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Andrew P. Horton, PhD

Assistant Research Professor of Pathology and Genomic Medicine, Academic Institute
Assistant Research Member, Research Institute
Houston Methodist


Publications

SARS-COV-2 Omicron variants conformationally escape a rare quaternary antibody binding mode
Goike, J, Hsieh, CL, Horton, AP, Gardner, EC, Zhou, L, Bartzoka, F, Wang, N, Javanmardi, K, Hebert, A, Abbasi, SA, Xie, X, Xia, H, Shi, PY, Renberg, R, Segall-Shapiro, T, Terrace, CI, Wu, W, Shroff, R, Byrom, M, Ellington, AD, Marcotte, EM, Musser, JM, Kuchipudi, SV, Kapur, V, Georgiou, G, Weaver, S, Dye, JM, Boutz, DR, McLellan, JS & Gollihar, JD 2023, , Communications Biology, vol. 6, 1250, pp. 1250. https://doi.org/10.1038/s42003-023-05649-6

Rapid characterization of spike variants via mammalian cell surface display
Javanmardi, K, Chou, CW, Terrace, CI, Annapareddy, A, Kaoud, TS, Guo, Q, Lutgens, J, Zorkic, H, Horton, AP, Gardner, EC, Nguyen, G, Boutz, DR, Goike, J, Voss, WN, Kuo, HC, Dalby, KN, Gollihar, JD & Finkelstein, IJ 2021, , Molecular Cell, vol. 81, no. 24, pp. 5099-5111.e8. https://doi.org/10.1016/j.molcel.2021.11.024

Influenza vaccination in the elderly boosts antibodies against conserved viral proteins and egg-produced glycans
Jung, J, Mundle, ST, Ustyugova, IV, Horton, AP, Boutz, DR, Pougatcheva, S, Prabakaran, P, McDaniel, JR, King, GR, Park, D, Person, MD, Ye, C, Tan, B, Tanno, Y, Kim, JE, Curtis, NC, DiNapoli, J, Delagrave, S, Ross, TM, Ippolito, GC, Kleanthous, H, Lee, J & Georgiou, G 2021, , Journal of Clinical Investigation, vol. 131, no. 13, e148763. https://doi.org/10.1172/JCI148763

Prevalent, protective, and convergent IgG recognition of SARS-CoV-2 non-RBD spike epitopes
Voss, WN, Hou, YJ, Johnson, NV, Delidakis, G, Kim, JE, Javanmardi, K, Horton, AP, Bartzoka, F, Paresi, CJ, Tanno, Y, Chou, CW, Abbasi, SA, Pickens, W, George, K, Boutz, DR, Towers, DM, McDaniel, JR, Billick, D, Goike, J, Rowe, L, Batra, D, Pohl, J, Lee, J, Gangappa, S, Sambhara, S, Gadush, M, Wang, N, Person, MD, Iverson, BL, Gollihar, JD, Dye, JM, Herbert, AS, Finkelstein, IJ, Baric, RS, McLellan, JS, Georgiou, G, Lavinder, JJ & Ippolito, GC 2021, , Science, vol. 372, no. 6546, pp. 1108-1112. https://doi.org/10.1126/science.abg5268

Separating distinct structures of multiple macromolecular assemblies from cryo-EM projections
Verbeke, EJ, Zhou, Y, Horton, AP, Mallam, AL, Taylor, DW & Marcotte, EM 2020, , Journal of Structural Biology, vol. 209, no. 1, 107416. https://doi.org/10.1016/j.jsb.2019.107416

Persistent Antibody Clonotypes Dominate the Serum Response to Influenza over Multiple Years and Repeated Vaccinations
Lee, J, Paparoditis, P, Horton, AP, Frühwirth, A, McDaniel, JR, Jung, J, Boutz, DR, Hussein, DA, Tanno, Y, Pappas, L, Ippolito, GC, Corti, D, Lanzavecchia, A & Georgiou, G 2019, , Cell Host and Microbe, vol. 25, no. 3, pp. 367-376.e5. https://doi.org/10.1016/j.chom.2019.01.010

Identification of tumor-reactive B cells and systemic IgG in breast cancer based on clonal frequency in the sentinel lymph node
McDaniel, JR, Pero, SC, Voss, WN, Shukla, GS, Sun, Y, Schaetzle, S, Lee, CH, Horton, AP, Harlow, S, Gollihar, JD, Ellefson, JW, Krag, CC, Tanno, Y, Sidiropoulos, N, Georgiou, G, Ippolito, GC & Krag, DN 2018, , Cancer Immunology, Immunotherapy, vol. 67, no. 5, pp. 729. https://doi.org/10.1007/s00262-018-2123-2

