Brian Castillo

Brian Castillo, MD

Assistant Professor of Clinical Pathology and Genomic Medicine, Academic Institute
Assistant Clinical Member, Research Institute
Houston Methodist
Weill Cornell Medical College


Biography

Dr. Castillo earned his MD from the University of Texas Health Science Center at Houston (UTHSC). He completed an anatomical and clinical pathology residency at UTHSC in 2014. Dr. Castillo then completed a blood banking/transfusion medicine fellowship at Baylor College of Medicine. He joined UTHSC as an Assistant Professor in the Department of Pathology and Laboratory Medicine in 2015 and served there for four years in the areas of transfusion medicine/apheresis, hemotherapy consultative service, coagulation, and immunology before joining Houston Methodist Hospital as a staff pathologist in 2019. He is board-certified in anatomic and clinical pathology as well as blood banking/transfusion medicine by the American Board of Pathology.

Dr. Castillo is a member of the College of American Pathologists, the Houston Society of Clinical Pathologists, the American Society for Clinical Pathology, AABB, and the Texas Society of Pathologists. His areas of expertise include transfusion medicine and coagulation.  His clinical interests include apheresis, coagulopathy, and the management of acquired bleeding with evidence-based transfusion practices and hemostatic agents.

Areas Of Expertise

Transfusion medicine Coagulotherapy Apheresis Acquired bleeding disorders
Publications

Significantly Decreased Mortality in a Large Cohort of Coronavirus Disease 2019 (COVID-19) Patients Transfused Early with Convalescent Plasma Containing High-Titer Anti–Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Spike Protein IgG
Salazar, E, Christensen, PA, Graviss, EA, Nguyen, DT, Castillo, B, Chen, J, Lopez, BV, Eagar, TN, Yi, X, Zhao, P, Rogers, J, Shehabeldin, A, Joseph, D, Masud, F, Leveque, C, Olsen, RJ, Bernard, DW, Gollihar, J & Musser, JM 2021, , American Journal of Pathology, vol. 191, no. 1, pp. 90-107. https://doi.org/10.1016/j.ajpath.2020.10.008

Convalescent plasma anti–SARS-CoV-2 spike protein ectodomain and receptor-binding domain IgG correlate with virus neutralization
Salazar, E, Kuchipudi, SV, Christensen, PA, Eagar, T, Yi, X, Zhao, P, Jin, Z, Long, SW, Olsen, RJ, Chen, J, Castillo, B, Leveque, C, Towers, D, Lavinder, J, Gollihar, J, Cardona, J, Ippolito, G, Nissly, R, Bird, I, Greenawalt, D, Rossi, RM, Gontu, A, Srinivasan, S, Poojary, I, Cattadori, IM, Hudson, PJ, Josleyn, NM, Prugar, L, Huie, K, Herbert, A, Bernard, DW, Dye, JM, Kapur, V & Musser, JM 2020, , Journal of Clinical Investigation, vol. 130, no. 12, pp. 6728-6738. https://doi.org/10.1172/JCI141206

Significantly Decreased Mortality in a Large Cohort of Coronavirus Disease 2019 (COVID-19) Patients Transfused Early with Convalescent Plasma Containing High-Titer Anti–Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Spike Protein IgG
Salazar, E, Christensen, PA, Graviss, EA, Nguyen, DT, Castillo, B, Chen, J, Lopez, BV, Eagar, TN, Yi, X, Zhao, P, Rogers, J, Shehabeldin, A, Joseph, D, Masud, F, Leveque, C, Olsen, RJ, Bernard, DW, Gollihar, J & Musser, JM 2021, , American Journal of Pathology, vol. 191, no. 1, pp. 90-107. https://doi.org/10.1016/j.ajpath.2020.10.008, https://doi.org/10.1016/j.ajpath.2020.10.008

Treatment of Coronavirus Disease 2019 Patients with Convalescent Plasma Reveals a Signal of Significantly Decreased Mortality
Salazar, E, Christensen, PA, Graviss, EA, Nguyen, DT, Castillo, B, Chen, J, Lopez, BV, Eagar, TN, Yi, X, Zhao, P, Rogers, J, Shehabeldin, A, Joseph, D, Leveque, C, Olsen, RJ, Bernard, DW, Gollihar, J & Musser, JM 2020, , American Journal of Pathology, vol. 190, no. 11, pp. 2290-2303. https://doi.org/10.1016/j.ajpath.2020.08.001

Early transfusion of a large cohort of COVID-19 patients with high titer anti-SARS-CoV-2 spike protein IgG convalescent plasma confirms a signal of significantly decreased mortality
Salazar, E, Christensen, PA, Graviss, EA, Nguyen, DT, Castillo, B, Chen, J, Lopez, BV, Eagar, TN, Yi, X, Zhao, P, Rogers, J, Shehabeldin, A, Joseph, D, Masud, FN, Leveque, C, Olsen, RJ, Bernard, DW, Gollihar, JD & Musser, JM 2020, , Unknown Journal. https://doi.org/10.1101/2020.10.02.20206029

