Donna Coffey, MD

Associate Professor of Clinical Pathology and Genomic Medicine, Academic Institute
Associate Clinical Member, Research Institute
Houston Methodist
Weill Cornell Medical College


Dr. Coffey received her MD degree from the University of Costa Rica in San Jose in 1991. She then completed a pathology residency and cytopathology fellowship at the Baylor College of Medicine in Houston, Texas, before joining the faculty at Baylor as an assistant professor in the Department of Pathology. She joined Houston Methodist in 2005 and received her Weill Cornell Faculty appointment in 2008.

Description of Research

Dr. Coffey is a general surgical pathologist with subspecialty training in cytopathology. Her areas of interest are gynecologic pathology and cytopathology. She is currently involved in several collaborative studies using tissue microarrays of gynecologic malignancies.

Education & Training

Residency, Baylor College of Medicine
Clinical Fellowship, Baylor College of Medicine
MD, Ciudad Universitaria

Targeting progesterone signaling prevents metastatic ovarian cancer
Kim, O, Park, EY, Kwon, SY, Shin, S, Emerson, RE, Shin, YH, DeMayo, FJ, Lydon, JP, Coffey, DM, Hawkins, SM, Quilliam, LA, Cheon, DJ, Fernández, FM, Nephew, KP, Karpf, AR, Widschwendter, M, Sood, AK, Bast, RC, Godwin, AK, Miller, KD, Cho, CH & Kim, J 2020, , Proceedings of the National Academy of Sciences of the United States of America, vol. 117, no. 50, pp. 31993-32004.

In vivo modeling of metastatic human highgrade serous ovarian cancer in mice
Kim, O, Park, EY, Klinkebie, DL, Pack, SD, Shin, YH, Abdullaev, Z, Emerson, RE, Coffey, DM, Kwon, SY, Creighton, CJ, Kwon, S, Chang, EC, Chiang, T, Yatsenko, AN, Chien, J, Cheon, DJ, Yang-Hartwich, Y, Nakshatri, H, Nephew, KP, Behringer, RR, Fernandez, FM, Cho, CH, Vanderhyden, B, Drapkin, R, Bast, RC, Miller, KD, Karpf, AR & Kim, J 2020, , PLoS Genetics, vol. 16, no. 6, e1008808.

Successful yolk-sac tumor treatment with fertility-sparing partial oophorectomy
Dunn, TN, Khazaeian, K, Coffey, D, Rohozinski, J, Kovanci, E, Edwards, CL & Tung, CS 2019, , Gynecologic Oncology Reports, vol. 27, pp. 22-24.

Cell origins of high-grade serous ovarian cancer
Kim, J, Park, EY, Kim, O, Schilder, JM, Coffey, D, Cho, CH & Bast, RC 2018, , Cancers, vol. 10, no. 11, 433.

Negative Pap tests in women with high-grade cervical lesions on follow-up biopsies: Contributing factors and role of human papillomavirus genotyping
Goodman, S, Mody, RR, Coffey, D, Gorman, B, Luna, E, Armylagos, D, Schwartz, MR, Mody, DR & Ge, Y 2018, , Diagnostic Cytopathology, vol. 46, no. 3, pp. 239-243.

Salivary Glands
Coffey, D & Ramzy, I 2018, . in I Ramzy, D Mody & R Laucirica (eds), Clinical Cytopathology, Fundamental Principles and Practice: Salivary Glands. 3rd edn, McGraw Hill Education, pp. 131-160.

The Utility of Core Needle Biopsy and Fine-Needle Aspiration in the Workup of Tumors of Suspected Müllerian Origin
Crumley, SM, Okoye, EI, Deavers, M & Coffey, D 2015, , Acta Cytologica, vol. 59, no. 6, pp. 465-473.

The ovary is an alternative site of origin for high-grade serous ovarian cancer in mice
Kim, J, Coffey, DM, Ma, L & Matzuk, MM 2015, , Endocrinology, vol. 156, no. 6, pp. 1975-1981.

