Daniel Y. Lee, MD, PhD

Assistant Professor of Clinical Radiology, Academic Institute
Assistant Research Member, Research Institute
Houston Methodist
Weill Cornell Medical College


Dr. Lee graduated with honors from the University of California at Berkeley where he also received the Eric Hoffer Essay Prize his senior year. From 1992 until 2001, he earned a M.D. and Ph.D. degrees from the Stanford University Medical School in Stanford, California. While there, Dr. Li was mentored under a Medical Scientist Training Program grant from the National Institute of General Medical Sciences. Dr. Lee is the first author on several key research papers, including one on histone acetylation that was published in Cell while he was still in medical school. Dr. Lee assumed his positions at Methodist in 2008.

Description of Research

Dr. Lee is an accomplished expert in nuclear medicine, biophysics, and molecular biology. His research specifically centers on pathophysiology from a molecular imaging approach. He studies the epigenetics of cancer, and develops new tools for the study of biochemical and intracellular signaling pathways, as well as platform technology for targeted radiotherapy.

Areas Of Expertise

Cancer Nanoparticles Pathophysiology Radiotherapy
Education & Training

Residency, UCLA School of Medicine
Internship, UCLA School of Medicine
Clinical Fellowship, Stanford School of Medicine
Postdoctoral Fellowship, Department of Nuclear Medicine, University of California at Los Angeles
PhD, Stanford University
MD, Stanford University
Postdoctoral Fellowship, Stanford University

Autologous EBV-specific T cell treatment results in sustained responses in patients with advanced extranodal NK/T lymphoma: results of a multicenter study
Kim, WS, Oki, Y, Kim, SJ, Yoon, SE, Ardeshna, KM, Lin, Y, Ruan, J, Porcu, P, Brammer, JE, Jacobsen, ED, Yoon, DH, Suh, C, Suarez, F, Radford, J, Budde, LE, Kim, JS, Bachy, E, Lee, HJ, Bollard, CM, Jaccard, A, Kang, HJ, Inman, S, Murray, M, Combs, KE, Lee, DY, Advani, R, Gunter, KC, Rooney, CM & Heslop, HE 2021, , Annals of Hematology, vol. 100, no. 10, pp. 2529-2539. https://doi.org/10.1007/s00277-021-04558-0

Cancer epigenomics and beyond: Advancing the precision oncology paradigm
Lee, DY 2020, , Journal of Immunotherapy and Precision Oncology, vol. 3, no. 4, pp. 147-156. https://doi.org/10.36401/JIPO-20-18

Tumor-specific t-cells engineered to overcome tumor immune evasion induce clinical responses in patients with relapsed hodgkin lymphoma
Bollard, CM, Tripic, T, Cruz, CR, Dotti, G, Gottschalk, S, Torrano, V, Dakhova, O, Carrum, G, Ramos, CA, Liu, H, Wu, MF, Marcogliese, AN, Barese, C, Zu, Y, Lee, DY, O’Connor, O, Gee, AP, Brenner, M, Heslop, H & Rooney, CM 2018, , Journal of Clinical Oncology, vol. 36, no. 11, pp. 1128-1139. https://doi.org/10.1200/JCO.2017.74.3179

Design and synthesis of a mitochondria-targeting carrier for small molecule drugs
Han, J, Lee, TH, Tung, CH & Lee, DY 2014, , Organic and Biomolecular Chemistry, vol. 12, no. 48, pp. 9793-9796. https://doi.org/10.1039/c4ob01981d

A tyrosine kinase inhibitor-based high-affinity PET radiopharmaceutical targets vascular endothelial growth factor receptor
Li, F, Jiang, S, Zu, Y, Lee, DY & Li, Z 2014, , Journal of Nuclear Medicine, vol. 55, no. 9, pp. 1525-1531. https://doi.org/10.2967/jnumed.114.138925

Current therapy and novel agents for relapsed or refractory acute lymphoblastic leukemia
Dinner, S, Lee, D & Liedtke, M 2014, , Leukemia and Lymphoma, vol. 55, no. 8, pp. 1715-1724. https://doi.org/10.3109/10428194.2013.856428

Positron emitting magnetic nanoconstructs for PET/MR imaging
Aryal, S, Key, J, Stigliano, C, Landis, MD, Lee, DY & Decuzzi, P 2014, , Small, vol. 10, no. 13, pp. 2688-2696. https://doi.org/10.1002/smll.201303933

Systemic inflammatory response syndrome after administration of unmodified T lymphocytes
Papadopoulou, A, Krance, RA, Allen, CE, Lee, DY, Rooney, CM, Brenner, M, Leen, AM & Heslop, H 2014, , Molecular Therapy, vol. 22, no. 6, pp. 1134-1138. https://doi.org/10.1038/mt.2014.48

In vivo imaging of T cells loaded with gold nanoparticles: A pilot study
Li, H, Diaz, L, Lee, D, Cui, L, Liang, X & Cheng, Y 2014, , Radiologia Medica, vol. 119, no. 4, pp. 269-276. https://doi.org/10.1007/s11547-013-0335-2

