Alan R. Prossin

Alan R. Prossin, MD

Adjunct Assistant Professor of Neurology, Academic Institute
Assistant Affiliate Member, Research Institute
Houston Methodist


Description of Research

Develop a greater understanding of molecular mediators and moderators underlying neuroimmune interactions in co-morbid pain and depression. Develop a greater understanding of how personality/coping styles contribute to state and trait disparities in central and peripheral immune activation, and how these disparities impact pain states and depression. Develop novel research paradigms to translate robust findings from psychoneuroimmunology research in animal models to humans and subsequently, to develop more efficacious immune based treatment strategies in negative affective states.

Publications

PET Imaging of Peripheral Benzodiazepine Receptor Standard Uptake Value Increases After Controlled Cortical Impact, a Rodent Model of Traumatic Brain Injury
Aertker, BM, Kumar, A, Cardenas, F, Gudenkauf, F, Sequeira, D, Prossin, AR, Srivastava, AK, Cox, CS & Bedi, SS 2021, , ASN Neuro, vol. 13. https://doi.org/10.1177/17590914211014135

Out of the Mouths of Babes: Links Between Linguistic Structure of Loss Narratives and Psychosocial Functioning in Parentally Bereaved Children
Kaplow, JB, Wardecker, BM, Layne, CM, Kross, E, Burnside, A, Edelstein, RS & Prossin, AR 2018, , Journal of Traumatic Stress, vol. 31, no. 3, pp. 342-351. https://doi.org/10.1002/jts.22293

Functional TSPO polymorphism predicts variance in the diurnal cortisol rhythm in bipolar disorder
Prossin, AR, Chandler, M, Ryan, KA, Saunders, EF, Kamali, M, Papadopoulos, V, Zöllner, S, Dantzer, R & McInnis, MG 2018, , Psychoneuroendocrinology, vol. 89, pp. 194-202. https://doi.org/10.1016/j.psyneuen.2018.01.013

Cohort profile: The Heinz C. Prechter longitudinal study of bipolar disorder
For the Prechter Bipolar Clinical Research Collaborative 2018, , International Journal of Epidemiology, vol. 47, no. 1, dyx218, pp. 28-28n. https://doi.org/10.1093/ije/dyx229

Ketamine potentiates oxidative stress and influences behavior and inflammation in response to lipolysaccharide (LPS) exposure in early life
Réus, GZ, Simões, LR, Colpo, GD, Scaini, G, Oses, JP, Generoso, JS, Prossin, AR, Kaddurah-Daouk, R, Quevedo, J & Barichello, T 2017, , Neuroscience, vol. 353, pp. 17-25. https://doi.org/10.1016/j.neuroscience.2017.04.016

Bipolar disorder moderates associations between linoleic acid and markers of inflammation
Chang, YW, Assari, S, Prossin, AR, Stertz, L, McInnis, MG & Evans, SJ 2017, , Journal of Psychiatric Research, vol. 85, pp. 29-36. https://doi.org/10.1016/j.jpsychires.2016.10.021

Reduced inhibitory control mediates the relationship between cortical thickness in the right superior frontal gyrus and body mass index
Lavagnino, L, Mwangi, B, Bauer, IE, Cao, B, Selvaraj, S, Prossin, A & Soares, JC 2016, , Neuropsychopharmacology, vol. 41, no. 9, pp. 2275-2282. https://doi.org/10.1038/npp.2016.26

A follow-up study of 50 chronic Hepatitis C patients: Adiponectin as a resilience biomarker for major depression
Fábregas, BC, Vieira, ÉLM, Moura, AS, Carmo, RA, Ávila, RE, Abreu, MNS, Prossin, AR & Teixeira, AL 2016, , NeuroImmunoModulation, vol. 23, no. 2, pp. 88-97. https://doi.org/10.1159/000444531

Experimental sadness induces relevant interactions between central endogenous opioid activation and plasma IL-18 concentrations in depressed volunteers
Prossin, AR, Koch, AE, Campbell, PL, Barichello, T, Zalcman, SS & Zubieta, JK 2016, , Molecular Psychiatry, vol. 21, no. 2, pp. 151. https://doi.org/10.1038/mp.2015.213

