Constance M. Mobley, MD, PhD, FACS

Assistant Professor of Surgery, Academic Institute
Houston Methodist
Weill Cornell Medical College


Biography

Dr. Constance M. Mobley earned her MD and PhD from Vanderbilt University School of Medicine in 2003. She completed her General Surgery residency and fellowship in Surgical Critical Care at the University of Michigan. Subsequently, she went on to complete a fellowship in Abdominal Multi-Organ Transplant and Hepatobiliary Surgery at UCLA David Geffen School of Medicine. In 2014, Dr. Mobley joined the staff of Houston Methodist Hospital in Houston, TX and is an Assistant Professor of Surgery at Weill Cornell Medical College.

Dr. Mobley is a board-certified surgeon in surgical critical care, and transplant surgery. She is currently the Medical Director of the Surgical & Liver ICU and Program Director for the Surgical Critical Care Fellowship. She serves as an active member on several hospital committees and professional societies and is a current member of the Legislative and Regulatory Committee.

 

Description of Research

Dr. Mobley’s areas of special interests include management of the critically ill liver failure patient, methodology to improve liver transplant success in high MELD patients, and management of cirrhotic cardiomyopathy and post-transplant cardiomyopathy. She is actively involved in several clinical research trials spanning transplant immunology, liver disease, and support devices to both prolong donor organ utility, and bridge to liver transplant.

Areas Of Expertise

Liver Disease Transplant immunology
Publications

Delayed Implantation of Pumped Kidneys Decreases Renal Allograft Futility in Combined Liver-Kidney Transplantation
Lunsford, KE, Agopian, VG, Yi, S, Nguyen, DTM, Graviss, EA, Harlander-Locke, MP, Saharia, A, Kaldas, FM, Mobley, CM, Zarrinpar, A, Hobeika, MJ, Veale, JL, Podder, H, Farmer, DG, Knight, RJ, Danovitch, GM, Gritsch, HA, Li, XC, Ghobrial, RM, Busuttil, RW & Gaber, AO 2020, Transplantation, pp. 1591-1603. https://doi.org/10.1097/TP.0000000000003040

Pathologic Response to Pretransplant Locoregional Therapy is Predictive of Patient Outcome after Liver Transplantation for Hepatocellular Carcinoma: Analysis from the US Multicenter HCC Transplant Consortium
Dinorcia, J, Florman, SS, Haydel, B, Tabrizian, P, Ruiz, RM, Klintmalm, GB, Senguttuvan, S, Lee, DD, Taner, CB, Verna, EC, Halazun, KJ, Hoteit, M, Levine, MH, Chapman, WC, Vachharajani, N, Aucejo, F, Nguyen, MH, Melcher, ML, Tevar, AD, Humar, A, Mobley, C, Ghobrial, M, Nydam, TL, Amundsen, B, Markmann, JF, Berumen, J, Hemming, AW, Langnas, AN, Carney, CA, Sudan, DL, Hong, JC, Kim, J, Zimmerman, MA, Rana, A, Kueht, ML, Jones, CM, Fishbein, TM, Markovic, D, Busuttil, RW & Agopian, VG 2020, , Annals of surgery, vol. 271, no. 4, pp. 616-624. https://doi.org/10.1097/SLA.0000000000003253

Outcomes of Liver Transplantation for Hepatocellular Carcinoma beyond the University of California San Francisco Criteria: A Single-center Experience
Victor, III, DW, Monsour, HP, Boktour, M, Lunsford, K, Balogh, J, Graviss, EA, Nguyen, DT, McFadden, RS, Divatia, MK, Heyne, K, Ankoma-Sey, V, Egwim, C, Galati, J, Duchini, A, Saharia, A, Mobley, CM, Gaber, AO & Ghobrial, RM 2020, Transplantation, pp. 113-121. https://doi.org/10.1097/TP.0000000000002835

Is Surgery-first Still a Reasonable Option in the Era of Neoadjuvant Chemotherapy for Resectable Pancreatic Cancer?
Saharia, A, Potter, LM, Baio, F, Elaileh, A, Mobley, C, Ghobrial, RM, Abdelrahim, M & Heyne, K 2019, American journal of clinical oncology. https://doi.org/10.1097/COC.0000000000000661

Impact of the new kidney allocation system A2/A2B ? B policy on access to transplantation among minority candidates
Martins, PN, Mustian, MN, MacLennan, PA, Ortiz, JA, Akoad, M, Caicedo, JC, Echeverri, GJ, Gray, SH, Lopez-Soler, RI, Gunasekaran, G, Kelly, B, Mobley, CM, Black, SM, Esquivel, C & Locke, JE 2018, , American Journal of Transplantation, vol. 18, no. 8, pp. 1947-1953. https://doi.org/10.1111/ajt.14719

Liver transplantation for locally advanced intrahepatic cholangiocarcinoma treated with neoadjuvant therapy: a prospective case-series
Lunsford, KE, Javle, M, Heyne, K, Shroff, RT, Abdel-Wahab, R, Gupta, N, Mobley, CM, Saharia, A, Victor, DW, Nguyen, DT, Graviss, EA, Kaseb, AO, McFadden, RS, Aloia, TA, Conrad, C, Li, XC, Monsour, HP, Gaber, AO, Vauthey, J-N, Ghobrial, RM & Methodist–MD Anderson Joint Cholangiocarcinoma Collaborative Committee (MMAJCCC) 2018, The Lancet Gastroenterology and Hepatology, vol. 3, no. 5, pp. 337-348. https://doi.org/10.1016/S2468-1253(18)30045-1

