Eamonn Martin Quigley, MD

David M. Underwood Chair of Medicine in Digestive Disorders, Department of Medicine
Professor of Medicine, Academic Institute
Director, Lynda K. and David M. Underwood Center for Digestive Disorders
Houston Methodist
Weill Cornell Medical College


Biography

Dr. Eamonn M. M. Quigley, past president of the American College of Gastroenterology and the World Gastroenterology Organization, joined the faculty at Houston Methodist Hospital as head of its Gastroenterology and Hepatology division in 2013.

Prior to his move to Houston, Quigley was professor of medicine and human physiology and a principal investigator at the Alimentary Pharmabiotic Centre at the National University of Ireland in Cork. He is internationally known for his research on gastrointestinal motility disorders, primarily irritable bowel syndrome (IBS); gastroesophageal reflux disease (GERD); neurogastroenterology (the relationship between the central nervous system and the gut); the gut microbiome and probiotics in health and disease. A highlight of his ongoing research includes how bacteria in the digestive tract play a major role in pulling nutrients from food to nourish the body, as well as participating in protecting the body from disease.

IBS is the most common, chronic medical condition in the United States. Approximately 40 percent of those with IBS have symptoms severe or frequent enough to disrupt their daily lives. While the cause of IBS has not been clearly identified, Quigley’s clinical research suggests that an alteration of the normal gut bacteria flora may be a cause. His research team is working toward developing new biomarkers for IBS which would eventually lead to the development of new treatments. Quigley’s clinical interests focus on the use of probiotics for the treatment of IBS.

He has published more than 800 peer-reviewed articles, reviews, editorials, book chapters and case reports, mostly in the areas of gut motility, functional gastrointestinal disorders, and GERD. Quigley has received numerous international honors and awards. He served as Editor-in-Chief of the American Journal of Gastroenterology from 1997 to 2003.

Quigley received his medical degree from  University College Cork in Cork, Ireland; completed internal medicine residency in Glasgow, Scotland; and did GI fellowship training at the Mayo Clinic and the University of Manchester in England.  He served as the Chief of Gastroenterology at the University of Nebraska from 1991 to 1998 and as Dean of the Medical School in Cork, Ireland from 2000 to 2007.

Description of Research

Some of his pioneering research over the past several decades has included how the function of the gut is affected in a variety of diseases and conditions, including chronic liver disease, high-dose chemoradiotherapy, intestinal failure and transplantation, and Parkinson’s disease.

Areas Of Expertise

Gastroesophageal Reflux Esophageal disorders/dysphagia Gastrointestinal motility disorders Functional GI disorders Irritable bowel syndrome Gastroparesis Constipation Diarrheal disorders Celiac disease Intestinal & colonic disorders Inflammatory bowel disease/colitis/Crohn's disease General gastroenterology EGD and colonoscopy Capsule endoscopy
Education & Training

Clinical Fellowship, University of Manchester
Residency, Western Infirmary & Associates Hospital
Internship, St. Finbarr's Hospital
MD, National University of Ireland;
Publications

Can diet change the natural history of gastrointestinal diseases?
Quigley, EMM 2024, , JGH Open, vol. 8, no. 5, e13063, pp. e13063. https://doi.org/10.1002/jgh3.13063

Dietary Interventions and Brain–Gut Disorders
Quigley, EMM 2024, . in The Gut-Brain Axis, Second Edition. Elsevier, pp. 283-305. https://doi.org/10.1016/B978-0-323-99971-7.00013-8

Consensus practice recommendations for management of gastrointestinal dysfunction in Parkinson disease
Other Non-motor Features Working Group of the Parkinson Study Group 2024, , Parkinsonism and Related Disorders. https://doi.org/10.1016/j.parkreldis.2024.106982

Recommendations to Improve Quality of Probiotic Systematic Reviews with Meta-Analyses
McFarland, LV, Hecht, G, Sanders, ME, Goff, DA, Goldstein, EJC, Hill, C, Johnson, S, Kashi, MR, Kullar, R, Marco, ML, Merenstein, DJ, Millette, M, Preidis, GA, Quigley, EMM, Reid, G, Salminen, S, Sniffen, JC, Sokol, H, Szajewska, H, Tancredi, DJ & Woolard, K 2023, , JAMA Network Open, vol. 6, no. 12, pp. E2346872. https://doi.org/10.1001/jamanetworkopen.2023.46872

Efficacy of Probiotics in Irritable Bowel Syndrome: Systematic Review and Meta-analysis
Goodoory, VC, Khasawneh, M, Black, CJ, Quigley, EMM, Moayyedi, P & Ford, AC 2023, , Gastroenterology, vol. 165, no. 5, pp. 1206-1218. https://doi.org/10.1053/j.gastro.2023.07.018

Look What the Cat Dragged in! Recurrent Clostridioides difficile from a Household Cat
Garza, MA, Thomas, B, Saleh, A, Nabbout, L, Quigley, EMM & Mathur, N 2023, , American Journal of Case Reports, vol. 24, e940923, pp. e940923-1-e940923-4. https://doi.org/10.12659/AJCR.940923

The Role of Fecal Microbiota Transplantation in the Induction of Remission in Ulcerative Colitis
Saleh, A, Parsa, S, Garza, M, Quigley, EMM & Abraham, BP 2023, , Digestive Diseases, vol. 41, no. 4, pp. 656-665. https://doi.org/10.1159/000529591

