Christopher Fan, MD

The Fondren Centennial Chair in Gastrointestinal Microbiome, Lynda K. and David M. Underwood Center for Digestive Disorders
Assistant Professor of Medicine, Academic Institute
Assistant Clinical Member, Research Institute
Houston Methodist
Weill Cornell Medical College


Dr. Christopher Fan is a clinical and research gastroenterologist interested in understanding the role of the gut microbiome and its interactions with mucosal immunology in disease pathogenesis. During his gastroenterology fellowship, he was also a clinical pharmacology T32 fellow and is interested in elucidating new targets for the treatment of disease processes that are mediated by these interactions. Dr. Fan is a member of the AGA.

Dr. Fan is a Houston native, having graduated from Bellaire High School and Rice University with a BSE in Bioengineering. He subsequently went on to medical school at Duke University where he was also a HHMI Medical Research Fellow at Massachusetts General Hospital/Harvard Medical School. This was followed by internal medicine residency and gastroenterology fellowship at Johns Hopkins. His clinical and research interest focus on immunotherapy related toxicities in the gastrointestinal tract due to cancer treatment, inflammatory bowel disease and general gastroenterology. 


The Role of Vitamin D in Patients with Inflammatory Bowel Disease Treated with Vedolizumab
Abraham, BP, Fan, C, Thurston, T, Moskow, J & Malaty, HM 2023, , Nutrients, vol. 15, no. 22, 4847.,

Clinical Evaluation of Upadacitinib in the Treatment of Adults with Moderately to Severely Active Ulcerative Colitis (UC): Patient Selection and Reported Outcomes
Irani, M, Fan, C, Glassner, K & Abraham, BP 2023, , Clinical and Experimental Gastroenterology, vol. 16, pp. 21-28.

Morphologic Severity of Acute Pancreatitis on Imaging Is Independently Associated with Opioid Dose Requirements in Hospitalized Patients
Ashok, A, Faghih, M, Azadi, JR, Parsa, N, Fan, C, Bhullar, F, Gonzalez, FG, Jalaly, NY, Boortalary, T, Khashab, MA, Kamal, A, Akshintala, VS, Zaheer, A, Afghani, E & Singh, VK 2022, , Digestive Diseases and Sciences, vol. 67, no. 4, pp. 1362-1370.

Malnutrition Increases Hospital Length of Stay and Mortality among Adult Inpatients with COVID-19
Vong, T, Yanek, LR, Wang, L, Yu, H, Fan, C, Zhou, E, Oh, SJ, Szvarca, D, Kim, A, Potter, JJ & Mullin, GE 2022, , Nutrients, vol. 14, no. 6, 1310.

Outcomes of immunotherapy-related hepatotoxicity from a multi-disciplinary toxicity team
Fan, C, Kim, A, Li, S, Naidoo, J, Cappelli, LC, Brahmer, JR, Anders, RA & Kim, AK 2023, , Journal of Cancer Research and Clinical Oncology, vol. 149, no. 2, pp. 877-883.

Impact of genetic testing and smoking on the distribution of risk factors in patients with recurrent acute and chronic pancreatitis
Gurakar, M, Jalaly, NY, Faghih, M, Boortalary, T, Azadi, JR, Khashab, MA, Fan, C, Kalloo, AN, Zaheer, A, Singh, VK & Afghani, E 2022, , Scandinavian Journal of Gastroenterology, vol. 57, no. 1, pp. 91-98.

Multidisciplinary approach to immune-mediated diarrhea and colitis from immunotherapy for cancer
Fan, C & Naidoo, J 2020, , JCO oncology practice, vol. 16, no. 8, pp. 462-463.

Low Serum Trypsin Levels Predict Deep Pancreatic Cannulation Failure during Endoscopic Retrograde Cholangiopancreatography in Patients with Symptomatic Obstructive Chronic Pancreatitis
Faghih, M, Boortalary, T, Jalaly, NY, Brewer Gutierrez, OI, Chen, YI, Azadi, JR, Parsa, N, Noë, M, Fan, C, Kumbhari, V, Kalloo, AN, Zaheer, A, Khashab, MA & Singh, VK 2019, , Pancreas, vol. 48, no. 6, pp. 844-849.

Remodeling of ECM patch into functional myocardium in an ovine model: A pilot study
Scully, BB, Fan, C, Grigoryan, B, Jacot, JG, Vick, GW, Kim, JJ, Fraser, CD, Grande-Allen, KJ & Morales, DLS 2016, , Journal of Biomedical Materials Research - Part B Applied Biomaterials, vol. 104, no. 8, pp. 1713-1720.

An orthotopic mouse model of hepatocellular carcinoma with underlying liver cirrhosis
Reiberger, T, Chen, Y, Ramjiawan, RR, Hato, T, Fan, C, Samuel, R, Roberge, S, Huang, P, Lauwers, GY, Zhu, AX, Bardeesy, N, Jain, RK & Duda, DG 2015, , Nature Protocols, vol. 10, no. 8, pp. 1264-1274.

CXCR4 inhibition in tumor microenvironment facilitates anti-programmed death receptor-1 immunotherapy in sorafenib-treated hepatocellular carcinoma in mice
Chen, Y, Ramjiawan, RR, Reiberger, T, Ng, MR, Hato, T, Huang, Y, Ochiai, H, Kitahara, S, Unan, EC, Reddy, TP, Fan, C, Huang, P, Bardeesy, N, Zhu, AX, Jain, RK & Duda, DG 2015, , Hepatology, vol. 61, no. 5, pp. 1591-1602.