Anisha A. Gupte

Anisha A. Gupte, PhD

Assistant Research Professor of Physiology in Medicine, Academic Institute
Assistant Research Member, Research Institute
Houston Methodist
Weill Cornell Medical College


aagupte@houstonmethodist.org
Description of Research

Cardiovascular health in women.

Bioenergetics changes in cardiac metablism in heart failure and diastolic dysfunction.

Areas Of Expertise

Diabetes Estrogen receptors Heart failure Diastolic heart failure Obesity
Publications

An ERK5-NRF2 Axis Mediates Senescence-Associated Stemness and Atherosclerosis
Abe, J-I, Imanishi, M, Li, S, Zhang, A, Ko, KA, Samanthapudi, VSK, Lee, L-L, Bojorges, AP, Gi, YJ, Hobbs, BP, Deswal, A, Herrmann, J, Lin, SH, Chini, EN, Shen, YH, Schadler, KL, Nguyen, T-H-M, Gupte, AA, Reyes-Gibby, C, Yeung, S-CJ, Abe, RJ, Olmsted-Davis, EA, Krishnan, S, Dantzer, R, Palaskas, NL, Cooke, JP, Pownall, HJ, Yoshimoto, M, Fujiwara, K, Hamilton, DJ, Burks, JK, Wang, G, Le, N-T & Kotla, S 2023, , Circulation Research, vol. 133, no. 1, pp. 25-44. https://doi.org/10.1161/CIRCRESAHA.122.322017

AIBP Regulates Metabolism of Ketone and Lipids but Not Mitochondrial Respiration
Kim, JD, Zhou, T, Zhang, A, Li, S, Gupte, AA, Hamilton, DJ & Fang, L 2022, , Cells, vol. 11, no. 22, 3643. https://doi.org/10.3390/cells11223643, https://doi.org/10.3390/cells11223643

AIBP Regulates Metabolism of Ketone and Lipids but Not Mitochondrial Respiration
Kim, JD, Zhou, T, Zhang, A, Li, S, Gupte, AA, Hamilton, DJ & Fang, L 2022, , Cells, vol. 11, no. 22, 3643. https://doi.org/10.3390/cells11223643

Enhanced Succinate Oxidation with Mitochondrial Complex II Reactive Oxygen Species Generation in Human Prostate Cancer
Zhang, A, Gupte, AA, Chatterjee, S, Li, S, Ayala, A, Miles, BJ & Hamilton, DJ 2022, , International journal of molecular sciences, vol. 23, no. 20, 12168, pp. 12168. https://doi.org/10.3390/ijms232012168, https://doi.org/10.3390/ijms232012168

Enhanced Succinate Oxidation with Mitochondrial Complex II Reactive Oxygen Species Generation in Human Prostate Cancer
Zhang, A, Gupte, AA, Chatterjee, S, Li, S, Ayala, AG, Miles, BJ & Hamilton, DJ 2022, , International journal of molecular sciences, vol. 23, no. 20. https://doi.org/10.3390/ijms232012168

Enhanced Succinate Oxidation with Mitochondrial Complex II Reactive Oxygen Species Generation in Human Prostate Cancer
Zhang, A, Gupte, AA, Chatterjee, S, Li, S, Ayala, A, Miles, BJ & Hamilton, DJ 2022, , International journal of molecular sciences, vol. 23, no. 20, 12168. https://doi.org/10.3390/ijms232012168

The Role of Calcium Signaling in Melanoma
Zhang, H, Chen, Z, Zhang, A, Gupte, AA & Hamilton, DJ 2022, , International journal of molecular sciences, vol. 23, no. 3, 1010. https://doi.org/10.3390/ijms23031010

Nucleus-mitochondria positive feedback loop formed by ERK5 S496 phosphorylation-mediated poly (ADP-ribose) polymerase activation provokes persistent pro-inflammatory senescent phenotype and accelerates coronary atherosclerosis after chemo-radiation
Kotla, S, Zhang, A, Imanishi, M, Ko, KA, Lin, SH, Gi, YJ, Moczygemba, M, Isgandarova, S, Schadler, KL, Chung, C, Milgrom, SA, Banchs, J, Yusuf, SW, Amaya, DN, Guo, H, Thomas, TN, Shen, YH, Deswal, A, Herrmann, J, Kleinerman, ES, Entman, ML, Cooke, JP, Schifitto, G, Maggirwar, SB, McBeath, E, Gupte, AA, Krishnan, S, Patel, ZS, Yoon, Y, Burks, JK, Fujiwara, K, Brookes, PS, Le, N-T, Hamilton, DJ & Abe, J-I 2021, , Redox Biology, vol. 47, 102132, pp. 102132. https://doi.org/10.1016/j.redox.2021.102132

Plumbagin elicits cell-specific cytotoxic effects and metabolic responses in melanoma cells
Zhang, H, Zhang, A, Gupte, AA & Hamilton, DJ 2021, , Pharmaceutics, vol. 13, no. 5, 706. https://doi.org/10.3390/pharmaceutics13050706

The effect of plumbagin on progression feature and bioenergetic function in melanoma with different aggressiveness
Zhang, H, Zhang, A, Gupte, AA & Hamilton, DJ 2020, , 2020 MAPTAs 3rd Annual Summer Science Symposium, 9/2/20 - 9/3/20.

