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Dan Gombos, MD

Associate Affiliate Member, Research Institute
Houston Methodist


Biography

After completing his postdoctoral training in London, UK, Dr. Gombos returned to The University of
Texas M.D. Anderson Cancer Center (MDACC) in Houston, Texas as an Assistant Professor in 2001. He also joined the faculty at The University of Texas Medical Branch in Galveston, Texas in 2005 as a Clinical Assistant Professor of Ophthalmology and Visual Sciences. Dr. Gombos became an Associate Professor at MDACC in 2007, and a Clinical Associate Professor at The University of Texas Medical Branch in 2008. At MDACC, he is currently developing a comprehensive program for the management of patients with intra and periocular tumors. The program will also include special services for children with intraocular retinoblastoma. Dr. Gombos was also a founding physician in the Retinoblastoma Center of Houston, a collaborative effort between The Methodist Hospital, Baylor College of Medicine, Texas Children's Hospital, and MDACC that provides a comprehensive treatment program for retinoblastoma patients and conducts groundbreaking research to improve diagnostic methods and treatment and public awareness campaigns to promote early detection.

Description of Research

Dr. Gombos' research involves clinical trials that use proton beam radiation therapy or gene transfer therapy for pediatric refractory retinoblastoma.

Areas Of Expertise

Retinoblastoma Intraocular tumors Radiation therapy Gene transfer
Publications

Utilizing T-cell Activation Signals 1, 2, and 3 for Tumor-infiltrating Lymphocytes (TIL) Expansion: The Advantage over the Sole Use of Interleukin-2 in Cutaneous and Uveal Melanoma
Tavera, RJ, Forget, MA, Kim, YU, Sakellariou-Thompson, D, Creasy, CA, Bhatta, A, Fulbright, OJ, Ramachandran, R, Thorsen, ST, Flores, E, Wahl, A, Gonzalez, AM, Toth, C, Wardell, S, Mansaray, R, Radvanyi, LG, Gombos, DS, Patel, SP, Hwu, P, Amaria, RN, Bernatchez, C & Haymaker, C 2018, Journal of Immunotherapy, vol. 41, no. 9, pp. 399-405. DOI: 10.1097/CJI.0000000000000230

Pazopanib in patients with von Hippel-Lindau disease: a single-arm, single-centre, phase 2 trial
Jonasch, E, McCutcheon, IE, Gombos, DS, Ahrar, K, Perrier, ND, Liu, D, Robichaux, CC, Villarreal, MF, Weldon, JA, Woodson, AH, Pilie, PG, Fuller, GN, Waguespack, SG & Matin, SF 2018, The Lancet Oncology, vol. 19, no. 10, pp. 1351-1359. DOI: 10.1016/S1470-2045(18)30487-X

Reply
Skalet, AH, Gombos, DS, Gallie, BL, Kim, JW, Shields, CL, Marr, BP, Plon, SE & Chévez-Barrios, P 2018, Ophthalmology, vol. 125, no. 9, pp. e64-e65. DOI: 10.1016/j.ophtha.2018.03.030

Metastatic Melanoma of the Optic Nerve Sheath
D’souza, NM, Nguyen, HD, Smith, SV, Nagarajan, P, Diab, A, Allen, RC, Gombos, DS & Lee, AG 2017, Neuro-Ophthalmology, pp. 1-4. DOI: 10.1080/01658107.2017.1372488

Systemic neoadjuvant chemotherapy for Group B intraocular retinoblastoma (ARET0331): A report from the Children's Oncology Group
Friedman, DL, Krailo, M, Villaluna, D, Gombos, D, Langholz, B, Jubran, R, Shields, C, Murphree, L, OBrien, J, Kessel, S, Rodriguez-Galindo, C, Chintagumpala, M & Meadows, AT 2017, Pediatric Blood and Cancer, vol. 64, no. 7, e26394. DOI: 10.1002/pbc.26394

Parallel profiling of immune infiltrate subsets in uveal melanoma versus cutaneous melanoma unveils similarities and differences: A pilot study
Qin, Y, Petaccia de Macedo, M, Reuben, A, Forget, MA, Haymaker, C, Bernatchez, C, Spencer, CN, Gopalakrishnan, V, Reddy, S, Cooper, ZA, Fulbright, OJ, Ramachandran, R, Wahl, A, Flores, E, Thorsen, ST, Tavera, RJ, Conrad, C, Williams, MD, Tetzlaff, MT, Wang, WL, Gombos, DS, Esmaeli, B, Amaria, RN, Hwu, P, Wargo, JA, Lazar, AJ & Patel, SP 2017, OncoImmunology, vol. 6, no. 6, e1321187. DOI: 10.1080/2162402X.2017.1321187

