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Alessandro Grattoni, PhD

Professor of Nanomedicine, Academic Institute
Full Member, Research Institute
Chair, Department of Nanomedicine
Frank J. and Jean Raymond Centennial Chair, Houston Methodist


Biography

Dr. Alessandro Grattoni obtained his bachelors and masters degrees in Mechanical Engineering at the Politecnico of Torino, Turin, Italy in 2005. During his masters degree thesis, he studied the osmotic pressure of non-ideal solutions though nanoporous membranes. This work produced two publications and two patents. A few months after starting graduate school in Biomedical Engineering at Politecnico of Torino in 2006, Alessandro Grattoni joined Dr. Mauro Ferrari’s research team as a visiting student in the Department of Nanomedicine and Biomedical Engineering at the University of Texas Health Science Center at Houston. In this new context, he engaged in the study of transport phenomena in silicon nanofluidic devices for drug delivery.

At the beginning of 2007, he began directing one of the four research platforms, the nanochannel Delivery System (nDS) project. Since then he has coordinated the work of his colleagues in the development and validation of nanochannel membranes for long-term administration of therapeutics from implantable capsules. His research focuses on the experimental and phenomenological analysis of concentration-driven transport in nanoconfinement tools and mathematical models of the nanofluidic system. Additionally he analyzes electrokinetic transport in nanochannels for the purpose of modulating the release of therapeutics from reservoirs. In collaboration with NanoMedical Systems Inc. of Austin, TX, Dr. Grattoni is working to translate innovations in nDS technology to clinical applications.

In April 2009 he was awarded the Heinlein Trust Microgravity Award to support diffusion experiments in microgravity conditions on-board the SpaceX Dragon spacecraft in early 2011. In May 2009 he completed his Ph.D. studies with fifteen peer-reviewed publications and five patent applications. In October 2010, he became an Assistant Member of The Methodist Hospital Research Institute and an Interim Co-Chair of the Nanomedicine Program.

Description of Research

Dr. Grattoni's research focuses on the development and clinical translation of implantable nanofluidic technologies for drug delivery, molecular sieving and cell transplantation. Silicon-based nanochannel membranes are developed for the controlled delivery of therapeutics by exploiting nanoscale physics, achieving a constant or tunable sustained release of molecules for extended periods of time. Dr. Grattoni’s research relates to the experimental and theoretical analysis of molecular transport at the nanoscale and the in vivo investigation of long term, sustained delivery of therapeutics. Dr. Grattoni's research has received the support of NASA and State of Texas Emerging Technology Funds, as well as from NanoMedical Systems, Inc.

Areas Of Expertise

Nanomedicine Nanofluidics Drug delivery Implantable devices Silicon technologies Space medicine
Education & Training

MSc, Politecnico di Torino
PhD, Politecnico di Torino
Postdoctoral Fellowship, The University of Texas Health Science Center
Publications

Neovascularized implantable cell homing encapsulation platform with tunable local immunosuppressant delivery for allogeneic cell transplantation
Paez-Mayorga, J, Capuani, S, Hernandez, N, Farina, M, Chua, YX, Blanchard, R, Sizovs, A, Liu, HC, Fraga, DW, Niles, JA, Salazar, HF, Corradetti, B, Sikora, AG, Kloc, M, Li, XC, Gaber, AO, Nichols, J & Grattoni, A 2020, , Biomaterials, vol. 257, 120232. https://doi.org/10.1016/j.biomaterials.2020.120232

Gold Nanoparticles Radio-Sensitize and Reduce Cell Survival in Lewis Lung Carcinoma
Pandey, A, Vighetto, V, Di Marzio, N, Ferraro, F, Hirsch, M, Ferrante, N, Mitra, S, Grattoni, A & Filgueira, CS 2020, , Nanomaterials, vol. 10, no. 9. https://doi.org/10.3390/nano10091717

Trans-urocanic acid enhances tenofovir alafenamide stability for long-acting HIV applications
Sizovs, A, Pons-Faudoa, FP, Malgir, G, Shelton, KA, Bushman, LR, Chua, YX, Anderson, PL, Nehete, PN, Sastry, KJ & Grattoni, A 2020, , International Journal of Pharmaceutics, vol. 587, 119623. https://doi.org/10.1016/j.ijpharm.2020.119623

