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Truc T. Tran, PharmD

Associate Research Professor of Medicine, Academic Institute
Associate Research Member, Research Institute
Houston Methodist
Weill Cornell Medical College


Areas Of Expertise

Enterococcus Daptomycin resistance Antimicrobial resistance
Education & Training

Residency, University of Texas Medical Branch
Research Fellowship, Department of Clinical Sciences and Administration, College of Pharmacy, University of Houston
Clinical Fellowship, St. Luke's Episcopal Hospital
PharmD, Department of Clinical Sciences and Administration, College of Pharmacy, University of Houston
Publications

Differential in vitro susceptibility to ampicillin/ceftriaxone combination therapy among Enterococcus faecalis infective endocarditis clinical isolates
Westbrook, KJ, Chilambi, GS, Stellfox, ME, Nordstrom, HR, Li, Y, Iovleva, A, Shah, NH, Jones, CE, Kline, EG, Squires, KM, Miller, WR, Tran, TT, Arias, CA, Doi, Y, Shields, RK & Tyne, DV 2024, , Journal of Antimicrobial Chemotherapy, vol. 79, no. 4, pp. 801-809. https://doi.org/10.1093/jac/dkae032

LiaX is a surrogate marker for cell envelope stress and daptomycin non-susceptibility in Enterococcus faecium
Axell-House, DB, Simar, SR, Panesso, D, Rincon, S, Miller, WR, Khan, A, Pemberton, OA, Valdez, L, Nguyen, AH, Hood, KS, Rydell, K, DeTranaltes, AM, Jones, MN, Atterstrom, R, Reyes, J, Sahasrabhojane, PV, Suleyman, G, Zervos, M, Shelburne, S, Singh, KV, Shamoo, Y, Hanson, BM, Tran, TT & Arias, CA 2024, , Antimicrobial Agents and Chemotherapy, vol. 68, no. 3. https://doi.org/10.1128/aac.01069-23

Cefiderocol heteroresistance associated with mutations in TonB-dependent receptor genes in Pseudomonas aeruginosa of clinical origin.
Egge, SL, Rizvi, SA, Simar, SR, Alcalde, M, Martinez, JRW, Hanson, BM, Dinh, AQ, Baptista, RP, Tran, TT, Shelburne, SA, Munita, JM, Arias, CA, Hakki, M & Miller, WR 2024, , bioRxiv. https://doi.org/10.1101/2024.01.30.578008

LiaX is a surrogate marker for cell envelope stress and daptomycin non-susceptibility in Enterococcus faecium
Axell-House, DB, Simar, SR, Panesso, D, Rincon, S, Miller, WR, Khan, A, Pemberton, OA, Valdez, L, Nguyen, AH, Hood, KS, Rydell, K, DeTranaltes, AM, Jones, MN, Atterstrom, R, Reyes, J, Sahasrabhojane, PV, Suleyman, G, Zervos, M, Shelburne, S, Singh, KV, Shamoo, Y, Hanson, BM, Tran, TT & Arias, CA 2024, , Antimicrobial Agents and Chemotherapy, vol. 68, no. 3. https://doi.org/10.1128/aac.01069-23

Clinical Outcomes and Bacterial Characteristics of Carbapenem-resistant Acinetobacter baumannii Among Patients From Different Global Regions
Multi-Drug Resistant Organism Network Investigators 2024, , Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, vol. 78, no. 2, pp. 248-258. https://doi.org/10.1093/cid/ciad556

Phage-Antibiotic Cocktail Rescues Daptomycin and Phage Susceptibility against Daptomycin-Nonsusceptible Enterococcus faecium in a Simulated Endocardial Vegetation Ex Vivo Model
Coyne, AJK, Stamper, KC, El Ghali , A, Kebriaei, R, Biswas, B, Wilson, M, Deschenes, MV, Tran, C, Arias, CA & Rybak, MJ 2023, , Microbiology Spectrum, vol. 11, no. 4, pp. e0034023. https://doi.org/10.1128/spectrum.00340-23

Identification of distinct impacts of CovS inactivation on the transcriptome of acapsular group A streptococci
Debroy, S, Shropshire, WC, Vega, L, Tran, CN, Horstmann, N, Mukherjee, P, Selvaraj-Anand, S, Tran, C, Bremer, J, Gohel, M, Arias, CA, Flores, AR & Shelburne, SA 2023, , mSystems, vol. 8, no. 4, pp. e0022723. https://doi.org/10.1128/msystems.00227-23

Membrane Phenotypic, Metabolic and Genotypic Adaptations of Streptococcus oralis Strains Destined to Rapidly Develop Stable, High-Level Daptomycin Resistance during Daptomycin Exposures
Mishra, NN, de Paula Baptista, R, Tran, TT, Lapitan, CK, Garcia-de-la-Maria, C, Miró, JM, Proctor, RA & Bayer, AS 2023, , Antibiotics, vol. 12, no. 7, 1083. https://doi.org/10.3390/antibiotics12071083

Membrane Phenotypic, Metabolic and Genotypic Adaptations of Streptococcus oralis Strains Destined to Rapidly Develop Stable, High-Level Daptomycin Resistance during Daptomycin Exposures
Mishra, NN, de Paula Baptista, R, Tran, TT, Lapitan, CK, Garcia-de-la-Maria, C, Miró, JM, Proctor, RA & Bayer, AS 2023, , Antibiotics, vol. 12, no. 7, 1083. https://doi.org/10.3390/antibiotics12071083, https://doi.org/10.3390/antibiotics12071083

