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Carly S. Filgueira, PhD

Assistant Research Professor of Nanomedicine, Institute for Academic Medicine
Assistant Research Member, Research Institute
Houston Methodist


Biography

Dr. Carly Filgueira obtained her Bachelor of Science degree in Chemistry Magna Cum Laude from The George Washington University in Washington, DC. In her second year as an undergraduate, she was awarded the A.D. Britt scholarship which sponsored her to perform research in the Chemistry Department at GWU under the direction of Dr. J. Houston Miller. She continued in the Miller lab until undergraduate graduation, where they worked on the application of UV-VIS spectroscopy and elastic/inelastic light scattering to examine the chemistry between gold nanoparticles and biopolymers.

Dr. Filgueira obtained her masters and doctorate degrees in Chemistry from Rice University in 2005 and 2009. As a pre-doctoral student, she fabricated and characterized optically responsive nanostructures and their plasmonic interactions under the direction of Dr. Naomi Halas. She was awarded several honors, including a NIH Keck Nanobiology training fellowship, NSF sponsorship to attend the 55th Lindau Nobel Laureate Meeting in Germany, and a Dean's Office Travel Award. She was also honored with both The Harry B. Weiser Award for Excellence in Service and The Harry B. Weiser Research Award in Recognition of Research Excellence at Rice University.

Dr. Filgueira joined Houston Methodist in 2011 as a postdoctoral student under the direction of Dr. Anders Berkenstam and Dr. Paul Webb in collaboration with Dr. Jan-Ake Gustafsson. She focused on nuclear hormone receptors, specifically Estrogen Receptor beta and Liver X Receptor beta, and small molecule screening using a combination of direct binding and cell based assays.

Dr. Filgueira is currently a member of the Department of Nanomedicine with appointments as Assistant Research Member in the Research Institute, and Assistant Research Professor of Nanomedicine in the Institute for Academic Medicine. 

Description of Research

Dr. Filgueira is currently interested in finding alternative treatment approaches for physiological disorders through sustained release harnessing nanotechnological approaches.

Areas Of Expertise

Nanomedicine Nanofluidics Cardiovascular disease Nanoparticles Thyroid hormones Implantable devices Metabolic Syndrome Bone growth Hormone Replacement Therapy
Patents

COCRYSTALLINE DHEA FORMULATIONS

Patent Number: EP2986634, Feb 24 2016


COCRYSTALLINE DHEA FORMULATIONS

Patent Number: WO2014172706, Oct 23 2014


Cocrystalline DHEA Formulations

Patent Number: US2014315833, Oct 23 2014

Publications

Nanofluidic microsystem for sustained intraocular delivery of therapeutics
Di Trani, N, Jain, P, Chua, CYX, Ho, JS, Bruno, G, Susnjar, A, Pons-Faudoa, FP, Sizovs, A, Lyle Hood, R, Smith, ZW, Ballerini, A, Filgueira, CS & Grattoni, A 2019, Nanomedicine: Nanotechnology, Biology, and Medicine, vol. 16, pp. 1-9. https://doi.org/10.1016/j.nano.2018.11.002

Technologies for intrapericardial delivery of therapeutics and cells
Filgueira, CS, Igo, SR, Wang, DK, Hirsch, M, Schulz, DG, Bruckner, BA & Grattoni, A 2019, Advanced Drug Delivery Reviews. https://doi.org/10.1016/j.addr.2019.02.006

Remotely controlled nanofluidic implantable platform for tunable drug delivery
Di Trani, N, Silvestri, A, Bruno, G, Geninatti, T, Chua, CYX, Gilbert, A, Rizzo, G, Filgueira, CS, Demarchi, D & Grattoni, A 2019, Lab on a Chip, vol. 19, no. 13, pp. 2192-2204. https://doi.org/10.1039/c9lc00394k

Transcutaneously refillable nanofluidic implant achieves sustained level of tenofovir diphosphate for HIV pre-exposure prophylaxis
Chua, CYX, Jain, P, Ballerini, A, Bruno, G, Hood, RL, Gupte, M, Gao, S, Di Trani, N, Susnjar, A, Shelton, K, Bushman, LR, Folci, M, Filgueira, CS, Marzinke, MA, Anderson, PL, Hu, M, Nehete, P, Arduino, RC, Sastry, JK & Grattoni, A 2018, Journal of Controlled Release, vol. 286, pp. 315-325. https://doi.org/10.1016/j.jconrel.2018.08.010

Nanofluidic drug-eluting seed for sustained intratumoral immunotherapy in triple negative breast cancer
Chua, CYX, Jain, P, Susnjar, A, Rhudy, J, Folci, M, Ballerini, A, Gilbert, A, Singh, S, Bruno, G, Filgueira, CS, Yee, C, Butler, EB & Grattoni, A 2018, Journal of Controlled Release, vol. 285, pp. 23-34. https://doi.org/10.1016/j.jconrel.2018.06.035

Efficacy of sustained delivery of GC-1 from a Nanofluidic system in a spontaneously obese non-human primate: a case study
Filgueira, CS, Bruno, G, Smith, ZW, Chua, CYX, Ballerini, A, Folci, M, Gilbert, AL, Jain, P, Sastry, JK, Nehete, PN, Shelton, KA, Hill, LR, Ali, A, Youker, KA & Grattoni, A 2018, Biomedical Microdevices, vol. 20, no. 2, 49. https://doi.org/10.1007/s10544-018-0296-2

