A. Osama Gaber, MD, FACS, FAST

John F., Jr. and Carolyn Bookout Presidential Distinguished Chair in Surgery, Department of Surgery
Chair, Department of Surgery
Professor of Surgery, Academic Institute
Full Member, Research Institute
Program Director, Transplant Surgery Fellowship, Department of Surgery
Houston Methodist
Weill Cornell Medical College


Transplantation Surgery Fellowship


Biography

Dr. Gaber serves as Chair of Houston Methodist's Department of Surgery.  He received his first academic appointment in 1987, as an Assistant Professor in the Department of Surgery at the University of Tennessee in Memphis. He became an Associate Professor there in 1991, and received his full professorship and was named to the Baptist Memorial Health Care Foundation chair of excellence in transplantation in 1994. While at the University of Tennessee, Dr. Gaber also held professorships in the Departments of Pharmacy and in the College of Nursing. He was also the Medical Director for the University of Tennessee Bowld Hospital, and the Methodist University Transplant Institute.

Dr. Gaber is a prolific researcher and has authored over 300 scientific papers, as well as more than 340 abstracts and numerous book chapters, and his research has been funded by numerous grants from the National Institutes of Health, the Juvenile Diabetes Research Foundation, and several national and local foundations. Dr. Gaber assumed his positions at the Houston Methodist Hospital and Research Institute in Houston in 2006.

Description of Research

While also conducting transplant immunotherapy research for liver and kidney whole organ transplants and allografts, the main focus of Dr. Gaber´s research is in the transplantation of islets to alleviate diabetic complications. He and his collaborators have developed the protocol for long term islet culture and described the clinical transplantation of islets through the intestinal veins. Dr. Gaber´s current studies center on the testing of gene therapy and other approaches to test for islet viability and assist the transplanted islets to develop a sustaining blood supply and resist rejection by the recipient's immune system.

Areas Of Expertise

Diabetes Transplant immunotherapy Islet cells Cell isolation protocols Kidney transplant Pancreas transplant Liver transplant Kidney disorders
Education & Training

Residency, Boston University Medical Center
Internship, Washington Hospital Center
MD, Ain Shams University School of Medicine
Clinical Fellowship, The University of Chicago
Publications

Utilization of Immunotherapy for the Treatment of Hepatocellular Carcinoma in the Peri-Transplant Setting: Transplant Oncology View
Abdelrahim, M, Esmail, A, Saharia, A, Abudayyeh, A, Abdel-Wahab, N, Diab, A, Murakami, N, Kaseb, AO, Chang, JC, Gaber, AO & Ghobrial, RM 2022, , Cancers, vol. 14, no. 7, 1760. https://doi.org/10.3390/cancers14071760

Premature Death in Kidney Transplant Recipients: The Time for Trials is Now
Vinson, AJ, Singh, S, Chadban, S, Cherney, D, Gaber, O, Gill, JS, Helgeson, E, Herzog, CA, Jardine, M, Jha, V, Kasiske, BL, Mannon, RB, Michos, ED, Mottl, AK, Newby, K, Roy-Chaudhury, P, Sawinski, D, Sharif, A, Sridhar, VS, Tuttle, KR, Vock, DM & Matas, A 2022, , Journal of the American Society of Nephrology, vol. 33, no. 4, pp. 665-673. https://doi.org/10.1681/ASN.2021111517

Early humoral immune response to two doses of severe acute respiratory syndrome coronavirus 2 vaccine in a diverse group of solid organ transplant candidates and recipients
Huang, HJ, Yi, SG, Mobley, CM, Saharia, A, Bhimaraj, A, Moore, LW, Kloc, M, Adrogue, HE, Graviss, EA, Nguyen, DT, Eagar, TN, Jones, SL, Ankoma-Sey, V, MacGillivray, TE, Knight, RJ, Gaber, AO & Ghobrial, RM 2022, , Clinical Transplantation, pp. e14600. https://doi.org/10.1111/ctr.14600

Early humoral immune response to two doses of severe acute respiratory syndrome coronavirus 2 vaccine in a diverse group of solid organ transplant candidates and recipients
Huang, HJ, Yi, SG, Mobley, CM, Saharia, A, Bhimaraj, A, Moore, LW, Kloc, M, Adrogue, HE, Graviss, EA, Nguyen, DT, Eagar, TN, Jones, SL, Ankoma-Sey, V, MacGillivray, TE, Knight, RJ, Gaber, AO & Ghobrial, RM 2022, , Clinical Transplantation, vol. 36, no. 5, e14600. https://doi.org/10.1111/ctr.14600

