Decha Pinkaew

Decha Pinkaew, PhD

Assistant Research Professor of Medicine, Academic Institute
Assistant Research Member, Research Institute
Houston Methodist
Weill Cornell Medical College


Description of Research

Oxidative stress, Chronic obstructive pulmonary disease, Asthma, Asthma-COPD overlap

Areas Of Expertise

Oxidative stress COPD lung diseases
Education & Training

PhD, Prince of Songkla University
BSc, Mahidol University
Postdoctoral Fellowship, University of Texas Medical Branch
Publications

Tobacco, Second-Hand Smoke and Cancer
Pinkaew, D, Dammad, T, Bitar, M, Sahay, S & Folz, RJ 2023, . in EH Bernicker (ed.), Environmental Oncology : Theory and Impact. Springer, pp. 119-145. https://doi.org/10.1007/978-3-031-33750-5_5

Fortilin interacts with TGF-ß1 and prevents TGF-ß receptor activation
Pinkaew, D, Martinez-Hackert, E, Jia, W, King, MD, Miao, F, Enger, NR, Silakit, R, Ramana, K, Chen, SY & Fujise, K 2022, , Communications Biology, vol. 5, no. 1, 157, pp. 157. https://doi.org/10.1038/s42003-022-03112-6

GRP78/BiP determines senescence evasion cell fate after cisplatin-based chemotherapy
Ei, ZZ, Choochuay, K, Tubsuwan, A, Pinkaew, D, Suksomtip, M, Vinayanuwattikun, C, Chanvorachote, P & Chunhacha, P 2021, , Scientific Reports, vol. 11, no. 1, 22448. https://doi.org/10.1038/s41598-021-01540-8

Fortilin inhibits p53, halts cardiomyocyte apoptosis, and protects the heart against heart failure
Chunhacha, P, Pinkaew, D, Sinthujaroen, P, Bowles, DE & Fujise, K 2021, , Cell Death Discovery, vol. 7, no. 1, 310. https://doi.org/10.1038/s41420-021-00692-w

Ticagrelor induces paraoxonase-1 (PON1) and better protects hypercholesterolemic mice against atherosclerosis compared to clopidogrel
Halim, H, Pinkaew, D, Chunhacha, P, Sinthujaroen, P, Thiagarajan, P & Fujise, K 2018, , PLoS ONE, vol. 14, no. 6, e0218934. https://doi.org/10.1371/journal.pone.0218934

Fortilin binds IRE1a and prevents ER stress from signaling apoptotic cell death
Pinkaew, D, Chattopadhyay, A, King, MD, Chunhacha, P, Liu, Z, Stevenson, HL, Chen, Y, Sinthujaroen, P, McDougal, OM & Fujise, K 2017, , Nature Communications, vol. 8, no. 1, 18. https://doi.org/10.1038/s41467-017-00029-1

Fortilin: A Potential Target for the Prevention and Treatment of Human Diseases
Pinkaew, D & Fujise, K 2017, . in Advances in Clinical Chemistry. Advances in Clinical Chemistry, vol. 82, Academic Press, pp. 265-300. https://doi.org/10.1016/bs.acc.2017.06.006

Fortilin potentiates the peroxidase activity of Peroxiredoxin-1 and protects against alcohol-induced liver damage in mice
Chattopadhyay, A, Pinkaew, D, Doan, HQ, Jacob, RB, Verma, SK, Friedman, H, Peterson, AC, Kuyumcu-Martinez, MN, McDougal, OM & Fujise, K 2016, , Scientific Reports, vol. 6, 18701. https://doi.org/10.1038/srep18701

Elevation of serum fortilin levels is specific for apoptosis and signifies cell death in vivo
Sinthujaroen, P, Wanachottrakul, N, Pinkaew, D, Petersen, JR, Phongdara, A, Sheffield-Moore, M & Fujise, K 2014, , BBA Clinical, vol. 2, pp. 103-111. https://doi.org/10.1016/j.bbacli.2014.10.002

