Alessandro Grattoni

Alessandro Grattoni, PhD

Professor of Nanomedicine, Academic Institute
Full Member, Research Institute
Chair, Department of Nanomedicine
Frank J. and Jean Raymond Centennial Chair, Houston Methodist


Grattoni Lab


Biography

Dr. Alessandro Grattoni obtained his bachelors and masters degrees in Mechanical Engineering at the Politecnico of Torino, Turin, Italy in 2005. During his masters degree thesis, he studied the osmotic pressure of non-ideal solutions though nanoporous membranes. This work produced two publications and two patents. A few months after starting graduate school in Biomedical Engineering at Politecnico of Torino in 2006, Alessandro Grattoni joined Dr. Mauro Ferrari’s research team as a visiting student in the Department of Nanomedicine and Biomedical Engineering at the University of Texas Health Science Center at Houston. In this new context, he engaged in the study of transport phenomena in silicon nanofluidic devices for drug delivery.

At the beginning of 2007, he began directing one of the four research platforms, the nanochannel Delivery System (nDS) project. Since then he has coordinated the work of his colleagues in the development and validation of nanochannel membranes for long-term administration of therapeutics from implantable capsules. His research focuses on the experimental and phenomenological analysis of concentration-driven transport in nanoconfinement tools and mathematical models of the nanofluidic system. Additionally he analyzes electrokinetic transport in nanochannels for the purpose of modulating the release of therapeutics from reservoirs. In collaboration with NanoMedical Systems Inc. of Austin, TX, Dr. Grattoni is working to translate innovations in nDS technology to clinical applications.

In April 2009 he was awarded the Heinlein Trust Microgravity Award to support diffusion experiments in microgravity conditions on-board the SpaceX Dragon spacecraft in early 2011. In May 2009 he completed his Ph.D. studies with fifteen peer-reviewed publications and five patent applications. In October 2010, he became an Assistant Member of The Methodist Hospital Research Institute and an Interim Co-Chair of the Nanomedicine Program.

Description of Research

Dr. Grattoni's research focuses on the development and clinical translation of implantable nanofluidic technologies for drug delivery, molecular sieving and cell transplantation. Silicon-based nanochannel membranes are developed for the controlled delivery of therapeutics by exploiting nanoscale physics, achieving a constant or tunable sustained release of molecules for extended periods of time. Dr. Grattoni’s research relates to the experimental and theoretical analysis of molecular transport at the nanoscale and the in vivo investigation of long term, sustained delivery of therapeutics. Dr. Grattoni's research has received the support of NASA and State of Texas Emerging Technology Funds, as well as from NanoMedical Systems, Inc.

Areas Of Expertise

Nanomedicine Nanofluidics Drug delivery Implantable devices Silicon technologies Space medicine
Education & Training

MSc, Politecnico di Torino
PhD, Politecnico di Torino
Postdoctoral Fellowship, University of Texas Health Science Center at Houston
Publications

Localization of drug biodistribution in a 3D-bioengineered subcutaneous neovascularized microenvironment
Capuani, S, Hernandez, N, Paez-Mayorga, J, Dogra, P, Wang, Z, Cristini, V, Chua, CYX, Nichols, JE & Grattoni, A 2022, , Materials Today Bio, vol. 16, pp. 100390. https://doi.org/10.1016/j.mtbio.2022.100390

Localization of drug biodistribution in a 3D-bioengineered subcutaneous neovascularized microenvironment
Capuani, S, Hernandez, N, Paez-Mayorga, J, Dogra, P, Wang, Z, Cristini, V, Chua, CYX, Nichols, JE & Grattoni, A 2022, , Materials Today Bio, vol. 16, 100390. https://doi.org/10.1016/j.mtbio.2022.100390

Biomedical microdevices: the next phase of highlighting scientific discoveries in the field of micro-nanotechnologies for medicine
Grattoni, A & Han, A 2022, , Biomedical Microdevices, vol. 24, no. 1, 1. https://doi.org/10.1007/s10544-021-00601-z

Engineered implantable vaccine platform for continuous antigen-specific immunomodulation
Viswanath, DI, Liu, HC, Capuani, S, Vander Pol, RS, Saunders, SZ, Chua, CYX & Grattoni, A 2022, , Biomaterials, vol. 281, 121374. https://doi.org/10.1016/j.biomaterials.2022.121374

Emerging nanotechnologies in cardiovascular medicine
Grattoni, A & Cooke, JP 2022, , Nanomedicine: Nanotechnology, Biology, and Medicine, vol. 39, 102472. https://doi.org/10.1016/j.nano.2021.102472

Emerging biomaterial-based strategies for personalized therapeutic in situ cancer vaccines
Viswanath, DI, Liu, HC, Huston, DP, Chua, CYX & Grattoni, A 2022, , Biomaterials, vol. 280, 121297. https://doi.org/10.1016/j.biomaterials.2021.121297, https://doi.org/10.1016/j.biomaterials.2021.121297

Emerging biomaterial-based strategies for personalized therapeutic in situ cancer vaccines
Viswanath, DI, Liu, HC, Huston, DP, Chua, CYX & Grattoni, A 2022, , Biomaterials, vol. 280, 121297. https://doi.org/10.1016/j.biomaterials.2021.121297

Advanced strategies to thwart foreign body response to implantable devices
Capuani, S, Malgir, G, Chua, CYX & Grattoni, A 2022, , Bioengineering and Translational Medicine. https://doi.org/10.1002/btm2.10300

