A. Osama Gaber, MD, FACS

J.C. Walter Jr. Presidential Distinguished Chair & Director, J.C. Walter Jr. Transplant Center
Professor of Surgery, Institute for Academic Medicine
Full Member, Research Institute
Program Director, Transplant Surgery Residency, Department of Surgery
Houston Methodist
Weill Cornell Medical College


Transplantation Surgery Fellowship


Biography

Dr. Gaber received his first academic appointment in 1987, as an Assistant Professor in the Department of Surgery at the University of Tennessee in Memphis. He became an Associate Professor there in 1991, and received his full professorship and was named to the Baptist Memorial Health Care Foundation chair of excellence in transplantation in 1994. While at the University of Tennessee, Dr. Gaber also held professorships in the Departments of Pharmacy and in the College of Nursing. He was also the Medical Director for the University of Tennessee Bowld Hospital, and the Methodist University Transplant Institute.

Dr. Gaber is a prolific researcher and has authored over 270 scientific papers, as well as more than 340 abstracts and numerous book chapters,and his research has been funded by numerous grants from the National Institutes of Health, the Juvenile Diabetes Research Foundation, and several national and local foundations. Dr. Gaber assumed his positions at the Houston Methodist Hospital and Research Institute in Houston in 2006.

Description of Research

While also conducting transplant immunotherapy research for liver and kidney whole organ transplants and allografts, the main focus of Dr. Gaber´s research is in the transplantation of islets to alleviate diabetic complications. He and his collaborators have developed the protocol for long term islet culture and described the clinical transplantation of islets through the intestinal veins. Dr. Gaber´s current studies center on the testing of gene therapy and other approaches to test for islet viability and assist the transplanted islets to develop a sustaining blood supply and resist rejection by the recipient´s immune system.

Areas Of Expertise

Diabetes Transplant immunotherapy Islet cells Cell isolation protocols Kidney transplant Pancreas transplant Liver transplant Kidney disorders
Education & Training

Clinical Fellowship, University of Chicago
Residency, Boston University Medical Center
Internship, Washington Hospital Center
MD, Ain Shams University School of Medicine
Active Clinical Trials

Single dose rATG for rejection

NCT02102854

Publications

Comparative Outcomes of Patients with Single 2-3cm Hepatocellular Carcinoma Lesions Transplanted before and after 18 Months of Loco-Regional Therapy
Soliman, BG, Samantha, B, Wong, A, Mobley, CM, Nguyen, DT, Graviss, EA, Hobeika, MJ, Luczon, J, Hayes, C, Gaber, AO & Ghobrial, RM 2019, ASTS 20th Annual State of the Art Winter Symposium, American Society of Transplant Surgeons (ASTS), Miami, United States, 1/9/20 - 1/12/20, .

Delayed Implantation of Pumped Kidneys Decreases Renal Allograft Futility in Combined Liver-Kidney Transplantation
Lunsford, KE, Agopian, VG, Yi, SG, Nguyen, DTM, Graviss, EA, Harlander-Locke, MP, Saharia, A, Kaldas, FM, Mobley, CM, Zarrinpar, A, Hobeika, M, Veale, JL, Podder, H, Farmer, DG, Knight, RJ, Danovitch, GM, Gritsch, HA, Li, XC, Ghobrial, RM, Busuttil, RW & Gaber, AO 2019, Transplantation. https://doi.org/10.1097/TP.0000000000003040

Weight Gain after Simultaneous Kidney and Pancreas Transplantation
Knight, RJ, Islam, AK, Pham, C, Graviss, EA, Nguyen, DT, Moore, LW, Kagan, A, Sadhu, AR, Podder, H & Gaber, AO 2019, Transplantation. https://doi.org/10.1097/TP.0000000000002862

Corrections to: Checkpoint inhibitor therapy for cancer in solid organ transplantation recipients: An institutional experience and a systematic review of the literature (Journal for ImmunoTherapy of Cancer (2019) 7:106 DOI: 10.1186/s40425-019-0585-1)
Abdel-Wahab, N, Safa, H, Abudayyeh, A, Johnson, DH, Trinh, VA, Zobniw, CM, Lin, H, Wong, MK, Abdelrahim, M, Gaber, AO, Suarez-Almazor, ME & Diab, A 2019, Journal for ImmunoTherapy of Cancer, vol. 7, no. 1, 158. https://doi.org/10.1186/s40425-019-0639-4

Outcomes of Liver transplantation for hepatocellular carcinoma (HCC) beyond the University of California San Francisco (UCSF) criteria: a single center experience
Victor, DW, Monsour, HP, Boktour, M, Lunsford, K, Balogh, J, Graviss, EA, Nguyen, DT, McFadden, R, Divatia, MK, Heyne, K, Ankoma-Sey, V, Egwim, C, Galati, J, Duchini, A, Saharia, A, Mobley, C, Gaber, AO & Ghobrial, RM 2019, Transplantation. https://doi.org/10.1097/TP.0000000000002835

Continuous 24-Hour vs. Daily Antithymocyte Globulin (ATG) Infusions for Treatment of Renal Allograft Rejection: Preliminary Results of a Prospective Trial
Patel, S, Kuten, SA, Nolte-Fong, J, Nguyen, DT, Graviss, EA & Gaber, AO 2019, 2019 American Transplant Congress, Boston, United States, 6/1/19 - 6/5/19, .

