Edward Brian Butler, MD

Jim and Joan Harrell Chair in Radiation Oncology, Department of Radiation Oncology
Professor of Radiation Oncology, Academic Institute
Full Clinical Member, Research Institute
Houston Methodist
Weill Cornell Medical College


After completing his postdoctoral training in 1987, Dr. Butler returned to the Wilford Hall USAF Medical Center in San Antonio, Texas where he became both the Chief of Radiation Oncology and the Chief of Brachytherapy. He also joined the faculty at The University of Texas Health Science Center at San Antonio as a Clinical Assistant Professor that same year. Dr. Butler would later join the Baylor College of Medicine where he would eventually become a full professor and the Chief of Radiation Oncology for both the medical school and the VA Hospital. He became the Medical Director of Radiation Oncology at Methodist in 1991, and received his faculty appointment at the Weill Medical School in 2006.

Description of Research

Dr. Butler’s research centers on preclinical and clinical studies that combine radiation therapy and gene therapy for the treatment of prostate cancer. In recent years, he has extended these successful studies to other cancers, notably pancreatic cancer. His research interests also include three-dimensional reconstruction of body organs to assist in better localization of radiation therapy.

Areas Of Expertise

Radiation therapy Prostate cancer Gene therapy Pancreatic cancer Computer visualization techniques
Education & Training

Residency, Stanford School of Medicine
MD, Georgetown University


Patent Number: US2018125780, May 10 2018


Patent Number: WO2016187100, Nov 24 2016


Comparison of outcomes between metaplastic and triple-negative breast cancer patients
Polamraju, P, Haque, WM, Cao, K, Verma, V, Schwartz, M, Klimberg, VS, Hatch, S, Niravath, PA, Butler, EB & Teh, BS 2020, Breast, vol. 49, pp. 8-16. https://doi.org/10.1016/j.breast.2019.10.003

Patterns of management and outcomes of unifocal versus multifocal glioblastoma
Haque, W, Thong, Y, Verma, V, Rostomily, R, Butler, EB & Teh, BS 2020, Journal of Clinical Neuroscience. https://doi.org/10.1016/j.jocn.2020.01.086

Neoadjuvant radiation therapy for esophageal cancer: Is a higher dose better?
Haque, W, Butler, EB & Teh, BS 2019, Journal of Thoracic Disease, vol. 11, no. 12, pp. 5631-5634. https://doi.org/10.21037/jtd.2019.11.77

Co-registration of MR and FDG-PET imaging for stereotactic radiotherapy planning; case report in a previously irradiated brain metastasis with recurrent tumor and radiation necrosis
Scranton, RA, Sadrameli, S, Butler, EB, Farach, A, Wang, H-C, Teh, BS, Tremont-Lukats, IW, Fung, SH, Zanotti-Fregonara, P & Rostomily, RC 2019, Practical Radiation Oncology. https://doi.org/10.1016/j.prro.2019.11.008

Biopsy proven metastatic meningioma: A case report and review of the literature
Vakil, H, Tran, L, Lewis, GD, Cykowski, MD, Butler, EB & Teh, BS 2019, Reports of Practical Oncology and Radiotherapy, vol. 24, no. 6, pp. 528-532. https://doi.org/10.1016/j.rpor.2019.08.002

A matter of comprehensive informed consent: Short-term mortality rates with definitive treatment options in elderly stage i NSCLC
Dalwadi, SM, Savjani, RR, Bernicker, EH, Butler, EB, Teh, BS & Farach, AM 2019, American Journal of Clinical Oncology: Cancer Clinical Trials, vol. 42, no. 11, pp. 851-855. https://doi.org/10.1097/COC.0000000000000606

Socioeconomic Factors Associated with Lack of Treatment in Early Stage Non-Small Cell Lung Cancer
Dalwadi, SM, Zhang, J, Bernicker, EH, Butler, EB, Teh, BS & Farach, AM 2019, Cancer Investigation, vol. 37, no. 9, pp. 506-511. https://doi.org/10.1080/07357907.2019.1666136