Sustained complete responses in patients with lymphoma receiving autologous cytotoxic T lymphocytes targeting Epstein-Barr virus latent membrane proteins
Bollard, CM, Gottschalk, S, Torrano, V, Diouf, O, Ku, S, Hazrat, Y, Carrum, G, Ramos, C, Fayad, L, Shpall, EJ, Pro, B, Liu, H, Wu, MF, Lee, D, Sheehan, AM, Zu, Y, Gee, AP, Brenner, MK, Heslop, HE & Rooney, CM 2014, , Journal of Clinical Oncology, vol. 32, no. 8, pp. 798-808. https://doi.org/10.1200/JCO.2013.51.5304

Imaging of genetically engineered T cells by PET using gold nanoparticles complexed to Copper-64
Bhatnagar, P, Li, Z, Choi, Y, Guo, J, Li, F, Lee, DY, Figliola, M, Huls, H, Lee, DA, Zal, T, Li, KC & Cooper, LJN 2013, , Integrative Biology (United Kingdom), vol. 5, no. 1, pp. 231-238. https://doi.org/10.1039/c2ib20093g

Molecular theranostics: A primer for the imaging professional
Lee, DY & Li, KCP 2011, , American Journal of Roentgenology, vol. 197, no. 2, pp. 318-324. https://doi.org/10.2214/AJR.11.6797

Radiosynthesis of [ 18F]fluoromethyldeoxyspergualin for molecular imaging of heat shock proteins
Ghosh, P, Li, KC & Lee, DY 2011, , Applied Radiation and Isotopes, vol. 69, no. 3, pp. 609-613. https://doi.org/10.1016/j.apradiso.2010.12.013

Computer-Assisted Quantitative Evaluation of Therapeutic Responses for Lymphoma Using Serial PET/CT Imaging
Gao, X, Xue, Z, Xing, J, Lee, DY, Gottschalk, SM, Heslop, HE, Bollard, CM & Wong, STC 2010, , Academic Radiology, vol. 17, no. 4, pp. 479-488. https://doi.org/10.1016/j.acra.2009.10.026

Synthesis and evaluation of a near-infrared fluorescent non-peptidic bivalent integrin avß3 antagonist for cancer imaging
Li, F, Liu, J, Jas, GS, Zhang, J, Qin, G, Xing, J, Cotes, C, Zhao, H, Wang, X, Diaz, LA, Shi, ZZ, Lee, DY, Li, KCP & Li, Z 2010, , Bioconjugate chemistry, vol. 21, no. 2, pp. 270-278. https://doi.org/10.1021/bc900313d

Combining gene therapy and nanomedicine to enhance the therapeutic potential of T cells
Choi, Y, Torikai, H, Lee, DY, Li, Z, Lo, D, Qin, G, Tung, CH, Tasciotti, E, Raphael, R, Biswal, SL, Ang, S, Lee, DA, Li, KC & Cooper, LJN 2010, . in Nanotechnology 2010: Bio Sensors, Instruments, Medical, Environment and Energy - Technical Proceedings of the 2010 NSTI Nanotechnology Conference and Expo, NSTI-Nanotech 2010. Nanotechnology 2010: Bio Sensors, Instruments, Medical, Environment and Energy - Technical Proceedings of the 2010 NSTI Nanotechnology Conference and Expo, NSTI-Nanotech 2010, vol. 3, pp. 376-379, Nanotechnology 2010: Bio Sensors, Instruments, Medical, Environment and Energy - 2010 NSTI Nanotechnology Conference and Expo, NSTI-Nanotech 2010, Anaheim, CA, United States, 6/21/10.

Systems diagnostics: The systems approach to molecular imaging
Lee, DY & Li, KCP 2009, , American Journal of Roentgenology, vol. 193, no. 2, pp. 287-294. https://doi.org/10.2214/AJR.09.2866

A novel antiangiogenesis therapy using an integrin antagonist or anti-Flk-1 antibody coated 90Y-labeled nanoparticles
Li, L, Wartchow, CA, Danthi, SN, Shen, Z, Dechene, N, Pease, J, Choi, HS, Doede, T, Chu, P, Ning, S, Lee, DY, Bednarski, MD & Knox, SJ 2004, , International Journal of Radiation Oncology Biology Physics, vol. 58, no. 4, pp. 1215-1227. https://doi.org/10.1016/j.ijrobp.2003.10.057

Functional genomics guided with MR imaging: Mouse tumor model study
Guccione, S, Yang, YS, Shi, G, Lee, DY, Li, KCP & Bednarski, MD 2003, , Radiology, vol. 228, no. 2, pp. 560-568. https://doi.org/10.1148/radiol.2282020907

Initiation of mitochondrial DNA replication by transcription and R-loop processing
Lee, DY & Clayton, DA 1998, , Journal of Biological Chemistry, vol. 273, no. 46, pp. 30614-30621. https://doi.org/10.1074/jbc.273.46.30614