Unexpected behaviors in molecular transport through size-controlled nanochannels down to the ultra-nanoscale
Bruno, G, Di Trani, N, Hood, RL, Zabre, E, Filgueira, CS, Canavese, G, Jain, P, Smith, Z, Demarchi, D, Hosali, S, Pimpinelli, A, Ferrari, M & Grattoni, A 2018, Nature communications, vol. 9, no. 1, 1682. https://doi.org/10.1038/s41467-018-04133-8

A pharmacokinetic study of GC-1 delivery using a nanochannel membrane device
Filgueira, CS, Ballerini, A, Nicolov, E, Chua, CYX, Jain, P, Smith, ZW, Gilbert, AL, Scaglione, F & Grattoni, A 2017, Nanomedicine: Nanotechnology, Biology, and Medicine, vol. 13, no. 5, pp. 1739-1744. https://doi.org/10.1016/j.nano.2017.02.012

Gold coated iron phosphide core-shell structures
Kelly, AT, Filgueira, CS, Schipper, DE, Halas, NJ & Whitmire, KH 2017, RSC Advances, vol. 7, no. 42, pp. 25848-25854. https://doi.org/10.1039/c7ra01195d

The active modulation of drug release by an ionic field effect transistor for an ultra-low power implantable nanofluidic system
Bruno, G, Canavese, G, Liu, X, Filgueira, CS, Sacco, A, Demarchi, D, Ferrari, M & Grattoni, A 2016, Nanoscale, vol. 8, no. 44, pp. 18718-18725. https://doi.org/10.1039/c6nr06235k

3,5-diodothyronine (3,5-T2) Reduces Blood Glucose Independently of Insulin Sensitization in Obese Mice
Teixeira, SDS, Filgueira, CS, Sieglaff, DH, Benod, C, Villagomez, R, Minze, LJ, Zhang, A, Webb, P & Nunes, MT 2016, Acta physiologica (Oxford, England). https://doi.org/10.1111/apha.12821

Timing performance of fast LGSO scintillators coupled to novel SiPMs
Cates, JW & Levin, CS 2016, . in 2015 IEEE Nuclear Science Symposium and Medical Imaging Conference, NSS/MIC 2015., 7582018, IEEE, 2015 IEEE Nuclear Science Symposium and Medical Imaging Conference, NSS/MIC 2015, San Diego, United States, 10/31/15. DOI: 10.1109/NSSMIC.2015.7582018

Sustained zero-order delivery of GC-1 from a nanochannel membrane device alleviates metabolic syndrome
Filgueira, CS, Nicolov, E, Hood, RL, Ballerini, A, Garcia-Huidobro, J, Lin, JZ, Fraga, D, Webb, P, Sabek, O, Gaber, AO, Phillips, KJ & Grattoni, A 2016, International Journal of Obesity. https://doi.org/10.1038/ijo.2016.129

Three-dimensional printed polymeric system to encapsulate human mesenchymal stem cells differentiated into islet-like insulin-producing aggregates for diabetes treatment
Sabek, O, Farina, M, Fraga, DW, Afshar, S, Ballerini, A, Filgueira, CS, Thekkedath, UR, Grattoni, A & Gaber, AO 2016, Journal of Tissue Engineering, vol. 7. https://doi.org/10.1177/2041731416638198

COCRYSTALLINE DHEA FORMULATIONS
Berkenstam, AL, Kuczynski, E, Andersson, Alf, S, Gustafsson, J-A & Filgueira, CS 2016, , Patent No. EP2986634, IPC No. A61K 38/ 22 A I.

Sustained Delivery of Tamoxifen from a Nanofluidic Delivery Platform
Ballerini, A, Filgueira, CS, Nicolov, E, Jain, P, Bruno, G, Hood, RL & Grattoni, FSAA 2016, Drug Delivery Letters, vol. 6, no. 2. https://doi.org/10.2174/2210303106666161129163850

PPAR? partial agonist GQ-16 strongly represses a subset of genes in 3T3-L1 adipocytes
Milton, FA, Cvoro, A, Amato, AA, Sieglaff, DH, Filgueira, CS, Arumanayagam, AS, De Lima, MDCA, Pitta, IR, De Assis Rocha Neves, F & Webb, P 2015, Biochemical and Biophysical Research Communications, vol. 464, no. 3, 34219, pp. 718-723. https://doi.org/10.1016/j.bbrc.2015.07.011

Mechanisms of peroxisome proliferator activated receptor ? regulation by non-steroidal anti-inflammatory drugs
Puhl, AC, Milton, FA, Cvoro, A, Sieglaff, DH, Campos, JCL, Bernardes, A, Filgueira, CS, Lindemann, JL, Deng, T, Neves, FAR, Polikarpov, I & Webb, P 2015, Nuclear receptor signaling, vol. 13, pp. e004. https://doi.org/10.1621/nrs.13004

COCRYSTALLINE DHEA FORMULATIONS
Berkenstam, AL, Kuczynski, E, Andersson, Alf, S, Gustafsson, J-A & Filgueira, CS 2014, , Patent No. WO2014172706, IPC No. A61K 38/ 22 A I.

Cocrystalline DHEA Formulations
Berkenstam, AL, Kuczynski, E, Andersson, Alf, S, Gustafsson, J-A & Filgueira, CS 2014, , Patent No. US2014315833, IPC No. C07C 49/ 727 A I.

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