Edward Brian Butler, MD

Jim and Joan Harrell Chair in Radiation Oncology, Department of Radiation Oncology
Professor of Radiation Oncology, Academic Institute
Full Clinical Member, Research Institute
Houston Methodist
Weill Cornell Medical College


Biography

Dr. Butler graduated from Georgetown University School of Medicine in Washington, D.C. in 1982.  He started his residency at Wilford Hall USAF Medical Center in San Antonio, Texas in 1982 and then completed his residency as Chief Resident at Stanford University Medical Center in 1986.  After completing his postdoctoral training in 1987, Dr. Butler returned to the Wilford Hall USAF Medical Center where he became both the Chief of Radiation Oncology and the Chief of Brachytherapy. He also joined the faculty at The University of Texas Health Science Center at San Antonio as a Clinical Assistant Professor that same year. Dr. Butler would later join the Baylor College of Medicine where he would eventually become a full professor and the Chief of Radiation Oncology for both the medical school and the VA Hospital. He became the Medical Director of Radiation Oncology at Methodist in 1991, and received his faculty appointment at the Weill Medical School in 2006.  He became Chair of Radiation Oncology at Houston Methodist in 2008.  In 2016, Dr. Butler was named the Jim and Joan Harrell Chair in Radiation Oncology.

Description of Research

Dr. Butler’s research centers on preclinical and clinical studies that combine radiation therapy and gene therapy for the treatment of prostate cancer. In recent years, he has extended these successful studies to other cancers, notably pancreatic cancer. His research interests also include three-dimensional reconstruction of body organs to assist in better localization of radiation therapy.

Areas Of Expertise

Radiation therapy Prostate cancer Gene therapy Pancreatic cancer Computer visualization techniques
Education & Training

Residency, Stanford School of Medicine
MD, Georgetown University
Patents

IMPLANTABLE NANOCHANNEL DELIVERY DEVICES

Patent Number: US2018125780, May 10 2018


IMPLANTABLE NANOCHANNEL DELIVERY DEVICES

Patent Number: WO2016187100, Nov 24 2016

Publications

Zonal Intratumoral Delivery of Nanoparticles Guided by Surface Functionalization
Terracciano, R, Carcamo-Bahena, Y, Royal, ALR, Messina, L, Delk, J, Butler, EB, Demarchi, D, Grattoni, A, Wang, Z, Cristini, V, Dogra, P & Filgueira, CS 2022, , Langmuir. https://doi.org/10.1021/acs.langmuir.2c02319

A Phase 2 Trial of Enhancing Immune Checkpoint Blockade by Stereotactic Radiation and In Situ Virus Gene Therapy in Metastatic Triple-Negative Breast Cancer
Sun, K, Xu, Y, Zhang, L, Niravath, P, Darcourt, J, Patel, T, Teh, BS, Farach, AM, Guerrero, C, Mathur, S, Sultenfuss, MA, Gupta, N, Schwartz, MR, Haley, SL, Nair, S, Li, X, Nguyen, TTA, Butner, JD, Ensor, J, Mejia, JA, Mei, Z, Butler, EB, Chen, SH, Bernicker, EH & Chang, JC 2022, , Clinical cancer research : an official journal of the American Association for Cancer Research, vol. 28, no. 20, pp. 4392-4401. https://doi.org/10.1158/1078-0432.CCR-22-0622

Prognostic Impact of Radiation Therapy in Pure Mucinous Breast Carcinoma
Chevli, N, Wang, K, Haque, W, Schwartz, MR, Nangia, J, Sasaki, J, Farach, AM, Hatch, SS, Butler, EB & Teh, BS 2022, , Clinical Breast Cancer, vol. 22, no. 7, pp. e807-e817. https://doi.org/10.1016/j.clbc.2022.06.005

21-Gene recurrence score predictive for prognostic benefit of radiotherapy in patients age = 70 with T1N0 ER/PR + HER2- breast cancer treated with breast conserving surgery and endocrine therapy
Chevli, N, Haque, W, Tran, KT, Farach, AM, Schwartz, MR, Hatch, SS, Butler, EB & Teh, BS 2022, , Radiotherapy and Oncology, vol. 174, pp. 37-43. https://doi.org/10.1016/j.radonc.2022.06.013

Three-year outcomes of uveal melanoma treated with intra-operative ultrasound-guided iodine-125 brachytherapy using custom-built eye plaques
Wong, AJ, Teh, BS, Nguyen, BT, Pino, R, Bretana, ME, Bernicker, EH, Chevez-Barrios, P, Butler, EB & Schefler, AC 2022, , Journal of Contemporary Brachytherapy, vol. 14, no. 2, pp. 130-139. https://doi.org/10.5114/jcb.2022.115379

Neoadjuvant Chemotherapy for Metaplastic Breast Cancer: Response Rates, Management, and Outcomes
Haque, W, Verma, V, Schwartz, MR, Lim, B, Mangalampalli, N, Butler, EB & Teh, BS 2022, , Clinical Breast Cancer, vol. 22, no. 5, pp. e691-e699. https://doi.org/10.1016/j.clbc.2022.01.006

Prognostic and predictive impact of MGMT promoter methylation status in high risk grade II glioma
Haque, W, Teh, C, Butler, EB & Teh, BS 2022, , Journal of Neuro-Oncology, vol. 157, no. 1, pp. 137-146. https://doi.org/10.1007/s11060-022-03955-3

