Constance M. Mobley, MD, PhD, FACS

Assistant Professor of Surgery, Academic Institute
Houston Methodist
Weill Cornell Medical College


Biography

Dr. Constance M. Mobley earned her MD and PhD from Vanderbilt University School of Medicine in 2003. She completed her General Surgery residency and fellowship in Surgical Critical Care at the University of Michigan. Subsequently, she went on to complete a fellowship in Abdominal Multi-Organ Transplant and Hepatobiliary Surgery at UCLA David Geffen School of Medicine. In 2014, Dr. Mobley joined the staff of Houston Methodist Hospital in Houston, TX and is an Assistant Professor of Surgery at Weill Cornell Medical College.

Dr. Mobley is a board-certified surgeon in surgical critical care, and transplant surgery. She is currently the Medical Director of the Surgical & Liver ICU and Program Director for the Surgical Critical Care Fellowship. She serves as an active member on several hospital committees and professional societies and is a current member of the Legislative and Regulatory Committee.

 

Description of Research

Dr. Mobley’s areas of special interests include management of the critically ill liver failure patient, methodology to improve liver transplant success in high MELD patients, and management of cirrhotic cardiomyopathy and post-transplant cardiomyopathy. She is actively involved in several clinical research trials spanning transplant immunology, liver disease, and support devices to both prolong donor organ utility, and bridge to liver transplant.

Areas Of Expertise

Liver Disease Transplant immunology
Publications

Combined liver transplant and sleeve gastrectomy: report of a brief-interval staged approach
Tariq, N, Saharia, A, Nwokedi, U, Hobeika, MJ, Mobley, CM, Hsu, D, Potter, LM, Moore, LW, Elaileh, A, Sherman, V & Ghobrial, RM 2022, , Liver Transplantation. https://doi.org/10.1002/lt.26560

Graft and Patient Survival after Liver Transplantation
Yi, S, Mobley, CM & Ghobrial, RM 2022, . in P Burra (ed.), Textbook of Liver Transplantation. Springer, pp. 433-448.

Perioperative cangrelor in patients with recent percutaneous coronary intervention undergoing liver transplantation: A case series
Succar, L, Lopez, CN, Victor, DW, Lindberg, SA, Saharia, A, Sheth, S & Mobley, CM 2022, , Pharmacotherapy, vol. 42, no. 3, pp. 263-267. https://doi.org/10.1002/phar.2661

Perioperative cangrelor in patients with recent percutaneous coronary intervention undergoing liver transplantation: A case series
Succar, L, Lopez, CN, Victor, DW, Lindberg, SA, Saharia, A, Sheth, S & Mobley, CM 2022, , Pharmacotherapy, vol. 42, no. 3, pp. 263-267. https://doi.org/10.1002/phar.2661

Early humoral immune response to two doses of severe acute respiratory syndrome coronavirus 2 vaccine in a diverse group of solid organ transplant candidates and recipients
Huang, HJ, Yi, SG, Mobley, CM, Saharia, A, Bhimaraj, A, Moore, LW, Kloc, M, Adrogue, HE, Graviss, EA, Nguyen, DT, Eagar, TN, Jones, SL, Ankoma-Sey, V, MacGillivray, TE, Knight, RJ, Gaber, AO & Ghobrial, RM 2022, , Clinical Transplantation, vol. 36, no. 5, e14600. https://doi.org/10.1111/ctr.14600, https://doi.org/10.1111/ctr.14600

Early humoral immune response to two doses of severe acute respiratory syndrome coronavirus 2 vaccine in a diverse group of solid organ transplant candidates and recipients
Huang, HJ, Yi, SG, Mobley, CM, Saharia, A, Bhimaraj, A, Moore, LW, Kloc, M, Adrogue, HE, Graviss, EA, Nguyen, DT, Eagar, TN, Jones, SL, Ankoma-Sey, V, MacGillivray, TE, Knight, RJ, Gaber, AO & Ghobrial, RM 2022, , Clinical Transplantation, vol. 36, no. 5, e14600. https://doi.org/10.1111/ctr.14600

Combined liver transplantation and sleeve gastrectomy: Report of a brief-interval staged approach
Tariq, N, Saharia, A, Nwokedi, U, Hobeika, MJ, Mobley, CM, Hsu, D, Potter, LM, Moore, LW, Elaileh, A, Sherman, V & Ghobrial, RM 2022, , Liver Transplantation. https://doi.org/10.1002/lt.26560

