Not found

Bin He, PhD

Associate Professor of Transplant Immunology in Surgery, Academic Institute
Associate Member, Research Institute
Houston Methodist
Weill Cornell Medical College


bhe@houstonmethodist.org
Areas Of Expertise

Prostate cancer Immunotherapy Biomarker CAR-T
Publications

Acetylation of histone H3K27 signals the transcriptional elongation for estrogen receptor alpha
Gao, Y, Chen, L, Han, Y, Wu, F, Yang, WS, Zhang, Z, Huo, T, Zhu, Y, Yu, C, Kim, H, Lee, M, Tang, Z, Phillips, K, He, B, Jung, SY, Song, Y, Zhu, B, Xu, RM & Feng, Q 2020, , Communications Biology, vol. 3, no. 1, 165. https://doi.org/10.1038/s42003-020-0898-0

Driver network as a biomarker: Systematic integration and network modeling of multi-omics data to derive driver signaling pathways for drug combination prediction
Huang, L, Brunell, D, Stephan, C, Mancuso, J, Yu, X, He, B, Thompson, TC, Zinner, R, Kim, J, Davies, P & Wong, STC 2019, , Bioinformatics, vol. 35, no. 19, pp. 3709-3717. https://doi.org/10.1093/bioinformatics/btz109

Androgen Receptor Signaling in the Development of Castration-Resistant Prostate Cancer
Feng, Q & He, B 2019, , Frontiers in Oncology, vol. 9, 858. https://doi.org/10.3389/fonc.2019.00858

Correction: Androgen receptor is the key transcriptional mediator of the tumor suppressor SPOP in prostate cancer (Cancer Research (2014) 74 (5631-5643) DOI: 10.1158/0008-5472.CAN-14-0476)
Geng, C, Rajapakshe, K, Shah, SS, Shou, J, Eedunuri, VK, Foley, C, Fiskus, W, Rajendran, M, Chew, SA, Zimmermann, M, Bond, R, He, B, Coarfa, C & Mitsiades, N 2019, , Cancer research, vol. 79, no. 17. https://doi.org/10.1158/0008-5472.CAN-19-1981

Erratum: “Prostate cancer-associated mutations in speckle-type POZ protein (SPOP) regulate steroid receptor coactivator 3 protein turnover,”(Proceedings of the National Academy of Sciences of the United States of America(2019)110(6997–7002)Doi:10.1073/pnas.1304502110)
Geng, C, He, B, Xu, L, Barbieri, CE, Eedunuri, VK, Chew, SA, Zimmermann, M, Bond, R, Shou, J, Li, C, Blattner, M, Lonard, DM, Demichelis, F, Coarfa, C, Rubin, MA, Zhou, P & O’Malley, BW 2019, , Proceedings of the National Academy of Sciences of the United States of America, vol. 116, no. 28, pp. 14386-14387. https://doi.org/10.1073/pnas.1908767116

Heterozygous deletion of chromosome 17p renders prostate cancer vulnerable to inhibition of RNA polymerase II
Li, Y, Liu, Y, Xu, H, Jiang, G, Van der Jeught, K, Fang, Y, Zhou, Z, Zhang, L, Frieden, M, Wang, L, Luo, Z, Radovich, M, Schneider, BP, Deng, Y, Liu, Y, Huang, K, He, B, Wang, J, He, X, Zhang, X, Ji, G & Lu, X 2018, Nature Communications, vol. 9, no. 1, 4394. https://doi.org/10.1038/s41467-018-06811-z

Uterine function in the mouse requires speckle-type poz protein
Hai, L, Szwarc, MM, He, B, Lonard, DM, Kommagani, R, DeMayo, FJ & Lydon, JP 2018, , Biology of Reproduction, vol. 98, no. 6, pp. 856-869. https://doi.org/10.1093/biolre/ioy060

Crosstalk between histone modifications indicates that inhibition of arginine methyltransferase CARM1 activity reverses HIV latency
Zhang, Z, Nikolai, BC, Gates, LA, Jung, SY, Siwak, EB, He, B, Rice, AP, OMalley, BW & Feng, Q 2017, , Nucleic Acids Research, vol. 45, no. 16, pp. 9348-9360. https://doi.org/10.1093/nar/gkx550

Mitochondrial activity in human white adipocytes is regulated by the ubiquitin carrier protein 9/microRNA-30a axis
Koh, EH, Chen, Y, Bader, DA, Hamilton, MP, He, B, York, B, Kajimura, S, McGuire, SE & Hartig, SM 2016, , Journal of Biological Chemistry, vol. 291, no. 47, pp. 24747-24755. https://doi.org/10.1074/jbc.M116.749408

The Germ Cell Gene TDRD1 as an ERG Target Gene and a Novel Prostate Cancer Biomarker
Xiao, L, Lanz, RB, Frolov, A, Castro, PD, Zhang, Z, Dong, B, Xue, W, Jung, SY, Lydon, JP, Edwards, DP, Mancini, MA, Feng, Q, Ittmann, MM & He, B 2016, , Prostate, vol. 76, no. 14, pp. 1271-1284. https://doi.org/10.1002/pros.23213

