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Corina Rosales, PhD

Assistant Professor of Bioenergetics, Institute for Academic Medicine
Assistant Member, Research Institute
Houston Methodist
Weill Cornell Medical College


crosales@houstonmethodist.org
Areas Of Expertise

HDL Serum opacity factor Lipoproteins Cholesterol metabolism
Publications

Is Free Cholesterol Bioavailability a Determinant of Dysfunctional, Atherogenic High Density Lipoproteins? Refining the Model of Reverse Cholesterol Transport.
Gillard, BK, Yelamanchili, D, Gotto, A, Rosales, C & Pownall, HJ 2018, ATVB/PVD 2018, San Francisco, United States, 5/9/18 - 5/12/18, .

Bacterial Serum Opacity Factor Rescues HDL Functionality in SR-B1-/- Mice.
Rosales, C, Yelamanchili, D, Gillard, BK, Gotto, A & Pownall, HJ 2018, ATVB/PVD 2018, San Francisco, United States, 5/9/18 - 5/12/18, .

Rethinking reverse cholesterol transport and dysfunctional high-density lipoproteins
Gillard, BK, Rosales, C, Xu, B, Gotto, AM & Pownall, HJ 2018, Journal of Clinical Lipidology, vol. 12, no. 4, pp. 849-856. https://doi.org/10.1016/j.jacl.2018.04.001

Revisiting Reverse Cholesterol Transport in the Context of Free Cholesterol Bioavailability.
Corina Rosales & Pownall, HJ.

ABCA1-Derived Nascent High-Density Lipoprotein-Apolipoprotein AI and Lipids Metabolically Segregate
Xu, B, Gillard, BK, Gotto, AM, Rosales, C & Pownall, HJ 2017, Arteriosclerosis, thrombosis, and vascular biology, vol. 37, no. 12, pp. 2260-2270. https://doi.org/10.1161/ATVBAHA.117.310290

Scavenger receptor B1 (SR-B1) profoundly excludes high density lipoprotein (HDL) apolipoprotein AII as it nibbles HDL-cholesteryl ester
Gillard, BK, Bassett, GR, Gotto, AM, Rosales, C & Pownall, HJ 2017, Journal of Biological Chemistry, vol 292, no. 21, pp. 8864-8873. DOI: 10.1074/jbc.M117.781963

Structural Stability of Streptococcal Serum Opacity Factor.
Rosales, C, Yelamanchili, D, Gillard, BK, Gotto, A & Pownall, HJ 2017, European Atherosclerosis Society, Prague, Czech Republic, 4/23/17 - 4/26/17, .

The HDL receptor, SR-B1, forms remnant HDL by a nibbling mechanism and releases apo AI.
Gillard, BK, Bassett, GR, Rosales, C, Gotto, A & Pownall, HJ 2017, European Atherosclerosis Society, Prague, Czech Republic, 4/23/17 - 4/26/17, .

Cellular ABCA1-Derived Nascent HDL-Cholesterol Transfers to the LDLR Pathway.
Xu, B, Gillard, BK, Gotto, A, Rosales, C & Pownall, HJ 2017, European Atherosclerosis Society, Prague, Czech Republic, 4/23/17 - 4/26/17, .

Metabolic Segregation of Nascent HDL-Lipid and Protein.
Xu, B, Gillard, BK, Gotto, A, Rosales, C & Pownall, HJ 2017, BCM CVRI Symposium, Houston, United States, 4/4/17 - 4/4/17, .

Structural Stability of Streptococcal Serum Opacity Factor
Yelamanchili, D, Gillard, BK, Gotto, AM, Pownall, HJ & Rosales, C 2017, Protein Journal, pp. 1-6. https://doi.org/10.1007/s10930-017-9711-4

Scavenger receptor B1 (SR-B1) profoundly excludes high density lipoprotein (HDL) apolipoprotein AII as it nibbles HDL-cholesteryl ester
Gillard, BK, Bassett, GR, Gotto, AM, Rosales, C & Pownall, HJ 2017, The Journal of biological chemistry, vol. 292, no. 21, pp. 8864-8873. https://doi.org/10.1074/jbc.M117.781963

Acylation of lysine residues in human plasma high density lipoprotein increases stability and plasma clearance in vivo
Yang, Y, Rosales, C, Gillard, BK, Gotto, A & Pownall, HJ 2016, Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids, vol. 1861, no. 11, pp. 1787-1795. https://doi.org/10.1016/j.bbalip.2016.08.017

Neo High-Density Lipoprotein Produced by the Streptococcal Serum Opacity Factor Activity against Human High-Density Lipoproteins Is Hepatically Removed via Dual Mechanisms
Rodriguez, PJ, Gillard, BK, Barosh, R, Gotto, AM, Rosales, C & Pownall, HJ 2016, Biochemistry, vol. 55, no. 41, pp. 5845-5853. https://doi.org/10.1021/acs.biochem.6b00946

Native and Reconstituted Plasma Lipoproteins in Nanomedicine: Physicochemical Determinants of Nanoparticle Structure, Stability, and Metabolism
Pownall, HJ, Rosales, C, Gillard, BK & Ferrari, M 2016, Methodist DeBakey Cardiovascular Journal, vol. 12, no. 3, pp. 146-150. https://doi.org/10.14797/mdcj-12-3-146

Speciated High-Density Lipoprotein Biogenesis and Functionality
Rosales, C, Davidson, WS, Gillard, BK, Gotto, A & Pownall, HJ 2016, Current atherosclerosis reports, vol. 18, no. 5, 25. https://doi.org/10.1007/s11883-016-0572-7

Streptococcal serum opacity factor promotes cholesterol ester metabolism and bile acid secretion in vitro and in vivo
Gillard, BK, Rodriguez, PJ, Fields, DW, Raya, JL, Lagor, WR, Rosales, C, Courtney, HS, Gotto, AM & Pownall, HJ 2016, Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids, vol. 1861, no. 3, pp. 196-204. https://doi.org/10.1016/j.bbalip.2015.12.006

High-Density Lipoprotein Processing and Premature Cardiovascular Disease
Rosales, C, Gillard, BK, Gotto, AM & Pownall, HJ 2015, Methodist DeBakey Cardiovascular Journal, vol. 11, no. 3, pp. 181-185. https://doi.org/10.14797/mdcj-11-3-181

Apolipoprotein AI deficiency inhibits serum opacity factor activity against plasma high density lipoprotein via a stabilization mechanism
Rosales, C, Patel, N, Gillard, BK, Yelamanchili, D, Yang, Y, Courtney, HS, Santos, RD, Gotto, A & Pownall, HJ 2015, Biochemistry, vol. 54, no. 14, pp. 2295-2302. https://doi.org/10.1021/bi501486z

High-Density Lipoprotein Therapies-Then and Now
Pownall, HJ, Rosales, C, Gillard, BK & Gotto, A 2015, . in Atherosclerosis: Risks, Mechanisms, and Therapies. Wiley, pp. 545-555. https://doi.org/10.1002/9781118828533.ch42