A. Osama Gaber, MD, FACS, FAST

John F., Jr. and Carolyn Bookout Presidential Distinguished Chair in Surgery, Department of Surgery
Chair, Department of Surgery
Professor of Surgery, Academic Institute
Full Member, Research Institute
Program Director, Transplant Surgery Fellowship, Department of Surgery
Houston Methodist
Weill Cornell Medical College


Transplantation Surgery Fellowship


Biography

Dr. Gaber serves as Chair of Houston Methodist's Department of Surgery.  He received his first academic appointment in 1987, as an Assistant Professor in the Department of Surgery at the University of Tennessee in Memphis. He became an Associate Professor there in 1991, and received his full professorship and was named to the Baptist Memorial Health Care Foundation chair of excellence in transplantation in 1994. While at the University of Tennessee, Dr. Gaber also held professorships in the Departments of Pharmacy and in the College of Nursing. He was also the Medical Director for the University of Tennessee Bowld Hospital, and the Methodist University Transplant Institute.

Dr. Gaber is a prolific researcher and has authored over 300 scientific papers, as well as more than 340 abstracts and numerous book chapters, and his research has been funded by numerous grants from the National Institutes of Health, the Juvenile Diabetes Research Foundation, and several national and local foundations. Dr. Gaber assumed his positions at the Houston Methodist Hospital and Research Institute in Houston in 2006.

Description of Research

While also conducting transplant immunotherapy research for liver and kidney whole organ transplants and allografts, the main focus of Dr. Gaber´s research is in the transplantation of islets to alleviate diabetic complications. He and his collaborators have developed the protocol for long term islet culture and described the clinical transplantation of islets through the intestinal veins. Dr. Gaber´s current studies center on the testing of gene therapy and other approaches to test for islet viability and assist the transplanted islets to develop a sustaining blood supply and resist rejection by the recipient's immune system.

Areas Of Expertise

Diabetes Transplant immunotherapy Islet cells Cell isolation protocols Kidney transplant Pancreas transplant Liver transplant Kidney disorders
Education & Training

Residency, Boston University Medical Center
Internship, Washington Hospital Center
MD, Ain Shams University School of Medicine
Clinical Fellowship, The University of Chicago
Active Clinical Trials

Single dose rATG for rejection

NCT02102854

Publications

Donation After Circulatory Death Liver Transplantation: An in Depth Analysis and Propensity-Score Matched Comparison
Hobeika, MJ, Saharia, A, Mobley, CM, Menser, T, Nguyen, DT, Graviss, EA, McMillan, RR, Podder, H, Nolte Fong, JV, Jones, SL, Yi, SG, Elshawwaf, M, Osama Gaber, A & Ghobrial, RM 2021, , Clinical Transplantation, pp. e14304. https://doi.org/10.1111/ctr.14304

Invited Commentary
Gaber, AO 2021, , Journal of the American College of Surgeons, vol. 232, no. 4. https://doi.org/10.1016/j.jamcollsurg.2020.12.036

Renal Function Improvement Following ANG-3777 Treatment in Patients at High Risk for Delayed Graft Function After Kidney Transplantation
Bromberg, JS, Weir, MR, Gaber, AO, Yamin, MA, Goldberg, ID, Mayne, TJ, Cal, W & Cooper, M 2021, , Transplantation, vol. 105, no. 2, pp. 443-450. https://doi.org/10.1097/TP.0000000000003255

Center-level Variation in HLA-incompatible Living Donor Kidney Transplantation Outcomes
Jackson, KR, Long, J, Motter, J, Bowring, MG, Chen, J, Waldram, MM, Orandi, BJ, Montgomery, RA, Stegall, MD, Jordan, SC, Benedetti, E, Dunn, TB, Ratner, LE, Kapur, S, Pelletier, RP, Roberts, JP, Melcher, ML, Singh, P, Sudan, DL, Posner, MP, El-Amm, JM, Shapiro, R, Cooper, M, Verbesey, JE, Lipkowitz, GS, Rees, MA, Marsh, CL, Sankari, BR, Gerber, DA, Wellen, J, Bozorgzadeh, A, Gaber, AO, Heher, E, Weng, FL, Djamali, A, Helderman, JH, Concepcion, BP, Brayman, KL, Oberholzer, J, Kozlowski, T, Covarrubias, K, Desai, N, Massie, AB, Segev, DL & Garonzik-Wang, J 2021, , Transplantation, vol. 105, no. 2, pp. 436-442. https://doi.org/10.1097/TP.0000000000003254

Alpha-Fetoprotein as a Modifier of Anatomic Criteria for Transplantation of HCC Patients
Daoud, A, Soliman, K, Teeter, L, Ali, H, Graviss, EA, Mogawer, S, Sholkamy, A, El-Shazli, M & Gaber, AO 2021, , Transplantation Proceedings, vol. 53, no. 3, pp. 833-838. https://doi.org/10.1016/j.transproceed.2021.01.024

In silico deceased donor intervention research: A potential accelerant for progress
Hobeika, MJ, Casarin, S, Saharia, A, Mobley, C, Yi, S, McMillan, R, Mark Ghobrial, R & Gaber, AO 2021, , American Journal of Transplantation. https://doi.org/10.1111/ajt.16482

Neovascularized implantable cell homing encapsulation platform with tunable local immunosuppressant delivery for allogeneic cell transplantation
Paez-Mayorga, J, Capuani, S, Hernandez, N, Farina, M, Chua, YX, Blanchard, R, Sizovs, A, Liu, HC, Fraga, DW, Niles, JA, Salazar, HF, Corradetti, B, Sikora, AG, Kloc, M, Li, XC, Gaber, AO, Nichols, J & Grattoni, A 2020, , Biomaterials, vol. 257, 120232. https://doi.org/10.1016/j.biomaterials.2020.120232

