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Aijun Zhang, MD, MS

Assistant Research Professor of Bioenergetics, Academic Institute
Assistant Research Member, Research Institute
Houston Methodist
Weill Cornell Medical College


Areas Of Expertise

Mitochondria
Publications

Polymer-Functionalized Mitochondrial Transplantation to Fibroblasts Counteracts a Pro-Fibrotic Phenotype
Baudo, G, Wu, S, Massaro, M, Liu, H, Lee, H, Zhang, A, Hamilton, DJ & Blanco, E 2023, , International journal of molecular sciences, vol. 24, no. 13, 10913. https://doi.org/10.3390/ijms241310913

Polymer-Functionalized Mitochondrial Transplantation to Fibroblasts Counteracts a Pro-Fibrotic Phenotype
Baudo, G, Wu, S, Massaro, M, Liu, H, Lee, H, Zhang, A, Hamilton, DJ & Blanco, E 2023, , International journal of molecular sciences, vol. 24, no. 13, 10913. https://doi.org/10.3390/ijms241310913

An ERK5-NRF2 Axis Mediates Senescence-Associated Stemness and Atherosclerosis
Abe, J-I, Imanishi, M, Li, S, Zhang, A, Ko, KA, Samanthapudi, VSK, Lee, L-L, Bojorges, AP, Gi, YJ, Hobbs, BP, Deswal, A, Herrmann, J, Lin, SH, Chini, EN, Shen, YH, Schadler, KL, Nguyen, T-H-M, Gupte, AA, Reyes-Gibby, C, Yeung, S-CJ, Abe, RJ, Olmsted-Davis, EA, Krishnan, S, Dantzer, R, Palaskas, NL, Cooke, JP, Pownall, HJ, Yoshimoto, M, Fujiwara, K, Hamilton, DJ, Burks, JK, Wang, G, Le, N-T & Kotla, S 2023, , Circulation Research, vol. 133, no. 1, pp. 25-44. https://doi.org/10.1161/CIRCRESAHA.122.322017

RELATIVE COMPLEX I & II SOURCED ROS IN HUMAN PROSTATE CANCER
Zhang, A, Hamkins, S, Vedula, I, Ayala, A, Miles, BJ & Hamilton, DJ 2023, , International Conference on Oxidative Stress Reduction, Redox Homeostasis and Antioxidants, Paris, France, 6/21/23.

AIBP Regulates Metabolism of Ketone and Lipids but Not Mitochondrial Respiration
Kim, JD, Zhou, T, Zhang, A, Li, S, Gupte, AA, Hamilton, DJ & Fang, L 2022, , Cells, vol. 11, no. 22, 3643. https://doi.org/10.3390/cells11223643, https://doi.org/10.3390/cells11223643

Mitochondrial DNA damage-repair defects in mutant FUS-linked motor neuron diseases and its mitigation via targeted expression of DNA Ligase I
Wang, H, Kodavati, M, Guo, W, Mitra, J, Zhang, A, Mitra, S, Tomkinson, AE, Hamilton, DJ, Van Den Bosch, L & Hegde, M 2022, , 7th US-EU Conference on Endogenous DNA Damage and Repair, Newyork, United States, 11/6/22 - 11/9/22.

Enhanced Succinate Oxidation with Mitochondrial Complex II Reactive Oxygen Species Generation in Human Prostate Cancer
Zhang, A, Gupte, AA, Chatterjee, S, Li, S, Ayala, A, Miles, BJ & Hamilton, DJ 2022, , International journal of molecular sciences, vol. 23, no. 20, 12168, pp. 12168. https://doi.org/10.3390/ijms232012168, https://doi.org/10.3390/ijms232012168

Suppression of FOXP3 expression by the AP-1 family transcription factor BATF3 requires partnering with IRF4
Arnold, PR, Wen, M, Zhang, L, Ying, Y, Xiao, X, Chu, X, Wang, G, Zhang, X, Mao, Z, Zhang, A, Hamilton, DJ, Chen, W & Li, XC 2022, , Frontiers in immunology, vol. 13, 966364, pp. 966364. https://doi.org/10.3389/fimmu.2022.966364, https://doi.org/10.3389/fimmu.2022.966364

Suppression of FOXP3 expression by the AP-1 family transcription factor BATF3 requires partnering with IRF4
Arnold, PR, Wen, M, Zhang, L, Ying, Y, Xiao, X, Chu, X, Wang, G, Zhang, X, Mao, Z, Zhang, A, Hamilton, DJ, Chen, W & Li, XC 2022, , Frontiers in immunology, vol. 13, 966364. https://doi.org/10.3389/fimmu.2022.966364

