Carly S. Filgueira

Carly S. Filgueira, PhD

Assistant Professor of Nanomedicine, Academic Institute
Assistant Member, Research Institute
Houston Methodist
Weill Cornell Medical College

Filgueira Lab


Dr. Carly Filgueira obtained her Bachelor of Science degree in Chemistry Magna Cum Laude from The George Washington University in Washington, DC. In her second year as an undergraduate, she was awarded the A.D. Britt scholarship which sponsored her to perform research in the Chemistry Department at GWU under the direction of Dr. J. Houston Miller. She continued in the Miller lab until undergraduate graduation, where they worked on the application of UV-VIS spectroscopy and elastic/inelastic light scattering to examine the chemistry between gold nanoparticles and biopolymers.

Dr. Filgueira obtained her masters and doctorate degrees in Chemistry from Rice University in 2005 and 2009. As a pre-doctoral student, she fabricated and characterized optically responsive nanostructures and their plasmonic interactions under the direction of Dr. Naomi Halas. She was awarded several honors, including a NIH Keck Nanobiology training fellowship, NSF sponsorship to attend the 55th Lindau Nobel Laureate Meeting in Germany, and a Dean's Office Travel Award. She was also honored with both The Harry B. Weiser Award for Excellence in Service and The Harry B. Weiser Research Award in Recognition of Research Excellence at Rice University.

Dr. Filgueira joined Houston Methodist in 2011 as a postdoctoral student under the direction of Dr. Anders Berkenstam and Dr. Paul Webb in collaboration with Dr. Jan-Ake Gustafsson. She focused on nuclear hormone receptors, specifically Estrogen Receptor beta and Liver X Receptor beta, and small molecule screening using a combination of direct binding and cell based assays.

Dr. Filgueira is currently a member of the Department of Nanomedicine with appointments as Assistant Member in the Research Institute, Assistant Professor of Nanomedicine in the Academic Institute, and with the Department of Cardiovascular Surgery. 

Description of Research

Dr. Filgueira is currently interested in finding alternative treatment approaches for physiological disorders through sustained release harnessing nanotechnological approaches.

Areas Of Expertise

Nanomedicine Nanofluidics Cardiovascular disease Nanoparticles Thyroid hormones Implantable devices Metabolic Syndrome Bone growth Hormone Replacement Therapy


Patent Number: EP2986634, Feb 24 2016


Patent Number: WO2014172706, Oct 23 2014

Cocrystalline DHEA Formulations

Patent Number: US2014315833, Oct 23 2014


Nanotechnology applications for cardiovascular disease treatment: Current and future perspectives
Wang, DK, Rahimi, M & Filgueira, CS 2021, , Nanomedicine: Nanotechnology, Biology, and Medicine, pp. 102387.

Effects of Surface Protein Adsorption on the Distribution and Retention of Intratumorally Administered Gold Nanoparticles
Terracciano, R, Zhang, A, Butler, EB, Demarchi, D, Hafner, J, Grattoni, A & Filgueira, CS 2021, , Pharmaceutics, vol. 13, no. 2, pp. 216.

Effects of surface protein adsorption on the distribution and retention of intratumorally administered gold nanoparticles
Terracciano, R, Zhang, A, Butler, EB, Demarchi, D, Hafner, JH, Grattoni, A & Filgueira, CS 2021, , Pharmaceutics, vol. 13, no. 2, 216, pp. 1-19.

Screening of Focused Compound Library Targeting Liver X Receptors in Pancreatic Cancer Identified Ligands with Inverse Agonist and Degrader Activity
Karaboga, H, Huang, W, Srivastava, S, Widmann, S, Addanki, S, Gamage, KT, Mazhar, Z, Ebalunode, JO, Briggs, JM, Gustafsson, J-Å, Filgueira, CS, Gilbertson, SR & Lin, C-Y 2020, , ACS Chemical Biology.

Gold nanoparticles radio-sensitize and reduce cell survival in lewis lung carcinoma
Pandey, A, Vighetto, V, Marzio, ND, Ferraro, F, Hirsch, M, Ferrante, N, Mitra, S, Grattoni, A & Filgueira, CS 2020, , Nanomaterials, vol. 10, no. 9, 1717, pp. 1-9.

Gold Nanoparticles Radio-Sensitize and Reduce Cell Survival in Lewis Lung Carcinoma
Pandey, A, Vighetto, V, Di Marzio, N, Ferraro, F, Hirsch, M, Ferrante, N, Mitra, S, Grattoni, A & Filgueira, CS 2020, , Nanomaterials, vol. 10, no. 9.

Technologies for intrapericardial delivery of therapeutics and cells
Filgueira, CS, Igo, SR, Wang, DK, Hirsch, M, Schulz, DG, Bruckner, BA & Grattoni, A 2019, , Advanced Drug Delivery Reviews, vol. 151-152, pp. 222-232.

Remotely controlled nanofluidic implantable platform for tunable drug delivery
Di Trani, N, Silvestri, A, Bruno, G, Geninatti, T, Chua, CYX, Gilbert, A, Rizzo, G, Filgueira, CS, Demarchi, D & Grattoni, A 2019, , Lab on a Chip, vol. 19, no. 13, pp. 2192-2204.

