Chih-Hang Anthony Tang

Chih-Hang Anthony Tang, MD, PhD

Assistant Professor of Oncology, Academic Institute
Assistant Member, Research Institute
Houston Methodist
Weill Cornell Medical College


Tang Lab


Biography

Dr. Chih-Hang Anthony Tang is a newly appointed Assistant Professor in the Houston Methodist Cancer Center at Houston Methodist Academic Institute. Dr. Tang received his MD degree from National Defense Medical Center in Taiwan and PhD degree from Brandeis University under the tutelage of Dr. Michael Rosbash (2017 Nobel Laureate in Physiology or Medicine). In the Rosbash laboratory, Dr. Tang studied circadian rhythms using fruit flies as a model. He provided the first quantitative assessment of the Drosophila brain clock neurons in response to light stimulation and demonstrated a systems view of light-mediated phase shifting. Later, Dr. Tang did his postdoctoral training in the laboratory of Dr. Chih-Chi Andrew Hu. Dr. Tang has studied the role of endoplasmic reticulum resident proteins in B cell leukemia with an outstanding publication record. Dr. Tang has been awarded a K22 grant from NCI to support his research.

Description of Research

To contribute to the treatment of cancer through the understanding of mechanisms of how tumors interact with immune systems in tumor microenvironment.

Education & Training

PhD, Brandeis University
MD, National Defense Medical Center Taiwan
Publications

Targeting the IRE1a/XBP1s pathway suppresses CARM1-expressing ovarian cancer
Lin, J, Liu, H, Fukumoto, T, Zundell, J, Yan, Q, Tang, CHA, Wu, S, Zhou, W, Guo, D, Karakashev, S, Hu, CCA, Sarma, K, Kossenkov, AV & Zhang, R 2021, , Nature Communications, vol. 12, no. 1, 5321. https://doi.org/10.1038/s41467-021-25684-3

XBP-1s Promotes B Cell Pathogenicity in Chronic GVHD by Restraining the Activity of Regulated IRE-1a-Dependent Decay
Choi, H-J, Tang, C-HA, Tian, L, Wu, Y, Sofi, MH, Ticer, T, Schutt, SD, Hu, C-CA & Yu, X-Z 2021, , Frontiers in immunology, vol. 12, pp. 705484. https://doi.org/10.3389/fimmu.2021.705484

Deletion of mFICD AMPylase alters cytokine secretion and affects visual short-term learning in vivo
McCaul, N, Porter, CM, Becker, A, Tang, CHA, Wijne, C, Chatterjee, B, Bousbaine, D, Bilate, A, Hu, CCA, Ploegh, H & Truttmann, MC 2021, , Journal of Biological Chemistry, vol. 297, no. 3, 100991. https://doi.org/10.1016/j.jbc.2021.100991

Distinct mechanisms govern populations of myeloid-derived suppressor cells in chronic viral infection and cancer
Tcyganov, EN, Hanabuchi, S, Hashimoto, A, Campbell, D, Kar, G, Slidel, TWF, Cayatte, C, Landry, A, Pilataxi, F, Hayes, S, Dougherty, B, Hicks, KC, Mulgrew, K, Tang, CHA, Hu, CCA, Guo, W, Grivennikov, S, Ali, MAA, Beltra, JC, Wherry, EJ, Nefedova, Y & Gabrilovich, DI 2021, , Journal of Clinical Investigation, vol. 131, no. 16, e145971. https://doi.org/10.1172/JCI145971

Endoplasmic reticulum-associated degradation is required for nephrin maturation and kidney glomerular filtration function
Yoshida, S, Wei, X, Zhang, G, OConnor, CL, Torres, M, Zhou, Z, Lin, L, Menon, R, Xu, X, Zheng, W, Xiong, Y, Otto, E, Tang, CHA, Hua, R, Verma, R, Mori, H, Zhang, Y, Hu, CCA, Liu, M, Garg, P, Hodgin, JB, Sun, S, Bitzer, M & Qi, L 2021, , Journal of Clinical Investigation, vol. 131, no. 7, e143988. https://doi.org/10.1172/JCI143988

STING negatively regulates allogeneic T-cell responses by constraining antigen-presenting cell function
Wu, Y, Tang, CHA, Mealer, C, Bastian, D, Hanief Sofi, M, Tian, L, Schutt, S, Choi, HJ, Ticer, T, Zhang, M, Sui, X, Huang, L, Mellor, AL, Hu, CCA & Yu, XZ 2021, , Cellular and Molecular Immunology, vol. 18, no. 3, pp. 632-643. https://doi.org/10.1038/s41423-020-00611-6

An interdomain helix in IRE1a mediates the conformational change required for the sensor's activation
Ricci, D, Tutton, S, Marrocco, I, Ying, M, Blumenthal, D, Eletto, D, Vargas, J, Boyle, S, Fazelinia, H, Qian, L, Suresh, K, Taylor, D, Paton, JC, Paton, AW, Tang, CHA, Hu, CCA, Radhakrishnan, R, Gidalevitz, T & Argon, Y 2021, , Journal of Biological Chemistry, vol. 296, 100781. https://doi.org/10.1016/J.JBC.2021.100781

Development of tumor-targeting ire-1 inhibitors for b-cell cancer therapy
Shao, A, Xu, Q, Spalek, WT, Cain, CF, Kang, CW, Tang, CHA, Del Valle, JR & Hu, CCA 2020, , Molecular Cancer Therapeutics, vol. 19, no. 12, pp. 2432-2444. https://doi.org/10.1158/1535-7163.MCT-20-0127

