Charles C. Wykoff, MD, PhD

Associate Professor of Clinical Ophthalmology, Institute for Academic Medicine
Associate Clinical Member, Research Institute
Houston Methodist
Weill Cornell Medical College


Charles Wykoff, MD, PhD, graduated Phi Beta Kappa from MIT, received his PhD from Oxford University in England while on a Marshall Scholarship, and his MD from Harvard Medical School. As a medical student he co-authored the book Fighting Global Blindness. While pursuing vitreoretinal training at Bascom Palmer Eye Institute he was awarded a Heed Fellowship, the Ronald G. Michels Fellowship Award, and served as Chief Resident/Co-Director of Ocular Trauma.

Dr. Wykoff has extensive expertise in clinical trial design and coordination. His research interests pertain to angiogenesis and retinal vascular diseases including age-related macular degeneration, diabetic retinopathy, and venous occlusive diseases, as well as vitreoretinal surgery topics such as retinal detachment and macular surgery. Dr. Wykoff has written and published over 120 peer-reviewed scientific manuscripts, book chapters, national meeting presentations and abstracts. Dr. Wykoff is Director of the Retina Consultants of Houston and Houston Methodist Hospital joint Argus II retinal prosthetic program – the only Gulf Coast site approved for surgical implantation of this unique technology for patients blind from retinitis pigmentosa. Dr. Wykoff is Co-Director of the Greater Houston Retina Research Foundation, was awarded the American Academy of Ophthalmology Achievement Award in 2015 and is an elected member of the Retina Society and the Macula Society. He also serves as the Academic Program Director for the Vit-buckle Society Annual Meeting, and is a member of the AAO, ARVO, ASRS and FACS.

Areas Of Expertise

Retina Diabetic retinopathy Macular degeneration Vitreoretinal surgery
Education & Training

Internship, Harvard University
MD, Harvard University
Clinical Fellowship, Bascom Palmer Eye Inst & Hosp
Residency, Bascom Palmer Eye Inst & Hosp

Retinopathy Regression with Treat and Extend Ranibizumab for Diabetic Macular Edema
Payne, JF, Clark, WL, Bruce, BB, Wykoff, CC, Brown, DM, Menke, BM, Iverson, SM, Allen, KF, Boyer, DS & Treat & Extend Protocol in Patients with Diabetic Macular Edema Study Group 2018, Ophthalmology. DOI: 10.1016/j.ophtha.2018.03.046

Identification of factors to increase efficacy of telemedicine screening for diabetic retinopathy in endocrinology practices using the Intelligent Retinal Imaging System (IRIS) platform
Naik, S, Wykoff, CC, Ou, WC, Stevenson, J, Gupta, S & Shah, AR 2018, Diabetes research and clinical practice, vol 140, pp. 265-270. DOI: 10.1016/j.diabres.2018.04.011

Changes in retinal ischaemic index correlate with recalcitrant macular oedema in retinal vein occlusion: WAVE study
Kwon, S, Wykoff, CC, Brown, DM, van Hemert, J, Fan, W & Sadda, SR 2018, British Journal of Ophthalmology. DOI: 10.1136/bjophthalmol-2017-311475

Long-term outcomes with as-needed aflibercept in diabetic macular oedema: 2-year outcomes of the ENDURANCE extension study
Wykoff, CC, Ou, WC, Khurana, RN, Brown, DM, Lloyd Clark, W, Boyer, DS & ENDURANCE Study Group 2018, British Journal of Ophthalmology, vol 102, no. 5, pp. 631-636. DOI: 10.1136/bjophthalmol-2017-310941

Neovascular age-related macular degeneration management in the third year: Final results from the TREX-AMD randomised trial
Wykoff, CC, Ou, WC, Croft, DE, Payne, JF, Brown, DM, Clark, WL, Abdelfattah, NS & Sadda, SVR 2018, British Journal of Ophthalmology, vol 102, no. 4, pp. 460-464. DOI: 10.1136/bjophthalmol-2017-310822

Longitudinal Quantification of Retinal Nonperfusion in the Macula of Eyes With Retinal Vein Occlusion Receiving Anti-VEGF Therapy: Secondary Analysis of the WAVE Randomized Trial
Ou, WC, Lampen, SIR & Wykoff, CC 2018, Ophthalmic surgery, lasers & imaging retina, vol 49, no. 4, pp. 258-264. DOI: 10.3928/23258160-20180329-08

Plasma Vascular Endothelial Growth Factor Concentrations after Intravitreous Anti-Vascular Endothelial Growth Factor Therapy for Diabetic Macular Edema
Jampol, LM, Glassman, AR, Liu, D, Aiello, LP, Bressler, NM, Duh, EJ, Quaggin, S, Wells, JA & Wykoff, CC 2018, Ophthalmology. DOI: 10.1016/j.ophtha.2018.01.019

When your diabetic patient requires anterior segment attention: How to successfully manage patients with diabetes during cataract surgery
Steinle, NC & Wykoff, CC 2018, Retina Today, vol 2018, no. March, pp. 50-52.