Prognosis of lymphotropic invasive micropapillary breast carcinoma analyzed by using data from the National Cancer Database
Lewis, GD, Xing, Y, Haque, WM, Patel, T, Schwartz, M, Chen, A, Farach, AM, Hatch, SS, Butler, EB, Chang, JC & Teh, BS 2019, Cancer Communications, vol. 39, no. 1, 60. https://doi.org/10.1186/s40880-019-0406-4

Patterns of End-of-Life Oncologic Care for Stage IV Non-small Cell Lung Cancer in the United States
Verma, V, Butler, EB, Teh, BS & Haque, WM 2019, Anticancer Research, vol. 39, no. 6, pp. 3137-3140. https://doi.org/10.21873/anticanres.13450

Pathologic nodal clearance and complete response following neoadjuvant chemoradiation for clinical N2 non-small cell lung cancer: Predictors and long-term outcomes
Haque, WM, Verma, V, Butler, EB & Teh, BS 2019, Lung Cancer, vol. 130, pp. 93-100. https://doi.org/10.1016/j.lungcan.2019.02.003

Postmastectomy radiation therapy for triple negative, node-negative breast cancer
Haque, WM, Verma, V, Farach, AM, Butler, EB & Teh, BS 2019, Radiotherapy and Oncology, vol. 132, pp. 48-54. https://doi.org/10.1016/j.radonc.2018.11.012

Outcomes of pleomorphic lobular carcinoma versus invasive lobular carcinoma
Haque, WM, Arms, A, Verma, V, Hatch, S, Brian Butler, E & Teh, BS 2019, Breast, vol. 43, pp. 67-73. https://doi.org/10.1016/j.breast.2018.11.007

Sequencing of Chemotherapy and Radiotherapy for Newly Diagnosed Anaplastic Oligodendroglioma and Oligoastrocytoma
Ryckman, JM, Surkar, SM, Haque, WM, Butler, EB, Teh, BS & Verma, V 2019, American Journal of Clinical Oncology: Cancer Clinical Trials. https://doi.org/10.1097/COC.0000000000000511

Post-treatment mortality after definitive chemoradiotherapy versus trimodality therapy for locally advanced non-small cell lung cancer
Haque, WM, Verma, V, Butler, EB, Teh, BS & Rusthoven, CG 2019, Lung Cancer, vol. 127, pp. 76-83. https://doi.org/10.1016/j.lungcan.2018.11.026

Stereotactic radiosurgery for brain metastases from newly diagnosed small cell lung cancer: practice patterns and outcomes
Jiang, W, Haque, WM, Verma, V, Butler, EB & Teh, BS 2019, Acta Oncologica. https://doi.org/10.1080/0284186X.2018.1562207

The Role of Adjuvant Radiotherapy in the Treatment of Pleural Mesothelioma
Lewis, GD, Dalwadi, SM, Farach, AM, Butler, EB & Teh, BS 2019, Annals of Surgical Oncology. https://doi.org/10.1245/s10434-019-07235-9

Racial and Socioeconomic Disparities in the Delivery of Immunotherapy for Metastatic Melanoma in the United States
Haque, WM, Verma, V, Butler, EB & Teh, BS 2019, Journal of Immunotherapy. https://doi.org/10.1097/CJI.0000000000000264

Neoadjuvant stereotactic body radiation therapy for nonmetastatic pancreatic adenocarcinoma
Jiang, W, Haque, WM, Verma, V, Butler, EB & Teh, BS 2019, Acta Oncologica. https://doi.org/10.1080/0284186X.2019.1631472

Cancer related fatigue in prostate cancer
Randall, J, Haque, WM, Butler, EB & Teh, BS 2019, Translational Andrology and Urology, vol. 8, pp. S106-S108. https://doi.org/10.21037/tau.2018.12.06

Omission of radiation therapy following breast conservation in older (=70 years) women with T1-2N0 triple-negative breast cancer
Haque, WM, Verma, V, Hsiao, KY, Hatch, S, Arentz, C, Szeja, S, Schwartz, M, Niravath, PA, Bonefas, E, Miltenburg, D, Butler, EB & Teh, BS 2019, Breast Journal. https://doi.org/10.1111/tbj.13443

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