David J. Lim, MD

Assistant Professor of Clinical Urology, Institute for Academic Medicine
Houston Methodist
Weill Cornell Medical College


Publications

In reference to A new theory on the pathogenesis of acquired cholesteatoma: Mucosal traction
Chole, RA & Lim, DJ 2016, Laryngoscope, vol. 126, no. 3, pp. E129-E130. https://doi.org/10.1002/lary.25651

Erdosteine protects HEI-OC1 auditory cells from cisplatin toxicity through suppression of inflammatory cytokines and induction of Nrf2 target proteins
Kim, SJ, Park, C, Lee, JN, Lim, H, Hong, GY, Moon, SK, Lim, DJ, Choe, SK & Park, R 2015, Toxicology and Applied Pharmacology, vol. 288, no. 2, pp. 192-202. https://doi.org/10.1016/j.taap.2015.07.014

Intratympanic Gene Delivery of Antimicrobial Molecules in Otitis Media
Moon, SK & Lim, DJ 2015, Current Allergy and Asthma Reports, vol. 15, no. 4, 14. https://doi.org/10.1007/s11882-015-0517-1

Middle Ear and Eustachian Tube Mucosal Immunology
Massa, HM, Lim, DJ, Kurono, Y & Cripps, AW 2015, . in Mucosal Immunology: Fourth Edition. vol. 2-2, Elsevier, pp. 1923-1942. https://doi.org/10.1016/B978-0-12-415847-4.00101-4

IL-10/HMOX1 signaling modulates cochlear inflammation via negative regulation of MCP-1/CCL2 expression in cochlear fibrocytes
Woo, JI, Kil, SH, Oh, S, Lee, YJ, Park, R, Lim, DJ & Moon, SK 2015, Journal of Immunology, vol. 194, no. 8, pp. 3953-3961. https://doi.org/10.4049/jimmunol.1402751

Bucillamine prevents cisplatin-induced ototoxicity through induction of glutathione and antioxidant genes
Kim, SJ, Hur, JH, Park, C, Kim, HJ, Oh, GS, Lee, JN, Yoo, SJ, Choe, SK, So, HS, Lim, DJ, Moon, SK & Park, R 2015, Experimental and Molecular Medicine, vol. 47, no. 2, e142. https://doi.org/10.1038/emm.2014.112

Therapeutic potential of adenovirus-mediated delivery of ß-defensin 2 for experimental otitis media
Woo, JI, Kil, SH, Brough, DE, Lee, YJ, Lim, DJ & Moon, SK 2015, Innate Immunity, vol. 21, no. 2, pp. 215-224. https://doi.org/10.1177/1753425914534002

NOD2/RICK-dependent ß-defensin 2 regulation is protective for nontypeable Haemophilus influenzae-induced middle ear infection
Woo, JI, Oh, S, Webster, P, Lee, YJ, Lim, DJ & Moon, SK 2014, PloS one, vol. 9, no. 3, e90933. https://doi.org/10.1371/journal.pone.0090933

Distal NF-kB binding motif functions as an enhancer for nontypeable H. influenzae-induced DEFB4 regulation in epithelial cells
Woo, JI, Kil, SH, Pan, H, Lee, YJ, Lim, DJ & Moon, SK 2014, Biochemical and Biophysical Research Communications, vol. 443, no. 3, pp. 1035-1040. https://doi.org/10.1016/j.bbrc.2013.12.091

Panel 4: Recent advances in otitis media in molecular biology, biochemistry, genetics, and animal models
Li, JD, Hermansson, A, Ryan, AF, Bakaletz, LO, Brown, SD, Cheeseman, MT, Juhn, SK, Jung, TTK, Lim, DJ, Lim, JH, Lin, J, Moon, SK & Post, JC 2013, Otolaryngology - Head and Neck Surgery (United States), vol. 148, no. 4 SUPPL.. https://doi.org/10.1177/0194599813479772

Panel 8: Complications and sequelae
Jung, TTK, Alper, CM, Hellstrom, SO, Hunter, LL, Casselbrant, ML, Groth, A, Kemaloglu, YK, Kim, SG, Lim, DJ, Nittrouer, S, Hyun Park, K, Sabo, D & Spratley, J 2013, Otolaryngology - Head and Neck Surgery (United States), vol. 148, no. 4 SUPPL.. https://doi.org/10.1177/0194599812467425

