Bin S. Teh, MD, FACR, FASTRO, FACRO

Professor of Radiation Oncology, Academic Institute
Full Member, Research Institute
Jim and Joan Harrell Centennial Chair in Radiation Oncology, Houston Methodist
Weill Cornell Medical College


Biography

Dr. Teh is a professor and vice chair of the Department of Radiation Oncology at Houston Methodist Hospital and Weill Medical School of Cornell. Dr. Teh has contributed significantly to the field of radiation oncology – encompassing radiotherapy technology, radiation physics, molecular radiobiology and the translation of advances in these areas to clinical use. He has been instrumental in pioneering new technology in radiation oncology including APBI (accelerated partial breast irradiation), IMRT (intensity-modulated radiation therapy), IGRT (image-guided radiation therapy), SBRT (stereotactic body radiation therapy), SRS (stereotactic radiosurgery), brachytherapy as well as combined radiotherapy and gene therapy. Dr. Teh treated the first breast cancer patient in Houston with multi-lumen catheter (Contura) high dose rate brachytherapy for partial breast irradiation. This is a short course of five days irradiation, as compared to the conventional six weeks irradiation for breast cancer. Partial breast irradiation is a novel approach to spare more normal tissues.

Dr. Teh earned his medical degree from the University of Queensland in Queensland, Australia. He completed his Radiation Oncology residency, training and fellowship in IMRT at the Baylor College of Medicine in Houston, Texas. Dr. Teh is active in ASTRO (American Society of Therapeutic Radiology and Oncology), RSNA (Radiological Society of North America and ARS (American Radium Society). He is the principal investigator for RTOG (Radiation Therapy Oncology Group) at Houston Methodist Hospital. Dr. Teh has published more than 100 peer-reviewed articles on topics such as IMRT for breast cancer, editorials, 15 book chapters and a textbook on PET-CT in radiotherapy. He plays an important role in breast cancer patient care, clinical research and the education of residents and students.

Description of Research

Dr. Teh’s research focuses on the treatment of genito-urinary malignancies and unlocking the myth of radio-resistance in cancers especially renal cell carcinoma. Other research interests include Intensity modulated radiation therapy (IMRT) for prostate cancer, head and neck cancer, central nervous system tumor, pediatric cancer and breast cancer, stereotactic radiosurgery (SRS), stereotactic body radiotherapy (SBRT), stereotactic radiation therapy (SRT) and image-guided radiation therapy (IGRT), brachytherapy for prostate cancer, breast cancer and endobronchial tumors, SRS and SBRT for primary and metastatic renal cell carcinoma as well as hepatocellular carcinoma, the role of combined radiotherapy and gene therapy for cancers including prostate cancer, renal cell carcinoma, bladder cancer, pancreatic cancer, glioblastoma multiforme, cervical cancer and head and neck cancer, combining targeted therapy (AKT-inhibitor, mTOR inhibitor, tyrosine kinase inhibitor) with radiotherapy for cancer treatment, and combining oncolytic virus with radiotherapy in overcoming radio-resistant tumors in oncology.

Areas Of Expertise

Cancer stem cells Radio-resistance Prostate Movement study Post-prostatectomy IMRT Gene expression profiling in cancer Proteomics in oncology
Education & Training

Residency, Baylor College of Medicine
Clinical Fellowship, Baylor College of Medicine
MD, University of Queensland
Publications

Three-year outcomes of uveal melanoma treated with intra-operative ultrasound-guided iodine-125 brachytherapy using custom-built eye plaques
Wong, AJ, Teh, BS, Nguyen, BT, Pino, R, Bretana, ME, Bernicker, EH, Chevez-Barrios, P, Butler, EB & Schefler, AC 2022, , Journal of Contemporary Brachytherapy, vol. 14, no. 2, pp. 130-139. https://doi.org/10.5114/jcb.2022.115379