Emerging local immunomodulatory strategies to circumvent systemic immunosuppression in cell transplantation
Campa-Carranza, JN, Paez-Mayorga, J, Chua, CYX, Nichols, JE & Grattoni, A 2022, , Expert Opinion on Drug Delivery, vol. 19, no. 5, pp. 1-16. https://doi.org/10.1080/17425247.2022.2076834

Comprehensive Analysis of Electrostatic Gating in Nanofluidic Systems
Di Trani, N, Racca, N, Demarchi, D & Grattoni, A 2022, , ACS Applied Materials and Interfaces, vol. 14, no. 31, pp. 35400-35408. https://doi.org/10.1021/acsami.2c08809

Hyaluronate-thiol passivation enhances gold nanoparticle peritumoral distribution when administered intratumorally in lung cancer
Terracciano, R, Carcamo-Bahena, Y, Butler, EB, Demarchi, D, Grattoni, A & Filgueira, CS 2021, , Biomedicines, vol. 9, no. 11, 1561. https://doi.org/10.3390/biomedicines9111561

Long-acting tunable release of amlodipine loaded PEG-PCL micelles for tailored treatment of chronic hypertension
Di Trani, N, Liu, HC, Qi, R, Viswanath, DI, Liu, X, Chua, CYX & Grattoni, A 2021, , Nanomedicine: Nanotechnology, Biology, and Medicine, vol. 37, 102417. https://doi.org/10.1016/j.nano.2021.102417

Silicon carbide-gated nanofluidic membrane for active control of electrokinetic ionic transport
Silvestri, A, Di Trani, N, Canavese, G, Ros, PM, Iannucci, L, Grassini, S, Wang, Y, Liu, X, Demarchi, D & Grattoni, A 2021, , Membranes, vol. 11, no. 7, 535. https://doi.org/10.3390/membranes11070535

Long-acting tunable release of amlodipine loaded PEG-PCL micelles for tailored treatment of chronic hypertension
Di Trani, N, Liu, HC, Qi, R, Viswanath, DI, Liu, X, Chua, CYX & Grattoni, A 2021, , Nanomedicine: Nanotechnology, Biology, and Medicine, vol. 37, 102417. https://doi.org/10.1016/j.nano.2021.102417

Tenofovir Alafenamide for HIV Prevention: Review of the Proceedings from the Gates Foundation Long-Acting TAF Product Development Meeting
Romano, JW, Baum, MM, Demkovich, ZR, DIana, F, Dobard, C, Feldman, PL, Garcia-Lerma, JG, Grattoni, A, Gunawardana, M, Ho, DK, Hope, TJ, Massud, I, Milad, M, Moss, JA, Pons-Faudoa, FP, Roller, S, Van Der Straten, A, Srinivasan, S, Veazey, RS & Zane, D 2021, , AIDS Research and Human Retroviruses, vol. 37, no. 6, pp. 409-420. https://doi.org/10.1089/aid.2021.0028

Carbon fiber reinforced polymers for implantable medical devices
Chua, CYX, Liu, HC, Di Trani, N, Susnjar, A, Ho, J, Scorrano, G, Rhudy, J, Sizovs, A, Lolli, G, Hernandez, N, Nucci, MC, Cicalo, R, Ferrari, M & Grattoni, A 2021, , Biomaterials, vol. 271, 120719. https://doi.org/10.1016/j.biomaterials.2021.120719

Preventive Efficacy of a Tenofovir Alafenamide Fumarate Nanofluidic Implant in SHIV-Challenged Nonhuman Primates
Pons-Faudoa, FP, Sizovs, A, Shelton, KA, Momin, Z, Niles, JA, Bushman, LR, Xu, J, Chua, CYX, Nichols, JE, Demaria, S, Ittmann, MM, Hawkins, T, Rooney, JF, Marzinke, MA, Kimata, JT, Anderson, PL, Nehete, PN, Arduino, RC, Ferrari, M, Sastry, KJ & Grattoni, A 2021, , advanced therapeutics, vol. 4, no. 3, 2000163. https://doi.org/10.1002/adtp.202000163

Preventive efficacy of a tenofovir alafenamide fumarate nanofluidic implant in SHIV-challenged nonhuman primates
Pons-Faudoa, FP, Sizovs, A, Shelton, KA, Momin, Z, Niles, JA, Bushman, LR, Xu, J, Chua, CYX, Nichols, JE, Demaria, S, Ittmann, MM, Hawkins, T, Rooney, JF, Marzinke, MA, Kimata, JT, Anderson, PL, Nehete, PN, Arduino, RC, Ferrari, M, Sastry, KJ & Grattoni, A 2021, , Advanced Therapeutics, vol. 4, no. 3. https://doi.org/10.1002/adtp.202000163

Effects of surface protein adsorption on the distribution and retention of intratumorally administered gold nanoparticles
Terracciano, R, Zhang, A, Butler, EB, Demarchi, D, Hafner, JH, Grattoni, A & Filgueira, CS 2021, , Pharmaceutics, vol. 13, no. 2, 216, pp. 1-19. https://doi.org/10.3390/pharmaceutics13020216

Effects of surface protein adsorption on the distribution and retention of intratumorally administered gold nanoparticles
Terracciano, R, Zhang, A, Butler, EB, Demarchi, D, Hafner, JH, Grattoni, A & Filgueira, CS 2021, , Pharmaceutics, vol. 13, no. 2, 216, pp. 1-19. https://doi.org/10.3390/pharmaceutics13020216