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Antonio Gotto, MD, DPhil

Full Member, Research Institute
Houston Methodist
Professor of Medicine, Provost for Medical Affairs & Dean Emeritus, Weill Cornell Medical College


Biography

Dr. Antonio M. Gotto is the Stephen and Suzanne Weiss Dean of Weill Cornell Medical College in New York, New York, where he is also Professor of Medicine. In addition, Dr. Gotto is Provost for Medical Affairs of Cornell University. He joined Houston Methodist Research Institute in 2011. Previously, at Baylor College of Medicine in Houston, Texas, he was the Bob and Vivian Smith Professor and Chairman of the Department of Medicine, Scientific Director of the DeBakey Heart Center, and the JS Abercrombie Chair for Atherosclerosis and Lipoprotein Research. He also served as Chief of the Internal Medicine Service at The Methodist Hospital in Houston. Dr. Gotto's postgraduate work included doctoral studies at Oxford University in England as a Rhodes Scholar, and residency training at the Massachusetts General Hospital in Boston, Massachusetts.

As a lifelong supporter of educational efforts aimed at cardiovascular risk reduction, Dr. Gotto has been National President of the American Heart Association and President of the International Atherosclerosis Society. He is a member of the Institute of Medicine and the American Academy of Arts and Sciences and a recipient of many honors, including the Gold Heart Award from the American Heart Association, the 2000 Distinguished Alumnus award from Vanderbilt University and the Vanderbilt University School of Medicine, honorary doctoral degrees from the University of Bologna and Abilene Christian University, honorary professorships from the University of Buenos Aires and Francisco Marroquin University (Guatemala), and the Order of the Lion from the Republic of Finland. Dr. Gotto was the 2004 recipient of the International Okamoto Award from the Japan Vascular Disease Research Foundation. In 2004 Dr. Gotto was also named Honorary Member of the Society for Progress in Internal Medicine (Ludwig Heilmeyer Society) in Germany. In 2010, he received the Maurice R. Greenberg Distinguished Service Award, the highest honor bestowed by New York-Presbyterian/Weill Cornell on members of the medical staff.

Dr. Gotto speaks nationally and internationally on cardiovascular disease and has contributed more than 500 scholarly articles and books to the medical literature. In addition, he is coauthor of a series of books that explain the origins and treatment of cardiovascular disease to the general public.

Description of Research

In the field of atherosclerosis, his basic science research interests include clinical disorders of lipid transport and the structure, metabolism, and function of lipoproteins and apolipoproteins. He and his associates were the first to achieve complete synthesis of a plasma apolipoprotein (apo C-I); they also determined the complete cDNA and amino acid sequence of apo B-100, one of the largest proteins ever sequenced and a key protein in atherosclerosis. In addition, Dr. Gotto has played a leading role in several landmark clinical trials demonstrating that cholesterol-lowering drug treatment can reduce the risk of heart disease.

Areas Of Expertise

Lipoproteins and apolipoproteins Atherosclerosis Lipid metabolism Statins
Education & Training

D Phil, University of Oxford
Publications

Rethinking reverse cholesterol transport and dysfunctional high-density lipoproteins
Gillard, BK, Rosales, C, Xu, B, Gotto, AM & Pownall, HJ 2018, Journal of Clinical Lipidology. DOI: 10.1016/j.jacl.2018.04.001

Effect of fibrates on glycemic parameters: A systematic review and meta-analysis of randomized placebo-controlled trials
Simental-Mendía, LE, Simental-Mendía, M, Sánchez-García, A, Banach, M, Atkin, SL, Gotto, AM & Sahebkar, A 2018, Pharmacological Research. DOI: 10.1016/j.phrs.2017.12.030

Effect of soy isoflavone supplementation on plasma lipoprotein(a) concentrations: A meta-analysis
Simental-Mendía, LE, Gotto, AM, Atkin, SL, Banach, M, Pirro, M & Sahebkar, A 2017, Journal of Clinical Lipidology. DOI: 10.1016/j.jacl.2017.10.004

Coronary Disease Survival with Diabetes
Hamilton, DJ & Gotto, AM 2017, Cardiology (Switzerland), pp. 40-42. DOI: 10.1159/000484518

ABCA1-Derived Nascent High-Density Lipoprotein-Apolipoprotein AI and Lipids Metabolically Segregate
Xu, B, Gillard, BK, Gotto, AM, Rosales, C & Pownall, HJ 2017, Arteriosclerosis, thrombosis, and vascular biology, vol 37, no. 12, pp. 2260-2270. DOI: 10.1161/ATVBAHA.117.310290

Scavenger receptor B1 (SR-B1) profoundly excludes high density lipoprotein (HDL) apolipoprotein AII as it nibbles HDL-cholesteryl ester
Gillard, BK, Bassett, GR, Gotto, AM, Rosales, C & Pownall, HJ 2017, Journal of Biological Chemistry, vol 292, no. 21, pp. 8864-8873. DOI: 10.1074/jbc.M117.781963

