David Beers

David Beers, PhD

Associate Research Professor of Neurology, Academic Institute
Associate Research Member, Research Institute
Houston Methodist


dbeers@houstonmethodist.org
Publications

Combined Regulatory T-Lymphocyte and IL-2 Treatment Is Safe, Tolerable, and Biologically Active for 1 Year in Persons With Amyotrophic Lateral Sclerosis
Thonhoff, JR, Berry, JD, Macklin, EA, Beers, DR, Mendoza, PA, Zhao, W, Thome, AD, Triolo, F, Moon, JJ, Paganoni, S, Cudkowicz, M & Appel, SH 2022, , Neurology(R) neuroimmunology & neuroinflammation, vol. 9, no. 6. https://doi.org/10.1212/NXI.0000000000200019

Ex vivo expanded human regulatory T cells modify neuroinflammation in a preclinical model of Alzheimer’s disease
Faridar, A, Vasquez, M, Thome, AD, Yin, Z, Xuan, H, Wang, JH, Wen, S, Li, X, Thonhoff, JR, Zhao, W, Zhao, H, Beers, DR, Wong, ST, Masdeu, JC & Appel, SH 2022, , Acta Neuropathologica Communications, vol. 10, no. 1, 144. https://doi.org/10.1186/s40478-022-01447-z

Extracellular Vesicles Derived From Ex Vivo Expanded Regulatory T Cells Modulate In Vitro and In Vivo Inflammation
Thome, AD, Thonhoff, JR, Zhao, W, Faridar, A, Wang, J, Beers, DR & Appel, SH 2022, , Frontiers in immunology, vol. 13, 875825. https://doi.org/10.3389/fimmu.2022.875825

Tregs Attenuate Peripheral Oxidative Stress and Acute Phase Proteins in ALS
Beers, DR, Thonhoff, JR, Faridar, A, Thome, AD, Zhao, W, Wen, S & Appel, SH 2022, , Annals of Neurology, vol. 92, no. 2, pp. 195-200. https://doi.org/10.1002/ana.26375

The role of inflammation in neurodegenerative diseases
Appel, SH, Beers, DR & Zhao, W 2022, . in Neurobiology of Brain Disorders: Biological Basis of Neurological and Psychiatric Disorders, Second Edition. Elsevier, pp. 403-421. https://doi.org/10.1016/B978-0-323-85654-6.00036-8

Ex vivo expansion of dysfunctional regulatory T lymphocytes restores suppressive function in Parkinson’s disease
Thome, AD, Atassi, F, Wang, J, Faridar, A, Zhao, W, Thonhoff, JR, Beers, DR, Lai, EC & Appel, SH 2021, , npj Parkinsons Disease, vol. 7, no. 1, 41. https://doi.org/10.1038/s41531-021-00188-5

Amyotrophic lateral sclerosis is a systemic disease: peripheral contributions to inflammation-mediated neurodegeneration
Appel, SH, Beers, DR & Zhao, W 2021, , Current opinion in neurology, vol. 34, no. 5, pp. 765-772. https://doi.org/10.1097/WCO.0000000000000983

Neuroinflammation is highest in areas of disease progression in semantic dementia
Pascual, B, Funk, Q, Zanotti Fregonara, P, Cykowski, MD, Veronese, M, Rockers, E, Bradbury, K, Yu, M, Nakawah, MO, Román, GC, Schulz, PE, Arumanayagam, AS, Beers, D, Faridar, A, Fujita, M, Appel, SH & Masdeu, JC 2021, , Brain, vol. 144, no. 5, pp. 1565-1575. https://doi.org/10.1093/brain/awab057

Neuroinflammation is highest in areas of disease progression in semantic dementia
Pascual, B, Funk, Q, Zanotti-Fregonara, P, Cykowski, MD, Veronese, M, Rockers, E, Bradbury, K, Yu, M, Nakawah, MO, Román, GC, Schulz, PE, Arumanayagam, AS, Beers, D, Faridar, A, Fujita, M, Appel, SH & Masdeu, JC 2021, , Brain, vol. 144, no. 5, pp. 1565-1575. https://doi.org/10.1093/brain/awab057

