David P. Huston, MD

W. Bryan Trammell Jr. Family Presidential Distinguished Chair in Allergy and Immunology, Department of Medicine
Director, Immunology Center
Full Affiliate Member, Research Institute
Houston Methodist


Biography

After completing his subspecialty training at the National Institutes of Health in 1980, Dr. Huston joined the faculty at the Baylor College of Medicine in Houston, Texas. While at Baylor, he became a full Professor of Medicine and Immunology, and held numerous leadership positions including the Cullen Chair of Immunology, the chief of the Immunology, Allergy, and Rheumatology Section, and director of the Immunology, Allergy, and Rheumatology Service at Houston Methodist Hospital. Dr. Huston also directed several training programs including the Allergy and Immunology Fellowship Training Program, the Clinical and Laboratory Immunology Fellowship Training Program, the Rheumatology Fellowship Training Program, the Translational Biology and Molecular Medicine Training Program in the Graduate School of Biomedical Sciences, and the Howard Hughes Medical Research Institute Grad into Med Program. He assumed his current positions at the Texas A&M Health Science Center in 2008. Dr. Huston serves on the American Board of Internal Medicine and the American Board of Allergy and Immunology, is a member of the American Association of Physicians, and consistently recognized as among the Best Doctors in America.

Description of Research

Dr. Huston’s research centers on the study of various mechanisms of allergic inflammation, utilizing basic science, pre-clinical, and clinical studies. He has been the principal investigator on several NIH grants, including an 11-year R01 from the National Institutes of Allergy and Infectious Diseases that defined the functional structure of Interleukin-5. Dr. Huston’s current studies investigate the role of human thymic stromal lymphopoietin in the development and maintenance of the Th2 immune response that dominates the allergic phenotype. Additional studies investigate the mechanisms of immune regulation in autoimmune and immune deficiency disorders.

Areas Of Expertise

Inflammation Immunology Cytokines Allergy Immunodeficiency
Publications

Epithelial immunomodulation by aerosolized Toll-like receptor agonists prevents allergic inflammation in airway mucosa in mice
Goldblatt, DL, Valverde Ha, G, Wali, S, Kulkarni, VV, Longmire, MK, Jaramillo, AM, Chittuluru, RP, Fouts, A, Martinez-Moczygemba, M, Lei, JT, Huston, DP, Tuvim, MJ, Dickey, BF & Evans, SE 2022, , Frontiers in Pharmacology, vol. 13, 833380. https://doi.org/10.3389/fphar.2022.833380

Guiding Preclinical Medical Students in Finding, Synthesizing, and Communicating Translational Basic Research Literature: Roles for Basic Science Research Mentors
Maxwell, SA, Fuchs-Young, R, Wells, GB, Kapler, GM, Conover, GM, Green, S, Pepper, C, Gastel, B & Huston, DP 2022, , Academic Medicine, vol. 97, no. 5, pp. 684-688. https://doi.org/10.1097/ACM.0000000000004511

Emerging biomaterial-based strategies for personalized therapeutic in situ cancer vaccines
Viswanath, DI, Liu, HC, Huston, DP, Chua, CYX & Grattoni, A 2022, , Biomaterials, vol. 280, 121297. https://doi.org/10.1016/j.biomaterials.2021.121297, https://doi.org/10.1016/j.biomaterials.2021.121297

Emerging biomaterial-based strategies for personalized therapeutic in situ cancer vaccines
Viswanath, DI, Liu, HC, Huston, DP, Chua, CYX & Grattoni, A 2022, , Biomaterials, vol. 280, 121297. https://doi.org/10.1016/j.biomaterials.2021.121297

Guiding Preclinical Medical Students in Finding, Synthesizing, and Communicating Translational Basic Research Literature: Roles for Basic Science Research Mentors
Maxwell, SA, Fuchs-Young, R, Wells, GB, Kapler, GM, Conover, GM, Green, S, Pepper, C, Gastel, B & Huston, DP 2021, , Academic medicine : journal of the Association of American Medical Colleges. https://doi.org/10.1097/ACM.0000000000004511

Innovations in MD-only physician-scientist training: Experiences from the Burroughs Wellcome Fund physician-scientist institutional award initiative
McElvaine, AT, Hawkins-Salsbury, JA, Arora, VM, Gladwin, MT, Goldenring, JR, Huston, DP, Krakow, D, Rhee, K, Solway, J, Steinman, RA, Towler, DA, Utz, PJ, Yokoyama, WM, Simpson, RL, Muglia, LJ, Permar, SR & Gbadegesin, RA 2021, , Journal of Clinical Investigation, vol. 131, no. 10, e149948. https://doi.org/10.1172/JCI149948