Risk Factors Associated with an Impaired Antibody Response in Kidney Transplant Recipients following 2 Doses of the SARS-CoV-2 mRNA Vaccine
Yi, SG, Moore, LW, Eagar, T, Graviss, EA, Nguyen, DT, Ibrahim, H, Huang, HJ, Hobeika, M, McMillan, R, Saharia, A, Mobley, C, Podder, H, Drews, A, Ghobrial, RM, Gaber, AO & Knight, RJ 2021, , Transplantation Direct, vol. 8, no. 1, e1257. https://doi.org/10.1097/TXD.0000000000001257

Pre-transplant T-cell Clonality: An Observational Study of a Biomarker for Prediction of Sepsis in Liver Transplant Recipients
Jones, SL, Moore, LW, Li, XC, Mobley, CM, Fields, PA, Graviss, EA, Nguyen, DT, Nolte Fong, J, Saharia, A, Hobeika, MJ, McMillan, RR, Victor, DW, Minze, LJ, Gaber, AO & Ghobrial, RM 2021, , Annals of surgery, vol. 274, no. 3, pp. 411-418. https://doi.org/10.1097/SLA.0000000000004998

In silico deceased donor intervention research: A potential accelerant for progress
Hobeika, MJ, Casarin, S, Saharia, A, Mobley, C, Yi, S, McMillan, R, Mark Ghobrial, R & Gaber, AO 2021, , American Journal of Transplantation, vol. 21, no. 6, pp. 2231-2239. https://doi.org/10.1111/ajt.16482

Donation after circulatory death liver transplantation: An in-depth analysis and propensity score–matched comparison
Hobeika, MJ, Saharia, A, Mobley, CM, Menser, T, Nguyen, DT, Graviss, EA, McMillan, RR, Podder, H, Nolte Fong, JV, Jones, SL, Yi, SG, Elshawwaf, M, Gaber, AO & Ghobrial, RM 2021, , Clinical Transplantation, vol. 35, no. 6, pp. e14304. https://doi.org/10.1111/ctr.14304

Donation after circulatory death liver transplantation: An in-depth analysis and propensity score–matched comparison
Hobeika, MJ, Saharia, A, Mobley, CM, Menser, T, Nguyen, DT, Graviss, EA, McMillan, RR, Podder, H, Nolte Fong, JV, Jones, SL, Yi, SG, Elshawwaf, M, Gaber, AO & Ghobrial, RM 2021, , Clinical Transplantation. https://doi.org/10.1111/ctr.14304

Donation after circulatory death liver transplantation: An in-depth analysis and propensity score–matched comparison
Hobeika, MJ, Saharia, A, Mobley, CM, Menser, T, Nguyen, DT, Graviss, EA, McMillan, RR, Podder, H, Nolte Fong, JV, Jones, SL, Yi, SG, Elshawwaf, M, Gaber, AO & Ghobrial, RM 2021, , Clinical Transplantation, vol. 35, no. 6, e14304. https://doi.org/10.1111/ctr.14304

Survival following liver transplantation for locally advanced, unresectable intrahepatic cholangiocarcinoma
McMillan, RR, Javle, M, Kodali, S, Saharia, A, Mobley, C, Heyne, K, Hobeika, MJ, Lunsford, KE, Victor, DW, Shetty, A, McFadden, RS, Abdelrahim, M, Kaseb, A, Divatia, M, Yu, N, Nolte Fong, J, Moore, LW, Nguyen, DT, Graviss, EA, Gaber, AO, Vauthey, JN & Ghobrial, RM 2022, , American Journal of Transplantation, vol. 22, no. 3, pp. 823-832. https://doi.org/10.1111/ajt.16906

Successful Treatment of Invasive Mucormycosis in Orthotopic Liver Transplant Population
Eubank, TA, Mobley, CM, Moaddab, M, Hobeika, MJ, ONeal, M, Musick, WL, Knight, JM, Galati, JS, Kodali, S, Shetty, A, Victor, DW, Saharia, A, Ghobrial, RM & Grimes, KA 2021, , Case reports in transplantation, vol. 2021, pp. 8667589. https://doi.org/10.1155/2021/8667589

