Alpesh R. Shah, MD, FACC, FSCAI

Associate Professor of Clinical Cardiology, Academic Institute
Associate Clinical Member, Research Institute
Houston Methodist
Weill Cornell Medical College


Alpesh Shah M.D. is an Interventional Cardiologist and Associate Professor at Houston Methodist Hospital. He is also faculty with Weill Cornell Medicine and Baylor College of Medicine and remains involved training Medical residents and cardiology Fellows.

Dr. Shah was born In India, and after finishing Medical School at Baroda Medical College in 1993, immigrated to USA to pursue advanced medical education and research. He did his Internal Medicine residency at Jacobi Medical Center with Albert Einstein Medical College in NewYork from 1993 to 1996. During residency he pursued research in the field of Apoptosis within cardiac myocytes. He did his General Cardiology fellowship at St. Vincent’s Hospital with NewYork Medical College in NewYork from 1996 to 1999. He moved to Houston and did Interventional Cardiology Fellowship at Methodist Hospital with Baylor College of Medicine from 1999 to 2000. Dr. Shah was in Single Speciality Cardiology practice and served as Cardiac catheterization laboratory director at Brazosport Memorial Hospital before he joined Houston Methodist Hospital to pursue a life in Academics and Research as an Interventional Cardiology faculty.

Dr. Shah performs a wide array of Interventional Cardiology procedures with expertise in complex coronary interventions such as chronic total occlusion, coronary brachytherapy for restenosis and novel stent implants such as bioabsorbable stent. He also specializes as Endovascular Interventionist with a large successful program in Carotid artery stent. He also has spearheaded the robotic assisted vascular intervention program in the Cardiac catheterization lab for carotid and peripheral arterial interventions.
Dr. Shah serves as a proctor for complex coronary interventions and carotid stent nationally and internationally.

Dr. Shah is an Associate fellow member of American College of Cardiology. He has served on several committees such as scientific section, academic section and vascular section. He also is an Associate member fellow of Society of Coronary angiography and Interventions. He has served on several committees including carotid stent and International membership. Dr. Shah received the award for distinguished physician at Houston Methodist Hospital in 2011.

Description of Research

Dr. Shah has been a primary investigator of more than 20 clinical trials at Houston Methodist Hospital.

Over the last decade, he has been involved with several clinical trials advancing new stent design and its wider clinical applications. Currently he is involved in clinical research for the Bioabsorbable stent in Coronary arteries. Such devices have the potential of promoting vascular healing by preventing long term neoatheresclerosis and restoring vasomotion. Dr. Shah is an integral part of the Heart Team at Houston Methodist Hospital which continues to look at optimizing outcomes of stenting vs. bypass surgery. He is involved in utilizing Fractional Flow Reserve Measurement as a guiding tool to perform selective coronary interventions in patients with multi vessel disease and comparing it to bypass surgery. He has been and continues to lead clinical research in complex coronary anatomy such as Left main artery stenting, Revascularisation and stenting of Chronic total occlusion and brachytherapy for coronary restenosis especially in the Drug eluting stent era. He is also interested in anti platelet therapy and its duration after stenting and its optimization with novel coronary stent designs or anti platelet agents.

Dr. Shah has particular research interest in advancing the field of Carotid artery stenting. After leading several trials at Houston Methodist Hospital, he is currently involved in assessing the benefit of stent compared to medical therapy in patients with asymptomatic carotid stenosis, a study which is sponsored by NIH. He also has interest in using Robotic navigation system to perform interventions in Carotid as well as endovascular arterial space.

Areas Of Expertise

Peripheral arterial disease Valvular heart disease Angioplasty Coronary stenting Carotid artery stenting Cardiac catherization Coronary atherectomy Coronary brachytherapy Complex coronary interventions Renal artery stenting
Education & Training

Clinical Fellowship, Baylor College of Medicine
Residency, Albert Einstein College Hospital
MD, University of Baroda
Active Clinical Trials




Percutaneous coronary intervention before transcatheter aortic valve implantation: A propensity score matched analysis
Khan, SU, Dani, SS, Ganatra, S, Ahmed, T, Agalan, A, Khadke, S, Agarwal, S, Zaid, S, Arshad, HB, Zahid, S, Shah, AR, Goel, SS & Kleiman, N 2024, , Cardiovascular Revascularization Medicine.