Kidney Transplants Following Donation after Circulatory Death and Donation after Brain Death Have Similar Early Outcomes
Hobeika, MJ, Nguyen, DT, Graviss, EA, Gaber, AO, Podder, H, Yi, S, Kuten, SA, Patel, S & Knight, RJ 2019, 2019 American Transplant Congress, Boston, United States, 6/1/19 - 6/5/19, .

Impact of Protease Inhibitor-Based Anti-Retroviral Therapy on TacrolimusIntrapatient Variability in HIV+ Kidney Transplant Recipients
Megan H. , C, I. E. D, Kuten, SA, A. E. C, Graviss, EA, Nguyen, DT, Hobeika, MJ & Gaber, AO 2019, 2019 American Transplant Congress, Boston, United States, 6/1/19 - 6/5/19, .

Impact of Protease Inhibitor-Based Anti-Retroviral Therapyon Tacrolimus Intrapatient Variability in HIV+ KidneyTransplant Recipients
Megan H, C, I. E. D, Kuten, SA, Graviss, EA, A. E. C, Nguyen, DT, Hobeika, MJ & Gaber, AO 2019, American Thoracic Society (ATS) 2019 International Conference, Dallas, United States, 5/17/19 - 5/22/19, .

The Houston Methodist lung transplant risk model - a validated tool for pre-transplant risk assessment
Houston Methodist Lung Outcomes Group 2019, The Annals of thoracic surgery. https://doi.org/10.1016/j.athoracsur.2019.03.108

Progression of Peripheral Vascular Disease after Kidney/Pancreas (KP) Transplantation
Knight, RJ, Nguyen, DT, Graviss, EA & Gaber, AO 2019, 17th World Congress of the IPITA, Lyon, France, 7/2/19 - 7/5/19, .

Symptomatic Coronary Artery Disease after Simultaneous Kidney-Pancreas Transplantation
Knight, RJ, Nguyen, DT, Graviss, EA & Gaber, AO 2019, 17th World Congress of the IPITA, Lyon, France, 7/2/19 - 7/5/19, .

Checkpoint inhibitor therapy for cancer in solid organ transplantation recipients: An institutional experience and a systematic review of the literature
Abdel-Wahab, N, Safa, H, Abudayyeh, A, Johnson, DH, Trinh, VA, Zobniw, CM, Lin, H, Wong, MK, Abdelrahim, M, Gaber, AO, Suarez-Almazor, ME & Diab, A 2019, Journal for ImmunoTherapy of Cancer, vol. 7, no. 1, 106. https://doi.org/10.1186/s40425-019-0585-1

Ciprofloxacin for BK viremia prophylaxis in kidney transplant recipients: Results of a prospective, double-blind, randomized, placebo-controlled trial
Patel, SJ, Knight, RJ, Kuten, SA, Graviss, EA, Nguyen, DT, Moore, LW, Musick, WL & Gaber, AO 2019, American Journal of Transplantation. https://doi.org/10.1111/ajt.15328

Combined Antithymocyte Globulin (ATG) and Rituximab (RTX) Induction in African American (AA) Kidney Transplant Recipients
Patel, S, Kuten, SA, Pham, C, Knight, RJ, Hobeika, MJ, Nguyen, DT, Graviss, EA, Yi, S, Eagar, TN & Gaber, AO 2019, 2019 American Transplant Congress, Boston, United States, 6/1/19 - 6/5/19, .

Cross-sectional evaluation of the relationship between Vitamin D status and supplement use across levels of kidney function in adults
Moore, LW, Suki, WN, Lunsford, KE, Sabek, O, Knight, RJ & Gaber, AO 2019, BMJ open, vol. 9, no. 2, e022471. https://doi.org/10.1136/bmjopen-2018-022471

The importance of drug safety and tolerability in the development of new immunosuppressive therapy for transplant recipients: The Transplant Therapeutics Consortium's position statement
Stegall, MD, Troy Somerville, K, Everly, MJ, Mannon, RB, Gaber, AO, First, MR, Agashivala, N, Perez, V, Newell, KA, Morris, RE, Sudan, D, Romero, K, Eremenco, S, Mattera, M, Spear, N, Porter, AC & ODoherty, I 2019, American Journal of Transplantation. https://doi.org/10.1111/ajt.15214

Disparate outcomes observed within Kidney Disease: Improving Global Outcomes (KDIGO) acute kidney injury stage 1
Sparrow, HG, Swan, JT, Moore, LW, Gaber, AO & Suki, WN 2019, Kidney International. https://doi.org/10.1016/j.kint.2018.11.030

Successful Kidney Transplantation Is Associated With Weight Gain From Truncal Obesity and Insulin Resistance
Workeneh, B, Moore, LW, Nolte Fong, JV, Shypailo, R, Gaber, AO & Mitch, WE 2019, Journal of Renal Nutrition. https://doi.org/10.1053/j.jrn.2019.01.009

The Houston Methodist Lung Transplant Risk Model: A Validated Tool for Pretransplant Risk Assessment
Houston Methodist Lung Outcomes Group 2019, Annals of Thoracic Surgery. https://doi.org/10.1016/j.athoracsur.2019.03.108

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