Decha Pinkaew

Decha Pinkaew, PhD

Assistant Research Professor of Medicine, Academic Institute
Assistant Research Member, Research Institute
Houston Methodist
Weill Cornell Medical College

Description of Research

Oxidative stress, Chronic obstructive pulmonary disease, Asthma, Asthma-COPD overlap

Areas Of Expertise

Oxidative stress COPD lung diseases
Education & Training

PhD, Prince of Songkla University
BSc, Mahidol University
Postdoctoral Fellowship, University of Texas Medical Branch

Tobacco, Second-Hand Smoke and Cancer
Pinkaew, D, Dammad, T, Bitar, M, Sahay, S & Folz, RJ 2023, . in EH Bernicker (ed.), Environmental Oncology : Theory and Impact. Springer, pp. 119-145.

Fortilin interacts with TGF-ß1 and prevents TGF-ß receptor activation
Pinkaew, D, Martinez-Hackert, E, Jia, W, King, MD, Miao, F, Enger, NR, Silakit, R, Ramana, K, Chen, SY & Fujise, K 2022, , Communications Biology, vol. 5, no. 1, 157, pp. 157.

GRP78/BiP determines senescence evasion cell fate after cisplatin-based chemotherapy
Ei, ZZ, Choochuay, K, Tubsuwan, A, Pinkaew, D, Suksomtip, M, Vinayanuwattikun, C, Chanvorachote, P & Chunhacha, P 2021, , Scientific Reports, vol. 11, no. 1, 22448.

Fortilin inhibits p53, halts cardiomyocyte apoptosis, and protects the heart against heart failure
Chunhacha, P, Pinkaew, D, Sinthujaroen, P, Bowles, DE & Fujise, K 2021, , Cell Death Discovery, vol. 7, no. 1, 310.

Ticagrelor induces paraoxonase-1 (PON1) and better protects hypercholesterolemic mice against atherosclerosis compared to clopidogrel
Halim, H, Pinkaew, D, Chunhacha, P, Sinthujaroen, P, Thiagarajan, P & Fujise, K 2018, , PLoS ONE, vol. 14, no. 6, e0218934.

Fortilin binds IRE1a and prevents ER stress from signaling apoptotic cell death
Pinkaew, D, Chattopadhyay, A, King, MD, Chunhacha, P, Liu, Z, Stevenson, HL, Chen, Y, Sinthujaroen, P, McDougal, OM & Fujise, K 2017, , Nature Communications, vol. 8, no. 1, 18.

Fortilin: A Potential Target for the Prevention and Treatment of Human Diseases
Pinkaew, D & Fujise, K 2017, . in Advances in Clinical Chemistry. Advances in Clinical Chemistry, vol. 82, Academic Press, pp. 265-300.

Fortilin potentiates the peroxidase activity of Peroxiredoxin-1 and protects against alcohol-induced liver damage in mice
Chattopadhyay, A, Pinkaew, D, Doan, HQ, Jacob, RB, Verma, SK, Friedman, H, Peterson, AC, Kuyumcu-Martinez, MN, McDougal, OM & Fujise, K 2016, , Scientific Reports, vol. 6, 18701.

Elevation of serum fortilin levels is specific for apoptosis and signifies cell death in vivo
Sinthujaroen, P, Wanachottrakul, N, Pinkaew, D, Petersen, JR, Phongdara, A, Sheffield-Moore, M & Fujise, K 2014, , BBA Clinical, vol. 2, pp. 103-111.

Fortilin reduces apoptosis in macrophages and promotes atherosclerosis
Pinkaew, D, Le, RJ, Chen, Y, Eltorky, M, Teng, BB & Fujise, K 2013, , American Journal of Physiology - Heart and Circulatory Physiology, vol. 305, no. 10, pp. H1519-H1529.

Insights into the Prostanoid Pathway in the Ovary Development of the Penaeid Shrimp Penaeus monodon
Wimuttisuk, W, Tobwor, P, Deenarn, P, Danwisetkanjana, K, Pinkaew, D, Kirtikara, K & Vichai, V 2013, , PLoS ONE, vol. 8, no. 10, e76934.

Morelloflavone, a biflavonoid inhibitor of migration-related kinases, ameliorates atherosclerosis in mice
Pinkaew, D, Hutadilok-Towatana, N, Teng, BB, Mahabusarakam, W & Fujise, K 2012, , American Journal of Physiology - Heart and Circulatory Physiology, vol. 302, no. 2, pp. H451-H458.

Physical and functional antagonism between tumor suppressor protein p53 and fortilin, an anti-apoptotic protein
Chen, Y, Fujita, T, Zhang, D, Doan, H, Pinkaew, D, Liu, Z, Wu, J, Koide, Y, Chiu, A, Lin, CCJ, Chang, JY, Ruan, KH & Fujise, K 2011, , Journal of Biological Chemistry, vol. 286, no. 37, pp. 32575-32585.

Morelloflavone from Garcinia dulcis as a novel biflavonoid inhibitor of HMG-CoA reductase
Tuansulong, KA, Hutadilok-Towatana, N, Mahabusarakam, W, Pinkaew, D & Fujise, K 2011, , Phytotherapy Research, vol. 25, no. 3, pp. 424-428.

Embryonic lethality of fortilin-null mutant mice by BMP-pathway overactivation
Koide, Y, Kiyota, T, Tonganunt, M, Pinkaew, D, Liu, Z, Kato, Y, Hutadilok-Towatana, N, Phongdara, A & Fujise, K 2009, , Biochimica et Biophysica Acta - General Subjects, vol. 1790, no. 5, pp. 326-338.

Morelloflavone, a biflavonoid, inhibits tumor angiogenesis by targeting Rho GTPases and extracellular signal-regulated kinase signaling pathways
Pang, X, Yi, T, Yi, Z, Cho, SG, Qu, W, Pinkaew, D, Fujise, K & Liu, M 2009, , Cancer research, vol. 69, no. 2, pp. 518-525.

Morelloflavone blocks injury-induced neointimal formation by inhibiting vascular smooth muscle cell migration
Pinkaew, D, Cho, SG, Hui, DY, Wiktorowicz, JE, Hutadilok-Towatana, N, Mahabusarakam, W, Tonganunt, M, Stafford, LJ, Phongdara, A, Liu, M & Fujise, K 2009, , Biochimica et Biophysica Acta - General Subjects, vol. 1790, no. 1, pp. 31-39.

Anti-atherogenic effects of morelloflavone from Garcinia dulcis leaves in cholesterol fed rabbits
Decha-Dier, U, Hutadilok-Towatana, N, Mahabusarakam, W, Sawangjaroen, K & Pinkaew, D 2008, , Journal of Natural Remedies, vol. 8, no. 2, pp. 151-159.

Human fortilin is a molecular target of dihydroartemisinin
Fujita, T, Felix, K, Pinkaew, D, Hutadilok-Towatana, N, Liu, Z & Fujise, K 2008, , FEBS Letters, vol. 582, no. 7, pp. 1055-1060.