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Carly S. Filgueira, PhD

Assistant Research Professor of Nanomedicine, Institute for Academic Medicine
Assistant Research Member, Research Institute
Houston Methodist


Biography

Dr. Carly Filgueira obtained her Bachelor of Science degree in Chemistry Magna Cum Laude from The George Washington University in Washington, DC. In her second year as an undergraduate, she was awarded the A.D. Britt scholarship which sponsored her to perform research in the Chemistry Department at GWU under the direction of Dr. J. Houston Miller. She continued in the Miller lab until undergraduate graduation, where they worked on the application of UV-VIS spectroscopy and elastic/inelastic light scattering to examine the chemistry between gold nanoparticles and biopolymers.

Dr. Filgueira obtained her masters and doctorate degrees in Chemistry from Rice University in 2005 and 2009. As a pre-doctoral student, she fabricated and characterized optically responsive nanostructures and their plasmonic interactions under the direction of Dr. Naomi Halas. She was awarded several honors, including a NIH Keck Nanobiology training fellowship, NSF sponsorship to attend the 55th Lindau Nobel Laureate Meeting in Germany, and a Dean's Office Travel Award. She was also honored with both The Harry B. Weiser Award for Excellence in Service and The Harry B. Weiser Research Award in Recognition of Research Excellence at Rice University.

Dr. Filgueira joined Houston Methodist in 2011 as a postdoctoral student under the direction of Dr. Anders Berkenstam and Dr. Paul Webb in collaboration with Dr. Jan-Ake Gustafsson. She focused on nuclear hormone receptors, specifically Estrogen Receptor beta and Liver X Receptor beta, and small molecule screening using a combination of direct binding and cell based assays.

Dr. Filgueira is currently a member of the Department of Nanomedicine with appointments as Assistant Research Member in the Research Institute, and Assistant Research Professor of Nanomedicine in the Institute for Academic Medicine. 

Description of Research

Dr. Filgueira is currently interested in finding alternative treatment approaches for physiological disorders through sustained release harnessing nanotechnological approaches.

Areas Of Expertise

Nanomedicine Nanofluidics Cardiovascular disease Nanoparticles Thyroid hormones Implantable devices Metabolic Syndrome Bone growth Hormone Replacement Therapy
Patents

COCRYSTALLINE DHEA FORMULATIONS

Patent Number: EP2986634, Feb 24 2016


COCRYSTALLINE DHEA FORMULATIONS

Patent Number: WO2014172706, Oct 23 2014


Cocrystalline DHEA Formulations

Patent Number: US2014315833, Oct 23 2014

Publications

PGI2 synthetic prostaglandins modulate expression of the c-MET signaling pathway
Sprouse, ML, Wang, DK, Schulz, DG, Igo, SR, Grattoni, A & Filgueira, CS 2019, Gulf Coast Vascular Research Consortium, Houston, United States, 8/23/19 - 8/24/19, .

Immune Cell Landscape of the Tumor Microenvironment in a Murine NSCLC Model Following Radiation and Immune Checkpoint Inhibition Therapies
Sprouse, ML, Wang, DK, Butler, EB, Grattoni, A & Filgueira, CS 2019, 2019 CSBC/PS-ON Annual Junior Investigator’s Meeting, Bethesda, United States, 8/22/19 - 8/23/19, .

Immune Cell Landscape of the Tumor Microenvironment Following Radiation and Immunotherapy
Sprouse, ML, Wang, DK, Butler, EB, Grattoni, A & Filgueira, CS 2019, 7th Annual Houston Methodist Cancer Symposium, Houston, United States, 8/16/19, .

Use of a nanochannel membrane device for release of GC-1 to combat obesity in old world non-human primates
Teixeira, SDS, Sprouse, ML, Di Trani, N, Chua, CYX, Sastry, JK, Shelton, KA, Nehete, PN, Filgueira, CS & Grattoni, A 2019, 2019 MAPTA Summer Science Symposium, Houston, United States, 8/8/19 - 8/9/19, .

Immune Cell Landscape of the Tumor Microenvironment Following Radiation and Immunotherapy
Sprouse, ML, Wang, DK, Butler, EB, Grattoni, A & Filgueira, CS 2019, 2019 MAPTA Summer Science Symposium, Houston, United States, 8/8/19 - 8/9/19, .

Technologies for intrapericardial delivery of therapeutics and cells
Filgueira, CS, Igo, SR, Wang, DK, Hirsch, M, Schulz, DG, Bruckner, BA & Grattoni, A 2019, Advanced Drug Delivery Reviews. https://doi.org/10.1016/j.addr.2019.02.006

Remotely controlled nanofluidic implantable platform for tunable drug delivery
Di Trani, N, Silvestri, A, Bruno, G, Geninatti, T, Chua, CYX, Gilbert, A, Rizzo, G, Filgueira, CS, Demarchi, D & Grattoni, A 2019, Lab on a Chip, vol. 19, no. 13, pp. 2192-2204. https://doi.org/10.1039/c9lc00394k

Nanofluidic microsystem for sustained intraocular delivery of therapeutics
Di Trani, N, Jain, P, Chua, CYX, Ho, JS, Bruno, G, Susnjar, A, Pons-Faudoa, FP, Sizovs, A, Lyle Hood, R, Smith, ZW, Ballerini, A, Filgueira, CS & Grattoni, A 2019, Nanomedicine: Nanotechnology, Biology, and Medicine, vol. 16, pp. 1-9. https://doi.org/10.1016/j.nano.2018.11.002

Nanofluidic drug-eluting seed for sustained intratumoral immunotherapy for cancer treatment
Chua, CYX, Filgueira, CS & Grattoni, A 2018, SITC 33rd Annual Meeting, Washington DC, United States, 11/9/18 - 11/11/18, .