Cancer Treatment (CTCT) Promotes Oxidative Stress and Alters Monocyte/ macrophage Biology
Kotla, S, Zhang, A, Ae Ko, K, Imanishi, M, Mazhar, H, Thomas, T, Gi, Y, Vu, HT, Krishnan, S, McBeath, E, Lin, S, Kleinerman, E, Schadler, K, Fujiwara, K, Gupte, AA, Le, N-T, Hamilton, DJ & Abe, JI 2019, , Free Radical Biology and Medicine, vol. 145, no. S1, pp. S134.

The Role of Estrogen in Protection of Skeletal Muscle Function in Diastolic Dysfunction
Chatterjee, S, Li, S, Zhang, A, Vedula, I, AlRukby, J, Hamilton, DJ & Gupte, AA 2019, , Circulation Research, vol. 125.

Cholesterol Induces CD8+ T Cell Exhaustion in the Tumor Microenvironment
Ma, X, Bi, E, Lu, Y, Su, P, Huang, C, Liu, L, Wang, Q, Yang, M, Kalady, MF, Qian, J, Zhang, A, Gupte, AA, Hamilton, DJ, Zheng, C & Yi, Q 2019, , Cell Metabolism, vol. 30, no. 1, pp. 143-156.e5. https://doi.org/10.1016/j.cmet.2019.04.002

Mitochondrial Function of Prostate Cancer
Miles, BJ, Zhang, A, Li, S, Chatterjee, S, Gupte, AA & Hamilton, DJ 2019, Paper presented at International Society of Anticxidant in Nutrition and Health (ISANH) Redox Congress, Muscat, Oman, 3/4/19, .

Improved cardiovascular function in old mice after N-Acetyl cysteine and glycine supplemented diet: Inflammation and mitochondrial factors
Cieslik, KA, Sekhar, RV, Granillo, A, Reddy, A, Medrano, G, Heredia, CP, Entman, ML, Hamilton, DJ, Li, S, Reineke, EL, Gupte, AA, Zhang, A & Taffet, G 2018, , Journals of Gerontology - Series A Biological Sciences and Medical Sciences, vol. 73, no. 9, pp. 1167-1177. https://doi.org/10.1093/gerona/gly034, https://doi.org/10.1093/gerona/gly034

Improved Cardiovascular Function in Old Mice After N-Acetyl Cysteine and Glycine Supplemented Diet: Inflammation and Mitochondrial Factors
Cieslik, KA, Sekhar, RV, Granillo, A, Reddy, A, Medrano, G, Heredia, CP, Entman, ML, Hamilton, DJ, Li, S, Reineke, E, Gupte, AA, Zhang, A & Taffet, GE 2018, , The journals of gerontology. Series A, Biological sciences and medical sciences, vol. 73, no. 9, pp. 1167-1177. https://doi.org/10.1093/gerona/gly034

Polymer Functionalization of Isolated Mitochondria for Cellular Transplantation and Metabolic Phenotype Alteration
Wu, S, Zhang, A, Li, S, Chatterjee, S, Qi, R, Segura-Ibarra, V, Ferrari, M, Gupte, A, Blanco, E & Hamilton, DJ 2018, , Advanced Science, vol. 5, no. 3, 1700530, pp. 1700530-n/a. https://doi.org/10.1002/advs.201700530

Tead1 is required for maintaining adult cardiomyocyte function, and its loss results in lethal dilated cardiomyopathy
Liu, R, Lee, J, Kim, BS, Wang, Q, Buxton, SK, Balasubramanyam, N, Kim, JJ, Dong, J, Zhang, A, Li, S, Gupte, AA, Hamilton, DJ, Martin, JF, Rodney, GG, Coarfa, C, Wehrens, XH, Yechoor, VK & Moulik, M 2017, , JCI insight, vol. 2, no. 17. https://doi.org/10.1172/jci.insight.93343

Mitochondrial function in non-ischemic heart failure
Gupte, AA & Hamilton, DJ 2017, . in Advances in Experimental Medicine and Biology. vol. 982, Advances in Experimental Medicine and Biology, vol. 982, Springer New York LLC, pp. 113-126. DOI: 10.1007/978-3-319-55330-6_6

Mitochondrial Function in Non-ischemic Heart Failure
Gupte, AA & Hamilton, DJ 2017, . in G Santulli (ed.), Mitochondrial Dynamics in Cardiovascular Medicine. vol. 982, Advances in Experimental Medicine and Biology, no. 1, Springer International Publishing, pp. 113-126. https://doi.org/https://link.springer.com/chapter/10.1007%2F978-3-319-55330-6_6

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