Serum programmed cell death proteins in amyotrophic lateral sclerosis
Beers, DR, Zhao, W, Thonhoff, JR, Faridar, A, Thome, AD, Wen, S, Wang, J & Appel, SH 2021, , Brain, behavior, & immunity - health, vol. 12, 100209. https://doi.org/10.1016/j.bbih.2021.100209, https://doi.org/10.1016/j.bbih.2021.100209

Serum programmed cell death proteins in amyotrophic lateral sclerosis
Beers, DR, Zhao, W, Thonhoff, JR, Faridar, A, Thome, AD, Wen, S, Wang, J & Appel, SH 2021, , Brain, Behavior, and Immunity - Health, vol. 12, 100209. https://doi.org/10.1016/j.bbih.2021.100209

Elevated acute phase proteins reflect peripheral inflammation and disease severity in patients with amyotrophic lateral sclerosis
Beers, DR, Zhao, W, Neal, DW, Thonhoff, JR, Thome, AD, Faridar, A, Wen, S, Wang, J & Appel, SH 2020, , Scientific Reports, vol. 10, no. 1, 15295, pp. 15295. https://doi.org/10.1038/s41598-020-72247-5

Elevated acute phase proteins reflect peripheral inflammation and disease severity in patients with amyotrophic lateral sclerosis
Beers, D, Zhao, W, Neal, D, Thonhoff, JR, Thome, AD, Faridar, A & Appel, SH 2020, , Scientific Reports, vol. 10, no. 1, 32943739.

Immunosuppressive Functions of M2 Macrophages Derived from iPSCs of Patients with ALS and Healthy Controls
Zhao, W, Beers, DR, Thonhoff, JR, Thome, AD, Faridar, A, Wang, J, Wen, S, Ornelas, L, Sareen, D, Goodridge, HS, Svendsen, CN & Appel, SH 2020, , iScience, vol. 23, no. 6, pp. 101192. https://doi.org/10.1016/j.isci.2020.101192

Immunosuppressive Functions of M2 Macrophages Derived from iPSCs of Patients with ALS and Healthy Controls
Zhao, W, Beers, DR, Thonhoff, JR, Thome, AD, Faridar, A, Wang, J, Wen, S, Ornelas, L, Sareen, D, Goodridge, HS, Svendsen, CN & Appel, SH 2020, , iScience, vol. 23, no. 6, 101192. https://doi.org/10.1016/j.isci.2020.101192

Restoring regulatory T-cell dysfunction in Alzheimer's disease through ex vivo expansion
Faridar, A, Thome, AD, Zhao, W, Thonhoff, JR, Beers, DR, Pascual, B, Masdeu, JC & Appel, SH 2020, , Brain communications, vol. 2, no. 2, pp. fcaa112. https://doi.org/10.1093/braincomms/fcaa112

Restoring regulatory T-cell dysfunction in Alzheimer's disease through ex vivo expansion
Faridar, A, Thome, AD, Zhao, W, Thonhoff, JR, Beers, DR, Pascual, B, Masdeu, JC & Appel, SH 2020, , Brain Communications, vol. 2, no. 2, fcaa112. https://doi.org/10.1093/braincomms/fcaa112

Head-to-head comparison of 11C-PBR28 and 11C-ER176 for quantification of the translocator protein in the human brain
Zanotti-Fregonara, P, Pascual, B, Veronese, M, Yu, M, Beers, D, Appel, SH & Masdeu, JC 2019, , European Journal of Nuclear Medicine and Molecular Imaging, vol. 46, no. 9, pp. 1822-1829. https://doi.org/10.1007/s00259-019-04349-w

Immune dysregulation in amyotrophic lateral sclerosis: mechanisms and emerging therapies
Beers, DR & Appel, SH 2019, , The Lancet Neurology, vol. 18, no. 2, pp. 211-220. https://doi.org/10.1016/S1474-4422(18)30394-6

Functional alterations of myeloid cells during the course of Alzheimer's disease
Thome, AD, Faridar, A, Beers, DR, Thonhoff, JR, Zhao, W, Wen, S, Pascual, B, Masdeu, JC & Appel, SH 2018, , Molecular Neurodegeneration, vol. 13, no. 1, pp. 61. https://doi.org/10.1186/s13024-018-0293-1