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Angelique Regnier-Golanov

Angelique Regnier-Golanov, PhD, MSc

Assistant Research Professor of Neurosurgery, Academic Institute
Assistant Research Member, Research Institute
Houston Methodist
Weill Cornell Medical College


aregnier-golanov@houstonmethodist.org
Biography

Angelique Regnier-Golanov, PhD, is a senior scientist in the Neurosurgery Department of the Houston Methodist Hospital. She has a strong expertise in neuroinflammation, microcirculation and remote neuronal damage after epilepsy, as she worked on an original model of temporal lobe epilepsy of thalamic origin during her PhD, in Paris VII University. She pursued a post-doctorate on the effects of NR2B-containing NMDARs in the prevention of epileptic seizures development after traumatic brain injury at the Uniformed Services University in Bethesda, MD. As a postdoctoral fellow at Baylor College of Medicine, she carried two different projects, the effects of mTOR inhibitor on neurocognitive behavior and protein translation in temporal lobe epilepsy as well as quantitative EEG changes in different animal models of epilepsy.
She had the chance to join the Laboratory of Cerebrovascular Research at the Department of Neurosurgery, where she integrated her previous experience in epilepsy studies to investigate primarily long-term consequences of subarachnoid hemorrhage including abnormalities of cerebrospinal fluid flow. During her tenure, she acquired a unique set of “in vivo” and “in vitro” skills in neuroscience and neurophysiology that make her a uniquely qualified investigator. In the present laboratory, she successfully conducted behavioral and transcriptomics experiments that have been published in peer-reviewed journals. Furthermore, she was fortunate to be chosen to participate in the hands-on Cajal training in 2019, “Brain homeostasis and neurovascular coupling,” which trained her in the theoretical and practical state-of-the art in this multifaceted field.

Publications

Subarachnoid Haemorrhage Leads to Desialilation of Hippocampal Glycocalyx Followed by Complement System Activation
Golanov, EV & Regnier-Golanov, A 2023, . in Desialilation of hippocampal glycocalyx after subarachnoid haemorrhage leads complement system activation.

Early and long-lasting white matter damage in the perforant pathway following subarachnoid hemorrhage in mice
Golanov, EV & Regnier-Golanov, A 2023, , Journal of Cerebral Blood Flow and Metabolism. https://doi.org/10.1177/0271678X231176482

Systems and methods for improving cerebrospinal fluid (csf) drainage
Golanov, EV, Britz, GW, Regnier-Golanov, A, Karmonik, C & Eskuri, A Oct. 27 2022, , Patent No. WO2022226155A1.

Subarachnoid hemorrhage induces subacute and early chronic impairment in learning and memory in mice
Golanov, EV, Britz, GW & Regnier-Golanov, A 2022, , Brain 22, Glasgow, United Kingdom, 5/28/22 - 6/1/22 pp. 1-71.

Subarachnoid Hemorrhage Induces Sub-acute and Early Chronic Impairment in Learning and Memory in Mice
Regnier-Golanov, AS, Gulinello, M, Hernandez, MS, Golanov, EV & Britz, GW 2022, , Translational Stroke Research, vol. 13, no. 4, pp. 625-640. https://doi.org/10.1007/s12975-022-00987-9

Review of wearable technologies and machine learning methodologies for systematic detection of mild traumatic brain injuries
Schmid, W, Fan, Y, Chi, T, Golanov, E, Regnier-Golanov, AS, Austerman, RJ, Podell, K, Cherukuri, P, Bentley, T, Steele, CT, Schodrof, S, Aazhang, B & Britz, GW 2021, , Journal of neural engineering, vol. 18, no. 4, 041006. https://doi.org/10.1088/1741-2552/ac1982

A contemporary review of therapeutic and regenerative management of intracerebral hemorrhage
Sadaf, H, Desai, VR, Misra, V, Golanov, E, Hegde, ML, Villapol, S, Karmonik, C, Regnier-Golanov, A, Sayenko, D, Horner, PJ, Krencik, R, Weng, YL, Vahidy, FS & Britz, GW 2021, , Annals of Clinical and Translational Neurology, vol. 8, no. 11, pp. 2211-2221. https://doi.org/10.1002/acn3.51443, https://doi.org/10.1002/acn3.51443, https://doi.org/doi: 10.1002/acn3.51443

Quantitative EEG Analysis in Angelman Syndrome: Candidate Method for Assessing Therapeutics
Martinez, LA, Born, HA, Harris, S, Regnier-Golanov, A, Grieco, JC, Weeber, EJ & Anderson, AE 2023, , Clinical EEG and Neuroscience, vol. 54, no. 2, pp. 203-212. https://doi.org/10.1177/1550059420973095

Fibrinogen chains intrinsic to the brain
Golanov, EV, Sharpe, MA, Regnier-Golanov, AS, Del Zoppo, GJ, Baskin, DS & Britz, GW 2019, , Frontiers in Neuroscience, vol. 13, no. MAY, 541. https://doi.org/10.3389/fnins.2019.00541

Integrity of cerebellar fastigial nucleus intrinsic neurons is critical for the global ischemic preconditioning
Golanov, EV, Regnier-Golanov, AS & Britz, GW 2017, , Brain Sciences, vol. 7, no. 10, 121. https://doi.org/10.3390/brainsci7100121

MTOR inhibition suppresses established epilepsy in a mouse model of cortical dysplasia
Nguyen, LH, Brewster, AL, Clark, ME, Regnier-Golanov, A, Sunnen, CN, Patil, VV, DArcangelo, G & Anderson, AE 2015, , Epilepsia, vol. 56, no. 4, pp. 636-646. https://doi.org/10.1111/epi.12946

Brain region-specific alterations in the gene expression of cytokines, immune cell markers and cholinergic system components during peripheral endotoxin-induced inflammation
Silverman, HA, Dancho, M, Regnier-Golanov, A, Nasim, M, Ochani, M, Olofsson, PS, Ahmed, M, Miller, EJ, Chavan, SS, Golanov, EV, Metz, CN, Tracey, KJ & Pavlov, VA 2014, , Molecular medicine (Cambridge, Mass.), vol. 20, pp. 601-611. https://doi.org/10.2119/molmed.2014.00147

Aggravation of seizure-associated microvascular injuries by ibuprofen may involve multiple pathways
Régnier, A, Vicaut, E & Mraovitch, S 2010, , Epilepsia, vol. 51, no. 12, pp. 2412-22. https://doi.org/10.1111/j.1528-1167.2009.02480.x

Post-seizures amygdaloallocortical microvascular lesion leading to atrophy and memory impairment
Mraovitch, S, Calando, Y, Régnier, A, Lamproglou, I & Vicaut, E 2005, , Neurobiology of Disease, vol. 19, no. 3, pp. 479-489. https://doi.org/10.1016/j.nbd.2005.01.029

Axon-tracing properties of indocyanine green
Paques, M, Genevois, O, Régnier, A, Tadayoni, R, Sercombe, R, Gaudric, A & Vicaut, E 2003, , Archives of Ophthalmology, vol. 121, no. 3, pp. 367-70. https://doi.org/10.1001/archopht.121.3.367