Bin He

Bin He, PhD

Associate Professor of Transplant Immunology in Surgery, Academic Institute
Associate Member, Research Institute
Houston Methodist
Weill Cornell Medical College
Areas Of Expertise

Prostate cancer Immunotherapy Biomarker CAR-T

The cancer testis antigen TDRD1 regulates prostate cancer proliferation by associating with the snRNP biogenesis machinery
Kim, H, Barua, A, Huang, L, Zhou, T, Bolaji, M, Zachariah, S, Mitra, A, Jung, SY, He, B & Feng, Q 2023, , Oncogene, vol. 42, no. 22, pp. 1821-1831.

From bench to bedside: the history and progress of CAR T cell therapy
Mitra, A, Barua, A, Huang, L, Ganguly, S, Feng, Q & He, B 2023, , Frontiers in immunology, vol. 14, 1188049, pp. 1188049.

Activation of mtorc1 and c-jun by prohibitin1 loss in schwann cells may link mitochondrial dysfunction to demyelination
Nunes, GDF, Wilson, ER, Hurley, E, He, B, Omalley, BW, Poitelon, Y, Wrabetz, L & Feltri, ML 2021, , eLife, vol. 10, e66278.

Prohibitin 1 is essential to preserve mitochondria and myelin integrity in Schwann cells
Della-Flora Nunes, G, Wilson, ER, Marziali, LN, Hurley, E, Silvestri, N, He, B, O’Malley, BW, Beirowski, B, Poitelon, Y, Wrabetz, L & Feltri, ML 2021, , Nature Communications, vol. 12, no. 1, 3285.

Targeted immunotherapy forHER2-low breast cancer with 17p loss
Li, Y, Sun, Y, Kulke, M, Hechler, T, Van Der Jeught, K, Dong, T, He, B, Miller, KD, Radovich, M, Schneider, BP, Pahl, A, Zhang, X & Lu, X 2021, , Science translational medicine, vol. 13, no. 580, eabc6894.

Acetylation of histone H3K27 signals the transcriptional elongation for estrogen receptor alpha
Gao, Y, Chen, L, Han, Y, Wu, F, Yang, WS, Zhang, Z, Huo, T, Zhu, Y, Yu, C, Kim, H, Lee, M, Tang, Z, Phillips, K, He, B, Jung, SY, Song, Y, Zhu, B, Xu, RM & Feng, Q 2020, , Communications Biology, vol. 3, no. 1, 165.

Adoptive CD8+ T cell therapy generates immunological memory to inhibit melanoma metastasis
Fu, J, Yu, A, Tang, J, He, B & Chen, W 2020, , American Journal of Translational Research, vol. 12, no. 11, pp. 7262-7274.

Driver network as a biomarker: Systematic integration and network modeling of multi-omics data to derive driver signaling pathways for drug combination prediction
Huang, L, Brunell, D, Stephan, C, Mancuso, J, Yu, X, He, B, Thompson, TC, Zinner, R, Kim, J, Davies, P & Wong, STC 2019, , Bioinformatics, vol. 35, no. 19, pp. 3709-3717.

Androgen Receptor Signaling in the Development of Castration-Resistant Prostate Cancer
Feng, Q & He, B 2019, , Frontiers in Oncology, vol. 9, 858.

Correction: Androgen receptor is the key transcriptional mediator of the tumor suppressor SPOP in prostate cancer (Cancer Research (2014) 74 (5631-5643) DOI: 10.1158/0008-5472.CAN-14-0476)
Geng, C, Rajapakshe, K, Shah, SS, Shou, J, Eedunuri, VK, Foley, C, Fiskus, W, Rajendran, M, Chew, SA, Zimmermann, M, Bond, R, He, B, Coarfa, C & Mitsiades, N 2019, , Cancer research, vol. 79, no. 17, pp. 4552.