Evolving landscape of carbapenem-resistant Pseudomonas aeruginosa at a single centre in the USA
Sakurai, A, Dinh, AQ, Hanson, BM, Shropshire, WC, Rizvi, SA, Rydell, K, Tran, TT, Wanger, A, Arias, CA & Miller, WR 2023, , JAC-Antimicrobial Resistance, vol. 5, no. 3, dlad070, pp. dlad070. https://doi.org/10.1093/jacamr/dlad070

Enolpyruvate transferase MurAAA149E, identified during adaptation of Enterococcus faecium to daptomycin, increases stability of MurAA–MurG interaction
Zhou, Y, Utama, B, Pratap, S, Supandy, A, Song, X, Tran, TT, Mehta, HH, Arias, CA & Shamoo, Y 2023, , Journal of Biological Chemistry, vol. 299, no. 3, 102912. https://doi.org/10.1016/j.jbc.2023.102912

Clinical characteristics, microbiology and outcomes of a cohort of patients treated with ceftolozane/tazobactam in acute care inpatient facilities, Houston, Texas, USA
Tran, TT, Cabrera, NL, Gonzales-Luna, AJ, Carlson, TJ, Alnezary, F, Miller, WR, Sakurai, A, Dinh, AQ, Rydell, K, Rios, R, Diaz, L, Hanson, BM, Munita, JM, Pedroza, C, Shelburne, SA, Aitken, SL, Garey, KW, Dillon, R, Puzniak, L & Arias, CA 2023, , JAC-Antimicrobial Resistance, vol. 5, no. 1, dlac131, pp. dlac131. https://doi.org/10.1093/jacamr/dlac131

Multisite Detection of Tn1549-Mediated vanB Vancomycin Resistance in Multidrug-Resistant Enterococcus faecalis ST6 in Texas and Florida
Simar, SR, Tran, TT, Rydell, KB, Panesso, D, Contreras, GA, Munita, JM, Cifuentes, RO, Abbo, LM, Sahasrabhojane, P, Dinh, AQ, Axell-House, DB, Savidge, T, Shelburne, SA, Hanson, BM & Arias, CA 2023, , Antimicrobial Agents and Chemotherapy, vol. 67, no. 1. https://doi.org/10.1128/aac.01284-22

Evaluation of Cefazolin High Inoculum Effect in Methicillin-Susceptible Staphylococcus aureus (MSSA) Using Gold standard MICs and Rapid Colorimetric Test (RCT)
Malikazad, H, Rizvi, S, Venugopalan, V, Santevechi, B, Panesso, D, Singh, KV, Gomez, S, Tran, C, Jacques-Palaz, KD, Miller, WR & Arias, CA 2023, , 6th Annual Texas Medical Center Antimicrobial Resistance and Stewardship Conference, January 18-20, 2023, Houston, United States, 1/18/23 - 1/20/23.

LiaX is a surrogate marker for cell-envelope stress and daptomycin non-susceptibility in Enterococcus faecium
Axell-House, DB, Simmar, S, Rincon, S, Miller, WR, Khan, A, Pemberton, O, Valdez, L, Nguyen, A, Hood, KS, Rydell, K, DeTranaltes, AM, Jones, MN, Atterstrom, R, Reyes, J, Sahasrabhojane, P, Suleyman, G, Zervos, MJ, Shelburne, SA, Singh, KV, Shamoo, Y, Hanson, BM, Tran, C & Arias, CA 2023, , bioRxiv.

Multisite Detection of Tn1549-Mediated vanB Vancomycin Resistance in Multidrug-Resistant Enterococcus faecalis ST6 in Texas and Florida
Simar, SR, Tran, TT, Rydell, KB, Panesso, D, Contreras, GA, Munita, JM, Cifuentes, RO, Abbo, LM, Sahasrabhojane, P, Dinh, AQ, Axell-House, DB, Savidge, T, Shelburne, SA, Hanson, BM & Arias, CA 2023, , Antimicrobial Agents and Chemotherapy, vol. 67, no. 1, pp. e0128422. https://doi.org/10.1128/aac.01284-22, https://doi.org/10.1128/aac.01284-22

Bacterial cell membranes and their role in daptomycin resistance: A review
Nguyen, AH, Hood, K, Mileykovskaya, E, Miller, WR & Tran, C 2022, , Frontiers in Molecular Biosciences, pp. 1035574. https://doi.org/10.3389/fmolb.2022.1035574

Bacterial cell membranes and their role in daptomycin resistance: A review
Nguyen, AH, Hood, KS, Mileykovskaya, E, Miller, WR & Tran, TT 2022, , Frontiers in Molecular Biosciences, vol. 9, 1035574. https://doi.org/10.3389/fmolb.2022.1035574

LiaF is required for LiaX mediated protection against daptomycin and LL-37 in Enterococcus faecalis OG1RF
Panesso, D, Singh, KV, Villegas, SG, Khan, A, Supandy, A, Nguyen, AH, Rincon, S, Wood, K, Dinh, A, Research, H, Miller, WR, Shamoo, Y, Tran, C & Arias, CA 2022, . in LiaF is required for LiaX mediated protection against daptomycin and LL-37 in Enterococcus faecalis OG1RF. <https://www.eventscribe.net/2022/IDWeek/searchGlobal.asp>

Characteristics of community-acquired carbapenem-resistant Enterobacterales
Shrestha, R, Luterbach, CL, Dai, W, Komarow, L, Earley, M, Weston, G, Herc, E, Jacob, JT, Salata, R, Wong, D, Anderson, D, Rydell, K, Arias, CA, Chen, L, VanDuin, D, Panesso, D & Tran, C 2022, , Journal of Antimicrobial Chemotherapy, vol. 77, no. 10, 10, pp. 2763-2771. https://doi.org/10.1093/jac/dkac239, https://doi.org/10.1093/jac/dkac239