Fortilin reduces apoptosis in macrophages and promotes atherosclerosis
Pinkaew, D, Le, RJ, Chen, Y, Eltorky, M, Teng, BB & Fujise, K 2013, , American Journal of Physiology - Heart and Circulatory Physiology, vol. 305, no. 10, pp. H1519-H1529. https://doi.org/10.1152/ajpheart.00570.2013

Insights into the Prostanoid Pathway in the Ovary Development of the Penaeid Shrimp Penaeus monodon
Wimuttisuk, W, Tobwor, P, Deenarn, P, Danwisetkanjana, K, Pinkaew, D, Kirtikara, K & Vichai, V 2013, , PLoS ONE, vol. 8, no. 10, e76934. https://doi.org/10.1371/journal.pone.0076934

Morelloflavone, a biflavonoid inhibitor of migration-related kinases, ameliorates atherosclerosis in mice
Pinkaew, D, Hutadilok-Towatana, N, Teng, BB, Mahabusarakam, W & Fujise, K 2012, , American Journal of Physiology - Heart and Circulatory Physiology, vol. 302, no. 2, pp. H451-H458. https://doi.org/10.1152/ajpheart.00669.2011

Physical and functional antagonism between tumor suppressor protein p53 and fortilin, an anti-apoptotic protein
Chen, Y, Fujita, T, Zhang, D, Doan, H, Pinkaew, D, Liu, Z, Wu, J, Koide, Y, Chiu, A, Lin, CCJ, Chang, JY, Ruan, KH & Fujise, K 2011, , Journal of Biological Chemistry, vol. 286, no. 37, pp. 32575-32585. https://doi.org/10.1074/jbc.M110.217836

Morelloflavone from Garcinia dulcis as a novel biflavonoid inhibitor of HMG-CoA reductase
Tuansulong, KA, Hutadilok-Towatana, N, Mahabusarakam, W, Pinkaew, D & Fujise, K 2011, , Phytotherapy Research, vol. 25, no. 3, pp. 424-428. https://doi.org/10.1002/ptr.3286

Embryonic lethality of fortilin-null mutant mice by BMP-pathway overactivation
Koide, Y, Kiyota, T, Tonganunt, M, Pinkaew, D, Liu, Z, Kato, Y, Hutadilok-Towatana, N, Phongdara, A & Fujise, K 2009, , Biochimica et Biophysica Acta - General Subjects, vol. 1790, no. 5, pp. 326-338. https://doi.org/10.1016/j.bbagen.2009.01.012

Morelloflavone, a biflavonoid, inhibits tumor angiogenesis by targeting Rho GTPases and extracellular signal-regulated kinase signaling pathways
Pang, X, Yi, T, Yi, Z, Cho, SG, Qu, W, Pinkaew, D, Fujise, K & Liu, M 2009, , Cancer research, vol. 69, no. 2, pp. 518-525. https://doi.org/10.1158/0008-5472.CAN-08-2531

Morelloflavone blocks injury-induced neointimal formation by inhibiting vascular smooth muscle cell migration
Pinkaew, D, Cho, SG, Hui, DY, Wiktorowicz, JE, Hutadilok-Towatana, N, Mahabusarakam, W, Tonganunt, M, Stafford, LJ, Phongdara, A, Liu, M & Fujise, K 2009, , Biochimica et Biophysica Acta - General Subjects, vol. 1790, no. 1, pp. 31-39. https://doi.org/10.1016/j.bbagen.2008.09.006

Anti-atherogenic effects of morelloflavone from Garcinia dulcis leaves in cholesterol fed rabbits
Decha-Dier, U, Hutadilok-Towatana, N, Mahabusarakam, W, Sawangjaroen, K & Pinkaew, D 2008, , Journal of Natural Remedies, vol. 8, no. 2, pp. 151-159.

Human fortilin is a molecular target of dihydroartemisinin
Fujita, T, Felix, K, Pinkaew, D, Hutadilok-Towatana, N, Liu, Z & Fujise, K 2008, , FEBS Letters, vol. 582, no. 7, pp. 1055-1060. https://doi.org/10.1016/j.febslet.2008.02.055