David P. Huston, MD

W. Bryan Trammell Jr. Family Presidential Distinguished Chair in Allergy and Immunology, Department of Medicine
Full Affiliate Member, Research Institute
Director, Immunology Center
Houston Methodist


After completing his subspecialty training at the National Institutes of Health in 1980, Dr. Huston joined the faculty at the Baylor College of Medicine in Houston, Texas. While at Baylor, he became a full Professor of Medicine and Immunology, and held numerous leadership positions including the Cullen Chair of Immunology, the chief of the Immunology, Allergy, and Rheumatology Section, and director of the Immunology, Allergy, and Rheumatology Service at Houston Methodist Hospital. Dr. Huston also directed several training programs including the Allergy and Immunology Fellowship Training Program, the Clinical and Laboratory Immunology Fellowship Training Program, the Rheumatology Fellowship Training Program, the Translational Biology and Molecular Medicine Training Program in the Graduate School of Biomedical Sciences, and the Howard Hughes Medical Research Institute Grad into Med Program. He assumed his current positions at the Texas A&M Health Science Center in 2008. Dr. Huston serves on the American Board of Internal Medicine and the American Board of Allergy and Immunology, is a member of the American Association of Physicians, and consistently recognized as among the Best Doctors in America.

Description of Research

Dr. Huston’s research centers on the study of various mechanisms of allergic inflammation, utilizing basic science, pre-clinical, and clinical studies. He has been the principal investigator on several NIH grants, including an 11-year R01 from the National Institutes of Allergy and Infectious Diseases that defined the functional structure of Interleukin-5. Dr. Huston’s current studies investigate the role of human thymic stromal lymphopoietin in the development and maintenance of the Th2 immune response that dominates the allergic phenotype. Additional studies investigate the mechanisms of immune regulation in autoimmune and immune deficiency disorders.

Areas Of Expertise

Inflammation Immunology Cytokines Allergy Immunodeficiency

Unneutral neutrophils in patients with late-phase allergic reactions
Huston, DP 2019, , Journal of Allergy and Clinical Immunology, vol. 144, no. 1, pp. 46-48. https://doi.org/10.1016/j.jaci.2019.03.023

Decoding the Enigma of Urticaria and Angioedema
Huston, DP & Sabato, V 2018, , Journal of Allergy and Clinical Immunology: In Practice, vol. 6, no. 4, pp. 1171-1175. https://doi.org/10.1016/j.jaip.2018.06.001

Evidence-based evaluation for allergies to avoid inappropriate testing, diagnosis, and treatment
Huston, DP & Cox, LS 2014, , JAMA Internal Medicine, vol. 174, no. 8, pp. 1223-1224. https://doi.org/10.1001/jamainternmed.2014.1413

Emerging role of human basophil biology in health and disease
Cromheecke, JL, Nguyen, KT & Huston, DP 2014, , Current Allergy and Asthma Reports, vol. 14, no. 1, 408. https://doi.org/10.1007/s11882-013-0408-2

Therapeutic strategies for harnessing human eosinophils in allergic inflammation, hypereosinophilic disorders, and cancer
Amini-Vaughan, ZJ, Martinez-Moczygemba, M & Huston, DP 2012, , Current Allergy and Asthma Reports, vol. 12, no. 5, pp. 402-412. https://doi.org/10.1007/s11882-012-0290-3

Defects in interleukin-17 immunity in the pathogenesis of chronic mucocutaneous candidiasis
Huston, DP 2011, , Current Allergy and Asthma Reports, vol. 11, no. 5, pp. 342-344. https://doi.org/10.1007/s11882-011-0209-4

A novel subset of CD4+ TH2 memory/ effector cells that produce inflammatory IL-17 cytokine and promote the exacerbation of chronic allergic asthma
Wang, YH, Voo, KS, Liu, B, Chen, CY, Uygungil, B, Spoede, W, Bernstein, JA, Huston, DP & Liu, YJ 2010, , Journal of Experimental Medicine, vol. 207, no. 11, pp. 2479-2491. https://doi.org/10.1084/jem.20101376

Immune dysregulation in the pathogenesis of pulmonary alveolar proteinosis
Martinez-Moczygemba, M & Huston, DP 2010, , Current Allergy and Asthma Reports, vol. 10, no. 5, pp. 320-325. https://doi.org/10.1007/s11882-010-0134-y