In reply
Wright, AM, Mody, D & Coffey, DM 2014, , Archives of Pathology and Laboratory Medicine, vol. 138, no. 3, pp. 300-301.

Genotype-specific prevalence and distribution of human papillomavirus genotypes in underserved Latino women with abnormal Papanicolaou tests
Zhou, H, Mody, DR, Schwartz, MR, Coffey, DM, Smith, D, Zwain, OA, Kamarapu, NP, Brown, JB, Medina, M, Hodgson, SR, Hobday, CD & Ge, Y 2014, , Journal of the American Society of Cytopathology, vol. 3, no. 1, pp. 42-48.

PAX2 and PAX8: Useful markers for metastatic effusions
Waters, L, Crumley, SM, Truong, L, Mody, DR & Coffey, D 2014, , Acta Cytologica, vol. 58, no. 1, pp. 60-66.

Tumor-to-tumor metastasis with Endometrial carcinoma metastatic to squamous cell carcinoma of vulva: The first reported case
Wimmer, JL, Coffey, DM, Kaplan, AL, Ayala, AG & Ro, JY 2013, , Archives of Pathology and Laboratory Medicine, vol. 137, no. 12, pp. 1825-1828.

Expression and functional pathway analysis of nuclear receptor NR2F2 in ovarian cancer
Hawkins, SM, Loomans, HA, Wan, YW, Ghosh-Choudhury, T, Coffey, D, Xiao, W, Liu, Z, Sangi-Haghpeykar, H & Anderson, ML 2013, , Journal of Clinical Endocrinology and Metabolism, vol. 98, no. 7, pp. E1152-E1162.

Digital slide imaging in cervicovaginal cytology: A pilot study
Wright, AM, Smith, D, Dhurandhar, B, Fairley, T, Scheiber-Pacht, M, Chakraborty, S, Gorman, BK, Mody, D & Coffey, DM 2013, , Archives of Pathology and Laboratory Medicine, vol. 137, no. 5, pp. 618-624.

Should LSIL-H be a distinct cytology category? A study on the frequency and distribution of 40 human papillomavirus genotypes in 808 Women
Zhou, H, Schwartz, MR, Coffey, D, Smith, D, Mody, DR & Ge, Y 2012, , Cancer cytopathology, vol. 120, no. 6, pp. 373-379.

High-grade serous ovarian cancer arises from fallopian tube in a mouse model
Kim, J, Coffey, D, Creighton, CJ, Yu, Z, Hawkins, SM & Matzuk, MM 2012, , Proceedings of the National Academy of Sciences of the United States of America, vol. 109, no. 10, pp. 3921-3926.

Identification of tissue of origin in body fluid specimens using a gene expression microarray assay
Stance, GA, Coffey, D, Alvarez, K, Halks-Miller, M, Lal, A, Mody, D, Koen, T, Fairley, T & Monzon, FA 2012, , Cancer cytopathology, vol. 120, no. 1, pp. 62-70.

PAX2 and PAX8 expression in primary and metastatic müllerian epithelial tumors: A comprehensive comparison
Ozcan, A, Liles, N, Coffey, D, Shen, SS & Truong, LD 2011, , American Journal of Surgical Pathology, vol. 35, no. 12, pp. 1837-1847.

Clinicopathologic and immunohistochemical characteristics of adult primary cardiac angiosarcomas: Analysis of 10 cases
Ge, Y, Ro, JY, Kim, D, Kim, CH, Reardon, MJ, Blackmon, S, Zhai, J, Coffey, D, Benjamin, RS & Ayala, AG 2011, , Annals of Diagnostic Pathology, vol. 15, no. 4, pp. 262-267.

PAX 8 expression in non-neoplastic tissues, primary tumors, and metastatic tumors: A comprehensive immunohistochemical study
Ozcan, A, Shen, S, Hamilton, C, Anjana, K, Coffey, D, Krishnan, B & Truong, L 2011, , Modern Pathology, vol. 24, no. 6, pp. 751-764.