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Daniel Y. Lee, MD, PhD

Assisant Professor of Clinical Radiology, Institute for Academic Medicine
Houston Methodist
Weill Cornell Medical College

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Biography

Dr. Lee graduated with honors from the University of California at Berkeley where he also received the Eric Hoffer Essay Prize his senior year. From 1992 until 2001, he earned a M.D. and Ph.D. degrees from the Stanford University Medical School in Stanford, California. While there, Dr. Li was mentored under a Medical Scientist Training Program grant from the National Institute of General Medical Sciences. Dr. Lee is the first author on several key research papers, including one on histone acetylation that was published in Cell while he was still in medical school. Dr. Lee assumed his positions at Methodist in 2008.

Description of Research

Dr. Lee is an accomplished expert in nuclear medicine, biophysics, and molecular biology. His research specifically centers on pathophysiology from a molecular imaging approach. He studies the epigenetics of cancer, and develops new tools for the study of biochemical and intracellular signaling pathways, as well as platform technology for targeted radiotherapy.

Areas Of Expertise

Cancer Nanoparticles Pathophysiology Radiotherapy

Education & Training

Residency, UCLA School of Medicine

Internship, UCLA School of Medicine

Clinical Fellowship, Stanford School of Medicine

MD, Stanford University School of Medicine

Postdoctoral Fellowship, Department of Nuclear Medicine, University of California at Los Angeles

Postdoctoral Fellowship, Department of Radiology, Stanford University Medical School, Stanford, CA

PhD, Stanford University Medical School

Publications

Tumor-specific t-cells engineered to overcome tumor immune evasion induce clinical responses in patients with relapsed hodgkin lymphoma

Bollard, CM, Tripic, T, Cruz, CR, Dotti, G, Gottschalk, S, Torrano, V, Dakhova, O, Carrum, G, Ramos, CA, Liu, H, Wu, MF, Marcogliese, AN, Barese, C, Zu, Y, Lee, DY, O’Connor, O, Gee, AP, Brenner, M, Heslop, H & Rooney, CM 2018, Journal of Clinical Oncology, vol. 36, no. 11, pp. 1128-1139. https://doi.org/10.1200/JCO.2017.74.3179

Design and synthesis of a mitochondria-targeting carrier for small molecule drugs

Han, J, Lee, TH, Tung, CH & Lee, DY 2014, Organic and Biomolecular Chemistry, vol. 12, no. 48, pp. 9793-9796. https://doi.org/10.1039/c4ob01981d

Sustained complete responses in patients with lymphoma receiving autologous cytotoxic T lymphocytes targeting Epstein-Barr virus latent membrane proteins

Bollard, CM, Gottschalk, S, Torrano, V, Diouf, O, Ku, S, Hazrat, Y, Carrum, G, Ramos, C, Fayad, L, Shpall, EJ, Pro, B, Liu, H, Wu, MF, Lee, DY, Sheehan, AM, Zu, Y, Gee, AP, Brenner, M, Heslop, H & Rooney, CM 2014, Journal of Clinical Oncology, vol. 32, no. 8, pp. 798-808. https://doi.org/10.1200/JCO.2013.51.5304

Current therapy and novel agents for relapsed or refractory acute lymphoblastic leukemia

Dinner, S, Lee, DY & Liedtke, M 2014, Leukemia and Lymphoma, vol. 55, no. 8, pp. 1715-1724. https://doi.org/10.3109/10428194.2013.856428

Systemic inflammatory response syndrome after administration of unmodified T lymphocytes

Papadopoulou, A, Krance, RA, Allen, CE, Lee, DY, Rooney, CM, Brenner, M, Leen, AM & Heslop, H 2014, Molecular Therapy, vol. 22, no. 6, pp. 1134-1138. https://doi.org/10.1038/mt.2014.48

In vivo imaging of T cells loaded with gold nanoparticles: A pilot study

Li, H, Diaz, L, Lee, DY, Cui, L, Liang, X & Cheng, Y 2014, Radiologia Medica, vol. 119, no. 4, pp. 269-276. https://doi.org/10.1007/s11547-013-0335-2

A tyrosine kinase inhibitor-based high-affinity PET radiopharmaceutical targets vascular endothelial growth factor receptor

Li, F, Jiang, S, Zu, Y, Lee, DY & Li, Z 2014, Journal of Nuclear Medicine, vol. 55, no. 9, pp. 1525-1531. https://doi.org/10.2967/jnumed.114.138925

Positron emitting magnetic nanoconstructs for PET/MR imaging

Aryal, S, Key, J, Stigliano, C, Landis, MD, Lee, DY & Decuzzi, P 2014, Small, vol. 10, no. 13, pp. 2688-2696. https://doi.org/10.1002/smll.201303933

