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Alessandro Grattoni, PhD

Professor of Nanomedicine, Institute for Academic Medicine
Full Member, Research Institute
Chair, Department of Nanomedicine
Houston Methodist


Biography

Dr. Alessandro Grattoni obtained his bachelors and masters degrees in Mechanical Engineering at the Politecnico of Torino, Turin, Italy in 2005. During his masters degree thesis, he studied the osmotic pressure of non-ideal solutions though nanoporous membranes. This work produced two publications and two patents. A few months after starting graduate school in Biomedical Engineering at Politecnico of Torino in 2006, Alessandro Grattoni joined Dr. Mauro Ferrari’s research team as a visiting student in the Department of Nanomedicine and Biomedical Engineering at the University of Texas Health Science Center at Houston. In this new context, he engaged in the study of transport phenomena in silicon nanofluidic devices for drug delivery.

At the beginning of 2007, he began directing one of the four research platforms, the nanochannel Delivery System (nDS) project. Since then he has coordinated the work of his colleagues in the development and validation of nanochannel membranes for long-term administration of therapeutics from implantable capsules. His research focuses on the experimental and phenomenological analysis of concentration-driven transport in nanoconfinement tools and mathematical models of the nanofluidic system. Additionally he analyzes electrokinetic transport in nanochannels for the purpose of modulating the release of therapeutics from reservoirs. In collaboration with NanoMedical Systems Inc. of Austin, TX, Dr. Grattoni is working to translate innovations in nDS technology to clinical applications.

In April 2009 he was awarded the Heinlein Trust Microgravity Award to support diffusion experiments in microgravity conditions on-board the SpaceX Dragon spacecraft in early 2011. In May 2009 he completed his Ph.D. studies with fifteen peer-reviewed publications and five patent applications. In October 2010, he became an Assistant Member of The Methodist Hospital Research Institute and an Interim Co-Chair of the Nanomedicine Program.

Description of Research

Dr. Grattoni's research focuses on the development and clinical translation of implantable nanofluidic technologies for drug delivery, molecular sieving and cell transplantation. Silicon-based nanochannel membranes are developed for the controlled delivery of therapeutics by exploiting nanoscale physics, achieving a constant or tunable sustained release of molecules for extended periods of time. Dr. Grattoni’s research relates to the experimental and theoretical analysis of molecular transport at the nanoscale and the in vivo investigation of long term, sustained delivery of therapeutics. Dr. Grattoni's research has received the support of NASA and State of Texas Emerging Technology Funds, as well as from NanoMedical Systems, Inc.

Areas Of Expertise

Nanomedicine Nanofluidics Drug delivery Implantable devices Silicon technologies Space medicine
Education & Training

MSc, Politecnico di Torino
PhD, Politecnico di Torino
Postdoctoral Fellowship, The University of Texas Health Science Center
Publications

Unexpected behaviors in molecular transport through size-controlled nanochannels down to the ultra-nanoscale
Bruno, G, Di Trani, N, Hood, RL, Zabre, E, Filgueira, CS, Canavese, G, Jain, P, Smith, Z, Demarchi, D, Hosali, S, Pimpinelli, A, Ferrari, M & Grattoni, A 2018, Nature communications, vol. 9, no. 1, 1682. DOI: 10.1038/s41467-018-04133-8

Nanofluidic microsystem for sustained intraocular delivery of therapeutics
Di Trani, N, Jain, P, Chua, CYX, Ho, JS, Bruno, G, Susnjar, A, Pons-Faudoa, FP, Sizovs, A, Lyle Hood, R, Smith, ZW, Ballerini, A, Filgueira, CS & Grattoni, A 2018, Nanomedicine: Nanotechnology, Biology, and Medicine. DOI: 10.1016/j.nano.2018.11.002

Nanofluidic drug-eluting seed for sustained intratumoral immunotherapy for cancer treatment
Chua, CYX, Filgueira, CS & Grattoni, A 2018, SITC 33rd Annual Meeting, Washington DC, United States, 11/9/18 - 11/11/18, .

METHOD AND APPARATUS FOR THE FAIL-SAFE TERMINATION OF IN VIVO DRUG DELIVERY FROM AN IMPLANTABLE DRUG DELIVERY SYSTEM
Farina, M, Hood, RL & Grattoni, A 2018, , Patent No. US2018280617, IPC No. A61M 5/ 142 A I.

Transcutaneously refillable nanofluidic implant achieves sustained level of tenofovir diphosphate for HIV pre-exposure prophylaxis
Chua, CYX, Jain, P, Ballerini, A, Bruno, G, Hood, RL, Gupte, M, Gao, S, Di Trani, N, Susnjar, A, Shelton, K, Bushman, LR, Folci, M, Filgueira, CS, Marzinke, MA, Anderson, PL, Hu, M, Nehete, P, Arduino, RC, Sastry, JK & Grattoni, A 2018, Journal of Controlled Release, vol. 286, pp. 315-325. DOI: 10.1016/j.jconrel.2018.08.010

Intratumoral Immunotherapy Delivery via Minimally Invasive Nanochannel Implant
Grattoni, A & Susnjar, A 2018, 3rd Bioengineering and Translational Medicine Conference , Boston, United States, 9/27/18 - 9/27/18, .

Intratumoral Immunotherapy Delivery Via Minimally Invasive Nanochannel Implant
Susnjar, A, Chua, CYX, Rhudy, JR, Ho, J, Jain, P, Singh, S, Yee, C, Filgueira, CS, Butler, EB & Grattoni, A 2018, 2018 AIChE Annual Meeting, 3rd Bioengineering & Translational Medicine Conference, Boston, United States, 9/27/18 - 9/28/18, .