Prognostic and predictive impact of MGMT promoter methylation status in high risk grade II glioma
Haque, W, Teh, C, Butler, EB & Teh, BS 2022, , Journal of Neuro-Oncology, vol. 157, no. 1, pp. 137-146. https://doi.org/10.1007/s11060-022-03955-3

Neoadjuvant Chemotherapy for Metaplastic Breast Cancer: Response Rates, Management, and Outcomes
Haque, W, Verma, V, Schwartz, MR, Lim, B, Mangalampalli, N, Butler, EB & Teh, BS 2022, , Clinical Breast Cancer. https://doi.org/10.1016/j.clbc.2022.01.006

Contemporary trends in management of uveal melanoma
Chevli, N, Zuhour, RJ, Messer, JA, Haque, W, Schefler, AC, Bernicker, EH, Chevez-Barrios, P, Farach, AM, Butler, EB & Teh, BS 2022, , Journal of Contemporary Brachytherapy, vol. 14, no. 2, pp. 123-129. https://doi.org/10.5114/jcb.2022.115210

Initial experience of the implementation of a cardio-oncology program for breast cancer patients receiving modern radiotherapy in a tertiary institution
Hou, PY, Wu, YW, Wu, LJ, Hsieh, CH, Hsu, CX, Kuo, DY, Lu, YF, Tien, HJ, Yeh, HP, Shueng, PW & Teh, BS 2021, , Therapeutic Radiology and Oncology, vol. 5, 21. https://doi.org/10.21037/TRO-21-20

Time Interval to Initiation of Whole-Brain Radiation Therapy in Patients With Small Cell Lung Cancer With Brain Metastasis
Chevli, N, Hunt, A, Haque, W, Farach, AM, Messer, JA, Sukpraprut-Braaten, S, Bernicker, EH, Zhang, J, Butler, EB & Teh, BS 2021, , Advances in Radiation Oncology, vol. 6, no. 6, 100783. https://doi.org/10.1016/j.adro.2021.100783

Prognostic Impact of Biologically Equivalent Dose in Stereotactic Body Radiation Therapy for Renal Cancer
Tran, KT, Chevli, NC, Messer, JA, Haque, W, Farach, AM, Satkunasivam, R, Zhang, J, Darcourt, J, Lo, SS, Siva, S, Butler, EB & Teh, BS 2021, , International Journal of Radiation Oncology, Biology, Physics, vol. 111, no. 3, pp. e262. https://doi.org/10.1016/j.ijrobp.2021.07.862

Postmastectomy Radiation Therapy Following Pathologic Complete Nodal Response to Neoadjuvant Chemotherapy
Haque, W, Verma, V, Teh, BS, Butler, EB, Hatch, SS, Desai, M, Arentz, SC, Jain, D, Schwartz, MR, Chevli, N & Farach, AM 2021, , International Journal of Radiation Oncology, Biology, Physics, vol. 111, no. 3, pp. e196. https://doi.org/10.1016/j.ijrobp.2021.07.707

21-Gene Recurrence Score Predictive for Patients Most Likely to Benefit From Postoperative Radiation Following Breast Conserving Surgery for T1N0 Breast Cancer
Chevli, NC, Haque, W, Tran, KT, Farach, AM, Schwartz, MR, Geyer, CE, Hatch, SS, Butler, EB & Teh, BS 2021, , International Journal of Radiation Oncology, Biology, Physics, vol. 111, no. 3, pp. e205. https://doi.org/10.1016/j.ijrobp.2021.07.728

DMSA-SPECT: A Novel Approach to Nephron Sparing SBRT for Renal Cell Carcinoma
Chevli, N, Chiang, S, Farach, AM, Haque, W, Satkunasivam, R, Bernicker, EH, Pino, R, Butler, EB & Teh, BS 2021, , Advances in Radiation Oncology, vol. 6, no. 6, 100719. https://doi.org/10.1016/j.adro.2021.100719, https://doi.org/10.1016/j.adro.2021.100719