Patterns of Alcohol Use After Early Liver Transplantation for Alcoholic Hepatitis
Lee, BP, Im, GY, Rice, JP, Lazar, A, Weinberg, E, Han, H, Maddur, H, Ghobrial, RM, Therapondos, G, Hsu, C, Fix, OK, Eswaran, S, Shetty, K, Chhatwal, J, Dalgic, OO, Jakhete, N, Mobley, C, Victor, DW, Mehta, N, Dinges, L, Rinella, M, Schiano, TD, Lucey, MR & Terrault, N 2020, , Clinical Gastroenterology and Hepatology, vol. 20, no. 2, pp. 409-418.e5. https://doi.org/10.1016/j.cgh.2020.11.024

Liver Transplantation Outcomes in a U.S. Multicenter Cohort of 789 Patients With Hepatocellular Carcinoma Presenting Beyond Milan Criteria
Kardashian, A, Florman, SS, Haydel, B, Ruiz, RM, Klintmalm, GB, Lee, DD, Taner, CB, Aucejo, F, Tevar, AD, Humar, A, Verna, EC, Halazun, KJ, Chapman, WC, Vachharajani, N, Hoteit, M, Levine, MH, Nguyen, MH, Melcher, ML, Langnas, AN, Carney, CA, Mobley, C, Ghobrial, M, Amundsen, B, Markmann, JF, Sudan, DL, Jones, CM, Berumen, J, Hemming, AW, Hong, JC, Kim, J, Zimmerman, MA, Nydam, TL, Rana, A, Kueht, ML, Fishbein, TM, Markovic, D, Busuttil, RW & Agopian, VG 2020, , Hepatology, vol. 72, no. 6, pp. 2014-2028. https://doi.org/10.1002/hep.31210

Pathologic Response to Pretransplant Locoregional Therapy is Predictive of Patient Outcome after Liver Transplantation for Hepatocellular Carcinoma: Analysis from the US Multicenter HCC Transplant Consortium
Dinorcia, J, Florman, SS, Haydel, B, Tabrizian, P, Ruiz, RM, Klintmalm, GB, Senguttuvan, S, Lee, DD, Taner, CB, Verna, EC, Halazun, KJ, Hoteit, M, Levine, MH, Chapman, WC, Vachharajani, N, Aucejo, F, Nguyen, MH, Melcher, ML, Tevar, AD, Humar, A, Mobley, C, Ghobrial, M, Nydam, TL, Amundsen, B, Markmann, JF, Berumen, J, Hemming, AW, Langnas, AN, Carney, CA, Sudan, DL, Hong, JC, Kim, J, Zimmerman, MA, Rana, A, Kueht, ML, Jones, CM, Fishbein, TM, Markovic, D, Busuttil, RW & Agopian, VG 2020, , Annals of surgery, vol. 271, no. 4, pp. 616-624. https://doi.org/10.1097/SLA.0000000000003253

Early experience with COVID-19 and solid organ transplantation at a US high-volume transplant center
Yi, SG, Rogers, AW, Saharia, A, Aoun, M, Faour, R, Abdelrahim, M, Knight, RJ, Grimes, K, Bullock, S, Hobeika, M, McMillan, R, Mobley, C, Moaddab, M, Huang, HJ, Bhimaraj, A, Ghobrial, RM & Gaber, AO 2020, , Transplantation, vol. 104, no. 11, pp. 2208-2214. https://doi.org/10.1097/TP.0000000000003339

Posttransplant Outcomes in Older Patients With Hepatocellular Carcinoma Are Driven by Non–Hepatocellular Carcinoma Factors
Adeniji, N, Arjunan, V, Prabhakar, V, Mannalithara, A, Ghaziani, T, Ahmed, A, Kwo, P, Nguyen, M, Melcher, ML, Busuttil, RW, Florman, SS, Haydel, B, Ruiz, RM, Klintmalm, GB, Lee, DD, Burcin Taner, C, Hoteit, MA, Verna, EC, Halazun, KJ, Tevar, AD, Humar, A, Chapman, WC, Vachharajani, N, Aucejo, F, Nydam, TL, Markmann, JF, Mobley, C, Ghobrial, M, Langnas, AN, Carney, CA, Berumen, J, Schnickel, GT, Sudan, DL, Hong, JC, Rana, A, Jones, CM, Fishbein, TM, Agopian, V & Dhanasekaran, R 2021, , Liver Transplantation, vol. 27, no. 5, pp. 684-698. https://doi.org/10.1002/lt.25974