Nanofluidic drug-eluting seed for sustained intratumoral immunotherapy for triple negative breast cancer
Grattoni, A & Susnjar, A 2018, 16th International Nanomedicine & Drug Delivery Symposium, Portland, United States, 9/23/18 - 9/23/18, .

Nanofluidic Systems for controlled drug and cell delivery for medicine on-Earth and in space
Chua, CYX, Di Trani, N, Farina, M, Filgueira, CS, Hirsch, M, Ho, J, Liu, X, Lotito, ML, Paez-Mayorga, J, Pons-Faudoa, FP, Rhudy, JR, Silvestri, A, Sizovs, A, Susnjar, A & Grattoni, A 2018, 16th International Nanomedicine & Drug Delivery Symposium, Portland, United States, 9/23/18 - 9/23/18, .

Metal Nanoparticle Radiosensitization and Immunotherapy as a Therapeutic Strategy for Non-Small Cell Lung Cancers
Hirsch, M, Vighetto, V, Di Marzio, N, Ferraro, F, Pandey, A, Liu, H, Xuan Chua, CY, Mitra, S, Sikora, AG, Halas, NJ, Filgueira, CS & Grattoni, A 2018, NanoX Symposium, Houston, United States, 9/21/18 - 9/21/18, .

Nanofluidic drug-eluting seed for sustained intratumoral immunotherapy in triple negative breast cancer
Chua, CYX, Jain, P, Susnjar, A, Rhudy, J, Folci, M, Ballerini, A, Gilbert, A, Singh, S, Bruno, G, Filgueira, CS, Yee, C, Butler, EB & Grattoni, A 2018, Journal of Controlled Release, vol. 285, pp. 23-34. DOI: 10.1016/j.jconrel.2018.06.035

Transcutaneously refillable, 3D-printed biopolymeric encapsulation system for the transplantation of endocrine cells
Farina, M, Chua, CYX, Ballerini, A, Thekkedath, U, Alexander, JF, Rhudy, JR, Torchio, G, Fraga, D, Pathak, RR, Villanueva, M, Shin, CS, Niles, JA, Sesana, R, Demarchi, D, Sikora, AG, Acharya, GS, Gaber, AO, Nichols, JE & Grattoni, A 2018, Biomaterials, vol. 177, pp. 125-138. DOI: 10.1016/j.biomaterials.2018.05.047

Metal Nanoparticle Radiosensitization and Immunotherapy as a Therapeutic Strategy for Non-Small Cell Lung Cancers
Hirsch, M, Vighetto, V, Di Marzio, N, Ferraro, F, Pandey, A, Liu, H, Xuan Chua, CY, Mitra, S, Sikora, AG, Halas, NJ, Filgueira, CS & Grattoni, A 2018, 6th Annual Houston Methodist Cancer Symposium, Houston, United States, 8/17/18 - 8/17/18, .

Delivery of Prostaglandins to the Pericardium
Estrella, C, Di Marzio, N, Hirsch, M, Igo, SR, Filgueira, CS & Grattoni, A 2018, 2018 Summer Undergraduate Internship Poster Retreat, Houston, United States, 8/8/18 - 8/8/18, .

Nanofluidic microsystem for sustained intraocular delivery of therapeutics
Grattoni, A, Di Trani, N, Ho, J, Chua, CYX, Jain, P, Bruno, G, Hood, RL, Smith, WZ, Ballerini, A & Filgueira, CS 2018, 2018 Methodist Association for Professional Affairs (MAPTA) Summer Symposium, 8/3/18, .

Active control of gated nanochannels membrane for therapeutics dose modulation
Grattoni, A, Silvestri, A & Di Trani, N 2018, 2018 Methodist Association for Professional Affairs (MAPTA) Summer Symposium, 8/3/18, .

Transcutaneously Refillable Nanofluidic System for HIV PrEP
Grattoni, A, Xuan Chua, CY, Jain, P, Ballerini, A, Bruno, G, Hood, RL, Gupte, AA, Gao, S, Di Trani, N, Susnjar, A, Shelton, KA, Bushman, LR, Folci, M, Filgueira, CS, Marzinke, MA, Anderson, PL, Hu, M, Nehete, P, Arduino, RC & Sastry, KJ 2018, 2018 Methodist Association for Professional Affairs (MAPTA) Summer Symposium, 8/3/18, .

Radioimmunotherapy via an Implantable Nanochannel Delivery Platform for Treatment of Solid Tumors
Grattoni, A, Ho, JS, Xuan Chua, CY, Susnjar, A, Rhudy, JR, Di Marzio, N & Stenning-Persivale, K 2018, 2018 Methodist Association for Professional Affairs (MAPTA) Summer Symposium, 8/3/18, .

2-hydrxypropyl-ß cyclodextrin enhances sustained release of cabotegravir from nanochannel delivery implant for HIV pre-exposure prophylaxis
Grattoni, A, Pons-Faudoa, FP, Sizovs, A, Bruno, G & Di Trani, N 2018, 2018 Methodist Association for Professional Affairs (MAPTA) Summer Symposium, 8/3/18, .

Radiosensitization of Gold Nanoparticles as a Therapeutic for Non-Small Cell Lung Cancers
Hirsch, M, Vighetto, V, Di Marzio, N, Ferraro, F, Pathak, R, Pandey, A, Liu, H-C, Villanueva, M, Chua, CYX, Mitra, S, Sikora, AG, Halas, NJ, Filgueira, CS & Grattoni, A 2018, 2018 Methodist Association for Professional Affairs (MAPTA) Summer Symposium, 8/3/18, .