Imaging of genetically engineered T cells by PET using gold nanoparticles complexed to Copper-64

Bhatnagar, P, Li, Z, Choi, Y, Guo, J, Li, F, Lee, DY, Figliola, M, Huls, H, Lee, DA, Zal, T, Li, KC & Cooper, LJN 2013, Integrative Biology (United Kingdom), vol. 5, no. 1, pp. 231-238. https://doi.org/10.1039/c2ib20093g

Molecular theranostics: A primer for the imaging professional

Lee, DY & Li, KCP 2011, American Journal of Roentgenology, vol. 197, no. 2, pp. 318-324. https://doi.org/10.2214/AJR.11.6797

Radiosynthesis of [ 18F]fluoromethyldeoxyspergualin for molecular imaging of heat shock proteins

Ghosh, P, Li, KC & Lee, DY 2011, Applied Radiation and Isotopes, vol. 69, no. 3, pp. 609-613. https://doi.org/10.1016/j.apradiso.2010.12.013

Combining gene therapy and nanomedicine to enhance the therapeutic potential of T cells

Choi, Y, Torikai, H, Lee, DY, Li, Z, Lo, D, Qin, G, Tung, CH, Tasciotti, E, Raphael, R, Biswal, SL, Ang, S, Lee, DA, Li, KC & Cooper, LJN 2010, . in Nanotechnology 2010: Bio Sensors, Instruments, Medical, Environment and Energy - Technical Proceedings of the 2010 NSTI Nanotechnology Conference and Expo, NSTI-Nanotech 2010. vol. 3, pp. 376-379, Nanotechnology 2010: Bio Sensors, Instruments, Medical, Environment and Energy - 2010 NSTI Nanotechnology Conference and Expo, NSTI-Nanotech 2010, Anaheim, CA, United States, 6/21/10.

Computer-Assisted Quantitative Evaluation of Therapeutic Responses for Lymphoma Using Serial PET/CT Imaging

Gao, X, Xue, Z, Xing, J, Lee, DY, Gottschalk, SM, Heslop, H, Bollard, CM & Wong, ST 2010, Academic radiology, vol. 17, no. 4, pp. 479-488. https://doi.org/10.1016/j.acra.2009.10.026

Synthesis and evaluation of a near-infrared fluorescent non-peptidic bivalent integrin avß3 antagonist for cancer imaging

Li, F, Liu, J, Jas, GS, Zhang, J, Qin, G, Xing, J, Cotes, C, Zhao, H, Wang, X, Diaz, LA, Shi, ZZ, Lee, DY, Li, KCP & Li, Z 2010, Bioconjugate Chemistry, vol. 21, no. 2, pp. 270-278. https://doi.org/10.1021/bc900313d

Systems diagnostics: The systems approach to molecular imaging

Lee, DY & Li, KCP 2009, American Journal of Roentgenology, vol. 193, no. 2, pp. 287-294. https://doi.org/10.2214/AJR.09.2866

A novel antiangiogenesis therapy using an integrin antagonist or anti-Flk-1 antibody coated 90Y-labeled nanoparticles

Li, L, Wartchow, CA, Danthi, SN, Shen, Z, Dechene, N, Pease, J, Choi, HS, Doede, T, Chu, P, Ning, S, Lee, DY, Bednarski, MD & Knox, SJ 2004, International Journal of Radiation Oncology Biology Physics, vol. 58, no. 4, pp. 1215-1227. https://doi.org/10.1016/j.ijrobp.2003.10.057

Functional genomics guided with MR imaging: Mouse tumor model study

Guccione, S, Yang, YS, Shi, G, Lee, DY, Li, KCP & Bednarski, MD 2003, Radiology, vol. 228, no. 2, pp. 560-568. https://doi.org/10.1148/radiol.2282020907

Initiation of mitochondrial DNA replication by transcription and R-loop processing

Lee, DY & Clayton, DA 1998, Journal of Biological Chemistry, vol. 273, no. 46, pp. 30614-30621. https://doi.org/10.1074/jbc.273.46.30614

RNase mitochondrial RNA processing correctly cleaves a novel R loop at the mitochondrial DNA leading-strand origin of replication

Lee, DY & Clayton, DA 1997, Genes and Development, vol. 11, no. 5, pp. 582-592.

Properties of a primer RNA-DNA hybrid at the mouse mitochondrial DNA leading-strand origin of replication

Lee, DY & Clayton, DA 1996, Journal of Biological Chemistry, vol. 271, no. 39, pp. 24262-24269. https://doi.org/10.1074/jbc.271.39.24262

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