Erratum: “Prostate cancer-associated mutations in speckle-type POZ protein (SPOP) regulate steroid receptor coactivator 3 protein turnover,”(Proceedings of the National Academy of Sciences of the United States of America(2019)110(6997–7002)Doi:10.1073/pnas.1304502110)
Geng, C, He, B, Xu, L, Barbieri, CE, Eedunuri, VK, Chew, SA, Zimmermann, M, Bond, R, Shou, J, Li, C, Blattner, M, Lonard, DM, Demichelis, F, Coarfa, C, Rubin, MA, Zhou, P & O’Malley, BW 2019, , Proceedings of the National Academy of Sciences of the United States of America, vol. 116, no. 28, pp. 14386-14387.

Heterozygous deletion of chromosome 17p renders prostate cancer vulnerable to inhibition of RNA polymerase II
Li, Y, Liu, Y, Xu, H, Jiang, G, Van der Jeught, K, Fang, Y, Zhou, Z, Zhang, L, Frieden, M, Wang, L, Luo, Z, Radovich, M, Schneider, BP, Deng, Y, Liu, Y, Huang, K, He, B, Wang, J, He, X, Zhang, X, Ji, G & Lu, X 2018, , Nature Communications, vol. 9, no. 1, 4394.

Uterine function in the mouse requires speckle-type poz protein
Hai, L, Szwarc, MM, He, B, Lonard, DM, Kommagani, R, DeMayo, FJ & Lydon, JP 2018, , Biology of Reproduction, vol. 98, no. 6, pp. 856-869.

Crosstalk between histone modifications indicates that inhibition of arginine methyltransferase CARM1 activity reverses HIV latency
Zhang, Z, Nikolai, BC, Gates, LA, Jung, SY, Siwak, EB, He, B, Rice, AP, OMalley, BW & Feng, Q 2017, , Nucleic Acids Research, vol. 45, no. 16, pp. 9348-9360.

Mitochondrial activity in human white adipocytes is regulated by the ubiquitin carrier protein 9/microRNA-30a axis
Koh, EH, Chen, Y, Bader, DA, Hamilton, MP, He, B, York, B, Kajimura, S, McGuire, SE & Hartig, SM 2016, , Journal of Biological Chemistry, vol. 291, no. 47, pp. 24747-24755.

The Germ Cell Gene TDRD1 as an ERG Target Gene and a Novel Prostate Cancer Biomarker
Xiao, L, Lanz, RB, Frolov, A, Castro, PD, Zhang, Z, Dong, B, Xue, W, Jung, SY, Lydon, JP, Edwards, DP, Mancini, MA, Feng, Q, Ittmann, MM & He, B 2016, , Prostate, vol. 76, no. 14, pp. 1271-1284.

The essential role of GATA transcription factors in adult murine prostate
Xiao, L, Feng, Q, Zhang, Z, Wang, F, Lydon, JP, Ittmann, MM, Xin, L, Mitsiades, N & He, B 2016, , Oncotarget, vol. 7, no. 30, pp. 47891-47903.

The tumor suppressive miR-200b subfamily is an ERG target gene in human prostate tumors
Zhang, Z, Lanz, RB, Xiao, L, Wang, L, Hartig, SM, Ittmann, MM, Feng, Q & He, B 2016, , Oncotarget, vol. 7, no. 25, pp. 37993-38003.

GATA2 facilitates steroid receptor coactivator recruitment to the androgen receptor complex
He, B, Lanz, RB, Fiskus, W, Geng, C, Yi, P, Hartig, SM, Rajapakshe, K, Shou, J, Wei, L, Shah, SS, Foley, C, Chew, SA, Eedunuri, VK, Bedoya, DJ, Feng, Q, Minami, T, Mitsiades, CS, Frolov, A, Weigel, NL, Hilsenbeck, SG, Rosen, DG, Palzkill, T, Ittmann, MM, Song, Y, Coarfa, C, OMalley, BW & Mitsiades, N 2014, , Proceedings of the National Academy of Sciences of the United States of America, vol. 111, no. 51, pp. 18261-18266.

Androgen receptoristhe keytranscriptional mediatorofthe tumor suppressor SPOP in prostate cancer
Geng, C, Rajapakshe, K, Shah, SS, Shou, J, Eedunuri, VK, Foley, C, Fiskus, W, Rajendran, M, Chew, SA, Zimmermann, M, Bond, R, He, B, Coarfa, C & Mitsiades, N 2014, , Cancer research, vol. 74, no. 19, pp. 5631-5643.