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Biana Godin, MScPharm, PhD

Assistant Professor of Nanomedicine, Institute for Academic Medicine
Assistant Member, Research Institute
Houston Methodist


Research Lab


Phone:
713.441.7329


bgodin@houstonmethodist.org
Biography

Dr. Biana Godin earned her Ph.D. in Pharmaceutical Sciences from the Hebrew University of Jerusalem in 2006. During her Ph.D. studies, Dr. Godin focused on designing a non-invasive treatment for the hard-to-treat skin deep infections and on nasal delivery of proteins. She was recruited as a Postdoctoral trainee in the field of Cancer Nanotechnology to the University of Texas Health Sciences Center. Her postdoctoral research focused on injectable multistage nanovectors (MSVs) for cancer treatment and imaging. Her work provided insightful understanding of the interactions of MSVs with immune cells in vivo and in vitro, biocompatibility of MSV, effect of geometry and targeting moieties on MSV biodistribution, and evaluation of MSV systems as near-infra red and MRI imaging agents. In October 2010, Dr. Godin joined the Department of Nanomedicine at the Research Institute. 

Research in Dr. Godin's lab, largely funded by federal and foundation grants, focuses on developing physiologically relevant in vitro and in vivo disease models and exploiting physical and biological mechanisms to improve currently available therapeutic options in oncology and obstetrics. Dr. Godin considers herself a translational scientist on the interception of biological and physical sciences, with the ultimate goal of bringing advanced and safe therapies and the techniques to personalize therapies into the clinic to benefit patients.

Dr. Godin has more than 200 scientific publications, received multiple federal and foundation-based grants and participated in multiple national and international grant review panels. 

Dr. Godin and her group published numerous peer-reviewed articles, book chapters and reviews in top journals including Nature Nanotechnology, Advanced Functional Materials, Journal of Controlled Release and Cancer Research. She also received national and international awards and other recognitions for her work and is on the editorial board and review board for numerous journals. 

Description of Research

Dr. Godin's research focuses primarily on the following areas:

-Employing principles of nanomedicine in Ob/Gyn

-Targeting liver metastasis with advanced nanocarriers

-Novel strategies to target tumor microenvironment

-Advanced patient-derived ex vivo disease models for personalized therapies

The main objective of these studies is to provide innovative approaches to treatment and diagnosis of cancer and Ob/Gyn disorders. 

Areas Of Expertise

Nanomedicine Cancer Physical sciences in oncology Ob/Gyn Nano-therapeutics targeting
Education & Training

Postdoctoral Fellowship, The Hebrew University of Jerusalem
PhD, The Hebrew University of Jerusalem
MSc Pharm, The Hebrew University of Jerusalem
Postdoctoral Fellowship, University of Texas Health Science Center
Publications

Pre-existing H4K16ac levels in euchromatin drive DNA repair by homologous recombination in S-phase
Horikoshi, N, Sharma, D, Leonard, F, Pandita, RK, Charaka, VK, Hambarde, S, Horikoshi, NT, Gaur Khaitan, P, Chakraborty, S, Cote, J, Godin, B, Hunt, CR & Pandita, TK 2019, Communications Biology, vol. 2, no. 1, 253. https://doi.org/10.1038/s42003-019-0498-z

Increased soluble crkl in serum of breast cancer patients is associated with advanced disease
Srinivasan, S & Godin, B 2019, Cancers, vol. 11, no. 7, 961. https://doi.org/10.3390/cancers11070961

Pancreatic adenocarcinoma response to chemotherapy enhanced with non-invasive radio frequency evaluated via an integrated experimental/computational approach
Ware, MJ, Curtis, LT, Wu, M, Ho, JC, Corr, SJ, Curley, SA, Godin, B & Frieboes, HB 2017, Scientific Reports, vol. 7, no. 1, 3437. https://doi.org/10.1038/s41598-017-03040-0

Thioaptamer targeted discoidal microparticles increase self immunity and reduce Mycobacterium tuberculosis burden in mice
Leonard, F, Ha, NP, Sule, P, Alexander, JF, Volk, DE, Lokesh, GLR, Liu, X, Cirillo, JD, Gorenstein, DG, Yuan, J, Chatterjee, S, Graviss, EA & Godin, B 2017, Journal of Controlled Release, vol. 266, pp. 238-247. https://doi.org/10.1016/j.jconrel.2017.09.038

Gemcitabine enhances the transport of nanovector-albumin-bound paclitaxel in gemcitabine-resistant pancreatic ductal adenocarcinoma
Borsoi, C, Leonard, F, Lee, Y, Zaid, M, Elganainy, D, Alexander, JF, Kai, M, Liu, YT, Kang, Y, Liu, X, Koay, EJ, Ferrari, M, Godin, B & Yokoi, K 2017, Cancer Letters, vol. 403, pp. 296-304. https://doi.org/10.1016/j.canlet.2017.06.026

Unraveling bio-social hierarchy in cancer collective invasion: Symbiosis between leaders and followers
Leonard, F & Godin, B 2017, Translational Cancer Research, vol. 6, pp. S1084-S1087. https://doi.org/10.21037/tcr.2017.08.09

Macrophage polarization contributes to the anti-tumoral efficacy of mesoporous nanovectors loaded with albumin-bound paclitaxel
Leonard, F, Curtis, LT, Ware, MJ, Nosrat, T, Liu, X, Yokoi, K, Frieboes, HB & Godin, B 2017, Frontiers in Immunology, vol. 8, no. JUN, 693. https://doi.org/10.3389/fimmu.2017.00693