Neuro-ophthalmologic manifestations of cholangiocarcinoma: A case series
Rico, G, Smith, SV, Siddiqui, Y, Whyte, A, Gombos, D & Lee, AG 2017, Eye (Basingstoke), vol. 31, no. 8, pp. 1245-1248. DOI: 10.1038/eye.2017.77

Vitreous Seeds in Retinoblastoma. Clinicopathologic Classification and Correlation
Amram, AL, Rico, G, Kim, JW, Chintagumpala, M, Herzog, CE, Gombos, DS & Chévez-Barrios, P 2017, Ophthalmology. DOI: 10.1016/j.ophtha.2017.04.015

Ocular toxicities associated with targeted anticancer agents: An analysis of clinical data with management suggestions
Fu, C, Gombos, DS, Lee, J, George, GC, Hess, K, Whyte, A & Hong, DS 2017, Oncotarget, vol. 8, no. 35, pp. 58709-58727. DOI: 10.18632/oncotarget.17634

Screening Children at Risk for Retinoblastoma. Consensus Report from the American Association of Ophthalmic Oncologists and Pathologists
Skalet, AH, Gombos, DS, Gallie, BL, Kim, JW, Shields, CL, Marr, BP, Plon, SE & Chévez-Barrios, P 2017, Ophthalmology. DOI: 10.1016/j.ophtha.2017.09.001

Late Presentation of Retinoblastoma in a Teen with Aicardi Syndrome
Akinfenwa, PY, Chévez-Barrios, P, Harper, CA & Gombos, DS 2016, Ocular Oncology and Pathology, vol. 2, no. 3, pp. 181-4. DOI: 10.1159/000439595

Intensive chemoimmunotherapy and bilateral globe irradiation as initial therapy for primary intraocular lymphoma
Cheah, CY, Milgrom, S, Chihara, D, Gombos, DS, Pinnix, CC, Dabaja, BS & Fowler, NH 2016, Neuro-Oncology, vol. 18, no. 4, pp. 575-581. DOI: 10.1093/neuonc/nov253

Acute and late toxicity of bilateral orbital irradiation in the management of primary intraocular lymphoma
Milgrom, SA, Cheah, CY, Pinnix, CC, Smith, GL, Dabaja, BS, Horace, P, Chevez-Barrios, P, Fowler, NH & Gombos, DS 2016, Leukemia and Lymphoma, pp. 1-7. DOI: 10.3109/10428194.2016.1166490

Uveal melanoma: From diagnosis to treatment and the science in between
Chattopadhyay, C, Kim, DW, Gombos, DS, Oba, J, Qin, Y, Williams, MD, Esmaeli, B, Grimm, EA, Wargo, JA, Woodman, SE & Patel, SP 2016, Cancer. DOI: 10.1002/cncr.29727

Expression of angiogenic factors in invasive retinoblastoma tumors is associated with increase in tumor cells expressing stem cell marker sox2
Garcia, JR, Gombos, DS, Prospero, CM, Ganapathy, A, Penland, RL & Chévez-Barrios, P 2015, Archives of Pathology and Laboratory Medicine, vol. 139, no. 12, pp. 1531-1538. DOI: 10.5858/arpa.2014-0262-OA

Conjunctival melanoma - Clinical pearls now, hope for the future
Gombos, DS 2015, JAMA Ophthalmology, vol. 133, no. 11, pp. 1303-1304. DOI: 10.1001/jamaophthalmol.2015.3564

Diagnostic Ophthalmic Ultrasound for Radiologists
Kendall, CJ, Prager, TC, Cheng, H, Gombos, D, Tang, RA & Schiffman, JS 2015, Neuroimaging Clinics of North America, vol. 25, no. 3, pp. 327-365. DOI: 10.1016/j.nic.2015.05.001

A choice of radionuclide: Comparative outcomes and toxicity of ruthenium-106 and iodine-125 in the definitive treatment of uveal melanoma
Takiar, V, Voong, KR, Gombos, DS, Mourtada, F, Rechner, LA, Lawyer, AA, Morrison, WH, Garden, AS & Beadle, BM 2015, Practical radiation oncology, vol. 5, no. 3, pp. e169-e176. DOI: 10.1016/j.prro.2014.09.005

Sinonasal melanoma arising from conjunctival primary acquired melanosis
Shehata, M, Gombos, D, Bishop, J & Zafereo, ME 2015, BMJ case reports, vol. 2015. DOI: 10.1136/bcr-2014-208522

Children’s Oncology Group (COG) Trials for Retinoblastoma
Gombos, DS, Meadows, AT, Chintagumpala, M, Dunkel, IJ, Friedman, D, Stoner, JA, Jubran, R & Villablanca, JG 2015, . in Clinical Ophthalmic Oncology: Retinoblastoma, Second Edition. Springer Berlin Heidelberg, pp. 215-223. DOI: 10.1007/978-3-662-43451-2_21