David M. Brown, MD

Associate Professor of Clinical Ophthalmology, Institute for Academic Medicine
Associate Clinical Member, Research Institute
Houston Methodist
Weill Cornell Medical College


Biography

After completing his postdoctoral training, Dr. Brown joined the faculty at the Baylor College of Medicine as a Clinical Instructor in the Department of Ophthalmology. He received his faculty appointment at the Weill Medical College in 2006.

Description of Research

Dr. Brown’s research centers on clinical investigations to evaluate treatments for diabetic retinopathy, neovascular age-related macular degeneration, central retinal vein occlusion, and retinal detachment. Dr. Brown was a key investigator on the Anti-VEGF Antibody for the Treatment of Predominantly Classic Choroidal Neovascularization in Age-related Macular Degeneration (ANCHOR) Study and the Minimally classic/occult trial of the anti-VEGF antibody ranibizumab in the treatment of neovascular AMD (MARINA) Study which both demonstrated a statistically significant benefit of Lucentis (ranibizumab) over Visudyne (verteporfin photodynamic therapy [PDT]) in predominantly classic choroidal neovascularization (CNV). Dr. Brown is also a member of the Diabetic Retinopathy Clinical Research Network.

Areas Of Expertise

Diabetic retinopathy Neovascular age-related macular degeneration Central retinal vein occlusion Retinal detachment
Education & Training

MD, Baylor College of Medicine
Internship, Baylor College of Medicine
Clinical Fellowship
Residency, University of Iowa Hospitals and Clinics
Publications

Retinopathy Regression with Treat and Extend Ranibizumab for Diabetic Macular Edema
Payne, JF, Clark, WL, Bruce, BB, Wykoff, CC, Brown, DM, Menke, BM, Iverson, SM, Allen, KF, Boyer, DS & Treat & Extend Protocol in Patients with Diabetic Macular Edema Study Group 2018, Ophthalmology. DOI: 10.1016/j.ophtha.2018.03.046

Long-term outcomes with as-needed aflibercept in diabetic macular oedema: 2-year outcomes of the ENDURANCE extension study
Wykoff, CC, Ou, WC, Khurana, RN, Brown, DM, Lloyd Clark, W, Boyer, DS & ENDURANCE Study Group 2018, British Journal of Ophthalmology, vol 102, no. 5, pp. 631-636. DOI: 10.1136/bjophthalmol-2017-310941

Long-term outcomes with as-needed aflibercept in diabetic macular oedema: 2-year outcomes of the ENDURANCE extension study
Wykoff, CC, Ou, WC, Khurana, RN, Brown, DM, Lloyd Clark, W & Boyer, DS 2018, British Journal of Ophthalmology, vol 102, no. 5, pp. 631-636. DOI: 10.1136/bjophthalmol-2017-310941

Changes in retinal ischaemic index correlate with recalcitrant macular oedema in retinal vein occlusion: WAVE study
Kwon, S, Wykoff, CC, Brown, DM, van Hemert, J, Fan, W & Sadda, SR 2018, British Journal of Ophthalmology. DOI: 10.1136/bjophthalmol-2017-311475

Neovascular age-related macular degeneration management in the third year: Final results from the TREX-AMD randomised trial
Wykoff, CC, Ou, WC, Croft, DE, Payne, JF, Brown, DM, Clark, WL, Abdelfattah, NS & Sadda, SVR 2018, British Journal of Ophthalmology, vol 102, no. 4, pp. 460-464. DOI: 10.1136/bjophthalmol-2017-310822

Targeted Retinal Photocoagulation for Diabetic Macular Edema with Peripheral Retinal Nonperfusion. Three-Year Randomized DAVE Trial
Brown, DM, Ou, WC, Wong, TP, Kim, RY, Croft, DE & Wykoff, CC 2018, Ophthalmology. DOI: 10.1016/j.ophtha.2017.11.026

Intravitreal aflibercept for proliferative diabetic retinopathy
Brown, DM & Wykoff, CC 2017, The Lancet, vol 390, no. 10108. DOI: 10.1016/S0140-6736(17)32445-5

Relationship Between Visual Acuity and Retinal Thickness During Anti–Vascular Endothelial Growth Factor Therapy for Retinal Diseases
Ou, WC, Brown, DM, Payne, JF & Wykoff, CC 2017, American Journal of Ophthalmology, vol 180, pp. 8-17. DOI: 10.1016/j.ajo.2017.05.014