Defective B-cell response to toll-like receptor-9 ligands in common variable immunodeficiency
Patel, JY, Singh, SK & Huston, DP 2010, , Current Allergy and Asthma Reports, vol. 10, no. 5, pp. 303-305. https://doi.org/10.1007/s11882-010-0135-x

T-regulatory cells in common variable immunodeficiency: Comments
Komarla, A, Patel, JY & Huston, DP 2009, , Current Allergy and Asthma Reports, vol. 9, no. 5, pp. 335-336. https://doi.org/10.1007/s11882-009-0059-5

Pulmonary alveolar proteinosis caused by deletion of the GM-CSFRa gene in the X chromosome pseudoautosomal region 1
Martinez-Moczygemba, M, Doan, ML, Elidemir, O, Fan, LL, Cheung, SW, Lei, JT, Moore, JP, Tavana, G, Lewis, LR, Zhu, Y, Muzny, DM, Gibbs, RA & Huston, DP 2008, , Journal of Experimental Medicine, vol. 205, no. 12, pp. 2711-2716. https://doi.org/10.1084/jem.20080759

Immune dysfunction in autoimmune pulmonary alveolar proteinosis
Singh, SK, Galicia, DG & Huston, DP 2007, , Current Allergy and Asthma Reports, vol. 7, no. 5, pp. 319-322. https://doi.org/10.1007/s11882-007-0048-5

IL-25 augments type 2 immune responses by enhancing the expansion and functions of TSLP-DC-activated Th2 memory cells
Wang, YH, Angkasekwinai, P, Lu, N, Voo, KS, Arima, K, Hanabuchi, S, Hippe, A, Corrigan, CJ, Dong, C, Homey, B, Yao, Z, Ying, S, Huston, DP & Liu, YJ 2007, , Journal of Experimental Medicine, vol. 204, no. 8, pp. 1837-1847. https://doi.org/10.1084/jem.20070406

JAK kinases control IL-5 receptor ubiquitination, degradation, and internalization
Martinez-Moczygemba, M, Huston, DP & Lei, JT 2007, , Journal of Leukocyte Biology, vol. 81, no. 4, pp. 1137-1148. https://doi.org/10.1189/jlb.0706465

Update in allergy and immunology
Huston, DP 2006, , Annals of Internal Medicine, vol. 145, no. 6, pp. 454-458. https://doi.org/10.7326/0003-4819-145-6-200609190-00009

Thymic stromal lymphopoietin: A potential therapeutic target for allergy and asthma
Huston, DP & Liu, YJ 2006, , Current Allergy and Asthma Reports, vol. 6, no. 5, pp. 372-376. https://doi.org/10.1007/s11882-996-0006-7

CXCL13 neutralization reduces the severity of collagen-induced arthritis
Zheng, B, Ozen, Z, Zhang, X, De Silva, S, Marinova, E, Guo, L, Wansley, D, Huston, DP, West, MR & Han, S 2005, , Arthritis and Rheumatism, vol. 52, no. 2, pp. 620-626. https://doi.org/10.1002/art.20768

Reduction of the incidence and severity of collagen-induced arthritis by constitutive Nur77 expression in the T cell lineage
De Silva, S, Han, S, Zhang, X, Huston, DP, Winoto, A & Zheng, B 2005, , Arthritis and Rheumatism, vol. 52, no. 1, pp. 333-338. https://doi.org/10.1002/art.20736

Fostering interdisciplinary immunology
Huston, DP, Utz, PJ & Fathman, CG 2005, , Clinical Immunology, vol. 115, no. 1 SPEC. ISS. pp. 1-2. https://doi.org/10.1016/j.clim.2005.02.012

Increased noncanonical splicing of autoantigen transcripts provides the structural basis for expression of untolerized epitopes
Ng, B, Yang, F, Huston, DP, Yan, Y, Yang, Y, Xiong, Z, Peterson, LE, Wang, H & Yang, XF 2004, , Journal of Allergy and Clinical Immunology, vol. 114, no. 6, pp. 1463-1470. https://doi.org/10.1016/j.jaci.2004.09.006