The echocardiographic course of pretransplant pulmonary hypertension following kidney transplantation and associated outcomes
Frost, AE, Moore, LW, Valdivia e Alvarado, M, Obi, C, Graviss, EA, Nguyen, DT, Gaber, AO & Suki, WN 2022, , Pulmonary Circulation, vol. 12, no. 1, e12030. https://doi.org/10.1002/pul2.12030

Risk Factors Associated with an Impaired Antibody Response in Kidney Transplant Recipients following 2 Doses of the SARS-CoV-2 mRNA Vaccine
Yi, SG, Moore, LW, Eagar, T, Graviss, EA, Nguyen, DT, Ibrahim, H, Huang, HJ, Hobeika, M, McMillan, R, Saharia, A, Mobley, C, Podder, H, Drews, A, Ghobrial, RM, Gaber, AO & Knight, RJ 2021, , Transplantation Direct, vol. 8, no. 1, e1257. https://doi.org/10.1097/TXD.0000000000001257

Neurogenic orthostatic hypotension: A common complication of successful pancreas transplantation
Kuten, SA, Graviss, EA, Nguyen, DT, Gaber, AO, Sadhu, AR, Simpson, EP, Yi, SG, Podder, H, Kagan, A & Knight, RJ 2021, , Transplantation Direct, vol. 7, no. 12, e795, pp. e795. https://doi.org/10.1097/TXD.0000000000001208

IRF4 ablation in B cells abrogates allogeneic B cell responses and prevents chronic transplant rejection
Wang, G, Zou, D, Wang, Y, Gonzalez, NM, Yi, SG, Li, XC, Chen, W & Gaber, AO 2021, , Journal of Heart and Lung Transplantation, vol. 40, no. 10, pp. 1122-1132. https://doi.org/10.1016/j.healun.2021.06.008

Transplant oncology: An evolving field in cancer care
Abdelrahim, M, Esmail, A, Abudayyeh, A, Murakami, N, Saharia, A, McMillan, R, Victor, D, Kodali, S, Shetty, A, Fong, JVN, Moore, LW, Heyne, K, Gaber, AO & Ghobrial, RM 2021, , Cancers, vol. 13, no. 19, 4911. https://doi.org/10.3390/cancers13194911

Pre-transplant T-cell Clonality: An Observational Study of a Biomarker for Prediction of Sepsis in Liver Transplant Recipients
Jones, SL, Moore, LW, Li, XC, Mobley, CM, Fields, PA, Graviss, EA, Nguyen, DT, Nolte Fong, J, Saharia, A, Hobeika, MJ, McMillan, RR, Victor, DW, Minze, LJ, Gaber, AO & Ghobrial, RM 2021, , Annals of surgery, vol. 274, no. 3, pp. 411-418. https://doi.org/10.1097/SLA.0000000000004998

First world consensus conference on pancreas transplantation: Part I—Methods and results of literature search
on behalf of the World Consensus Group on Pancreas Transplantation 2021, , American Journal of Transplantation, vol. 21, no. S3, pp. 1-16. https://doi.org/10.1111/ajt.16738

First World Consensus Conference on pancreas transplantation: Part II – recommendations
Boggi, U, Vistoli, F, Andres, A, Arbogast, HP, Badet, L, Baronti, W, Bartlett, ST, Benedetti, E, Branchereau, J, Burke, GW, Buron, F, Caldara, R, Cardillo, M, Casanova, D, Cipriani, F, Cooper, M, Cupisti, A, Davide, J, Drachenberg, C, de Koning, EJP, Ettorre, GM, Fernandez Cruz, L, Fridell, JA, Friend, PJ, Furian, L, Gaber, OA, Gruessner, AC, Gruessner, RWG, Gunton, JE, Han, DJ, Iacopi, S, Kauffmann, EF, Kaufman, D, Kenmochi, T, Khambalia, HA, Lai, Q, Langer, RM, Maffi, P, Marselli, L, Menichetti, F, Miccoli, M, Mittal, S, Morelon, E, Napoli, N, Neri, F, Oberholzer, J, Odorico, JS, Öllinger, R, Oniscu, G, Orlando, G, Ortenzi, M, Perosa, M, Perrone, VG, Pleass, H, Redfield, RR, Ricci, C, Rigotti, P, Paul Robertson, R, Ross, LF, Rossi, M, Saudek, F, Scalea, JR, Schenker, P, Secchi, A, Socci, C, Sousa Silva, D, Squifflet, JP, Stock, PG, Stratta, RJ, Terrenzio, C, Uva, P, Watson, CJE, White, SA, Marchetti, P, Kandaswamy, R & Berney, T 2021, , American Journal of Transplantation, vol. 21, no. S3, pp. 17-59. https://doi.org/10.1111/ajt.16750

