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David Beers, PhD

Associate Research Professor of Neurology, Academic Institute
Associate Research Member, Research Institute
Houston Methodist

Elevated acute phase proteins reflect peripheral inflammation and disease severity in patients with amyotrophic lateral sclerosis
Beers, DR, Zhao, W, Neal, DW, Thonhoff, JR, Thome, AD, Faridar, A, Wen, S, Wang, J & Appel, SH 2020, , Scientific Reports, vol. 10, no. 1, 15295.

Immunosuppressive Functions of M2 Macrophages Derived from iPSCs of Patients with ALS and Healthy Controls
Zhao, W, Beers, DR, Thonhoff, JR, Thome, AD, Faridar, A, Wang, J, Wen, S, Ornelas, L, Sareen, D, Goodridge, HS, Svendsen, CN & Appel, SH 2020, , iScience, vol. 23, no. 6, 101192.

Head-to-head comparison of 11C-PBR28 and 11C-ER176 for quantification of the translocator protein in the human brain
Zanotti-Fregonara, P, Pascual, B, Veronese, M, Yu, M, Beers, D, Appel, SH & Masdeu, JC 2019, , European Journal of Nuclear Medicine and Molecular Imaging, vol. 46, no. 9, pp. 1822-1829.

Immune dysregulation in amyotrophic lateral sclerosis: mechanisms and emerging therapies
Beers, DR & Appel, SH 2019, , The Lancet Neurology, vol. 18, no. 2, pp. 211-220.

Functional alterations of myeloid cells during the course of Alzheimer's disease
Thome, AD, Faridar, A, Beers, DR, Thonhoff, JR, Zhao, W, Wen, S, Pascual, B, Masdeu, JC & Appel, SH 2018, Molecular Neurodegeneration, vol. 13, no. 1, pp. 61.

Head-to-head comparison of 11C-PBR28 and 18F-GE180 for quantification of the translocator protein in the human brain
Zanotti Fregonara, P, Pascual, MB, Rizzo, G, Yu, MM, Pal, N, Beers, D, Carter, R, Appel, SH, Atassi, N & Masdeu, JC 2018, , Journal of Nuclear Medicine, vol. 59, no. 8, pp. 1260-1266.

Expanded autologous regulatory T-lymphocyte infusions in ALS A phase I, first-in-human study
Thonhoff, JR, Beers, DR, Zhao, W, Pleitez, M, Simpson, EP, Berry, JD, Cudkowicz, ME & Appel, SH 2018, , Neurology: Neuroimmunology and NeuroInflammation, vol. 5, no. 4, e465, pp. e465.

Expanded autologous regulatory T-lymphocyte infusions in ALS
Thonhoff, JR, Beers, DR, Zhao, W, Pleitez, M, Simpson, EP, Berry, JD, Cudkowicz, ME & Appel, SH 2018, Neurology - Neuroimmunology Neuroinflammation, vol. 5, no. 4.

The role of regulatory T lymphocytes in amyotrophic lateral sclerosis
Beers, D, Zhao, W & Appel, SH 2018, , JAMA Neurology, vol. 75, no. 6, pp. 656-658.

An open label study of a novel immunosuppression intervention for the treatment of amyotrophic lateral sclerosis
Fournier, CN, Schoenfeld, D, Berry, JD, Cudkowicz, ME, Chan, J, Quinn, C, Brown, RH, Salameh, JS, Tansey, MG, Beers, DR, Appel, SH & Glass, JD 2018, , Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration, vol. 19, no. 3-4, pp. 242-249.

Characterization of Gene Expression Phenotype in Amyotrophic Lateral Sclerosis Monocytes
Zhao, W, Beers, DR, Hooten, KG, Sieglaff, DH, Zhang, A, Kalyana-Sundaram, S, Traini, CM, Halsey, WS, Hughes, AM, Sathe, GM, Livi, GP, Fan, GH & Appel, SH 2017, , JAMA Neurology, vol. 74, no. 6, pp. 677-685.

ALS patients' regulatory T lymphocytes are dysfunctional, and correlate with disease progression rate and severity
Beers, DR, Zhao, W, Wang, J, Zhang, X, Wen, S, Neal, D, Thonhoff, JR, Alsuliman, AS, Shpall, EJ, Rezvani, K & Appel, SH 2017, , JCI insight, vol. 2, no. 5, pp. e89530.

A robust, good manufacturing practice–compliant, clinical-scale procedure to generate regulatory T cells from patients with amyotrophic lateral sclerosis for adoptive cell therapy
Alsuliman, A, Appel, SH, Beers, DR, Basar, R, Shaim, H, Kaur, I, Zulovich, J, Yvon, E, Muftuoglu, M, Imahashi, N, Kondo, K, Liu, E, Shpall, EJ & Rezvani, K 2016, , Cytotherapy, vol. 18, no. 10, pp. 1312-1324.

TDP-43 activates microglia through NF-?B and NLRP3 inflammasome
Zhao, W, Beers, DR, Bell, S, Wang, J, Wen, S, Baloh, RH & Appel, SH 2015, , Experimental Neurology, vol. 273, pp. 24-35.

Protective and Toxic Neuroinflammation in Amyotrophic Lateral Sclerosis
Hooten, KG, Beers, DR, Zhao, W & Appel, SH 2015, , Neurotherapeutics, vol. 12, no. 2, pp. 364-375.

The Role of Regulatory T Cells and Microglia in Amyotrophic Lateral Sclerosis
Beers, D, Zhao, W, Hooten, KG & Appel, SH 2015, . in S David (ed.), Neuroinflammation: New Insights into Beneficial and Detrimental Functions. Wiley, pp. 235-249.

Role of Inflammation in Neurodegenerative Diseases
Appel, SH, Beers, D & Zhao, W 2015, . in Neurobiology of Brain Disorders: Biological Basis of Neurological and Psychiatric Disorders. Elsevier, pp. 380-395.

Neuroimmunology of Amyotrophic Lateral Sclerosis
Henkel, JS, Beers, D, Zhao, W & Appel, SH 2014, . in Neuroinflammation and CNS Disorders. Wiley, pp. 185-209.

Immune-mediated mechanisms in the pathoprogression of amyotrophic lateral sclerosis
Zhao, W, Beers, DR & Appel, SH 2013, , Journal of Neuroimmune Pharmacology, vol. 8, no. 4, pp. 888-899.

Erratum: Regulatory T-lymphocytes mediate amyotrophic lateral sclerosis progression and survival [EMBO Mol Med 5, 1] DOI: 10.1002/emmm.201201544
Henkel, JS, Beers, D, Wen, S, Rivera, AL, Toennis, KM, Appel, JE, Zhao, W, Moore, DH, Powell, SZ-E & Appel, SH 2013, , EMBO Molecular Medicine, vol. 5, no. 2.