Not found

Yuliang Zhao, PhD

Full Affiliate Member, Research Institute
Houston Methodist


Biography

Dr. Yuliang Zhao earned his Ph.D. in Chemical Science from the Tokyo Metropolitan University in 1999. He held faculty appointments at the Chinese Academy of Sciences in Beijing before becoming a member of Houston Methodist Research Institute in 2011. Dr. Zhao also holds adjunct faculty appointments at Peking University (Beijing), the Medical School of Jilin University (Changchun), and Sichuan University (Chengdu).

As the the founder and Director of CAS Key Lab for Biomedical Effects of Nanomaterials & Nanosafety, he directs a research program that is developing a new generation of cancer chemotherapeutics using low-toxic nanoparticles. Dr. Zhao has also been a member of nine study sections and review boards in China and Europe. He is the founder and Director of Research Center for Cancer Nanotechnology at Tianjin Cancer Hospital in China. He has served as the Associate Editor and editorial board member of seven scientific research journals since 2006.

Description of Research

Dr. Zhao's research program focuses on nanotoxicology, cancer nanotechnology, and nanochemistry. He is developing molecular dynamics modeling for designing low-toxic nanosurfaces for cancer nanotechnology applications, and for lowering the toxicity of nanomaterials in living systems. A major aim of his research is to understand the mechanisms of nanotoxicity of engineered nanoparticles in vivo. In addition, a major research goal is to characterize the structure-function relationships between the tumor microenvironment (like extracellular matrices) and engineered nanoparticles that inhibit tumor growth and metastasis. Dr. Zhao's research team at CAS collaborates with Dr. Mauro Ferrari, Dr. Ye "Tony" Hu and other faculty members of the Department of Nanomedicine at the Research Institute in the research of cancer nanotechnology and nanotechnology based biomarker identification.

Areas Of Expertise

Nanotoxicology Cancer nanotechnology Chemistry Nanoscale molecular dynamics modeling
Education & Training

Postdoctoral Fellowship, Japan Society for the Promotion of Science, Tokyo Metropolitan University, Tokyo
PhD, Tokyo Metropolitan University
Publications

Molecular mechanism of Gd@C82(OH)22 increasing collagen expression: Implication for encaging tumor
Liu, J, Kang, SG, Wang, P, Wang, Y, Lv, X, Liu, Y, Wang, F, Gu, Z, Yang, Z, Weber, JK, Tao, N, Qin, Z, Miao, Q, Chen, C, Zhou, R & Zhao, Y 2018, Biomaterials, vol 152, pp. 24-36. DOI: 10.1016/j.biomaterials.2017.10.027

Application of multifunctional nanomaterials in tumor radiosensitization
Gong, L, Xie, J, Zhu, S, Gu, Z & Zhao, Y 2018, Wuli Huaxue Xuebao/ Acta Physico - Chimica Sinica, vol 34, no. 2, pp. 140-167. DOI: 10.3866/PKU.WHXB201707174

Bifunctional Tellurium Nanodots for Photo-Induced Synergistic Cancer Therapy
Yang, T, Ke, H, Wang, Q, Tang, YA, Deng, Y, Yang, H, Yang, X, Yang, P, Ling, D, Chen, C, Zhao, Y, Wu, H & Chen, H 2017, ACS Nano, vol 11, no. 10, pp. 10012-10024. DOI: 10.1021/acsnano.7b04230

Metallofullerenol Inhibits Cellular Iron Uptake by Inducing Transferrin Tetramerization
Li, J, Xing, X, Sun, B, Zhao, Y & Wu, Z 2017, Chemistry - An Asian Journal, vol 12, no. 20, pp. 2646-2651. DOI: 10.1002/asia.201700910