Optimization of acute kidney injury (Aki) time definitions using the electronic health record: A first step in automating in-hospital aki detection
Swan, JT, Moore, LW, Sparrow, HG, Frost, AE, Gaber, AO & Suki, WN 2021, , Journal of Clinical Medicine, vol. 10, no. 15, 3304. https://doi.org/10.3390/jcm10153304

Optimization of Acute Kidney Injury (AKI) Time Definitions Using the Electronic Health Record: A First Step in Automating In-Hospital AKI Detection
Swan, JT, Moore, LW, Sparrow, HG, Frost, AE, Gaber, AO & Suki, WN 2021, , journal of clinical medicine, vol. 10, no. 15, 3304. https://doi.org/10.3390/jcm10153304, https://doi.org/10.3390/jcm10153304

Kidney Transplant Recipients Rarely Show an Early Antibody Response Following the First COVID-19 Vaccine Administration
Yi, SG, Knight, RJ, Graviss, EA, Moore, LW, Nguyen, DT, Ghobrial, RM, Gaber, AO & Huang, HJ 2021, , Transplantation, vol. 105, no. 7, pp. e72-e73. https://doi.org/10.1097/TP.0000000000003764

Long-Term Follow-Up of Renal Transplant Recipients Treated With IVIG for De Novo Donor-Specific Antibodies
Knight, RJ, Loucks-Devos, J, Khan, NA, Nguyen, DT, Graviss, EA, Eagar, TN, Patel, SJ & Osama Gaber, A 2021, , Transplantation Proceedings, vol. 53, no. 6, pp. 1865-1871. https://doi.org/10.1016/j.transproceed.2021.05.011

Invited Commentary
Gaber, AO 2021, , Journal of the American College of Surgeons, vol. 232, no. 4, pp. 450. https://doi.org/10.1016/j.jamcollsurg.2020.12.036

Delayed graft function and acute rejection following HLA-incompatible living donor kidney transplantation
Motter, JD, Jackson, KR, Long, JJ, Waldram, MM, Orandi, BJ, Montgomery, RA, Stegall, MD, Jordan, SC, Benedetti, E, Dunn, TB, Ratner, LE, Kapur, S, Pelletier, RP, Roberts, JP, Melcher, ML, Singh, P, Sudan, DL, Posner, MP, El-Amm, JM, Shapiro, R, Cooper, M, Verbesey, JE, Lipkowitz, GS, Rees, MA, Marsh, CL, Sankari, BR, Gerber, DA, Wellen, JR, Bozorgzadeh, A, Gaber, AO, Heher, EC, Weng, FL, Djamali, A, Helderman, JH, Concepcion, BP, Brayman, KL, Oberholzer, J, Kozlowski, T, Covarrubias, K, Massie, AB, Segev, DL & Garonzik-Wang, JM 2021, , American Journal of Transplantation, vol. 21, no. 4, pp. 1612-1621. https://doi.org/10.1111/ajt.16471

Renal Function Improvement following ANG-3777 Treatment in Patients at High Risk for Delayed Graft Function after Kidney Transplantation
Bromberg, JS, Weir, MR, Gaber, AO, Yamin, MA, Goldberg, ID, Mayne, TJ, Cal, W & Cooper, M 2021, , Transplantation, pp. 443-450. https://doi.org/10.1097/TP.0000000000003255

Alpha-Fetoprotein as a Modifier of Anatomic Criteria for Transplantation of HCC Patients
Daoud, A, Soliman, K, Teeter, L, Ali, H, Graviss, EA, Mogawer, S, Sholkamy, A, El-Shazli, M & Gaber, AO 2021, , Transplantation Proceedings, vol. 53, no. 3, pp. 833-838. https://doi.org/10.1016/j.transproceed.2021.01.024