A. Osama Gaber, MD, FACS, FAST

J.C. Walter Jr. Presidential Distinguished Chair & Director, J.C. Walter Jr. Transplant Center
Chair, Department of Surgery
Professor of Surgery, Academic Institute
Full Member, Research Institute
Program Director, Transplant Surgery Fellowship, Department of Surgery
Houston Methodist
Weill Cornell Medical College

Transplantation Surgery Fellowship


Dr. Gaber serves as Chair of Houston Methodist's Department of Surgery.  He received his first academic appointment in 1987, as an Assistant Professor in the Department of Surgery at the University of Tennessee in Memphis. He became an Associate Professor there in 1991, and received his full professorship and was named to the Baptist Memorial Health Care Foundation chair of excellence in transplantation in 1994. While at the University of Tennessee, Dr. Gaber also held professorships in the Departments of Pharmacy and in the College of Nursing. He was also the Medical Director for the University of Tennessee Bowld Hospital, and the Methodist University Transplant Institute.

Dr. Gaber is a prolific researcher and has authored over 300 scientific papers, as well as more than 340 abstracts and numerous book chapters, and his research has been funded by numerous grants from the National Institutes of Health, the Juvenile Diabetes Research Foundation, and several national and local foundations. Dr. Gaber assumed his positions at the Houston Methodist Hospital and Research Institute in Houston in 2006.

Description of Research

While also conducting transplant immunotherapy research for liver and kidney whole organ transplants and allografts, the main focus of Dr. Gaber´s research is in the transplantation of islets to alleviate diabetic complications. He and his collaborators have developed the protocol for long term islet culture and described the clinical transplantation of islets through the intestinal veins. Dr. Gaber´s current studies center on the testing of gene therapy and other approaches to test for islet viability and assist the transplanted islets to develop a sustaining blood supply and resist rejection by the recipient's immune system.

Areas Of Expertise

Diabetes Transplant immunotherapy Islet cells Cell isolation protocols Kidney transplant Pancreas transplant Liver transplant Kidney disorders
Education & Training

Residency, Boston University Medical Center
Internship, Washington Hospital Center
MD, Ain Shams University School of Medicine
Clinical Fellowship, The University of Chicago
Active Clinical Trials

Single dose rATG for rejection



Neovascularized implantable cell homing encapsulation platform with tunable local immunosuppressant delivery for allogeneic cell transplantation
Paez-Mayorga, J, Capuani, S, Hernandez, N, Farina, M, Chua, YX, Blanchard, R, Sizovs, A, Liu, HC, Fraga, DW, Niles, JA, Salazar, HF, Corradetti, B, Sikora, AG, Kloc, M, Li, XC, Gaber, AO, Nichols, J & Grattoni, A 2020, , Biomaterials, vol. 257, 120232. https://doi.org/10.1016/j.biomaterials.2020.120232

Delayed Implantation of Pumped Kidneys Decreases Renal Allograft Futility in Combined Liver-Kidney Transplantation
Lunsford, KE, Agopian, VG, Yi, S, Nguyen, DTM, Graviss, EA, Harlander-Locke, MP, Saharia, A, Kaldas, FM, Mobley, CM, Zarrinpar, A, Hobeika, MJ, Veale, JL, Podder, H, Farmer, DG, Knight, RJ, Danovitch, GM, Gritsch, HA, Li, XC, Ghobrial, RM, Busuttil, RW & Gaber, AO 2020, Transplantation, pp. 1591-1603. https://doi.org/10.1097/TP.0000000000003040

Unexplained Methemoglobinemia in Coronavirus Disease 2019: A Case Report
Faisal, H, Bloom, A & Gaber, AO 2020, , A&A practice, vol. 14, no. 9, pp. e01287. https://doi.org/10.1213/XAA.0000000000001287

Novel Silicon Titanium Diboride Micropatterned Substrates for Cellular Patterning
Friguglietti, J, Das, S, Le, P, Fraga, D, Quintela, M, Gazze, SA, McPhail, D, Gu, J, Sabek, O, Gaber, AO, Francis, LW, Zagozdzon-Wosik, W & Merchant, FA 2020, , Biomaterials, vol. 244, 119927. https://doi.org/10.1016/j.biomaterials.2020.119927

Assessment of infectious complications in elderly kidney transplant recipients receiving induction with anti-thymocyte globulin versus basiliximab
Pham, C, Kuten, SA, Knight, R, Nguyen, DT, Graviss, E & Gaber, AO 2020, , Transplant Infectious Disease, pp. e13257. https://doi.org/10.1111/tid.13257

Serum C-peptide and osteocalcin levels in children with recently diagnosed diabetes
Sabek, OM, Redondo, MJ, Nguyen, DT, Beamish, CA, Fraga, DW, Hampe, CS, Mulukutla, SN, Graviss, EA & Gaber, AO 2020, Endocrinology, diabetes & metabolism, vol. 3, no. 1, pp. e00104. https://doi.org/10.1002/edm2.104

Outcomes of Liver Transplantation for Hepatocellular Carcinoma beyond the University of California San Francisco Criteria: A Single-center Experience
Victor, III, DW, Monsour, HP, Boktour, M, Lunsford, K, Balogh, J, Graviss, EA, Nguyen, DT, McFadden, RS, Divatia, MK, Heyne, K, Ankoma-Sey, V, Egwim, C, Galati, J, Duchini, A, Saharia, A, Mobley, CM, Gaber, AO & Ghobrial, RM 2020, Transplantation, pp. 113-121. https://doi.org/10.1097/TP.0000000000002835