Distribution of Nonperfusion Area on Ultra-widefield Fluorescein Angiography in Eyes With Diabetic Macular Edema: DAVE Study
Fan, W, Wang, K, Ghasemi Falavarjani, K, Sagong, M, Uji, A, Ip, M, Wykoff, CC, Brown, DM, van Hemert, J & Sadda, SVR 2017, American Journal of Ophthalmology. DOI: 10.1016/j.ajo.2017.05.024

Oral tyrosine kinase inhibitor for neovascular age-related macular degeneration: A phase 1 dose-escalation study
Jackson, TL, Boyer, D, Brown, DM, Chaudhry, N, Elman, M, Liang, C, OShaughnessy, D, Parsons, EC, Patel, S, Slakter, JS & Rosenfeld, PJ 2017, JAMA Ophthalmology, vol 135, no. 7, pp. 761-767. DOI: 10.1001/jamaophthalmol.2017.1571

Randomized Trial of Treat-and-Extend versus Monthly Dosing for Neovascular Age-Related Macular Degeneration: 2-Year Results of the TREX-AMD Study
Wykoff, CC, Ou, WC, Brown, DM, Croft, DE, Wang, R, Payne, JF, Clark, WL, Abdelfattah, NS, Sadda, SVR & TREX-AMD Study Group 2017, Kidney International Reports, vol 2, no. 4, pp. 314-321. DOI: 10.1016/j.oret.2016.12.004