Management of the critically ill liver failure patient: Surpassing our limitations to reach transplantation
Mobley, CM & Saharia, A 2018, , Current opinion in organ transplantation, vol. 23, no. 2, pp. 145-150. https://doi.org/10.1097/MOT.0000000000000518

Impact of Pretransplant Bridging Locoregional Therapy for Patients with Hepatocellular Carcinoma Within Milan Criteria Undergoing Liver Transplantation: Analysis of 3601 Patients from the US Multicenter HCC Transplant Consortium
Agopian, VG, Harlander-Locke, MP, Ruiz, RM, Klintmalm, GB, Senguttuvan, S, Florman, SS, Haydel, B, Hoteit, M, Levine, MH, Lee, DD, Taner, CB, Verna, EC, Halazun, KJ, Abdelmessih, R, Tevar, AD, Humar, A, Aucejo, F, Chapman, WC, Vachharajani, N, Nguyen, MH, Melcher, ML, Nydam, TL, Mobley, CM, Ghobrial, RM, Amundsen, B, Markmann, JF, Langnas, AN, Carney, CA, Berumen, J, Hemming, AW, Sudan, DL, Hong, JC, Kim, J, Zimmerman, MA, Rana, A, Kueht, ML, Jones, CM, Fishbein, TM & Busuttil, RW 2017, , Annals of surgery, vol. 266, no. 3, pp. 525-535. https://doi.org/10.1097/SLA.0000000000002381

Strongyloides stercoralis in solid organ transplantation: early diagnosis gets the worm
Mobley, CM, Dhala, A & Ghobrial, RM 2017, , Current opinion in organ transplantation. https://doi.org/10.1097/MOT.0000000000000428

Risk Analysis of Patients with Proven Coronary Artery Disease Undergoing Liver Transplant
Balogh, J, Lunsford, KE, Nguyen, DTM, Graviss, EA, Cercio, O, Mobley, CM, Saharia, A, Burroughs, SG, Gaber, AO & Ghobrial, RM 2017, American Journal of Transplantation, vol. 17, no. suppl 3.

Intraoperative Laparoscopic Near-Infrared Fluorescence Cholangiography to Facilitate Anatomical Identification: When to Give Indocyanine Green and How Much
Zarrinpar, A, Dutson, EP, Mobley, CM, Busuttil, RW, Lewis, CE, Tillou, A, Cheaito, A, Hines, OJ, Agopian, VG & Hiyama, DT 2016, , Surgical Innovation, vol. 23, no. 4, pp. 360-365. https://doi.org/10.1177/1553350616637671

Portable device for the analysis of liver function: A boon to liver surgery and critical care
Mobley, CM & Zarrinpar, A 2016, , Expert Review of Medical Devices, vol. 13, no. 1, pp. 1-4. https://doi.org/10.1586/17434440.2016.1126178

Post-Transplant Length of Stay and Discharge Disposition Is Impacted By Pre-Transplant Location But Not Transplant Survival
Victor, III, DW, Monsour, Jr. HP, Boktour, MR, Gordon Burroughs, S, Saharia, A, McFadden, R, Ankoma-Sey, V, Egwim, C, Galati, J, Mobley, CM, Gaber, AO & Ghobrial, RM.

Muscle Mass Measurement is Objective and More Predictive of Expected Mortality than Functional Status in High MELD Liver Transplant Recipients
Victor, III, DW, Nolte, JV, Gordon Burroughs, S, Mobley, CM, Yu, N, Hirase, T, Saharia, A, Rajaraman, A, Moore, LW, Gaber, AO & Ghobrial, RM.

Molecular and Cellular Basis of Liver Failure
Mobley, CM & Zarrinpar, A 2015, . in Transplantation of the Liver: Third Edition. Elsevier, pp. 40-57. https://doi.org/10.1016/B978-1-4557-0268-8.00003-8

Iatrogenic pancreatic cyst perforation successfully managed by a minimally invasive combined endoscopic-laparoscopic approach
Elmunzer, BJ, Boetticher, NC, Mobley, CM, Brewster, ME & Sonnenday, CJ 2010, Journal of Laparoendoscopic and Advanced Surgical Techniques, vol. 20, no. 8, pp. 717-719. https://doi.org/10.1089/lap.2010.0308

The Rous sarcoma virus long terminal repeat promoter is regulated by TFII-I
Mobley, CM & Sealy, L 2000, , Journal of virology, vol. 74, no. 14, pp. 6511-6519. https://doi.org/10.1128/JVI.74.14.6511-6519.2000

Role of the transcription start site core region and transcription factor YY1 in rous sarcoma virus long terminal repeat promoter activity
Mobley, CM & Sealy, L 1998, , Journal of virology, vol. 72, no. 8, pp. 6592-6601. https://doi.org/10.1128/jvi.72.8.6592-6601.1998