Silicon nanofluidic membrane for electrostatic control of drugs and analytes elution
Di Trani, N, Silvestri, A, Wang, Y, Demarchi, D, Liu, X & Grattoni, A 2020, , Pharmaceutics, vol. 12, no. 7, 679, pp. 1-16. https://doi.org/10.3390/pharmaceutics12070679

Electrostatically gated nanofluidic membrane for ultra-low power controlled drug delivery
Di Trani, N, Silvestri, A, Sizovs, A, Wang, Y, Erm, DR, Demarchi, D, Liu, X & Grattoni, A 2020, , Lab on a Chip, vol. 20, no. 9, pp. 1562-1576. https://doi.org/10.1039/d0lc00121j

Finite-Size Charged Species Diffusion and pH Change in Nanochannels
Di Trani, N, Pimpinelli, A & Grattoni, A 2020, , ACS Applied Materials and Interfaces, vol. 12, no. 10, pp. 12246-12255. https://doi.org/10.1021/acsami.9b19182

Preventive efficacy of a tenofovir alafenamide fumarate nanofluidic implant in SHIV-challenged nonhuman primates
Pons-Faudoa, FP, Sizovs, A, Shelton, KA, Momin, Z, Bushman, LR, Xu, J, Chua, CYX, Nichols, JE, Hawkins, T, Rooney, JF, Marzinke, MA, Kimata, JT, Anderson, PL, Nehete, PN, Arduino, RC, Ferrari, M, Sastry, KJ & Grattoni, A 2020, , bioRxiv, pp. 2020.05.13.091694. https://doi.org/10.1101/2020.05.13.091694

Enhanced In Vivo Vascularization of 3D-Printed Cell Encapsulation Device Using Platelet-Rich Plasma and Mesenchymal Stem Cells
Paez-Mayorga, J, Capuani, S, Farina, M, Lotito, ML, Niles, JA, Salazar, HF, Rhudy, J, Esnaola, L, Chua, CYX, Taraballi, F, Corradetti, B, Shelton, KA, Nehete, PN, Nichols, JE & Grattoni, A 2020, , Advanced Healthcare Materials, vol. 9, no. 19, 2000670. https://doi.org/10.1002/adhm.202000670

Potentiating Antitumor Efficacy Through Radiation and Sustained Intratumoral Delivery of Anti-CD40 and Anti-PDL1
Liu, HC, Viswanath, DI, Pesaresi, F, Xu, Y, Zhang, L, Di Trani, N, Paez-Mayorga, J, Hernandez, N, Wang, Y, Erm, DR, Ho, J, Susnjar, A, Liu, X, Demaria, S, Chen, SH, Teh, BS, Butler, EB, Xuan Chua, CY & Grattoni, A 2020, , International Journal of Radiation Oncology Biology Physics. https://doi.org/10.1016/j.ijrobp.2020.07.2326

Technologies for intrapericardial delivery of therapeutics and cells
Filgueira, CS, Igo, SR, Wang, DK, Hirsch, M, Schulz, DG, Bruckner, BA & Grattoni, A 2019, , Advanced Drug Delivery Reviews, vol. 151-152, pp. 222-232. https://doi.org/10.1016/j.addr.2019.02.006

2-Hydroxypropyl-ß-cyclodextrin-enhanced pharmacokinetics of cabotegravir from a nanofluidic implant for HIV pre-exposure prophylaxis
Pons-Faudoa, FP, Sizovs, A, Di Trani, N, Paez-Mayorga, J, Bruno, G, Rhudy, J, Manohar, M, Gwenden, K, Martini, C, Chua, YX, Varchi, G, Marzinke, MA & Grattoni, A 2019, , Journal of Controlled Release, vol. 306, pp. 89-96. https://doi.org/10.1016/j.jconrel.2019.05.037

Remotely controlled nanofluidic implantable platform for tunable drug delivery
Di Trani, N, Silvestri, A, Bruno, G, Geninatti, T, Chua, CYX, Gilbert, A, Rizzo, G, Filgueira, CS, Demarchi, D & Grattoni, A 2019, , Lab on a Chip, vol. 19, no. 13, pp. 2192-2204. https://doi.org/10.1039/c9lc00394k