Subfoveal choroidal thickness predicts macular atrophy in age-related macular degeneration: results from the TREX-AMD trial
Fan, W, Abdelfattah, NS, Uji, A, Lei, J, Ip, M, Sadda, SVR, Wykoff, CC & on behalf of the TREX-AMD Study Group 2018, Graefes Archive for Clinical and Experimental Ophthalmology, pp. 1-8. DOI: 10.1007/s00417-017-3888-2

Optimizing Anti-VEGF Treatment Outcomes for Patients with Neovascular Age-Related Macular Degeneration
Wykoff, CC, Clark, WL, Nielsen, JS, Brill, JV, Greene, LS & Heggen, CL 2018, Journal of managed care & specialty pharmacy, vol 24, no. 2-a Suppl, pp. S3-S15. DOI: 10.18553/jmcp.2018.24.2-a.s3

Targeted Retinal Photocoagulation for Diabetic Macular Edema with Peripheral Retinal Nonperfusion. Three-Year Randomized DAVE Trial
Brown, DM, Ou, WC, Wong, TP, Kim, RY, Croft, DE & Wykoff, CC 2018, Ophthalmology. DOI: 10.1016/j.ophtha.2017.11.026

Diagnostic and Therapeutic Challenges
Burgess, FR, Radwan, M, Croft, DE & Wykoff, CC 2017, Retina. DOI: 10.1097/IAE.0000000000001549

Positive visual phenomena following implantation of the argus II retinal prosthesis
Sadaka, A, Iqbal, C, Nazari, H, Berry, S, Wykoff, CC, Humayun, MS & Lee, AG 2017, Ophthalmic Surgery Lasers and Imaging Retina, vol 48, no. 12, pp. 1022-1025. DOI: 10.3928/23258160-20171130-11

Intravitreal aflibercept for proliferative diabetic retinopathy
Brown, DM & Wykoff, CC 2017, The Lancet, vol 390, no. 10108. DOI: 10.1016/S0140-6736(17)32445-5

Erratum. Diabetic Retinopathy: A Position Statement by the American Diabetes Association. Diabetes Care 2017;40:412-418
Solomon, SD, Chew, E, Duh, EJ, Sobrin, L, Sun, JK, VanderBeek, BL, Wykoff, CC & Gardner, TW 2017, Diabetes Care, vol 40, no. 9, pp. 1285. DOI: 10.2337/dc17-er09

Relationship Between Visual Acuity and Retinal Thickness During Anti–Vascular Endothelial Growth Factor Therapy for Retinal Diseases
Ou, WC, Brown, DM, Payne, JF & Wykoff, CC 2017, American Journal of Ophthalmology, vol 180, pp. 8-17. DOI: 10.1016/j.ajo.2017.05.014

Distribution of Nonperfusion Area on Ultra-widefield Fluorescein Angiography in Eyes With Diabetic Macular Edema: DAVE Study
Fan, W, Wang, K, Ghasemi Falavarjani, K, Sagong, M, Uji, A, Ip, M, Wykoff, CC, Brown, DM, van Hemert, J & Sadda, SVR 2017, American Journal of Ophthalmology. DOI: 10.1016/j.ajo.2017.05.024

Randomized Trial of Treat-and-Extend versus Monthly Dosing for Neovascular Age-Related Macular Degeneration: 2-Year Results of the TREX-AMD Study
Wykoff, CC, Ou, WC, Brown, DM, Croft, DE, Wang, R, Payne, JF, Clark, WL, Abdelfattah, NS, Sadda, SVR & TREX-AMD Study Group 2017, Kidney International Reports, vol 2, no. 4, pp. 314-321. DOI: 10.1016/j.oret.2016.12.004

Erratum. Diabetic Retinopathy: A Position Statement by the American Diabetes Association. Diabetes Care 2017;40:412-418
Solomon, SD, Chew, E, Duh, EJ, Sobrin, L, Sun, JK, VanderBeek, BL, Wykoff, CC & Gardner, TW 2017, Diabetes Care, vol 40, no. 6, pp. 809. DOI: 10.2337/dc17-er06e

Wykoff, CC, Le, RT, Khurana, RN, Brown, DM, Ou, WC, Wang, R, Clark, WL & Boyer, DS 2017, American Journal of Ophthalmology, vol 177, pp. 236-237. DOI: 10.1016/j.ajo.2017.02.024