Transcutaneously refillable nanofluidic implant achieves sustained level of tenofovir diphosphate for HIV pre-exposure prophylaxis
Chua, CYX, Jain, P, Ballerini, A, Bruno, G, Hood, RL, Gupte, M, Gao, S, Di Trani, N, Susnjar, A, Shelton, K, Bushman, LR, Folci, M, Filgueira, CS, Marzinke, MA, Anderson, PL, Hu, M, Nehete, P, Arduino, RC, Sastry, JK & Grattoni, A 2018, Journal of Controlled Release, vol. 286, pp. 315-325. https://doi.org/10.1016/j.jconrel.2018.08.010

Intratumoral Immunotherapy Delivery Via Minimally Invasive Nanochannel Implant
Susnjar, A, Chua, CYX, Rhudy, JR, Ho, J, Jain, P, Singh, S, Yee, C, Filgueira, CS, Butler, EB & Grattoni, A 2018, 2018 AIChE Annual Meeting, 3rd Bioengineering & Translational Medicine Conference, Boston, United States, 9/27/18 - 9/28/18, .

Nanofluidic Systems for controlled drug and cell delivery for medicine on-Earth and in space
Chua, CYX, Di Trani, N, Farina, M, Filgueira, CS, Hirsch, M, Ho, J, Liu, X, Lotito, ML, Paez-Mayorga, J, Pons-Faudoa, FP, Rhudy, JR, Silvestri, A, Sizovs, A, Susnjar, A & Grattoni, A 2018, 16th International Nanomedicine & Drug Delivery Symposium, Portland, United States, 9/23/18 - 9/23/18, .

Metal Nanoparticle Radiosensitization and Immunotherapy as a Therapeutic Strategy for Non-Small Cell Lung Cancers
Hirsch, M, Vighetto, V, Di Marzio, N, Ferraro, F, Pandey, A, Liu, H, Xuan Chua, CY, Mitra, S, Sikora, AG, Halas, NJ, Filgueira, CS & Grattoni, A 2018, NanoX Symposium, Houston, United States, 9/21/18 - 9/21/18, .

Nanofluidic drug-eluting seed for sustained intratumoral immunotherapy in triple negative breast cancer
Chua, CYX, Jain, P, Susnjar, A, Rhudy, J, Folci, M, Ballerini, A, Gilbert, A, Singh, S, Bruno, G, Filgueira, CS, Yee, C, Butler, EB & Grattoni, A 2018, Journal of Controlled Release, vol. 285, pp. 23-34. https://doi.org/10.1016/j.jconrel.2018.06.035

Metal Nanoparticle Radiosensitization and Immunotherapy as a Therapeutic Strategy for Non-Small Cell Lung Cancers
Hirsch, M, Vighetto, V, Di Marzio, N, Ferraro, F, Pandey, A, Liu, H, Xuan Chua, CY, Mitra, S, Sikora, AG, Halas, NJ, Filgueira, CS & Grattoni, A 2018, 6th Annual Houston Methodist Cancer Symposium, Houston, United States, 8/17/18 - 8/17/18, .

Delivery of Prostaglandins to the Pericardium
Estrella, C, Di Marzio, N, Hirsch, M, Igo, SR, Filgueira, CS & Grattoni, A 2018, 2018 Summer Undergraduate Internship Poster Retreat, Houston, United States, 8/8/18 - 8/8/18, .

Nanofluidic microsystem for sustained intraocular delivery of therapeutics
Grattoni, A, Di Trani, N, Ho, J, Chua, CYX, Jain, P, Bruno, G, Hood, RL, Smith, WZ, Ballerini, A & Filgueira, CS 2018, 2018 Methodist Association for Professional Affairs (MAPTA) Summer Symposium, 8/3/18, .

Transcutaneously Refillable Nanofluidic System for HIV PrEP
Grattoni, A, Xuan Chua, CY, Jain, P, Ballerini, A, Bruno, G, Hood, RL, Gupte, AA, Gao, S, Di Trani, N, Susnjar, A, Shelton, KA, Bushman, LR, Folci, M, Filgueira, CS, Marzinke, MA, Anderson, PL, Hu, M, Nehete, P, Arduino, RC & Sastry, KJ 2018, 2018 Methodist Association for Professional Affairs (MAPTA) Summer Symposium, 8/3/18, .

Radiosensitization of Gold Nanoparticles as a Therapeutic for Non-Small Cell Lung Cancers
Hirsch, M, Vighetto, V, Di Marzio, N, Ferraro, F, Pathak, R, Pandey, A, Liu, H-C, Villanueva, M, Chua, CYX, Mitra, S, Sikora, AG, Halas, NJ, Filgueira, CS & Grattoni, A 2018, 2018 Methodist Association for Professional Affairs (MAPTA) Summer Symposium, 8/3/18, .

Controlled Intrapericardial Delivery of Prostaglandin Formulations For Heart Failure
Filgueira, CS, Igo, SR, Bruckner, BA, Ferraro, F, Di Marzio, N, Vighetto, V & Grattoni, A 2018, Annual Meeting & Exposition of the Controlled Release Society, 7/22/18 - 7/24/18, .

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