Liposomal encapsulation masks genotoxicity of a chemotherapeutic agent in regulatory toxicology assessments
Alexander, J, Aguirre-Villarreal, D & Godin, B 2017, Nanomedicine: Nanotechnology, Biology, and Medicine, vol. 13, no. 3, pp. 829-833. https://doi.org/10.1016/j.nano.2016.12.016

Magnetically bioprinted human myometrial 3D cell rings as a model for uterine contractility
Souza, GR, Tseng, H, Gage, JA, Mani, A, Desai, P, Leonard, F, Liao, A, Longo, M, Refuerzo, JS & Godin, B 2017, International Journal of Molecular Sciences, vol. 18, no. 4, 683. https://doi.org/10.3390/ijms18040683

Targeted nanoparticles in pregnancy: a new frontier in perinatal therapeutics
Refuerzo, JS, Longo, M & Godin, B 2017, American journal of obstetrics and gynecology, vol. 216, no. 3, pp. 204-205. https://doi.org/10.1016/j.ajog.2017.01.025

Mechanisms and Barriers in Cancer Nanomedicine: Addressing Challenges, Looking for Solutions
Anchordoquy, TJ, Barenholz, Y, Boraschi, D, Chorny, M, Decuzzi, P, Dobrovolskaia, MA, Farhangrazi, ZS, Farrell, D, Gabizon, A, Ghandehari, H, Godin, B, La-Beck, NM, Ljubimova, J, Moghimi, SM, Pagliaro, L, Park, JH, Peer, D, Ruoslahti, E, Serkova, NJ & Simberg, D 2017, ACS Nano, vol. 11, no. 1, pp. 12-18. https://doi.org/10.1021/acsnano.6b08244

Generation of an in vitro 3D PDAC stroma rich spheroid model
Ware, MJ, Keshishian, V, Law, JJ, Ho, JC, Favela, CA, Rees, P, Smith, B, Mohammad, S, Hwang, RF, Rajapakshe, K, Coarfa, C, Huang, S, Edwards, DP, Corr, SJ, Godin, B & Curley, SA 2016, Biomaterials, vol. 108, pp. 129-142. https://doi.org/10.1016/j.biomaterials.2016.08.041

Uterus-targeted liposomes for preterm labor management: Studies in pregnant mice
Refuerzo, JS, Leonard, F, Bulayeva, N, Gorenstein, D, Chiossi, G, Ontiveros, A, Longo, M & Godin, B 2016, Scientific Reports, vol. 6, 34710. https://doi.org/10.1038/srep34710

Multiscale benchmarking of drug delivery vectors
Summers, HD, Ware, MJ, Majithia, R, Meissner, KE, Godin, B & Rees, P 2016, Nanomedicine: Nanotechnology, Biology, and Medicine, vol. 12, no. 7, pp. 1843-1851. https://doi.org/10.1016/j.nano.2016.03.006

Enhanced performance of macrophage-encapsulated nanoparticle albumin-bound-paclitaxel in hypo-perfused cancer lesions
Leonard, F, Curtis, LT, Yesantharao, P, Tanei, T, Alexander, JF, Wu, M, Lowengrub, J, Liu, X, Ferrari, M, Yokoi, K, Frieboes, HB & Godin, B 2016, Nanoscale, vol. 8, no. 25, pp. 12544-12552. https://doi.org/10.1039/c5nr07796f

Nanotechnology toward advancing personalized medicine
Sakamoto, JH, Godin, B, Hu, Y, Blanco, E, van de Ven, AL, Vellaichamy, A, Murphy, MB, La Francesca, S, Schuenemeyer, T, Given, B, Meyn, A & Ferrari, M 2016, . in Handbook of Clinical Nanomedicine: Law, Business, Regulation, Safety, and Risk. vol. 2, Pan Stanford Publishing Pte. Ltd. pp. 1347-1411. https://doi.org/10.4032/9789814669238

Generation of homogenous three-dimensional pancreatic cancer cell spheroids using an improved hanging drop technique
Ware, MJ, Colbert, K, Keshishian, V, Ho, J, Corr, SJ, Curley, SA & Godin, B 2016, Tissue Engineering - Part C: Methods, vol. 22, no. 4, pp. 312-321. https://doi.org/10.1089/ten.tec.2015.0280

10: Targeted liposomes direct the delivery of indomethacin to the uterus enhancing its tocolytic efficacy to reduce uterine contractions and preterm birth rate: 36th Annual Meeting of the Society for Maternal Fetal MedicineThe Pregnancy Meeting36th Annual Meeting of the Society for Maternal Fetal Medicine
Refuerzo, J, Leonard, F, Ontiveros, AE, Buleyeva, N, Godin, B & Longo, M 2016, American journal of obstetrics and gynecology, vol. 214, no. 1, Supplement, pp. S8-S9. https://doi.org/10.1016/j.ajog.2015.10.032

Ethosomes: Enhanced delivery of drugs to and across the skin
Ainbinder, D, Godin, B & Touitou, E 2016, . in Percutaneous Penetration Enhancers Chemical Methods in Penetration Enhancement: Nanocarriers. Springer Berlin Heidelberg, pp. 61-75. https://doi.org/10.1007/978-3-662-47862-2_4

3D In Vitro Model for Breast Cancer Research Using Magnetic Levitation and Bioprinting Method
Leonard, F & Godin, B 2016, . in J Cao (ed.), Breast Cancer: Methods and Protocols. vol. 1406, Methods in Molecular Biology, vol. 1406, Springer, pp. 239-251. https://doi.org/10.1007/978-1-4939-3444-7_21

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