The essential role of GATA transcription factors in adult murine prostate
Xiao, L, Feng, Q, Zhang, Z, Wang, F, Lydon, JP, Ittmann, MM, Xin, L, Mitsiades, N & He, B 2016, , Oncotarget, vol. 7, no. 30, pp. 47891-47903. https://doi.org/10.18632/oncotarget.10294

The tumor suppressive miR-200b subfamily is an ERG target gene in human prostate tumors
Zhang, Z, Lanz, RB, Xiao, L, Wang, L, Hartig, SM, Ittmann, MM, Feng, Q & He, B 2016, , Oncotarget, vol. 7, no. 25, pp. 37993-38003. https://doi.org/10.18632/oncotarget.9366

GATA2 facilitates steroid receptor coactivator recruitment to the androgen receptor complex
He, B, Lanz, RB, Fiskus, W, Geng, C, Yi, P, Hartig, SM, Rajapakshe, K, Shou, J, Wei, L, Shah, SS, Foley, C, Chew, SA, Eedunuri, VK, Bedoya, DJ, Feng, Q, Minami, T, Mitsiades, CS, Frolov, A, Weigel, NL, Hilsenbeck, SG, Rosen, DG, Palzkill, T, Ittmann, MM, Song, Y, Coarfa, C, OMalley, BW & Mitsiades, N 2014, , Proceedings of the National Academy of Sciences of the United States of America, vol. 111, no. 51, pp. 18261-18266. https://doi.org/10.1073/pnas.1421415111

Androgen receptoristhe keytranscriptional mediatorofthe tumor suppressor SPOP in prostate cancer
Geng, C, Rajapakshe, K, Shah, SS, Shou, J, Eedunuri, VK, Foley, C, Fiskus, W, Rajendran, M, Chew, SA, Zimmermann, M, Bond, R, He, B, Coarfa, C & Mitsiades, N 2014, , Cancer research, vol. 74, no. 19, pp. 5631-5643. https://doi.org/10.1158/0008-5472.CAN-14-0476

An epigenomic approach to therapy for tamoxifen-resistant breast cancer
Feng, Q, Zhang, Z, Shea, MJ, Creighton, CJ, Coarfa, C, Hilsenbeck, SG, Lanz, R, He, B, Wang, L, Fu, X, Nardone, A, Song, Y, Bradner, J, Mitsiades, N, Mitsiades, CS, Osborne, CK, Schiff, R & OMalley, BW 2014, , Cell Research, vol. 24, no. 7, pp. 809-819. https://doi.org/10.1038/cr.2014.71

Androgen receptor agonism promotes an osteogenic gene program in preadipocytes
Hartig, SM, Feng, Q, Ochsner, SA, Xiao, R, McKenna, NJ, McGuire, SE & He, B 2013, , Biochemical and Biophysical Research Communications, vol. 434, no. 2, pp. 357-362. https://doi.org/10.1016/j.bbrc.2013.03.078

Prostate cancer-associated mutations in speckle-type POZ protein (SPOP) regulate steroid receptor coactivator 3 protein turnover
Geng, C, He, B, Xu, L, Barbieri, CE, Eedunuri, VK, Chew, SA, Zimmermann, M, Bond, R, Shou, J, Li, C, Blattner, M, Lonard, DM, Demichelis, F, Coarfa, C, Rubin, MA, Zhou, P, OMalley, BW & Mitsiades, N 2013, , Proceedings of the National Academy of Sciences of the United States of America, vol. 110, no. 17, pp. 6997-7002. https://doi.org/10.1073/pnas.1304502110

Gonadotropin-releasing hormone-regulated prohibitin mediates apoptosis of the gonadotrope cells
Savulescu, D, Feng, J, Ping, YS, Mai, O, Boehm, U, He, B, OMalley, BW & Melamed, P 2013, , Molecular Endocrinology, vol. 27, no. 11, pp. 1856-1870. https://doi.org/10.1210/me.2013-1210

Distinct patterns of dysregulated expression of enzymes involved in androgen synthesis and metabolism in metastatic prostate cancer tumors
Mitsiades, N, Sung, CC, Schultz, N, Danila, DC, He, B, Eedunuri, VK, Fleisher, M, Sander, C, Sawyers, CL & Scher, HI 2012, , Cancer research, vol. 72, no. 23, pp. 6142-6152. https://doi.org/10.1158/0008-5472.CAN-12-1335

Prohibitin-1 deficiency promotes inflammation and increases sensitivity to liver injury
Sánchez-Quiles, V, Segura, V, Bigaud, E, He, B, OMalley, BW, Santamaría, E, Prieto, J & Corrales, FJ 2012, , Journal of Proteomics, vol. 75, no. 18, pp. 5783-5792. https://doi.org/10.1016/j.jprot.2012.08.009