Nuclear cardiology practices and radiation exposure in Africa: Results from the IAEA Nuclear Cardiology Protocols Study (INCAPS)
Bouyoucef, SE, Mercuri, M, Pascual, TNB, Allam, AH, Vangu, M, Vitola, JV, Better, N, Karthikeyan, G, Mahmarian, J, Rehani, MM, Kashyap, R, Dondi, M, Paez, D, Einstein, AJ, Einstein, AJ, Pascual, TNB, Paez, D, Dondi, M, Better, N, Bouyoucef, SE, Karthikeyan, G, Kashyap, R, Lele, V, Magboo, VPC, Mercuri, M, Mut, F, Rehani, MM, Vitola, JV, Alexánderson, E, Allam, A, Al-Mallah, MH, Better, N, Bouyoucef, SE, Bom, H, Flotats, A, Jerome, S, Kaufmann, PA, Lele, V, Luxenburg, O, Shaw, LJ, Underwood, SR, Vitola, J, Amouri, W, Essabbah, H, Gassama, SS, Makhdomi, KB, El Mustapha, GIE, El Ouchdi, N, Qaïs, N, Soni, N, Vangu, W, Abazid, RM, Adams, B, Agarwal, V, Alfeeli, MA, Alnafisi, N, Bernabe, L, Bural, GG, Chaiwatanarat, T, Chandraguptha, JM, Cheon, GJ, Cho, I, Dogan, AS, Eftekhari, M, Frenkel, A, Garty, I, George, S, Geramifar, P, Golan, H, Habib, S, Hussain, R, Im, H, Jeon, HJ, Kalawat, T, Kang, WJ, Keng, F, Klaipetch, A, Kumar, PG, Lee, J, Lee, WW, Lim, I, Macaisa, CMM, Malhotra, G, Mittal, BR, Mohammad, MH, Mohan, P, Mulyanto, ID, Nariman, D, Nayak, UN, Niaz, K, Nikolov, G, Obaldo, JM, Ozturk, E, Park, JM, Park, S, Patel, CD, Phuong, HK, Quinon, AP, Rajini, TR, Saengsuda, Y, Santiago, J, Sayman, HB, Shinto, AS, Sivasubramaniyan, V, Son, MH, Sudhakar, P, Syed, GMS, Tamaki, N, Thamnirat, K, Thientunyakit, T, Thongmak, S, Velasco, DN, Verma, A, Vutrapongwatana, U, Wang, Y, Won, KS, Yao, Z, Yingsa-Nga, T, Yudistiro, R, Yue, KT, Zafrir, N, Adrian, SC, Agostini, D, Aguadé, S, Armitage, G, Backlund, M, Backman, M, Baker, M, Balducci, MT, Bavelaar, C, Berovic, M, Bertagna, F, Beuchel, R, Biggi, A, Bisi, G, Bonini, R, Bradley, A, Brudin, L, Bruno, I, Busnardo, E, Casoni, R, Choudhri, A, Cittanti, C, Clauss, R, Costa, DC, Costa, M, Dixon, K, Dziuk, M, Egelic, N, Eriksson, I, Fagioli, G, De Faria, DB, Florimonte, L, Francini, A, French, M, Gallagher, E, Garai, I, Geatti, O, Genovesi, D, Gianolli, L, Gimelli, A, Del Giudice, E, Halliwell, S, Hansson, MJ, Harrison, C, Homans, F, Horton, F, J?drzejuk, D, Jogi, J, Johansen, A, Johansson, H, Kalnina, M, Kaminek, M, Kiss, A, Kobylecka, M, Kostkiewicz, M, Kropp, J, Kullenberg, R, Lahoutte, T, Lang, O, Larsson, YH, Lázár, M, Leccisotti, L, Leners, N, Lindner, O, Lipp, RW, Maenhout, A, Maffioli, L, Marcassa, C, Martins, B, Marzullo, P, Medolago, G, Mendiguchía, CG, Mirzaei, S, Mori, M, Nardi, B, Nazarenko, S, Nikoletic, K, Oleksa, R, Parviainen, T, Patrina, J, Peace, R, Pirich, C, Piwowarska-Bilska, H, Popa, S, Prakash, V, Pubul, V, Puklavec, L, Rac, S, Ratniece, M, Rogan, SA, Romeo, A, Rossi, M, Ruiz, D, Sabharwal, N, Salobir, BG, Santos, AI, Saranovic, S, Sarkozi, A, Schneider, RP, Sciagra, R, Scotti, S, Servini, Z, Setti, LR, Starck, S, Vajauskas, D, Veselý, J, Vieni, A, Vignati, A, Vito, IM, Weiss, K, Wild, D, Zdraveska-Kochovska, M, Agüro, RN, Alvarado, N, Barral, CM, Beretta, M, Berrocal, I, Batista Cuellar, JF, Cabral Chang, TM, Cabrera Rodríguez, LO, Canessa, J, Castro Mora, G, Claudia, AC, Clavelo, GF, Cruz, AF, Faccio, FF, Fernández, KM, Gomez Garibo, JR, Gonzalez, U, González, PE, Guzzo, MA, Jofre, J, Kapitán, M, Kempfer, G, Lopez, JL, Massardo, TV, Medeiros Colaco, I, Mesquita, CT, Montecinos, M, Neubauer, S, Pabon, LM, Puente, A, Rochela Vazquez, LM, Serna Macias, JA, Silva Pino, AG, Tártari Huber, FZ, Tovar, AP, Vargas, L, Wiefels, C, Aljizeeri, A, Alvarez, RJ, Barger, D, Beardwood, W, Behrens, J, Brann, L, Brown, D, Carr, H, Churchwell, K, Comingore, GA, Corbett, J, Costello, M, Cruz, F, Depinet, T, Dorbala, S, Earles, M, Esteves, FP, Etherton, E, Fanning, RJ, Fornace, J, Franks, L, Gewirtz, H, Gulanchyn, K, Hannah, CL, Hays, J, Hendrickson, J, Hester, J, Holmes, K, Jerome, S, Johnson, A, Jopek, C, Lewin, H, Lyons, J, Manley, C, Meden, J, Moore, S, Moore, WH, Murthy, V, Nace, R, Neely, D, Nelson, L, Niedermaier, O, Rice, D, Rigs, R, Schiffer, K, Schockling, E, Schultz, T, Schumacker, T, Sheesley, B, Sheikh, A, Siegel, B, Slim, AM, Smith, J, Szulc, MC, Tanskersley, N, Tilkemeier, P, Valdez, GD, Vrooman, R, Wawrowicz, D, Winchester, DE, Alcheikh, A, Allen, B, Atkins, E, Bevan, J, Bonomini, C, Christiansen, J, Clack, L, Craig, E, Dixson, H, Duncan, I, Fredericks, S, Gales, S, Hampson, R, Hanley, T, Hartcher, K, Hassall, J, Kelley, B, Kelly, S, Kidd, T, De Kort, T, Larcos, G, Macdonald, W, McGrath, C, Murdoch, E, OMalley, S, ORourke, M, Pack, M, Pearce, R, Praehofer, R, Ramsay, S, Scarlett, L, Smidt, K, Souvannavong, F, Taubman, K, Taylor, G, Tse, K, Unger, S, Weale, J & INCAPS investigators group 2017, Cardiovascular Journal of Africa, vol 28, no. 4, pp. 229-234. DOI: 10.5830/CVJA-2016-091