DMSA-SPECT: A Novel Approach to Nephron Sparing SBRT for Renal Cell Carcinoma
Chevli, N, Chiang, S, Farach, AM, Haque, W, Satkunasivam, R, Bernicker, EH, Pino, R, Butler, EB & Teh, BS 2021, , Advances in Radiation Oncology, vol. 6, no. 6, 100719. https://doi.org/10.1016/j.adro.2021.100719

Comparison of Survival Outcomes With/Without Adjuvant Radiation Therapy in Desmoplastic Melanoma
Lewis, GD, Guzman, AK, Haque, W, McLellan, BN & Teh, BS 2021, , Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.], vol. 47, no. 10, pp. 1333-1336. https://doi.org/10.1097/DSS.0000000000003177

Postmastectomy radiation therapy following pathologic complete nodal response to neoadjuvant chemotherapy: A prelude to NSABP B-51?
Haque, W, Singh, A, Verma, V, Schwartz, MR, Chevli, N, Hatch, S, Desai, M, Butler, EB, Arentz, C, Farach, A & Teh, BS 2021, , Radiotherapy and Oncology, vol. 162, pp. 52-59. https://doi.org/10.1016/j.radonc.2021.06.032

Staged Eye-Plaque Brachytherapy: A Novel Approach for Large Uveal Melanoma
Chevli, N, Schefler, AC, Bretana, ME, Pino, R, Butler, EB & Teh, BS 2021, , Advances in Radiation Oncology, vol. 6, no. 4, 100712, pp. 100712. https://doi.org/10.1016/j.adro.2021.100712

Solitary Leptomeningeal Recurrence From Prostate Adenocarcinoma After Treatment With Cytotoxic Gene Therapy, Radiation Therapy, and Androgen Deprivation Therapy
Chevli, N, Curtis, AE, Powell, S, New, P, Butler, EB & Teh, BS 2021, , Advances in Radiation Oncology, vol. 6, no. 4, 100711. https://doi.org/10.1016/j.adro.2021.100711

Prognostic impact of radiation therapy in tubular carcinoma of the breast
Stauber, J, Chevli, N, Haque, W, Messer, JA, Farach, AM, Schwartz, MR, Geyer, CE, Bonefas, E, Zuhour, R, Wong, A, Hatch, S, Butler, EB & Teh, BS 2021, , Radiotherapy and Oncology, vol. 159, pp. 202-208. https://doi.org/10.1016/j.radonc.2021.03.009

Adaptive radiation therapy for intact thymoma: An illustrative report
Chevli, N, Bland, RE, Farach, AM, Pino, R, Mathews, T, Okoye, EI, Blackmon, S, Butler, EB & Teh, BS 2021, , Anticancer Research, vol. 41, no. 5, pp. 2467-2571. https://doi.org/10.21873/ANTICANRES.15022

Prognostic and predictive impact of MGMT promoter methylation in grade 3 gliomas
Haque, WM, Thong, E, Andrabi, S, Verma, V, Butler, EB & Teh, BS 2021, , Journal of Clinical Neuroscience, vol. 85, pp. 115-121. https://doi.org/10.1016/j.jocn.2020.12.028

Staged stereotactic radiosurgery decreases symptomatic radionecrosis in large brain metastasis
Chevli, N, Wang, HC, Dubey, P, Haque, W, Farach, AM, Pino, R, Rostomily, RC, Butler, EB & Teh, BS 2021, , Anticancer Research, vol. 41, no. 3, pp. 1445-1449. https://doi.org/10.21873/ANTICANRES.14902

Staged stereotactic radiosurgery decreases symptomatic radionecrosis in large brain metastasis
Chevli, N, Wang, HC, Dubey, P, Haque, W, Farach, AM, Pino, R, Rostomily, RC, Butler, EB & Teh, BS 2021, , Anticancer Research, vol. 41, no. 3, pp. 1445-1449. https://doi.org/10.21873/anticanres.14902