The effects of orally administered Ag, TiO2 and SiO2 nanoparticles on gut microbiota composition and colitis induction in mice
Chen, H, Zhao, R, Wang, B, Cai, C, Zheng, L, Wang, H, Wang, M, Ouyang, H, Zhou, X, Chai, Z, Zhao, Y & Feng, W 2017, NanoImpact, vol 8, pp. 80-88. DOI: 10.1016/j.impact.2017.07.005

Ultrasmall Superparamagnetic Iron Oxide Nanoparticle for T2-Weighted Magnetic Resonance Imaging
Wang, Y, Xu, C, Chang, Y, Zhao, L, Zhang, K, Zhao, Y, Gao, F & Gao, X 2017, ACS Applied Materials and Interfaces, vol 9, no. 34, pp. 28959-28966. DOI: 10.1021/acsami.7b10030

Photothermal Effect Enhanced Cascade-Targeting Strategy for Improved Pancreatic Cancer Therapy by Gold Nanoshell@Mesoporous Silica Nanorod
Zhao, R, Han, X, Li, Y, Wang, H, Ji, T, Zhao, Y & Nie, G 2017, ACS Nano, vol 11, no. 8, pp. 8103-8113. DOI: 10.1021/acsnano.7b02918

Fullerenol inhibits the cross-talk between bone marrow-derived mesenchymal stem cells and tumor cells by regulating MAPK signaling
Nie, X, Tang, J, Liu, Y, Cai, R, Miao, Q, Zhao, Y & Chen, C 2017, Nanomedicine: Nanotechnology, Biology, and Medicine, vol 13, no. 6, pp. 1879-1890. DOI: 10.1016/j.nano.2017.03.013

Polyoxometalate-Based Radiosensitization Platform for Treating Hypoxic Tumors by Attenuating Radioresistance and Enhancing Radiation Response
Yong, Y, Zhang, C, Gu, Z, Du, J, Guo, Z, Dong, X, Xie, J, Zhang, G, Liu, X & Zhao, Y 2017, ACS Nano, vol 11, no. 7, pp. 7164-7176. DOI: 10.1021/acsnano.7b03037

MoS2-Nanosheet-Assisted Coordination of Metal Ions with Porphyrin for Rapid Detection and Removal of Cadmium Ions in Aqueous Media
Yin, W, Dong, X, Yu, J, Pan, J, Yao, Z, Gu, Z & Zhao, Y 2017, ACS Applied Materials and Interfaces, vol 9, no. 25, pp. 21362-21370. DOI: 10.1021/acsami.7b04185

Design of TPGS-functionalized Cu3BiS3 nanocrystals with strong absorption in the second near-infrared window for radiation therapy enhancement
Du, J, Zheng, X, Yong, Y, Yu, J, Dong, X, Zhang, C, Zhou, R, Li, B, Yan, L, Chen, C, Gu, Z & Zhao, Y 2017, Nanoscale, vol 9, no. 24, pp. 8229-8239. DOI: 10.1039/c7nr02213a

MoS2-Nanosheet-Assisted Coordination of Metal Ions with Porphyrin for Rapid Detection and Removal of Cadmium Ions in Aqueous Media
Yin, W, Dong, X, Yu, J, Pan, J, Yao, Z, Gu, Z & Zhao, Y 2017, ACS Applied Materials and Interfaces, vol 9, no. 25, pp. 21362-21370. DOI: 10.1021/acsami.7b04185

MoS2-Nanosheet-Assisted Coordination of Metal Ions with Porphyrin for Rapid Detection and Removal of Cadmium Ions in Aqueous Media
Yin, W, Dong, X, Yu, J, Pan, J, Yao, Z, Gu, Z & Zhao, Y 2017, ACS Applied Materials and Interfaces, vol 9, no. 25, pp. 21362-21370. DOI: 10.1021/acsami.7b04185

Ceria Nanoparticles as Enzyme Mimetics
Wang, G, Zhang, J, He, X, Zhang, Z & Zhao, Y 2017, Chinese Journal of Chemistry, vol 35, no. 6, pp. 791-800. DOI: 10.1002/cjoc.201600845