Acute experimental changes in mood state regulate immune function in relation to central opioid neurotransmission: A model of human CNS-peripheral inflammatory interaction
Prossin, AR, Koch, AE, Campbell, PL, Barichello, T, Zalcman, SS & Zubieta, JK 2016, , Molecular Psychiatry, vol. 21, no. 2, pp. 243-251. https://doi.org/10.1038/mp.2015.110

Peripheral inflammation during abnormal mood states in bipolar I disorder
Fiedorowicz, JG, Prossin, AR, Johnson, CP, Christensen, GE, Magnotta, VA & Wemmie, JA 2015, , Journal of Affective Disorders, vol. 187, pp. 172-8. https://doi.org/10.1016/j.jad.2015.08.036

Dynamic interactions between plasma IL-1 family cytokines and central endogenous opioid neurotransmitter function in humans
Prossin, AR, Zalcman, SS, Heitzeg, MM, Koch, AE, Campbell, PL, Phan, KL, Stohler, CS & Zubieta, JK 2015, , Neuropsychopharmacology, vol. 40, no. 3, pp. 554-565. https://doi.org/10.1038/npp.2014.202

Cytomegalovirus antibody elevation in bipolar disorder: Relation to elevated mood states
Prossin, AR, Yolken, RH, Kamali, M, Heitzeg, MM, Kaplow, JB, Coryell, WH & McInnis, MG 2015, , Neural Plasticity, vol. 2015, 939780. https://doi.org/10.1155/2015/939780

Psychological and Environmental Correlates of HPA Axis Functioning in Parentally Bereaved Children: Preliminary Findings
Kaplow, JB, Shapiro, DN, Wardecker, BM, Howell, KH, Abelson, JL, Worthman, CM & Prossin, AR 2013, , Journal of Traumatic Stress, vol. 26, no. 2, pp. 233-240. https://doi.org/10.1002/jts.21788

A pilot study investigating tumor necrosis factor-a as a potential intervening variable of atypical antipsychotic-associated metabolic syndrome in bipolar disorder
Prossin, AR, Zalcman, SS, Evans, SJ, McInnis, MG & Ellingrod, VL 2013, , Therapeutic Drug Monitoring, vol. 35, no. 2, pp. 194-202. https://doi.org/10.1097/FTD.0b013e31827e18d2

Association of plasma omega-3 and omega-6 lipids with burden of disease measures in bipolar subjects
Evans, SJ, Kamali, M, Prossin, AR, Harrington, GJ, Ellingrod, VL, McInnis, MG & Burant, CF 2012, , Journal of Psychiatric Research, vol. 46, no. 11, pp. 1435-1441. https://doi.org/10.1016/j.jpsychires.2012.07.016

Associations between suicide attempts and elevated bedtime salivary cortisol levels in bipolar disorder
Kamali, M, Saunders, EFH, Prossin, AR, Brucksch, CB, Harrington, GJ, Langenecker, SA & McInnis, MG 2012, , Journal of Affective Disorders, vol. 136, no. 3, pp. 350-358. https://doi.org/10.1016/j.jad.2011.11.027

Fats and factors: Lipid profiles associate with personality factors and suicidal history in bipolar subjects
Evans, SJ, Prossin, AR, Harrington, GJ, Kamali, M, Ellingrod, VL, Burant, CF & McInnis, MG 2012, , PLoS ONE, vol. 7, no. 1, e29297. https://doi.org/10.1371/journal.pone.0029297

Association of plasma interleukin-18 levels with emotion regulation and µ-opioid neurotransmitter function in major depression and healthy volunteers
Prossin, AR, Koch, AE, Campbell, PL, McInnis, MG, Zalcman, SS & Zubieta, JK 2011, , Biological Psychiatry, vol. 69, no. 8, pp. 808-812. https://doi.org/10.1016/j.biopsych.2010.10.014

A genetic network model of cellular responses to lithium treatment and cocaine abuse in bipolar disorder
McEachin, RC, Chen, H, Sartor, MA, Saccone, SF, Keller, BJ, Prossin, AR, Cavalcoli, JD & McInnis, MG 2010, , BMC systems biology, vol. 4, 158. https://doi.org/10.1186/1752-0509-4-158