Middle-Down 193-nm Ultraviolet Photodissociation for Unambiguous Antibody Identification and its Implications for Immunoproteomic Analysis
Cotham, VC, Horton, AP, Lee, J, Georgiou, G & Brodbelt, JS 2017, , Analytical Chemistry, vol. 89, no. 12, pp. 6498-6504. https://doi.org/10.1021/acs.analchem.7b00564

Comprehensive de Novo Peptide Sequencing from MS/MS Pairs Generated through Complementary Collision Induced Dissociation and 351 nm Ultraviolet Photodissociation
Horton, AP, Robotham, SA, Cannon, JR, Holden, DD, Marcotte, EM & Brodbelt, JS 2017, , Analytical Chemistry, vol. 89, no. 6, pp. 3747-3753. https://doi.org/10.1021/acs.analchem.7b00130

Molecular-level analysis of the serum antibody repertoire in young adults before and after seasonal influenza vaccination
Lee, J, Boutz, DR, Chromikova, V, Joyce, MG, Vollmers, C, Leung, K, Horton, AP, DeKosky, BJ, Lee, CH, Lavinder, JJ, Murrin, EM, Chrysostomou, C, Hoi, KH, Tsybovsky, Y, Thomas, PV, Druz, A, Zhang, B, Zhang, Y, Wang, L, Kong, WP, Park, D, Popova, LI, Dekker, CL, Davis, MM, Carter, CE, Ross, TM, Ellington, AD, Wilson, PC, Marcotte, EM, Mascola, JR, Ippolito, GC, Krammer, F, Quake, SR, Kwong, PD & Georgiou, G 2016, , Nature Medicine, vol. 22, no. 12, pp. 1456-1464. https://doi.org/10.1038/nm.4224

UVnovo: A de Novo Sequencing Algorithm Using Single Series of Fragment Ions via Chromophore Tagging and 351 nm Ultraviolet Photodissociation Mass Spectrometry
Robotham, SA, Horton, AP, Cannon, JR, Cotham, VC, Marcotte, EM & Brodbelt, JS 2016, , Analytical Chemistry, vol. 88, no. 7, pp. 3990-3997. https://doi.org/10.1021/acs.analchem.6b00261

Serology in the 21st century: The molecular-level analysis of the serum antibody repertoire
Wine, Y, Horton, AP, Ippolito, GC & Georgiou, G 2015, , Current Opinion in Immunology, vol. 35, pp. 89-97. https://doi.org/10.1016/j.coi.2015.06.009

Next-generation sequencing and protein mass spectrometry for the comprehensive analysis of human cellular and serum antibody repertoires
Lavinder, JJ, Horton, AP, Georgiou, G & Ippolito, GC 2015, , Current Opinion in Chemical Biology, vol. 24, pp. 112-120. https://doi.org/10.1016/j.cbpa.2014.11.007

Proteomic identification of monoclonal antibodies from serum
Boutz, DR, Horton, AP, Wine, Y, Lavinder, JJ, Georgiou, G & Marcotte, EM 2014, , Analytical Chemistry, vol. 86, no. 10, pp. 4758-4766. https://doi.org/10.1021/ac4037679

Identification and characterization of the constituent human serum antibodies elicited by vaccination
Lavinder, JJ, Wine, Y, Giesecke, C, Ippolito, GC, Horton, AP, Lungu, OI, Hoi, KH, DeKosky, BJ, Murrin, EM, Wirth, MM, Ellington, AD, Dörner, T, Marcotte, EM, Boutz, DR & Georgiou, G 2014, , Proceedings of the National Academy of Sciences of the United States of America, vol. 111, no. 6, pp. 2259-2264. https://doi.org/10.1073/pnas.1317793111

High-throughput database search and large-scale negative polarity liquid chromatography-tandem mass spectrometry with ultraviolet photodissociation for complex proteomic samples
Madsen, JA, Xu, H, Robinson, MR, Horton, AP, Shaw, JB, Giles, DK, Kaoud, TS, Dalby, KN, Trent, MS & Brodbelt, JS 2013, , Molecular and Cellular Proteomics, vol. 12, no. 9, pp. 2604-2614. https://doi.org/10.1074/mcp.O113.028258

Molecular deconvolution of the monoclonal antibodies that comprise the polyclonal serum response
Wine, Y, Boutz, DR, Lavinder, JJ, Miklos, AE, Hughes, RA, Hoi, KH, Jung, ST, Horton, AP, Murrin, EM, Ellington, AD, Marcotte, EM & Georgiou, G 2013, , Proceedings of the National Academy of Sciences of the United States of America, vol. 110, no. 8, pp. 2993-2998. https://doi.org/10.1073/pnas.1213737110

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