Unneutral neutrophils in patients with late-phase allergic reactions
Huston, DP 2019, , Journal of Allergy and Clinical Immunology, vol. 144, no. 1, pp. 46-48. https://doi.org/10.1016/j.jaci.2019.03.023

Decoding the Enigma of Urticaria and Angioedema
Huston, DP & Sabato, V 2018, , Journal of Allergy and Clinical Immunology: In Practice, vol. 6, no. 4, pp. 1171-1175. https://doi.org/10.1016/j.jaip.2018.06.001

Evidence-based evaluation for allergies to avoid inappropriate testing, diagnosis, and treatment
Huston, DP & Cox, LS 2014, , JAMA Internal Medicine, vol. 174, no. 8, pp. 1223-1224. https://doi.org/10.1001/jamainternmed.2014.1413

Emerging role of human basophil biology in health and disease
Cromheecke, JL, Nguyen, KT & Huston, DP 2014, , Current Allergy and Asthma Reports, vol. 14, no. 1, 408. https://doi.org/10.1007/s11882-013-0408-2

Therapeutic strategies for harnessing human eosinophils in allergic inflammation, hypereosinophilic disorders, and cancer
Amini-Vaughan, ZJ, Martinez-Moczygemba, M & Huston, DP 2012, , Current Allergy and Asthma Reports, vol. 12, no. 5, pp. 402-412. https://doi.org/10.1007/s11882-012-0290-3

Defects in interleukin-17 immunity in the pathogenesis of chronic mucocutaneous candidiasis
Huston, DP 2011, , Current Allergy and Asthma Reports, vol. 11, no. 5, pp. 342-344. https://doi.org/10.1007/s11882-011-0209-4

A novel subset of CD4+ TH2 memory/ effector cells that produce inflammatory IL-17 cytokine and promote the exacerbation of chronic allergic asthma
Wang, YH, Voo, KS, Liu, B, Chen, CY, Uygungil, B, Spoede, W, Bernstein, JA, Huston, DP & Liu, YJ 2010, , Journal of Experimental Medicine, vol. 207, no. 11, pp. 2479-2491. https://doi.org/10.1084/jem.20101376

Immune dysregulation in the pathogenesis of pulmonary alveolar proteinosis
Martinez-Moczygemba, M & Huston, DP 2010, , Current Allergy and Asthma Reports, vol. 10, no. 5, pp. 320-325. https://doi.org/10.1007/s11882-010-0134-y

Defective B-cell response to toll-like receptor-9 ligands in common variable immunodeficiency
Patel, JY, Singh, SK & Huston, DP 2010, , Current Allergy and Asthma Reports, vol. 10, no. 5, pp. 303-305. https://doi.org/10.1007/s11882-010-0135-x

T-regulatory cells in common variable immunodeficiency: Comments
Komarla, A, Patel, JY & Huston, DP 2009, , Current Allergy and Asthma Reports, vol. 9, no. 5, pp. 335-336. https://doi.org/10.1007/s11882-009-0059-5

Pulmonary alveolar proteinosis caused by deletion of the GM-CSFRa gene in the X chromosome pseudoautosomal region 1
Martinez-Moczygemba, M, Doan, ML, Elidemir, O, Fan, LL, Cheung, SW, Lei, JT, Moore, JP, Tavana, G, Lewis, LR, Zhu, Y, Muzny, DM, Gibbs, RA & Huston, DP 2008, , Journal of Experimental Medicine, vol. 205, no. 12, pp. 2711-2716. https://doi.org/10.1084/jem.20080759

Immune dysfunction in autoimmune pulmonary alveolar proteinosis
Singh, SK, Galicia, DG & Huston, DP 2007, , Current Allergy and Asthma Reports, vol. 7, no. 5, pp. 319-322. https://doi.org/10.1007/s11882-007-0048-5

IL-25 augments type 2 immune responses by enhancing the expansion and functions of TSLP-DC-activated Th2 memory cells
Wang, YH, Angkasekwinai, P, Lu, N, Voo, KS, Arima, K, Hanabuchi, S, Hippe, A, Corrigan, CJ, Dong, C, Homey, B, Yao, Z, Ying, S, Huston, DP & Liu, YJ 2007, , Journal of Experimental Medicine, vol. 204, no. 8, pp. 1837-1847. https://doi.org/10.1084/jem.20070406

JAK kinases control IL-5 receptor ubiquitination, degradation, and internalization
Martinez-Moczygemba, M, Huston, DP & Lei, JT 2007, , Journal of Leukocyte Biology, vol. 81, no. 4, pp. 1137-1148. https://doi.org/10.1189/jlb.0706465