Advanced implantable drug delivery technologies: transforming the clinical landscape of therapeutics for chronic diseases
Pons-Faudoa, FP, Ballerini, A, Sakamoto, J & Grattoni, A 2019, Biomedical Microdevices, vol. 21, no. 2, 47. https://doi.org/10.1007/s10544-019-0389-6

Nanofluidic microsystem for sustained intraocular delivery of therapeutics
Di Trani, N, Jain, P, Chua, CYX, Ho, JS, Bruno, G, Susnjar, A, Pons-Faudoa, FP, Sizovs, A, Lyle Hood, R, Smith, ZW, Ballerini, A, Filgueira, CS & Grattoni, A 2019, , Nanomedicine: Nanotechnology, Biology, and Medicine, vol. 16, pp. 1-9. https://doi.org/10.1016/j.nano.2018.11.002

METHOD AND APPARATUS FOR THE FAIL-SAFE TERMINATION OF IN VIVO DRUG DELIVERY FROM AN IMPLANTABLE DRUG DELIVERY SYSTEM
Farina, M, Hood, RL & Grattoni, A 2018, , Patent No. US2018280617, IPC No. A61M 5/ 142 A I.

Transcutaneously refillable nanofluidic implant achieves sustained level of tenofovir diphosphate for HIV pre-exposure prophylaxis
Chua, CYX, Jain, P, Ballerini, A, Bruno, G, Hood, RL, Gupte, M, Gao, S, Di Trani, N, Susnjar, A, Shelton, K, Bushman, LR, Folci, M, Filgueira, CS, Marzinke, MA, Anderson, PL, Hu, M, Nehete, P, Arduino, RC, Sastry, JK & Grattoni, A 2018, , Journal of Controlled Release, vol. 286, pp. 315-325. https://doi.org/10.1016/j.jconrel.2018.08.010

Nanofluidic drug-eluting seed for sustained intratumoral immunotherapy in triple negative breast cancer
Chua, YX, Jain, P, Susnjar, A, Rhudy, J, Folci, M, Ballerini, A, Gilbert, A, Singh, S, Bruno, G, Filgueira, CS, Yee, C, Butler, EB & Grattoni, A 2018, , Journal of Controlled Release, vol. 285, pp. 23-34. https://doi.org/10.1016/j.jconrel.2018.06.035

Transcutaneously refillable, 3D-printed biopolymeric encapsulation system for the transplantation of endocrine cells
Farina, M, Chua, YX, Ballerini, A, Thekkedath, U, Alexander, JF, Rhudy, JR, Torchio, G, Fraga, D, Pathak, RR, Villanueva, M, Shin, CS, Niles, JA, Sesana, R, Demarchi, D, Sikora, AG, Acharya, GS, Gaber, AO, Nichols, J & Grattoni, A 2018, , Biomaterials, vol. 177, pp. 125-138. https://doi.org/10.1016/j.biomaterials.2018.05.047

Efficacy of sustained delivery of GC-1 from a Nanofluidic system in a spontaneously obese non-human primate: a case study
Filgueira, CS, Bruno, G, Smith, ZW, Chua, YX, Ballerini, A, Folci, M, Gilbert, AL, Jain, P, Sastry, JK, Nehete, PN, Shelton, KA, Hill, LR, Ali, A, Youker, KA & Grattoni, A 2018, , Biomedical Microdevices, vol. 20, no. 2, 49. https://doi.org/10.1007/s10544-018-0296-2

Adipocytes impair efficacy of antiretroviral therapy
Couturier, J, Winchester, LC, Suliburk, JW, Wilkerson, GK, Podany, AT, Agarwal, N, Xuan Chua, CY, Nehete, PN, Nehete, BP, Grattoni, A, Sastry, KJ, Fletcher, CV, Lake, JE, Balasubramanyam, A & Lewis, DE 2018, , Antiviral Research, vol. 154, pp. 140-148. https://doi.org/10.1016/j.antiviral.2018.04.002