Drug Treatments for Gastroparesis—Why Is the Cupboard So Bare?
Quigley, EMM 2023, , Gastroenterology, vol. 164, no. 4, pp. 522-524. https://doi.org/10.1053/j.gastro.2023.01.029

A systematic review of gut microbiota profile in COVID-19 patients and among those who have recovered from COVID-19
Simadibrata, DM, Lesmana, E, Gunawan, J, Quigley, EM & Simadibrata, M 2023, , Journal of Digestive Diseases, vol. 24, no. 4, pp. 244-261. https://doi.org/10.1111/1751-2980.13195

Probiotics in irritable bowel syndrome and inflammatory bowel disease: review of mechanisms and effectiveness
So, D, Quigley, EMM & Whelan, K 2023, , Current opinion in gastroenterology, vol. 39, no. 2, pp. 103-109. https://doi.org/10.1097/MOG.0000000000000902

Editorial: bacterial gut symbionts as live biotherapeutic agents in IBS-a rosy future despite potential long-term safety concerns. Authors' reply
Quigley, EMM, Stevenson, A, Jeffery, I & Masters, J 2023, , Alimentary Pharmacology and Therapeutics, vol. 57, no. 3, pp. 347-348. https://doi.org/10.1111/apt.17354

Impact of pre-operative transjugular intrahepatic portosystemic shunt on post-operative outcomes following non-transplant surgeries in patients with decompensated cirrhosis
Patel, P, Irani, M, Graviss, EA, Nguyen, DT, Quigley, EMM & Victor, DW 2023, , Translational Gastroenterology and Hepatology, vol. 8, 9, pp. 9. https://doi.org/10.21037/tgh-21-133, https://doi.org/10.21037/tgh-21-133

Randomised clinical trial: efficacy and safety of the live biotherapeutic product MRx1234 in patients with irritable bowel syndrome
Quigley, EMM, Markinson, L, Stevenson, A, Treasure, FP & Lacy, BE 2023, , Alimentary Pharmacology and Therapeutics, vol. 57, no. 1, pp. 81-93. https://doi.org/10.1111/apt.17310

Face-to-face interviews versus Internet surveys: Comparison of two data collection methods in the Rome foundation global epidemiology study: Implications for population-based research
Sperber, AD, Bor, S, Fang, X, Bangdiwala, SI, Drossman, DA, Ghoshal, UC, Simren, M, Tack, J, Whitehead, WE, Dumitrascu, DL, Fukudo, S, Kellow, J, Okeke, E, Quigley, EMM, Schmulson, M, Whorwell, P, Archampong, T, Adibi, P, Andresen, V, Benninga, MA, Bonaz, B, Fernandez, LB, Choi, SC, Corazziari, ES, Francisconi, C, Hani, A, Lazebnik, L, Lee, YY, Mulak, A, Rahman, MM, Santos, J, Setshedi, M, Syam, AF, Vanner, S, Wong, RK, Lopez-Colombo, A, Costa, V, Dickman, R, Kanazawa, M, Keshteli, AH, Khatun, R, Maleki, I, Poitras, P, Pratap, N, Stefanyuk, O, Thomson, S, Buyruk, M, Unal, N, Huang, D, Song, J, Hreinsson, JP & Palsson, OS 2023, , Neurogastroenterology and Motility, vol. 35, no. 6, e14583, pp. e14583. https://doi.org/10.1111/nmo.14583

Randomized Placebo-Controlled Phase 3 Trial of Vibrating Capsule for Chronic Constipation
Rao, SSC, Quigley, EMM, Chey, WD, Sharma, A & Lembo, AJ 2023, , Gastroenterology, vol. 164, no. 7, pp. 1202-1210.e6. https://doi.org/10.1053/j.gastro.2023.02.013

Constipation in Parkinson's Disease
Quigley, EMM 2023, , Seminars in Neurology, vol. 43, no. 4, pp. 562-571. https://doi.org/10.1055/s-0043-1771457

Exploring the Small Intestinal Microbiome: Relationships to Symptoms and Small Intestinal Bacterial Overgrowth
Quigley, EMM 2023, , Clinical Gastroenterology and Hepatology, vol. 22, no. 2, pp. 241-242. https://doi.org/10.1016/j.cgh.2023.09.025

Fecal bacterial microbiota in constipated patients before and after eight weeks of daily Bifidobacterium infantis 35624 administration
Amieva-Balmori, M, García-Mazcorro, JF, Martínez-Conejo, A, Hernández-Ramírez, GA, García-Zermeño, KR, Rodríguez-Aguilera, O, Aja-Cadena, M, Barradas-Cortés, M, Quigley, EMM & Remes-Troche, JM 2023, , Revista de gastroenterologia de Mexico (English), vol. 88, no. 4, pp. 369-380. https://doi.org/10.1016/j.rgmxen.2022.06.014

Look What the Cat Dragged in! Recurrent Clostridioides difficile from a Household Cat
Garza, MA, Thomas, B, Saleh, A, Nabbout, L, Quigley, EMM & Mathur, N 2023, , American Journal of Case Reports, vol. 24, e940923, pp. e940923-1-e940923-4. https://doi.org/10.12659/AJCR.940923

Editorial: 5-aminosalicylic acid fails to impact on irritable bowel syndrome—wrong population, intervention, target or hypothesis?
Quigley, EMM 2022, , Alimentary Pharmacology and Therapeutics, vol. 56, no. 10, pp. 1497-1498. https://doi.org/10.1111/apt.17210