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David Beers

David Beers, PhD

Associate Research Professor of Neurology, Academic Institute
Associate Research Member, Research Institute
Houston Methodist


dbeers@houstonmethodist.org
Publications

Ex vivo expansion of dysfunctional regulatory T lymphocytes restores suppressive function in Parkinson’s disease
Thome, AD, Atassi, F, Wang, J, Faridar, A, Zhao, W, Thonhoff, JR, Beers, DR, Lai, EC & Appel, SH 2021, , npj Parkinsons Disease, vol. 7, no. 1, 41. https://doi.org/10.1038/s41531-021-00188-5

Amyotrophic lateral sclerosis is a systemic disease: peripheral contributions to inflammation-mediated neurodegeneration
Appel, SH, Beers, DR & Zhao, W 2021, , Current opinion in neurology, vol. 34, no. 5, pp. 765-772. https://doi.org/10.1097/WCO.0000000000000983

Neuroinflammation is highest in areas of disease progression in semantic dementia
Pascual, B, Funk, Q, Zanotti Fregonara, P, Cykowski, MD, Veronese, M, Rockers, E, Bradbury, K, Yu, M, Nakawah, MO, Román, GC, Schulz, PE, Arumanayagam, AS, Beers, D, Faridar, A, Fujita, M, Appel, SH & Masdeu, JC 2021, , Brain, vol. 144, no. 5, pp. 1565-1575. https://doi.org/10.1093/brain/awab057

Neuroinflammation is highest in areas of disease progression in semantic dementia
Pascual, B, Funk, Q, Zanotti-Fregonara, P, Cykowski, MD, Veronese, M, Rockers, E, Bradbury, K, Yu, M, Nakawah, MO, Román, GC, Schulz, PE, Arumanayagam, AS, Beers, D, Faridar, A, Fujita, M, Appel, SH & Masdeu, JC 2021, , Brain, vol. 144, no. 5, pp. 1565-1575. https://doi.org/10.1093/brain/awab057

Serum programmed cell death proteins in amyotrophic lateral sclerosis
Beers, DR, Zhao, W, Thonhoff, JR, Faridar, A, Thome, AD, Wen, S, Wang, J & Appel, SH 2021, , Brain, behavior, & immunity - health, vol. 12, pp. 100209. https://doi.org/10.1016/j.bbih.2021.100209

Elevated acute phase proteins reflect peripheral inflammation and disease severity in patients with amyotrophic lateral sclerosis
Beers, DR, Zhao, W, Neal, DW, Thonhoff, JR, Thome, AD, Faridar, A, Wen, S, Wang, J & Appel, SH 2020, , Scientific Reports, vol. 10, no. 1, 15295, pp. 15295. https://doi.org/10.1038/s41598-020-72247-5

Elevated acute phase proteins reflect peripheral inflammation and disease severity in patients with amyotrophic lateral sclerosis
Beers, D, Zhao, W, Neal, D, Thonhoff, JR, Thome, AD, Faridar, A & Appel, SH 2020, , Scientific Reports, vol. 10, no. 1, 32943739.

Immunosuppressive Functions of M2 Macrophages Derived from iPSCs of Patients with ALS and Healthy Controls
Zhao, W, Beers, DR, Thonhoff, JR, Thome, AD, Faridar, A, Wang, J, Wen, S, Ornelas, L, Sareen, D, Goodridge, HS, Svendsen, CN & Appel, SH 2020, , iScience, vol. 23, no. 6, pp. 101192. https://doi.org/10.1016/j.isci.2020.101192

Immunosuppressive Functions of M2 Macrophages Derived from iPSCs of Patients with ALS and Healthy Controls
Zhao, W, Beers, DR, Thonhoff, JR, Thome, AD, Faridar, A, Wang, J, Wen, S, Ornelas, L, Sareen, D, Goodridge, HS, Svendsen, CN & Appel, SH 2020, , iScience, vol. 23, no. 6, 101192. https://doi.org/10.1016/j.isci.2020.101192

Restoring regulatory T-cell dysfunction in Alzheimer's disease through ex vivo expansion
Faridar, A, Thome, AD, Zhao, W, Thonhoff, JR, Beers, DR, Pascual, B, Masdeu, JC & Appel, SH 2020, , Brain communications, vol. 2, no. 2, pp. fcaa112. https://doi.org/10.1093/braincomms/fcaa112