The Association of Pretransplant Pulmonary Hypertension With Patient and Graft Survival After Kidney Transplantation: A Retrospective Cohort Study
Obi, C, Frost, AE, Graviss, EA, Nguyen, DT, Gaber, AO & Suki, WN 2020, , Transplantation Proceedings. https://doi.org/10.1016/j.transproceed.2020.05.003

Outcomes of Kidney Transplantation using Deceased Donors with History of Diabetes
Khan, FN, Truong, LD, Nguyen, DT, Graviss, EA, Bhatti, MI, Frost, AE, Gaber, AO & Suki, WN 2019, , Clinical Transplantation, pp. e13775. https://doi.org/10.1111/ctr.13775

Successful Kidney Transplantation Is Associated With Weight Gain From Truncal Obesity and Insulin Resistance
Workeneh, B, Moore, LW, Nolte Fong, JV, Shypailo, R, Gaber, AO & Mitch, WE 2019, , Journal of Renal Nutrition, vol. 29, no. 6, pp. 548-555. https://doi.org/10.1053/j.jrn.2019.01.009

Safety and efficacy of eculizumab in the prevention of antibody-mediated rejection in living-donor kidney transplant recipients requiring desensitization therapy: A randomized trial
C10-001 Study Group 2019, , American Journal of Transplantation, vol. 19, no. 10, pp. 2876-2888. https://doi.org/10.1111/ajt.15364

Kidney donors with diabetes: Renal biopsy findings at time of transplantation and their significance
Truong, L, Suki, WN, Gaber, LW, Gaber, AO & Khan, F 2019, Transplantation Direct, vol. 5, no. 7, e465. https://doi.org/10.1097/TXD.0000000000000903

Weight Gain after Simultaneous Kidney and Pancreas Transplantation
Knight, RJ, Islam, AK, Pham, C, Graviss, EA, Nguyen, DT, Moore, LW, Kagan, A, Sadhu, AR, Podder, H & Gaber, AO 2019, , Transplantation. https://doi.org/10.1097/TP.0000000000002862

Corrections to: Checkpoint inhibitor therapy for cancer in solid organ transplantation recipients: An institutional experience and a systematic review of the literature (Journal for ImmunoTherapy of Cancer (2019) 7:106 DOI: 10.1186/s40425-019-0585-1)
Abdel-Wahab, N, Safa, H, Abudayyeh, A, Johnson, DH, Trinh, VA, Zobniw, CM, Lin, H, Wong, MK, Abdelrahim, M, Gaber, AO, Suarez-Almazor, ME & Diab, A 2019, Journal for immunotherapy of cancer, vol. 7, no. 1, 158. https://doi.org/10.1186/s40425-019-0639-4

The Houston Methodist Lung Transplant Risk Model: A Validated Tool for Pretransplant Risk Assessment
Houston Methodist Lung Outcomes Group 2019, , The Annals of thoracic surgery, vol. 108, no. 4, pp. 1094-1100. https://doi.org/10.1016/j.athoracsur.2019.03.108

Checkpoint inhibitor therapy for cancer in solid organ transplantation recipients: An institutional experience and a systematic review of the literature
Abdel-Wahab, N, Safa, H, Abudayyeh, A, Johnson, DH, Trinh, VA, Zobniw, CM, Lin, H, Wong, MK, Abdelrahim, M, Gaber, AO, Suarez-Almazor, ME & Diab, A 2019, , Journal for immunotherapy of cancer, vol. 7, no. 1, 106. https://doi.org/10.1186/s40425-019-0585-1

Ciprofloxacin for BK viremia prophylaxis in kidney transplant recipients: Results of a prospective, double-blind, randomized, placebo-controlled trial
Patel, SJ, Knight, RJ, Kuten, SA, Graviss, EA, Nguyen, DT, Moore, LW, Musick, WL & Gaber, AO 2019, , American Journal of Transplantation. https://doi.org/10.1111/ajt.15328

Cross-sectional evaluation of the relationship between Vitamin D status and supplement use across levels of kidney function in adults
Moore, LW, Suki, WN, Lunsford, KE, Sabek, OM, Knight, RJ & Gaber, AO 2019, , BMJ open, vol. 9, no. 2, e022471. https://doi.org/10.1136/bmjopen-2018-022471

The importance of drug safety and tolerability in the development of new immunosuppressive therapy for transplant recipients: The Transplant Therapeutics Consortium's position statement
Stegall, MD, Troy Somerville, K, Everly, MJ, Mannon, RB, Gaber, AO, First, MR, Agashivala, N, Perez, V, Newell, KA, Morris, RE, Sudan, D, Romero, K, Eremenco, S, Mattera, M, Spear, N, Porter, AC & ODoherty, I 2019, , American Journal of Transplantation, vol. 19, no. 3, pp. 625-632. https://doi.org/10.1111/ajt.15214

Disparate outcomes observed within Kidney Disease: Improving Global Outcomes (KDIGO) acute kidney injury stage 1
Sparrow, HG, Swan, JT, Moore, LW, Gaber, AO & Suki, WN 2019, , Kidney international. https://doi.org/10.1016/j.kint.2018.11.030