Outcomes With Intravascular Ultrasound and Optical Coherence Tomography Guidance in Percutaneous Coronary Intervention
Arora, S, Jaswaney, R, Khawaja, T, Jain, A, Khan, SU, Gidwani, UK, Osman, MN, Goel, S, Shah, AR & Kleiman, NS 2023, , American Journal of Cardiology, vol. 207, pp. 470-478.

Three-Year Outcomes After Bifurcation Stenting With Zotarolimus-Eluting Stents: Final Results From the RESOLUTE ONYX Postapproval Study
Price, MJ, Boutis, L, Kirtane, AJ, Chetcuti, S, Poliaciková, P, Dens, J, Attubato, M, Wang, Y, Hu, P, Spriggs, D, Krasnow, J, Chatzizisis, Y, Aminian, A, Caputo, R, Shah, A, Dauler, M, Ibrahim, S, Lung, TH & Mehran, R 2023, , Journal of the Society for Cardiovascular Angiography and Interventions, vol. 2, no. 6, 101116.

Assessment of Repeat Revascularization in Percutaneous Coronary Intervention Randomized Controlled Trials as a Surrogate for Mortality: A Meta-Regression Analysis
Khan, SU, Lone, AN, Akbar, UA, Arshad, HB, Arshad, A, Arora, S, Kaluski, E, Aoun, J, Goel, SS, Shah, AR & Kleiman, NS 2023, , Current Problems in Cardiology, vol. 48, no. 4, 101555, pp. 101555.

Site-level variability in the processes of care and outcomes over time among patients with COVID-19 and myocardial injury: Insights from the American Heart Association's COVID-19 Cardiovascular Disease Registry
Sammour, YM, Spertus, JA, Kennedy, K, Morrow, DA, Daniels, LB, Jones, P, Alger, H, Stevens, L, Shah, A, Goel, SS, de Lemos, JA, Hayek, SS, Sutton, NR & Kleiman, NS 2023, , American Heart Journal Plus: Cardiology Research and Practice, vol. 27, 100265, pp. 100265.

Intravascular imaging guided versus coronary angiography guided percutaneous coronary intervention: Systematic review and meta-Analysis
Khan, SU, Agarwal, S, Arshad, HB, Akbar, UA, Mamas, MA, Arora, S, Baber, U, Goel, SS, Kleiman, NS & Shah, AR 2023, , BMJ, vol. 383, 077848, pp. e077848.

Spontaneous Coronary Artery Dissection: An Elusive Disease of the Coronaries
Gowda, SN, Sathyanarayanan, SP & Shah, A 2022, , Methodist DeBakey cardiovascular journal, vol. 18, no. 3, pp. 89-93.

Computed tomography angiography co-registration with real-time fluoroscopy in percutaneous coronary intervention for chronic total occlusions
Xenogiannis, I, Jaffer, FA, Shah, AR, Omer, M, Megaly, M, Vemmou, E, Nikolakopoulos, I, Rangan, BV, Garcia, S, Lesser, JR, Cavalcante, JL, Burke, MN & Brilakis, ES 2021, , EuroIntervention, vol. 17, no. 5, pp. e433-e435.

Outcomes of patients with moderate-to-severe Ischemia excluded from the ischemia trial
Al-Mallah, MH, Ahmed, AI, Nabi, F, Chang, SM, Kleiman, NS, Chamsi-Pasha, MA, Shah, A, Han, Y, Zoghbi, WA & Mahmarian, JJ 2022, , Journal of Nuclear Cardiology, vol. 29, no. 3, pp. 1100-1105.

Impacto de la adherencia a un algoritmo híbrido para la selección de la estrategia inicial de cruce en la intervención coronaria percutánea de oclusiones crónicas
Xenogiannis, I, Alaswad, K, Krestyaninov, O, Khelimskii, D, Khatri, JJ, Choi, JW, Jaffer, FA, Patel, M, Mahmud, E, Doing, AH, Dattilo, P, Koutouzis, M, Tsiafoutis, I, Uretsky, B, Jefferson, BK, Patel, T, Jaber, W, Samady, H, Sheikh, AM, Yeh, RW, Tamez, H, Elbarouni, B, Love, MP, Abi Rafeh, N, Maalouf, A, Fadi, AJ, Toma, C, Shah, AR, Chandwaney, RH, Omer, M, Megaly, MS, Vemmou, E, Nikolakopoulos, I, Rangan, BV, Garcia, S, Abdullah, S, Banerjee, S, Burke, MN, Karmpaliotis, D & Brilakis, ES 2021, , Revista Espanola de Cardiologia, vol. 74, no. 12, pp. 1024-1032.