Contemporary trends in management of uveal melanoma
Chevli, N, Zuhour, RJ, Messer, JA, Haque, W, Schefler, AC, Bernicker, EH, Chevez-Barrios, P, Farach, AM, Butler, EB & Teh, BS 2022, , Journal of Contemporary Brachytherapy, vol. 14, no. 2, pp. 123-129. https://doi.org/10.5114/jcb.2022.115210

Role of 21-Gene Recurrence Score in Predicting Prognostic Benefit of Radiation Therapy After Breast-Conserving Surgery for T1N0 Breast Cancer
Chevli, N, Haque, W, Tran, KT, Farach, AM, Schwartz, MR, Hatch, SS, Butler, EB & Teh, BS 2022, , Practical Radiation Oncology. https://doi.org/10.1016/j.prro.2022.08.004

Time Interval to Initiation of Whole-Brain Radiation Therapy in Patients With Small Cell Lung Cancer With Brain Metastasis
Chevli, N, Hunt, A, Haque, W, Farach, AM, Messer, JA, Sukpraprut-Braaten, S, Bernicker, EH, Zhang, J, Butler, EB & Teh, BS 2021, , Advances in Radiation Oncology, vol. 6, no. 6, 100783. https://doi.org/10.1016/j.adro.2021.100783

Prognostic Impact of Biologically Equivalent Dose in Stereotactic Body Radiation Therapy for Renal Cancer
Tran, KT, Chevli, NC, Messer, JA, Haque, W, Farach, AM, Satkunasivam, R, Zhang, J, Darcourt, J, Lo, SS, Siva, S, Butler, EB & Teh, BS 2021, , International Journal of Radiation Oncology, Biology, Physics, vol. 111, no. 3, pp. e262. https://doi.org/10.1016/j.ijrobp.2021.07.862

Postmastectomy Radiation Therapy Following Pathologic Complete Nodal Response to Neoadjuvant Chemotherapy
Haque, W, Verma, V, Teh, BS, Butler, EB, Hatch, SS, Desai, M, Arentz, SC, Jain, D, Schwartz, MR, Chevli, N & Farach, AM 2021, , International Journal of Radiation Oncology, Biology, Physics, vol. 111, no. 3, pp. e196. https://doi.org/10.1016/j.ijrobp.2021.07.707

21-Gene Recurrence Score Predictive for Patients Most Likely to Benefit From Postoperative Radiation Following Breast Conserving Surgery for T1N0 Breast Cancer
Chevli, NC, Haque, W, Tran, KT, Farach, AM, Schwartz, MR, Geyer, CE, Hatch, SS, Butler, EB & Teh, BS 2021, , International Journal of Radiation Oncology, Biology, Physics, vol. 111, no. 3, pp. e205. https://doi.org/10.1016/j.ijrobp.2021.07.728

DMSA-SPECT: A Novel Approach to Nephron Sparing SBRT for Renal Cell Carcinoma
Chevli, N, Chiang, S, Farach, AM, Haque, W, Satkunasivam, R, Bernicker, EH, Pino, R, Butler, EB & Teh, BS 2021, , Advances in Radiation Oncology, vol. 6, no. 6, 100719. https://doi.org/10.1016/j.adro.2021.100719, https://doi.org/10.1016/j.adro.2021.100719

DMSA-SPECT: A Novel Approach to Nephron Sparing SBRT for Renal Cell Carcinoma
Chevli, N, Chiang, S, Farach, AM, Haque, W, Satkunasivam, R, Bernicker, EH, Pino, R, Butler, EB & Teh, BS 2021, , Advances in Radiation Oncology, vol. 6, no. 6, 100719. https://doi.org/10.1016/j.adro.2021.100719

Hyaluronate-thiol passivation enhances gold nanoparticle peritumoral distribution when administered intratumorally in lung cancer
Terracciano, R, Carcamo-Bahena, Y, Butler, EB, Demarchi, D, Grattoni, A & Filgueira, CS 2021, , Biomedicines, vol. 9, no. 11, 1561. https://doi.org/10.3390/biomedicines9111561

Postmastectomy radiation therapy following pathologic complete nodal response to neoadjuvant chemotherapy: A prelude to NSABP B-51?
Haque, W, Singh, A, Verma, V, Schwartz, MR, Chevli, N, Hatch, S, Desai, M, Butler, EB, Arentz, C, Farach, A & Teh, BS 2021, , Radiotherapy and Oncology, vol. 162, pp. 52-59. https://doi.org/10.1016/j.radonc.2021.06.032

Staged Eye-Plaque Brachytherapy: A Novel Approach for Large Uveal Melanoma
Chevli, N, Schefler, AC, Bretana, ME, Pino, R, Butler, EB & Teh, BS 2021, , Advances in Radiation Oncology, vol. 6, no. 4, 100712, pp. 100712. https://doi.org/10.1016/j.adro.2021.100712

Solitary Leptomeningeal Recurrence From Prostate Adenocarcinoma After Treatment With Cytotoxic Gene Therapy, Radiation Therapy, and Androgen Deprivation Therapy
Chevli, N, Curtis, AE, Powell, S, New, P, Butler, EB & Teh, BS 2021, , Advances in Radiation Oncology, vol. 6, no. 4, 100711. https://doi.org/10.1016/j.adro.2021.100711

Prognostic impact of radiation therapy in tubular carcinoma of the breast
Stauber, J, Chevli, N, Haque, W, Messer, JA, Farach, AM, Schwartz, MR, Geyer, CE, Bonefas, E, Zuhour, R, Wong, A, Hatch, S, Butler, EB & Teh, BS 2021, , Radiotherapy and Oncology, vol. 159, pp. 202-208. https://doi.org/10.1016/j.radonc.2021.03.009