Chiral Surface of Nanoparticles Determines the Orientation of Adsorbed Transferrin and Its Interaction with Receptors
Wang, X, Wang, M, Lei, R, Zhu, SF, Zhao, Y & Chen, C 2017, ACS Nano, vol 11, no. 5, pp. 4606-4616. DOI: 10.1021/acsnano.7b00200

Therapeutic Nanoparticles Based on Curcumin and Bamboo Charcoal Nanoparticles for Chemo-Photothermal Synergistic Treatment of Cancer and Radioprotection of Normal Cells
Xie, J, Yong, Y, Dong, X, Du, J, Guo, Z, Gong, L, Zhu, S, Tian, G, Yu, S, Gu, Z & Zhao, Y 2017, ACS Applied Materials and Interfaces, vol 9, no. 16, pp. 14281-14291. DOI: 10.1021/acsami.7b02622

Biodistribution, excretion, and toxicity of polyethyleneimine modified NaYF4: Yb,Er upconversion nanoparticles in mice via different administration routes
Yu, J, Yin, W, Peng, T, Chang, YN, Zu, Y, Li, J, He, X, Ma, X, Gu, Z & Zhao, Y 2017, Nanoscale, vol 9, no. 13, pp. 4497-4507. DOI: 10.1039/c7nr00078b

Au Nanoclusters and Photosensitizer Dual Loaded Spatiotemporal Controllable Liposomal Nanocomposites Enhance Tumor Photodynamic Therapy Effect by Inhibiting Thioredoxin Reductase
Gao, F, Zheng, W, Gao, L, Cai, P, Liu, R, Wang, Y, Yuan, Q, Zhao, Y & Gao, X 2017, Advanced Healthcare Materials, vol 6, no. 7, 1601453. DOI: 10.1002/adhm.201601453

Diverse Applications of Nanomedicine
Pelaz, B, Alexiou, C, Alvarez-Puebla, RA, Alves, F, Andrews, AM, Ashraf, S, Balogh, LP, Ballerini, L, Bestetti, A, Brendel, C, Bosi, S, Carril, M, Chan, WCW, Chen, C, Chen, X, Chen, X, Cheng, Z, Cui, D, Du, J, Dullin, C, Escudero, A, Feliu, N, Gao, M, George, M, Gogotsi, Y, Grünweller, A, Gu, Z, Halas, NJ, Hampp, N, Hartmann, RK, Hersam, MC, Hunziker, P, Jian, J, Jiang, X, Jungebluth, P, Kadhiresan, P, Kataoka, K, Khademhosseini, A, Kopecek, J, Kotov, NA, Krug, HF, Lee, DS, Lehr, CM, Leong, KW, Liang, XJ, Ling Lim, M, Liz-Marzán, LM, Ma, X, Macchiarini, P, Meng, H, Möhwald, H, Mulvaney, P, Nel, AE, Nie, S, Nordlander, P, Okano, T, Oliveira, J, Park, TH, Penner, RM, Prato, M, Puntes, V, Rotello, VM, Samarakoon, A, Schaak, RE, Shen, Y, Sjöqvist, S, Skirtach, AG, Soliman, MG, Stevens, MM, Sung, HW, Tang, BZ, Tietze, R, Udugama, BN, VanEpps, JS, Weil, T, Weiss, PS, Willner, I, Wu, Y, Yang, L, Yue, Z, Zhang, Q, Zhang, Q, Zhang, XE, Zhao, Y, Zhou, X & Parak, WJ 2017, ACS Nano, vol 11, no. 3, pp. 2313-2381. DOI: 10.1021/acsnano.6b06040

mTOR Signaling in Parkinson’s Disease
Lan, AP, Chen, J, Zhao, Y, Chai, Z & Hu, Y 2017, NeuroMolecular Medicine, vol 19, no. 1. DOI: 10.1007/s12017-016-8417-7