ATF4/TXNIP/REDD1/mTOR signaling mediates the antitumor activities of liver X receptor in pancreatic cancers
Chen, Z, Xiaobo, L, Ding, H, Zhang, A, Sun, Y, Ling, J, Chiao, P, Chen, Z & Xia, X 2022, , Cancer Innovation, vol. 1, no. 1, pp. 55-69. https://doi.org/10.1002/cai2.12

ATF4/TXNIP/REDD1/mTOR signaling mediates the antitumor activities of liver X receptor in pancreatic cancers
Chen, Z, Lai, X, Ding, H, Zhang, A, Sun, Y, Ling, J, Chiao, PJ, Chen, Z & Xia, X 2022, , Cancer Innovation, vol. 1, no. 1, pp. 55-69. https://doi.org/10.1002/cai2.12

The Role of Calcium Signaling in Melanoma
Zhang, H, Chen, Z, Zhang, A, Gupte, AA & Hamilton, DJ 2022, , International journal of molecular sciences, vol. 23, no. 3, 1010. https://doi.org/10.3390/ijms23031010

Polymer-Functionalized Mitochondrial Transplantation to Plaque Macrophages as a Therapeutic Strategy Targeting Atherosclerosis
Liu, H, Wu, S, Lee, H, Baudo, G, Massaro, M, Zhang, A, Hamilton, DJ & Blanco, E 2022, , advanced therapeutics, vol. 5, no. 5, 2100232. https://doi.org/10.1002/adtp.202100232

NAD+ depletion-induced vascular senescence via p90RSK-ERK5 S496 phosphorylation
Kotla, S, Zhang, A, Imanishi, M, Lin, SH, Le, N-T, Hamilton, DJ & Abe, JI 2022, , Cell Symposia, Lisbon, Portugal, 4/3/22 - 4/5/22.

Nucleus-mitochondria positive feedback loop formed by ERK5 S496 phosphorylation-mediated poly (ADP-ribose) polymerase activation provokes persistent pro-inflammatory senescent phenotype and accelerates coronary atherosclerosis after chemo-radiation
Kotla, S, Zhang, A, Imanishi, M, Ko, KA, Lin, SH, Gi, YJ, Moczygemba, M, Isgandarova, S, Schadler, KL, Chung, C, Milgrom, SA, Banchs, J, Yusuf, SW, Amaya, DN, Guo, H, Thomas, TN, Shen, YH, Deswal, A, Herrmann, J, Kleinerman, ES, Entman, ML, Cooke, JP, Schifitto, G, Maggirwar, SB, McBeath, E, Gupte, AA, Krishnan, S, Patel, ZS, Yoon, Y, Burks, JK, Fujiwara, K, Brookes, PS, Le, N-T, Hamilton, DJ & Abe, J-I 2021, , Redox Biology, vol. 47, 102132, pp. 102132. https://doi.org/10.1016/j.redox.2021.102132

Antagonistic surround responses in different cones are mediated by feedback synapses from different horizontal cells
Zhang, AJ & Wu, SM 2021, , Vision Research, vol. 186, pp. 13-22. https://doi.org/10.1016/j.visres.2021.03.013

Antagonistic surround responses in different cones are mediated by feedback synapses from different horizontal cells
Zhang, AJ & Wu, SM 2021, , Vision Research, vol. 186, pp. 13-22. https://doi.org/10.1016/j.visres.2021.03.013

Plumbagin elicits cell-specific cytotoxic effects and metabolic responses in melanoma cells
Zhang, H, Zhang, A, Gupte, AA & Hamilton, DJ 2021, , Pharmaceutics, vol. 13, no. 5, 706. https://doi.org/10.3390/pharmaceutics13050706

DNAzyme Cleavage of CAG Repeat RNA in Polyglutamine Diseases
Zhang, N, Bewick, B, Schultz, J, Tiwari, A, Krencik, R, Zhang, A, Adachi, K, Xia, G, Yun, K, Sarkar, P & Ashizawa, T 2021, , Neurotherapeutics, vol. 18, no. 3, pp. 1710-1728. https://doi.org/10.1007/s13311-021-01075-w

Stress-induced premature aging mediated by mitochoindrial hibernation promotes atherosclerosis
Kotla, S, Zhang, A, Imanishi, M, Ae Ko, K, Lin, S, Gi, Y, Fujiwara, K, Burks, JK, Le, N-T, Hamilton, DJ & Abe, JI 2020, , The 21st International Vascular Biology Meeting, 9/9/20 - 9/12/20.

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