Convalescent plasma anti-SARS-CoV-2 spike protein ectodomain and receptor binding domain IgG correlate with virus neutralization
Salazar, E, Kuchipudi, SV, Christensen, PA, Eagar, T, Yi, X, Zhao, P, Jin, Z, Long, SW, Olsen, RJ, Chen, J, Castillo, B, Leveque, C, Towers, D, Lavinder, JJ, Gollihar, J, Cardona, JA, Ippolito, GC, Nissly, RH, Bird, I, Greenawalt, D, Rossi, RM, Gontu, A, Srinivasan, S, Poojary, I, Cattadori, IM, Hudson, P, Josleyn, NM, Prugar, L, Huie, KE, Herbert, AS, Bernard, DW, Dye, JM, Kapur, V & Musser, JM 2020, , The Journal of clinical investigation, vol. 130, no. 12, pp. 6728-6738. https://doi.org/10.1172/JCI141206

Treatment of Coronavirus Disease 2019 (COVID-19) Patients with Convalescent Plasma
Salazar, E, Perez, KK, Ashraf, M, Chen, J, Castillo, B, Christensen, PA, Eubank, T, Bernard, DW, Eagar, TN, Long, SW, Subedi, S, Olsen, RJ, Leveque, C, Schwartz, MR, Dey, M, Chavez-East, C, Rogers, J, Shehabeldin, A, Joseph, D, Williams, G, Thomas, K, Masud, F, Talley, C, Dlouhy, KG, Lopez, BV, Hampton, C, Lavinder, J, Gollihar, JD, Maranhao, AC, Ippolito, GC, Saavedra, MO, Cantu, CC, Yerramilli, P, Pruitt, L & Musser, JM 2020, , American Journal of Pathology, vol. 190, no. 8, pp. 1680-1690. https://doi.org/10.1016/j.ajpath.2020.05.014

Anticoagulation of impella with a bivalirudin purge solution
Szymanski, TW, Weeks, PA, Lee, Y, Kumar, S, Castillo, B, Kar, B & Gregoric, ID 2020, , ASAIO Journal, pp. E117-E120. https://doi.org/10.1097/MAT.0000000000001126

Utilization of therapeutic plasma exchange for hyperbilirubinemia in a premature newborn on extracorporeal membrane oxygenation
Belousova, T, Tong, Y, Bai, Y, Klein, K, Tint, H & Castillo, B 2019, , Journal of Clinical Apheresis, vol. 34, no. 5, pp. 615-622. https://doi.org/10.1002/jca.21708

New onset iron deficiency anemia in chronic therapeutic plasma exchange patients
Compton, F, Salazar, E, Klein, K, Tint, H, Castillo, B & Bai, Y 2018, , Annals of clinical and laboratory science, vol. 48, no. 3, pp. 273-278.

Successful management of severe red blood cell alloimmunization in pregnancy with a combination of therapeutic plasma exchange, intravenous immune globulin, and intrauterine transfusion
Nwogu, LC, Moise, KJ, Klein, KL, Tint, H, Castillo, B & Bai, Y 2018, , Transfusion, vol. 58, no. 3, pp. 677-684. https://doi.org/10.1111/trf.14453

A case of suspected streptococcus pneumoniae hemolytic uremic syndrome (pHUS) with utilization of minor crossmatching for platelet blood products lead to a diagnosis of atypical hemolytic uremic syndrome (aHUS)
Tong, YT, Al-Salihi, S, Belousova, T, Bai, Y, Klein, K, Tint, H & Castillo, B 2018, , Annals of clinical and laboratory science, vol. 48, no. 6, pp. 797-800.

Intra-pericardial use of recombinant factor VIIa in a patient with acute hemorrhagic pericardial effusion following transcutaneous aortic valve replacement-a case report
Jaitly, V, Klein, K, Tint, H, Chen, A, Allison, P, Akkanti, B, Loyalka, P & Castillo, B 2017, , Lab Medicine, vol. 48, no. 3, pp. 262-265. https://doi.org/10.1093/labmed/lmx048

Historical perspectives, current status, and ethical issues in granulocyte transfusion
Klein, K & Castillo, B 2017, , Annals of clinical and laboratory science, vol. 47, no. 4, pp. 501-507.

A Rare Case of Acquired Fanconi's Syndrome With Monoclonal Gammopathy in an Infant
Castillo, B, Chang, BN, Wahed, A & Tholpady, A 2016, , Journal of Clinical Laboratory Analysis, vol. 30, no. 5, pp. 510-512. https://doi.org/10.1002/jcla.21888

Bleeding related to cardiac surgery
Tint, H, Castillo, B, Allison, P & Chen, AJ 2016, . in Management of Bleeding Patients. Springer International Publishing, pp. 255-262. https://doi.org/10.1007/978-3-319-30726-8_28

Providing hemostatic and blood conservation options for Jehovah's Witness patients in a large medical system
Bai, Y, Castillo, B, Tchakarov, A, Escobar, MA, Cotton, BA, Holcomb, JB & Brown, RE 2016, , Annals of clinical and laboratory science, vol. 46, no. 6, pp. 654-661.

Primary hyperoxaluria type 1 with systemic calcium oxalate deposition: Case report and literature review
Falk, N, Castillo, B, Gupta, A, McKelvy, B, Bhattacharjee, M & Papasozomenos, S 2013, , Annals of clinical and laboratory science, vol. 43, no. 3, pp. 328-331.