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David Beers, PhD

Associate Research Professor of Neurology, Institute for Academic Medicine
Associate Research Member, Research Institute
Houston Methodist

Expanded autologous regulatory T-lymphocyte infusions in ALS
Thonhoff, JR, Beers, DR, Zhao, W, Pleitez, M, Simpson, EP, Berry, JD, Cudkowicz, ME & Appel, SH 2018, Neurology - Neuroimmunology Neuroinflammation, vol 5, no. 4.

The role of regulatory T lymphocytes in amyotrophic lateral sclerosis
Beers, DR, Zhao, W & Appel, SH 2018, JAMA Neurology, vol 75, no. 6, pp. 656-658. DOI: 10.1001/jamaneurol.2018.0043

An open label study of a novel immunosuppression intervention for the treatment of amyotrophic lateral sclerosis
Fournier, CN, Schoenfeld, D, Berry, JD, Cudkowicz, ME, Chan, J, Quinn, C, Brown, RH, Salameh, JS, Tansey, MG, Beers, DR, Appel, SH & Glass, JD 2018, Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration, pp. 1-8. DOI: 10.1080/21678421.2017.1421666

Characterization of Gene Expression Phenotype in Amyotrophic Lateral Sclerosis Monocytes
Zhao, W, Beers, DR, Hooten, KG, Sieglaff, DH, Zhang, A, Kalyana-Sundaram, S, Traini, CM, Halsey, WS, Hughes, AM, Sathe, GM, Livi, GP, Fan, GH & Appel, SH 2017, JAMA Neurology, vol 74, no. 6, pp. 677-685. DOI: 10.1001/jamaneurol.2017.0357

ALS patients' regulatory T lymphocytes are dysfunctional, and correlate with disease progression rate and severity
Beers, DR, Zhao, W, Wang, J, Zhang, X, Wen, S, Neal, D, Thonhoff, JR, Alsuliman, AS, Shpall, EJ, Rezvani, K & Appel, SH 2017, JCI insight, vol 2, no. 5, pp. e89530. DOI: 10.1172/jci.insight.89530

A robust, good manufacturing practice–compliant, clinical-scale procedure to generate regulatory T cells from patients with amyotrophic lateral sclerosis for adoptive cell therapy
Alsuliman, A, Appel, SH, Beers, DR, Basar, R, Shaim, H, Kaur, I, Zulovich, J, Yvon, E, Muftuoglu, M, Imahashi, N, Kondo, K, Liu, E, Shpall, EJ & Rezvani, K 2016, Cytotherapy, vol 18, no. 10, pp. 1312-1324. DOI: 10.1016/j.jcyt.2016.06.012

TDP-43 activates microglia through NF-?B and NLRP3 inflammasome
Zhao, W, Beers, DR, Bell, S, Wang, J, Wen, S, Baloh, RH & Appel, SH 2015, Experimental Neurology, vol 273, pp. 24-35. DOI: 10.1016/j.expneurol.2015.07.019

Protective and Toxic Neuroinflammation in Amyotrophic Lateral Sclerosis
Hooten, KG, Beers, DR, Zhao, W & Appel, SH 2015, Neurotherapeutics, vol 12, no. 2, pp. 364-375. DOI: 10.1007/s13311-014-0329-3

The Role of Regulatory T Cells and Microglia in Amyotrophic Lateral Sclerosis
Beers, DR, Zhao, W, Hooten, KG & Appel, SH 2015, . in S David (ed.), Neuroinflammation: New Insights into Beneficial and Detrimental Functions. John Wiley & Sons, Inc. pp. 235-249. DOI: 10.1002/9781118732748.ch15

Role of Inflammation in Neurodegenerative Diseases
Appel, SH, Beers, DR & Zhao, W 2014, . in Neurobiology of Brain Disorders: Biological Basis of Neurological and Psychiatric Disorders. Elsevier, pp. 380-395. DOI: 10.1016/B978-0-12-398270-4.00025-2

Neuroimmunology of Amyotrophic Lateral Sclerosis
Henkel, JS, Beers, DR, Zhao, W & Appel, SH 2014, . in Neuroinflammation and CNS Disorders. Wiley-Blackwell, pp. 185-209. DOI: 10.1002/9781118406557.ch8

Immune-mediated mechanisms in the pathoprogression of amyotrophic lateral sclerosis
Zhao, W, Beers, DR & Appel, SH 2013, Journal of Neuroimmune Pharmacology, vol 8, no. 4, pp. 888-899. DOI: 10.1007/s11481-013-9489-x

Erratum: Regulatory T-lymphocytes mediate amyotrophic lateral sclerosis progression and survival [EMBO Mol Med 5, 1] DOI: 10.1002/emmm.201201544
Henkel, JS, Beers, DR, Wen, S, Rivera, AL, Toennis, KM, Appel, JE, Zhao, W, Moore, DH, Powell, SZ & Appel, SH 2013, EMBO Molecular Medicine, vol 5, no. 2. DOI: 10.1002/emmm.201390002

Regulatory T-lymphocytes mediate amyotrophic lateral sclerosis progression and survival
Henkel, JS, Beers, DR, Wen, S, Rivera, AL, Toennis, KM, Appel, JE, Zhao, W, Moore, DH, Powell, SZ & Appel, SH 2013, EMBO Molecular Medicine, vol 5, no. 1, pp. 64-79. DOI: 10.1002/emmm.201201544

Regulatory T lymphocytes from ALS mice suppress microglia and effector T lymphocytes through different cytokine-mediated mechanisms
Zhao, W, Beers, DR, Liao, B, Henkel, JS & Appel, SH 2012, Neurobiology of Disease, vol 48, no. 3, pp. 418-428. DOI: 10.1016/j.nbd.2012.07.008

Transformation from a neuroprotective to a neurotoxic microglial phenotype in a mouse model of ALS
Liao, B, Zhao, W, Beers, DR, Henkel, JS & Appel, SH 2012, Experimental Neurology, vol 237, no. 1, pp. 147-152. DOI: 10.1016/j.expneurol.2012.06.011

Reactive oxygen and nitrogen species - A driving force in amyotrophic lateral sclerosis
Henkel, JS, Beers, DR, Zhao, W & Appel, SH 2012, . in Systems Biology of Free Radicals and Antioxidants. Springer-Verlag Berlin Heidelberg, pp. 3141-3165. DOI: 10.1007/978-3-642-30018-9_131

Peripheral nerve inflammation in als mice: Cause or consequence
Kano, O, Beers, DR, Henkel, JS & Appel, SH 2012, Neurology, vol 78, no. 11, pp. 833-835. DOI: 10.1212/WNL.0b013e318249f776

Excess circulating alternatively activated myeloid (M2) cells accelerate ALS progression while inhibiting experimental autoimmune encephalomyelitis
Vaknin, I, Kunis, G, Miller, O, Butovsky, O, Bukshpan, S, Beers, DR, Henkel, JS, Yoles, E, Appel, SH & Schwartz, M 2011, PLoS ONE, vol 6, no. 11, e26921. DOI: 10.1371/journal.pone.0026921

Neuroinflammation modulates distinct regional and temporal clinical responses in ALS mice
Beers, DR, Zhao, W, Liao, B, Kano, O, Wang, J, Huang, A, Appel, SH & Henkel, JS 2011, Brain, Behavior, and Immunity, vol 25, no. 5, pp. 1025-1035. DOI: 10.1016/j.bbi.2010.12.008