Delayed implantation of pumped kidneys decreases renal allograft futility in combined liver-kidney transplantation
Lunsford, KE, Agopian, VG, Yi, S, Nguyen, DTM, Graviss, EA, Harlander-Locke, MP, Saharia, A, Kaldas, FM, Mobley, CM, Zarrinpar, A, Hobeika, MJ, Veale, JL, Podder, H, Farmer, DG, Knight, RJ, Danovitch, GM, Gritsch, HA, Li, XC, Ghobrial, RM, Busuttil, RW & Gaber, AO 2020, , Transplantation, vol. 104, no. 8, pp. 1591-1603. https://doi.org/10.1097/TP.0000000000003040

Unexplained Methemoglobinemia in Coronavirus Disease 2019: A Case Report
Faisal, H, Bloom, A & Gaber, AO 2020, , A&A practice, vol. 14, no. 9, pp. e01287. https://doi.org/10.1213/XAA.0000000000001287

Novel Silicon Titanium Diboride Micropatterned Substrates for Cellular Patterning
Friguglietti, J, Das, S, Le, P, Fraga, D, Quintela, M, Gazze, SA, McPhail, D, Gu, J, Sabek, O, Gaber, AO, Francis, LW, Zagozdzon-Wosik, W & Merchant, FA 2020, , Biomaterials, vol. 244, 119927. https://doi.org/10.1016/j.biomaterials.2020.119927

Assessment of infectious complications in elderly kidney transplant recipients receiving induction with anti-thymocyte globulin versus basiliximab
Pham, C, Kuten, SA, Knight, R, Nguyen, DT, Graviss, E & Gaber, AO 2020, , Transplant Infectious Disease, pp. e13257. https://doi.org/10.1111/tid.13257

Serum C-peptide and osteocalcin levels in children with recently diagnosed diabetes
Sabek, OM, Redondo, MJ, Nguyen, DT, Beamish, CA, Fraga, DW, Hampe, CS, Mulukutla, SN, Graviss, EA & Gaber, AO 2020, , Endocrinology, diabetes & metabolism, vol. 3, no. 1, pp. e00104. https://doi.org/10.1002/edm2.104

The Association of Pretransplant Pulmonary Hypertension With Patient and Graft Survival After Kidney Transplantation: A Retrospective Cohort Study
Obi, C, Frost, AE, Graviss, EA, Nguyen, DT, Gaber, AO & Suki, WN 2020, , Transplantation Proceedings, vol. 52, no. 10, pp. 3023-3032. https://doi.org/10.1016/j.transproceed.2020.05.003

Early experience with COVID-19 and solid organ transplantation at a US high-volume transplant center
Yi, SG, Rogers, AW, Saharia, A, Aoun, M, Faour, R, Abdelrahim, M, Knight, RJ, Grimes, K, Bullock, S, Hobeika, M, McMillan, R, Mobley, C, Moaddab, M, Huang, HJ, Bhimaraj, A, Ghobrial, RM & Gaber, AO 2020, , Transplantation, vol. 104, no. 11, pp. 2208-2214. https://doi.org/10.1097/TP.0000000000003339

Impact of Protease Inhibitor-Based Antiretroviral Therapy on Tacrolimus Intrapatient Variability in HIV-Positive Kidney Transplant Recipients
Cooper, M, Dunne, I, Kuten, S, Curtis, A, Graviss, EA, Nguyen, DT, Hobeika, M & Gaber, AO 2021, , Transplantation Proceedings, vol. 53, no. 3, pp. 984-988. https://doi.org/10.1016/j.transproceed.2020.10.003

Kidneycare guided immuno-optimization in renal allografts: The kira protocol
Gray, JN, Wolf-Doty, T, Sulejmani, N, Gaber, O, Axelrod, D, Abdalla, B & Danovitch, G 2020, , Methods and Protocols, vol. 3, no. 4, 68, pp. 1-9. https://doi.org/10.3390/mps3040068

Outcomes of Kidney Transplantation using Deceased Donors with History of Diabetes
Khan, FN, Truong, LD, Nguyen, DT, Graviss, EA, Bhatti, MI, Frost, AE, Gaber, AO & Suki, WN 2019, , Clinical Transplantation, pp. e13775. https://doi.org/10.1111/ctr.13775

Successful Kidney Transplantation Is Associated With Weight Gain From Truncal Obesity and Insulin Resistance
Workeneh, B, Moore, LW, Nolte Fong, JV, Shypailo, R, Gaber, AO & Mitch, WE 2019, , Journal of Renal Nutrition, vol. 29, no. 6, pp. 548-555. https://doi.org/10.1053/j.jrn.2019.01.009

Safety and efficacy of eculizumab in the prevention of antibody-mediated rejection in living-donor kidney transplant recipients requiring desensitization therapy: A randomized trial
C10-001 Study Group 2019, , American Journal of Transplantation, vol. 19, no. 10, pp. 2876-2888. https://doi.org/10.1111/ajt.15364

Kidney donors with diabetes: Renal biopsy findings at time of transplantation and their significance
Truong, L, Suki, WN, Gaber, LW, Gaber, AO & Khan, F 2019, , Transplantation Direct, vol. 5, no. 7, e465. https://doi.org/10.1097/TXD.0000000000000903