Reply
Wykoff, CC, Le, RT, Khurana, RN, Brown, DM, Ou, WC, Wang, R, Clark, WL & Boyer, DS 2017, American Journal of Ophthalmology, vol 177, pp. 236-237. DOI: 10.1016/j.ajo.2017.02.024

The potential importance of detection of neovascular age-related macular degeneration when visual acuity is relatively good
Ho, AC, Albini, TA, Brown, DM, Boyer, DS, Regillo, CD & Heier, JS 2017, JAMA ophthalmology, vol 135, no. 3, pp. 268-273. DOI: 10.1001/jamaophthalmol.2016.5314

Macular Atrophy in Neovascular Age-Related Macular Degeneration with Monthly versus Treat-and-Extend Ranibizumab: Findings from the TREX-AMD Trial
Abdelfattah, NS, Al-Sheikh, M, Pitetta, S, Mousa, A, Sadda, SVR, Wykoff, CC, Wykoff, CC, Croft, DE, Brown, DM, Wang, R, Payne, JF, Clark, L, Abdelfattah, NS, Sadda, SVR, Benz, MS, Chen, E, Fish, RH, Johnson, DL, Kim, RY, Major, JC, OMalley, RE, Schefler, AC, Shah, AR, Vance, SK, Wells, JA & Wong, TP 2017, Ophthalmology, vol 124, no. 2, pp. 215-223. DOI: 10.1016/j.ophtha.2016.10.002

Peripheral Laser for Recalcitrant Macular Edema Owing to Retinal Vein Occlusion: The WAVE Trial
Wykoff, CC, Ou, WC, Wang, R, Brown, DM, Cone, C, Zamora, D, Le, RT, Sagong, M, Wang, K & Sadda, SVR 2017, Ophthalmology. DOI: 10.1016/j.ophtha.2017.01.049

Randomized Trial of Treat and Extend Ranibizumab with and without Navigated Laser for Diabetic Macular Edema: TREX-DME 1 Year Outcomes
Payne, JF, Wykoff, CC, Clark, WL, Bruce, BB, Boyer, DS, Brown, DM & TREX-DME Study Group 2017, Ophthalmology, vol 124, no. 1, pp. 74-81. DOI: 10.1016/j.ophtha.2016.09.021

Outcomes With As-Needed Aflibercept and Macular Laser Following the Phase III VISTA DME Trial: ENDURANCE 12-Month Extension Study
Wykoff, CC, Le, RT, Khurana, RN, Brown, DM, Ou, WC, Wang, R, Clark, WL & Boyer, DS 2017, American Journal of Ophthalmology, vol 173, pp. 56-63. DOI: 10.1016/j.ajo.2016.09.029

Intravitreal Aflibercept for Diabetic Macular Edema: 148-Week Results from the VISTA and VIVID Studies
Heier, JS, Korobelnik, JF, Brown, DM, Schmidt-Erfurth, U, Do, DV, Midena, E, Boyer, DS, Terasaki, H, Kaiser, PK, Marcus, DM, Nguyen, QD, Jaffe, GJ, Slakter, JS, Simader, C, Soo, Y, Schmelter, T, Vitti, R, Berliner, AJ, Zeitz, O, Metzig, C & Holz, FG 2016, Ophthalmology, vol 123, no. 11, pp. 2376-2385. DOI: 10.1016/j.ophtha.2016.07.032

Reply
Clark, WL, Boyer, DS, Heier, JS, Brown, DM, Haller, JA, Vitti, R, Kazmi, H, Berliner, AJ, Erickson, K, Chu, KW, Soo, Y, Cheng, Y & Campochiaro, PA 2016, Ophthalmology, vol 123, no. 10, pp. e60-e61. DOI: 10.1016/j.ophtha.2016.03.020