Sel1L-Hrd1 ER-associated degradation maintains ß cell identity via TGF-ß signaling
Shrestha, N, Liu, T, Ji, Y, Reinert, RB, Torres, M, Li, X, Zhang, M, Tang, CHA, Hu, CCA, Liu, C, Naji, A, Liu, M, Lin, JD, Kersten, S, Arvan, P & Qi, L 2020, , Journal of Clinical Investigation, vol. 130, no. 7, pp. 3499-3510. https://doi.org/10.1172/JCI134874

STING regulates BCR signaling in normal and malignant B cells
Tang, CHA, Lee, AC, Chang, S, Xu, Q, Shao, A, Lo, Y, Spalek, WT, Pinilla-Ibarz, JA, Del Valle, JR & Hu, CCA 2021, , Cellular and Molecular Immunology, vol. 18, no. 4, pp. 1016-1031. https://doi.org/10.1038/s41423-020-00552-0

Structural Tailoring of a Novel Fluorescent IRE-1 RNase Inhibitor to Precisely Control Its Activity
Shao, A, Kang, CW, Tang, CHA, Cain, CF, Xu, Q, Phoumyvong, CM, Del Valle, JR & Hu, CCA 2019, , Journal of Medicinal Chemistry, vol. 62, no. 11, pp. 5404-5413. https://doi.org/10.1021/acs.jmedchem.9b00269

Inhibition of Human Dendritic Cell ER Stress Response Reduces T Cell Alloreactivity Yet Spares Donor Anti-tumor Immunity
Betts, BC, Locke, FL, Sagatys, EM, Pidala, J, Walton, K, Menges, M, Reff, J, Saha, A, Djeu, JY, Kiluk, JV, Lee, MC, Kim, J, Kang, CW, Tang, CHA, Frieling, J, Lynch, CC, List, A, Rodriguez, PC, Blazar, BR, Conejo-Garcia, JR, Del Valle, JR, Hu, CCA & Anasetti, C 2018, , Frontiers in immunology, vol. 9, 2887. https://doi.org/10.3389/fimmu.2018.02887

CD19 alterations emerging after CD19-directed immunotherapy cause retention of the misfolded protein in the endoplasmic reticulum
Bagashev, A, Sotillo, E, Tang, CHA, Black, KL, Perazzelli, J, Seeholzer, SH, Argon, Y, Barrett, DM, Grupp, SA, Hu, CCA & Thomas-Tikhonenkoa, A 2018, , Molecular and Cellular Biology, vol. 38, no. 21, e0038318. https://doi.org/10.1128/MCB.00383-18

Secretory IgM exacerbates tumor progression by inducing accumulations of MDSCs in mice
Tang, CHA, Chang, S, Hashimoto, A, Chen, YJ, Kang, CW, Mato, AR, Del Valle, JR, Gabrilovich, DI & Hu, CCA 2018, , Cancer immunology research, vol. 6, no. 6, pp. 696-710. https://doi.org/10.1158/2326-6066.CIR-17-0582

Phosphorylation of IRE1 at S729 regulates RIDD in B cells and antibody production after immunization
Anthony Tang, CH, Chang, S, Paton, AW, Paton, JC, Gabrilovich, DI, Ploegh, HL, Del Valle, JR & Andrew Hu, CC 2018, , Journal of Cell Biology, vol. 217, no. 5, pp. 1739-1755. https://doi.org/10.1083/jcb.201709137

IRE1a RNase-dependent lipid homeostasis promotes survival in Myc-transformed cancers
Xie, H, Tang, CHA, Song, JH, Mancuso, A, Del Valle, JR, Cao, J, Xiang, Y, Dang, CV, Lan, R, Sanchez, DJ, Keith, B, Hu, CCA & Simon, MC 2018, , Journal of Clinical Investigation, vol. 128, no. 4, pp. 1300-1316. https://doi.org/10.1172/JCI95864

Inhibition of the IRE-1a/XBP-1 pathway prevents chronic GVHD and preserves the GVL effect in mice
Schutt, SD, Wu, Y, Tang, CHA, Bastian, D, Nguyen, H, Sofi, MH, Zhang, MM, Liu, C, Helke, K, Wilson, C, Schnapp, LM, Del Valle, JR, Hu, CCA & Yu, XZ 2018, , Blood Advances, vol. 2, no. 4, pp. 414-427. https://doi.org/10.1182/bloodadvances.2017009068

Agonist-mediated activation of STING induces apoptosis in malignant B cells
Tang, CHA, Zundell, JA, Ranatunga, S, Lin, C, Nefedova, Y, Del Valle, JR & Hu, CCA 2016, , Cancer research, vol. 76, no. 8, pp. 2137-2152. https://doi.org/10.1158/0008-5472.CAN-15-1885

Site-specific proteolysis mobilizes TorsinA from the membrane of the endoplasmic reticulum (ER) in response to ER stress and B cell stimulation
Zhao, C, Brown, RSH, Tang, CHA, Hu, CCA & Schlieker, C 2016, , Journal of Biological Chemistry, vol. 291, no. 18, pp. 9469-9481. https://doi.org/10.1074/jbc.M115.709337

Inhibition of ER stress-associated IRE-1/XBP-1 pathway reduces leukemic cell survival
Tang, CHA, Ranatunga, S, Kriss, CL, Cubitt, CL, Tao, J, Pinilla-Ibarz, JA, Del Valle, JR & Hu, CCA 2014, , Journal of Clinical Investigation, vol. 124, no. 6, pp. 2585-2598. https://doi.org/10.1172/JCI73448