation strategies for patients with gastrointestinal diseases in the aftermath of the COVID-19 pandemic
Holtmann, G, Quigley, EM, Shah, A, Camilleri, M, Tan, VPY, Gwee, KA, Sugano, K, Sollano, JD, Fock, KM, Ghoshal, UC, Chen, M, Dignass, A & Cohen, H 2020, , Journal of Gastroenterology and Hepatology (Australia), vol. 35, no. 7, pp. 1117-1123. https://doi.org/10.1111/jgh.15133

Erratum: Antibiotics and probiotics in inflammatory bowel disease: When to use them? (Frontline Gastroenterology (2020) 11 (62–69) DOI: 10.1136/flgastro-2018-101057)
Abraham, B & Quigley, EMM 2020, , Frontline Gastroenterology, vol. 11, no. 3, pp. E1. https://doi.org/10.1136/flgastro-2018-101057corr1

Irritable bowel syndrome in celiac disease - relationships to celiac disease antibodies and levels of pro-inflammatory cytokines
Olano, C, López, V, Freire, T, Rodríguez, X, Pontet, Y, Alemán, A, Rodríguez, N, Rovira, L, Trucco, E, Osinaga, E, Cohen, H & Quigley, EM 2020, , Revista de gastroenterología del Perú : órgano oficial de la Sociedad de Gastroenterología del Perú, vol. 40, no. 2, pp. 127-135.

Nutraceuticals as modulators of gut microbiota: Role in therapy
Quigley, EMM 2020, , British Journal of Pharmacology, vol. 177, no. 6, pp. 1351-1362. https://doi.org/10.1111/bph.14902

Editorial: Nutrition in gastroenterology: More relevant than ever yet largely ignored in our education and training
Quigley, EMM 2020, , Current opinion in gastroenterology, vol. 36, no. 2, pp. 99-100. https://doi.org/10.1097/MOG.0000000000000602

Cancer cachexia: A multifactoral disease that needs a multimodal approach
Stubbins, R, Bernicker, EH & Quigley, EM 2020, , Current opinion in gastroenterology, vol. 36, no. 2, pp. 141-146. https://doi.org/10.1097/MOG.0000000000000603

Polyethylene glycol-based laxatives for chronic constipation – Authors' reply
Luthra, P, Camilleri, M, Burr, NE, Quigley, EMM, Black, CJ & Ford, AC 2020, , The Lancet Gastroenterology and Hepatology, vol. 5, no. 2, pp. 110-111. https://doi.org/10.1016/S2468-1253(19)30381-4

Gut microbiota abnormalities, small intestinal bacterial overgrowth, and non-alcoholic fatty liver disease: An emerging paradigm
Ghoshal, UC, Goel, A & Quigley, EMM 2020, , Indian Journal of Gastroenterology, vol. 39, no. 1, pp. 9-21. https://doi.org/10.1007/s12664-020-01027-w

Efficacy of soluble fibre, antispasmodic drugs, and gut–brain neuromodulators in irritable bowel syndrome: a systematic review and network meta-analysis
Black, CJ, Yuan, Y, Selinger, CP, Camilleri, M, Quigley, EMM, Moayyedi, P & Ford, AC 2020, , The Lancet Gastroenterology and Hepatology, vol. 5, no. 2, pp. 117-131. https://doi.org/10.1016/S2468-1253(19)30324-3

Antibiotics and probiotics in inflammatory bowel disease: When to use them?
Abraham, B & Quigley, EMM 2020, , Frontline Gastroenterology, vol. 11, no. 1, pp. 62-69. https://doi.org/10.1136/flgastro-2018-101057

Editorial: Colon updates 2020 - Some old, some new but novel insights throughout
Quigley, EM 2020, Current opinion in gastroenterology, vol. 36, no. 1, pp. 17-18. https://doi.org/10.1097/MOG.0000000000000595

Commentary: faecal microbiota transplantation—from home brew to holy grail
Quigley, EM 2020, Alimentary Pharmacology and Therapeutics, vol. 51, no. 1, pp. 208-209. https://doi.org/10.1111/apt.15553

Choosing a Prokinetic for Your Patient Beyond Metoclopramide
Gudsoorkar, V & Quigley, EM 2020, The American Journal of Gastroenterology, vol. 115, no. 1, pp. 5-8. https://doi.org/10.14309/ajg.0000000000000463

Recent advances in modulating the microbiome
Quigley, EM & Gajula, P 2020, F1000Research, vol. 9. https://doi.org/10.12688/f1000research.20204.1

Efficacy of pharmacological therapies in patients with IBS with diarrhoea or mixed stool pattern: systematic review and network meta-analysis
Black, CJ, Burr, NE, Camilleri, M, Earnest, DL, Quigley, EMM, Moayyedi, P, Houghton, LA & Ford, AC 2020, , Gut, vol. 69, no. 1, pp. 74-82. https://doi.org/10.1136/gutjnl-2018-318160

Effects of the vibrating capsule on colonic circadian rhythm and bowel symptoms in chronic idiopathic constipation
Rao, SSC, Lembo, A, Chey, WD, Friedenberg, K & Quigley, EM 2020, Neurogastroenterology and Motility. https://doi.org/10.1111/nmo.13890

The microbiome and inflammatory bowel disease
Glassner, KL, Abraham, BP & Quigley, EMM 2020, , Journal of Allergy and Clinical Immunology, vol. 145, no. 1, pp. 16-27. https://doi.org/10.1016/j.jaci.2019.11.003

Rectal Distension Increased the Rectoanal Gradient in Patients with Normal Rectal Sensory Function
Neshatian, L, Williams, MJOU & Quigley, EM 2020, , Digestive Diseases and Sciences. https://doi.org/10.1007/s10620-020-06519-5