Panel 3: Recent advances in anatomy, pathology, and cell biology in relation to otitis media pathogenesis
Caye-Thomasen, P, Hermansson, A, Bakaletz, L, Hellstrm, S, Kanzaki, S, Kerschner, J, Lim, DJ, Lin, J, Mason, K & Spratley, J 2013, Otolaryngology - Head and Neck Surgery (United States), vol. 148, no. 4 SUPPL.. https://doi.org/10.1177/0194599813476257

Intranasal immunization of the combined Lipooligosaccharide conjugates protects mice from the challenges with three serotypes of Moraxella catarrhalis
Ren, D, Xie, H, Zhang, W, Hassan, F, Petralia, RS, Yu, S, Lim, DJ & Gu, XX 2011, PloS one, vol. 6, no. 12, e29553. https://doi.org/10.1371/journal.pone.0029553

Establishment of cell lines from the human middle and inner ear epithelial cells
Lim, DJ & Moon, SK 2011, . in J Rhim & R Kremer (eds), Human Cell Transformation: Role of Stem Cells and the Microenvironment. Advances in Experimental Medicine and Biology, vol. 720, pp. 15-25. https://doi.org/10.1007/978-1-4614-0254-1_2

Mutant lipooligosaccharide-based conjugate vaccine demonstrates a broad-spectrum effectiveness against Moraxella catarrhalis
Ren, D, Yu, S, Gao, S, Peng, D, Petralia, RS, Muszynski, A, Carlson, RW, Robbins, JB, Tsai, CM, Lim, DJ & Gu, XX 2011, Vaccine, vol. 29, no. 25, pp. 4210-4217. https://doi.org/10.1016/j.vaccine.2011.03.102

Cisplatin ototoxicity involves cytokines and STAT6 signaling network
Kim, HJ, Oh, GS, Lee, JH, Lyu, AR, Ji, HM, Lee, SH, Song, J, Park, SJ, You, YO, Sul, JD, Park, C, Chung, SY, Moon, SK, Lim, DJ, So, HS & Park, R 2011, Cell Research, vol. 21, no. 6, pp. 944-956. https://doi.org/10.1038/cr.2011.27

Spiral ligament fibrocyte-derived MCP-1/CCL2 contributes to inner ear inflammation secondary to nontypeable H. influenzae-induced otitis media
Woo, JI, Pan, H, Oh, S, Lim, DJ & Moon, SK 2010, BMC Infectious Diseases, vol. 10, 314. https://doi.org/10.1186/1471-2334-10-314

Lysozyme M deficiency leads to an increased susceptibility to Streptococcus pneumoniae-induced otitis media
Shimada, J, Moon, SK, Lee, HY, Takeshita, T, Pan, H, Woo, JI, Gellibolian, R, Yamanaka, N & Lim, DJ 2008, BMC Infectious Diseases, vol. 8, 134. https://doi.org/10.1186/1471-2334-8-134

Induction of beta defensin 2 by NTHi requires TLR2 mediated MyD88 and IRAK-TRAF6-p38MAPK signaling pathway in human middle ear epithelial cells
Lee, HY, Takeshita, T, Shimada, J, Akopyan, A, Woo, JI, Pan, H, Moon, SK, Andalibi, A, Park, RK, Kang, SH, Kang, SS, Gellibolian, R & Lim, DJ 2008, BMC Infectious Diseases, vol. 8, 87. https://doi.org/10.1186/1471-2334-8-87

Cisplatin cytotoxicity of auditory cells requires secretions of proinflammatory cytokines via activation of ERK and NF-?B
So, H, Kim, HJ, Lee, JH, Park, C, Kim, Y, Kim, E, Kim, JK, Yun, KJ, Lee, KM, Lee, HY, Moon, SK, Lim, DJ & Park, R 2007, JARO - Journal of the Association for Research in Otolaryngology, vol. 8, no. 3, pp. 338-355. https://doi.org/10.1007/s10162-007-0084-9

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