Nanofluidic microsystem for sustained intraocular delivery of therapeutics
Di Trani, N, Jain, P, Chua, CYX, Ho, JS, Bruno, G, Susnjar, A, Pons-Faudoa, FP, Sizovs, A, Lyle Hood, R, Smith, ZW, Ballerini, A, Filgueira, CS & Grattoni, A 2019, , Nanomedicine: Nanotechnology, Biology, and Medicine, vol. 16, pp. 1-9.

Transcutaneously refillable nanofluidic implant achieves sustained level of tenofovir diphosphate for HIV pre-exposure prophylaxis
Chua, CYX, Jain, P, Ballerini, A, Bruno, G, Hood, RL, Gupte, M, Gao, S, Di Trani, N, Susnjar, A, Shelton, K, Bushman, LR, Folci, M, Filgueira, CS, Marzinke, MA, Anderson, PL, Hu, M, Nehete, P, Arduino, RC, Sastry, JK & Grattoni, A 2018, , Journal of Controlled Release, vol. 286, pp. 315-325.

Nanofluidic drug-eluting seed for sustained intratumoral immunotherapy in triple negative breast cancer
Chua, CYX, Jain, P, Susnjar, A, Rhudy, J, Folci, M, Ballerini, A, Gilbert, A, Singh, S, Bruno, G, Filgueira, CS, Yee, C, Butler, EB & Grattoni, A 2018, , Journal of Controlled Release, vol. 285, pp. 23-34.

Efficacy of sustained delivery of GC-1 from a Nanofluidic system in a spontaneously obese non-human primate: a case study
Filgueira, CS, Bruno, G, Smith, ZW, Chua, CYX, Ballerini, A, Folci, M, Gilbert, AL, Jain, P, Sastry, JK, Nehete, PN, Shelton, KA, Hill, LR, Ali, A, Youker, KA & Grattoni, A 2018, , Biomedical Microdevices, vol. 20, no. 2, 49.

Unexpected behaviors in molecular transport through size-controlled nanochannels down to the ultra-nanoscale
Bruno, G, Di Trani, N, Hood, RL, Zabre, E, Filgueira, CS, Canavese, G, Jain, P, Smith, Z, Demarchi, D, Hosali, S, Pimpinelli, A, Ferrari, M & Grattoni, A 2018, , Nature Communications, vol. 9, no. 1, 1682.

A pharmacokinetic study of GC-1 delivery using a nanochannel membrane device
Filgueira, CS, Ballerini, A, Nicolov, E, Chua, CYX, Jain, P, Smith, ZW, Gilbert, AL, Scaglione, F & Grattoni, A 2017, , Nanomedicine: Nanotechnology, Biology, and Medicine, vol. 13, no. 5, pp. 1739-1744.

Gold coated iron phosphide core-shell structures
Kelly, AT, Filgueira, CS, Schipper, DE, Halas, NJ & Whitmire, KH 2017, , RSC Advances, vol. 7, no. 42, pp. 25848-25854.

The active modulation of drug release by an ionic field effect transistor for an ultra-low power implantable nanofluidic system
Bruno, G, Canavese, G, Liu, X, Filgueira, CS, Sacco, A, Demarchi, D, Ferrari, M & Grattoni, A 2016, , Nanoscale, vol. 8, no. 44, pp. 18718-18725.

3,5-diodothyronine (3,5-T2) Reduces Blood Glucose Independently of Insulin Sensitization in Obese Mice
Teixeira, SDS, Filgueira, CS, Sieglaff, DH, Benod, C, Villagomez, R, Minze, LJ, Zhang, A, Webb, P & Nunes, MT 2016, , Acta physiologica (Oxford, England).

Timing performance of fast LGSO scintillators coupled to novel SiPMs
Cates, JW & Levin, CS 2016, . in 2015 IEEE Nuclear Science Symposium and Medical Imaging Conference, NSS/MIC 2015., 7582018, IEEE, 2015 IEEE Nuclear Science Symposium and Medical Imaging Conference, NSS/MIC 2015, San Diego, United States, 10/31/15. DOI: 10.1109/NSSMIC.2015.7582018

Sustained zero-order delivery of GC-1 from a nanochannel membrane device alleviates metabolic syndrome
Filgueira, CS, Nicolov, E, Hood, RL, Ballerini, A, Garcia-Huidobro, J, Lin, JZ, Fraga, D, Webb, P, Sabek, O, Gaber, AO, Phillips, KJ & Grattoni, A 2016, , International Journal of Obesity.

Three-dimensional printed polymeric system to encapsulate human mesenchymal stem cells differentiated into islet-like insulin-producing aggregates for diabetes treatment
Sabek, O, Farina, M, Fraga, DW, Afshar, S, Ballerini, A, Filgueira, CS, Thekkedath, UR, Grattoni, A & Gaber, AO 2016, , Journal of Tissue Engineering, vol. 7.