Scavenger receptor B1 (SR-B1) profoundly excludes high density lipoprotein (HDL) apolipoprotein AII as it nibbles HDL-cholesteryl ester
Gillard, BK, Bassett, GR, Gotto, AM, Rosales, C & Pownall, HJ 2017, The Journal of biological chemistry, vol 292, no. 21, pp. 8864-8873. DOI: 10.1074/jbc.M117.781963

Update on the use of PCSK9 inhibitors in adults: Recommendations from an Expert Panel of the National Lipid Association
Orringer, CE, Jacobson, TA, Saseen, JJ, Brown, AS, Gotto, AM, Ross, JL & Underberg, JA 2017, Journal of Clinical Lipidology. DOI: 10.1016/j.jacl.2017.05.001

Cellular ABCA1-Derived Nascent HDL-Cholesterol Transfers to the LDLR Pathway.
Xu, B, Gillard, BK, Gotto, A, Rosales, C & Pownall, HJ 2017, European Atherosclerosis Society, Prague, Czech Republic, 4/23/17 - 4/26/17, .

The HDL receptor, SR-B1, forms remnant HDL by a nibbling mechanism and releases apo AI.
Gillard, BK, Bassett, GR, Rosales, C, Gotto, A & Pownall, HJ 2017, European Atherosclerosis Society, Prague, Czech Republic, 4/23/17 - 4/26/17, .

Structural Stability of Streptococcal Serum Opacity Factor.
Rosales, C, Yelamanchili, D, Gillard, BK, Gotto, A & Pownall, HJ 2017, European Atherosclerosis Society, Prague, Czech Republic, 4/23/17 - 4/26/17, .

Structural Stability of Streptococcal Serum Opacity Factor
Yelamanchili, D, Gillard, BK, Gotto, AM, Pownall, HJ & Rosales, C 2017, Protein Journal, pp. 1-6. DOI: 10.1007/s10930-017-9711-4

Metabolic Segregation of Nascent HDL-Lipid and Protein.
Xu, B, Gillard, BK, Gotto, A, Rosales, C & Pownall, HJ 2017, BCM CVRI Symposium, Houston, United States, 4/4/17 - 4/4/17, .

HDL functionality in familial hypercholesterolemia: Effects of treatment modalities and pharmacological interventions
Ganjali, S, Momtazi-Borojeni, AA, Banach, M, Kovanen, PT, Gotto, AM & Sahebkar, A 2017, Drug Discovery Today. DOI: 10.1016/j.drudis.2017.09.014

Acylation of lysine residues in human plasma high density lipoprotein increases stability and plasma clearance in vivo
Yang, Y, Rosales, C, Gillard, BK, Gotto, AM & Pownall, HJ 2016, Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids, vol 1861, no. 11, pp. 1787-1795. DOI: 10.1016/j.bbalip.2016.08.017

Neo High-Density Lipoprotein Produced by the Streptococcal Serum Opacity Factor Activity against Human High-Density Lipoproteins Is Hepatically Removed via Dual Mechanisms
Rodriguez, PJ, Gillard, BK, Barosh, R, Gotto, AM, Rosales, C & Pownall, HJ 2016, Biochemistry, vol 55, no. 41, pp. 5845-5853. DOI: 10.1021/acs.biochem.6b00946

Pitavastatin differentially modulates MicroRNA-Associated cholesterol transport proteins in macrophages
Zhang, H, Lamon, BD, Moran, G, Sun, T, Gotto, AM & Hajjar, DP 2016, PLoS ONE, vol 11, no. 7, e0159130. DOI: 10.1371/journal.pone.0159130

Speciated High-Density Lipoprotein Biogenesis and Functionality
Rosales, C, Davidson, WS, Gillard, BK, Gotto, AM & Pownall, HJ 2016, Current Atherosclerosis Reports, vol 18, no. 5, 25. DOI: 10.1007/s11883-016-0572-7

Streptococcal serum opacity factor promotes cholesterol ester metabolism and bile acid secretion in vitro and in vivo
Gillard, BK, Rodriguez, PJ, Fields, DW, Raya, JL, Lagor, WR, Rosales, C, Courtney, HS, Gotto, AM & Pownall, HJ 2016, Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids, vol 1861, no. 3, pp. 196-204. DOI: 10.1016/j.bbalip.2015.12.006

Integrated Measure for Atherogenic Lipoproteins in the Modern Era Risk Assessment Based on Apolipoprotein B
Rosenson, RS, Hegele, RA & Gotto, AM 2016, Journal of the American College of Cardiology, vol 67, no. 2, pp. 202-204. DOI: 10.1016/j.jacc.2015.10.059