Impact of network performance on remote robotic-assisted endovascular interventions in porcine model
Legeza, P, Britz, GW, Shah, A, Sconzert, K, Sungur, JM, Chinnadurai, P, Sinha, K & Lumsden, AB 2022, , Journal of Robotic Surgery, vol. 16, no. 1, pp. 29-35.

Follow-up outcomes after chronic total occlusion percutaneous coronary intervention in patients with and without prior coronary artery bypass graft surgery: Insights from the progress-cto registry
Nikolakopoulos, I, Choi, JW, Khatri, JJ, Alaswad, K, Doing, AH, Dattilo, P, Rafeh, NA, Maalouf, A, Jaoudeh, FA, Tamez, H, Shah, A, Gkargkoulas, F, Lembo, NJ, Parikh, M, Kirtane, AJ, Ali, ZA, Vemmou, E, Xenogiannis, I, Rangan, BV, Abdullah, S, Banerjee, S, Garcia, S, Burke, MN, Brilakis, ES & Karmpaliotis, D 2020, , Journal of Invasive Cardiology, vol. 32, no. 8, pp. 315-320.

C-reactive protein and prognosis after percutaneous coronary intervention and bypass graft surgery for left main coronary artery disease: Analysis from the EXCEL trial
Kosmidou, I, Redfors, B, Chen, S, Crowley, A, Lembo, NJ, Karmpaliotis, D, Brown, WM, Maupas, E, Durrleman, N, Shah, A, Reardon, MJ, Dressler, O, Ben-Yehuda, O, Kappetein, AP, Sabik, JF, Serruys, PW & Stone, GW 2019, , American Heart Journal, vol. 210, pp. 49-57.

Chronic Total Occlusion Coronary Intervention: In Search of a Definitive Benefit
Shah, A 2018, , Methodist DeBakey cardiovascular journal, vol. 14, no. 1, pp. 50-59.

9-Month Clinical and Angiographic Outcomes of the COBRA Polyzene-F NanoCoated Coronary Stent System
Cutlip, DE, Garratt, KN, Novack, V, Barakat, M, Meraj, P, Maillard, L, Erglis, A, Jauhar, R, Popma, JJ, Stoler, R, Silber, S, Cutlip, D, Allaqaband, S, Caputo, R, Beohar, N, Brown, D, Garratt, K, Jauhar, R, George, J, Varghese, V, Huth, M, Larrain, G, Lee, T, Malik, A, Martin, S, McGarry, T, Phillips, C, Shah, A, Stoler, R, Ball, M, Price, RJ, Rossi, J, Taylor, C, Tolleson, T, Nicholson, W, Kesanakurthy, S, Shoukfeh, M, Finn, A, Devireddy, C, Shoultz, C, Robbins, M, Kiesz, R, Menon, P, Weilenmann, D, Sievert, H, Stankovic, G, Berland, J, Delarche, N, Hirsch, JL, Maillard, L, Shayne, J, Serra, A, Fernandez-Ortiz, A, Monassier, JP & Silber, S 2017, , JACC: Cardiovascular Interventions, vol. 10, no. 2, pp. 160-167.

Guidewire and microcatheter utilization patterns during antegrade wire escalation in chronic total occlusion percutaneous coronary intervention: Insights from a contemporary multicenter registry
Karatasakis, A, Tarar, MNJ, Karmpaliotis, D, Alaswad, K, Yeh, RW, Jaffer, FA, Wyman, RM, Lombardi, WL, Grantham, JA, Kandzari, DE, Lembo, NJ, Moses, JW, Kirtane, AJ, Parikh, M, Garcia, S, Doing, A, Pershad, A, Shah, A, Patel, M, Bahadorani, J, Shoultz, CA, Danek, BA, Thompson, CA, Banerjee, S & Brilakis, ES 2017, , Catheterization and Cardiovascular Interventions, vol. 89, no. 4, pp. E90-E98.

Assessment of acute right ventricular dysfunction induced by right coronary artery occlusion using echocardiographic atrioventricular plane displacement
Shah, AR, Grodman, R, Salazar, MF, Rehman, NU, Coppola, J & Braff, R 2000, , Echocardiography, vol. 17, no. 6 I, pp. 513-519.

External migration of an infected subcutaneous ICD patch through mammary tissue
Shah, AR, Rehman, NU, Shaikh, N & Isber, N 1999, , Journal of Cardiovascular Electrophysiology, vol. 10, no. 12.