Head-to-head comparison of 11C-PBR28 and 11C-ER176 for quantification of the translocator protein in the human brain
Zanotti-Fregonara, P, Pascual, B, Veronese, M, Yu, M, Beers, D, Appel, SH & Masdeu, JC 2019, , European Journal of Nuclear Medicine and Molecular Imaging, vol. 46, no. 9, pp. 1822-1829. https://doi.org/10.1007/s00259-019-04349-w

Immune dysregulation in amyotrophic lateral sclerosis: mechanisms and emerging therapies
Beers, DR & Appel, SH 2019, , The Lancet Neurology, vol. 18, no. 2, pp. 211-220. https://doi.org/10.1016/S1474-4422(18)30394-6

Functional alterations of myeloid cells during the course of Alzheimer's disease
Thome, AD, Faridar, A, Beers, DR, Thonhoff, JR, Zhao, W, Wen, S, Pascual, B, Masdeu, JC & Appel, SH 2018, , Molecular Neurodegeneration, vol. 13, no. 1, pp. 61. https://doi.org/10.1186/s13024-018-0293-1

Head-to-head comparison of 11C-PBR28 and 18F-GE180 for quantification of the translocator protein in the human brain
Zanotti-Fregonara, P, Pascual, B, Rizzo, G, Yu, M, Pal, N, Beers, D, Carter, R, Appel, SH, Atassi, N & Masdeu, JC 2018, , Journal of Nuclear Medicine, vol. 59, no. 8, pp. 1260-1266. https://doi.org/10.2967/jnumed.117.203109

Expanded autologous regulatory T-lymphocyte infusions in ALS A phase I, first-in-human study
Thonhoff, JR, Beers, DR, Zhao, W, Pleitez, M, Simpson, EP, Berry, JD, Cudkowicz, ME & Appel, SH 2018, , Neurology: Neuroimmunology and NeuroInflammation, vol. 5, no. 4, e465, pp. e465. https://doi.org/10.1212/NXI.0000000000000465

Expanded autologous regulatory T-lymphocyte infusions in ALS
Thonhoff, JR, Beers, DR, Zhao, W, Pleitez, M, Simpson, EP, Berry, JD, Cudkowicz, ME & Appel, SH 2018, Neurology - Neuroimmunology Neuroinflammation, vol. 5, no. 4.

The role of regulatory T lymphocytes in amyotrophic lateral sclerosis
Beers, DR, Zhao, W & Appel, SH 2018, , JAMA Neurology, vol. 75, no. 6, pp. 656-658. https://doi.org/10.1001/jamaneurol.2018.0043

An open label study of a novel immunosuppression intervention for the treatment of amyotrophic lateral sclerosis
Fournier, CN, Schoenfeld, D, Berry, JD, Cudkowicz, ME, Chan, J, Quinn, C, Brown, RH, Salameh, JS, Tansey, MG, Beers, DR, Appel, SH & Glass, JD 2018, , Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration, vol. 19, no. 3-4, pp. 242-249. https://doi.org/10.1080/21678421.2017.1421666

Characterization of Gene Expression Phenotype in Amyotrophic Lateral Sclerosis Monocytes
Zhao, W, Beers, DR, Hooten, KG, Sieglaff, DH, Zhang, A, Kalyana-Sundaram, S, Traini, CM, Halsey, WS, Hughes, AM, Sathe, GM, Livi, GP, Fan, GH & Appel, SH 2017, , JAMA Neurology, vol. 74, no. 6, pp. 677-685. https://doi.org/10.1001/jamaneurol.2017.0357

ALS patients' regulatory T lymphocytes are dysfunctional, and correlate with disease progression rate and severity
Beers, DR, Zhao, W, Wang, J, Zhang, X, Wen, S, Neal, D, Thonhoff, JR, Alsuliman, AS, Shpall, EJ, Rezvani, K & Appel, SH 2017, , JCI insight, vol. 2, no. 5, pp. e89530. https://doi.org/10.1172/jci.insight.89530

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